最高學歷

美國喬治城大學
細胞生物學博士

研究興趣

致癌基因c-myc所驅動的apoptosis的機轉以及可能的抗藥機制。

探討matriptase在癌症以及正常上皮中所扮演的角色。

研究論文

Chu, L.L., Xu, Y., Yang, J.R., Hu, Y.A., Chang, H.H., Lai, H.Y., Tseng, C.C., Wang, H.Y., Johnson, M.D., Wang, J.K., and Lin, C.Y. (2014) Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activation. PLoS One 9(3), e92244. doi: 10.1371/journal.pone.0092244. eCollection (co-corresponding author) （IF = 3.73; Multidisciplinary Sciences, 7/56 = 12.5%）

Wang, J.K., Teng, I.J., Lo, T.J., Moore, S., Yeo, Y.H., Teng, Y.C., Kaul, M., Chen, C.C., Zuo, A.H., Chou, F.P., Yang, X., Tseng, I.C., Johnson, M.D., and Lin, C.Y. (2014) Matriptase: a molecular sensor of the cellular chemical environment. PLoS One 9(4), e93899. doi: 10.1371/journal.pone.0093899. eCollection （IF = 3.73; Multidisciplinary Sciences, 7/56 = 12.5%）

Chang, H.D., Xu, Y., Lai, H., Yang, X., Tseng, C.C., Lai, Y.J., Pan Y., Zhou, E., Johnson, M.D., Wang, J.K., and Lin, C.Y. (2015) Differential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cells. PLoS One 10(3):e0120489. doi: 10.1371/journal.pone.0120489 (corresponding author) （IF = 3.73; Multidisciplinary Sciences, 7/56 = 12.5%）

Lai, Y.J., Chang, H.H., Lai, H., Xu, Y., Shiao, F., Huang N., Li, L., Lee, M.S., Johnson, M.D., Wang, J.K., and Lin, C.Y. (2015) N-Glycan Branching Affects the Subcellular Distribution of and Inhibition of Matriptase by HAI-2/Placental Bikunin. PLoS One 10(7):e0132163. doi: 10.1371/journal.pone.0132163. eCollection (co-corresponding author) （IF = 3.73; Multidisciplinary Sciences, 7/56 = 12.5%）

Lai, C.H., Lai, Y.-J.J., Chou, F.-P., Chang, H.-H.D., Tseng, C.-C., Johnson, M.D., Wang, J.K., and Lin C.-Y. (2016) Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation. PLoS One 11(4):e0152904. doi: 10.1371/journal.pone.0152904. eCollection PMID: 27043831 (co-corresponding author) （IF = 3.73; Multidisciplinary Sciences, 7/56 = 12.5%）

Chen, C.Y., Chen, C.J., Lai, C.H., Wu, B.Y., Lee, S.P., Johnson, M.D., Lin, C.Y., and Wang, J.K. (2016) Increased Matriptase Zymogen Activation by UV Irradiation Protects Keratinocyte from Cell Death. J. Dermatol. Sci. 83, 34-44 (corresponding author) (IF = 3.762; Dermatology, 7/61 = 11.48%)

Lai, C.H., Chang, S.C., Chen, Y.J., Wang, Y.-J.J., Lai, Y.-J.J., Chang, H.-H.D., Berens, E.B., Johnson, M.D., Wang, J.K., and Lin C.-Y. (2016) Matriptase and prostasin are expressed in human skin in an inverse trend over the course of differentiation and are targeted to different regions of the plasma membrane. Biology Open, 5, 1380-1387. (co-corresponding author) (IF = 2.135; Biology, 24/86 = 27.9%)

Su, H.C., Liang, Y.A., Lai, Y.-J.J., Chiu, Y.-L., Barndt, R.B., Shiao, F., Chang, H.-H.D., Lu, D.D., Huang, N., Tseng, C.-C., Wang, J.-K., Lee, M.-S., Johnson, M.D., Huang, S.-M., and Lin, C.-Y. (2016) Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled manner. PLoS One 11(12): e0167894. doi:10.1371/journal. pone.0167894（IF = 2.806; Multidisciplinary Sciences, 15/64 = 23.44%）

Shiao, F., Liu, L.O., Huang, N., Lai, Y.J., Barndt, R.J., Tseng, C.C., Wang, J.K., Jia, B., Johnson, M.D., Lin, C.Y. (2017) Selective inhibition of prostasin in human enterocytes by the integral membrane Kunitz-type serine protease inhibitor HAI-2. PLoS One 12(1): e0170944. doi: 10.1371/journal.pone.0170944 (co-corresponding author)（IF = 2.806; Multidisciplinary Sciences, 15/64 = 23.44%）

Tseng, C.C., Jia, B., Barndt, R., Gu, Y., Chen, C.Y., Tseng, I.C., Su, S.F., Wang, J.K., Johnson, M.D., and Lin, C.Y. (2017) Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity. PLoS One 12(8): e0183507. doi: 10.1371/journal.pone.0183507 （IF = 2.806; Multidisciplinary Sciences, 15/64 = 23.44%）

Lee, S.P., Kao, C.Y., Chang, S.C., Chiu, Y.L., Chen, Y.J., Chen, M.-H. G., Chang, C.C., Lin, Y.W., Chiang, C.P., Wang, J.K., Lin, C.Y., and Johnson, M.D. (2018) Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin. PLoS One 13(2): e0192632. https://doi.org/10.1371/journal.pone.0192632（IF = 2.806; Multidisciplinary Sciences, 15/64 = 23.44%）

Chiu, Y.L., Wu, Y.Y., Barndt, R.B., Yeo, Y.H., Lin, Y.W., Sytwo, H.P., Liu, H.C., Xu, Y., Jia, B., Wang, J.K., Johnson, M.D., and Lin, C.Y. (2019) Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HA-2. Journal of Enzyme Inhibition and Medical Chemistry 34(1), 692-702. (IF = 4.027; Chemistry, medicinal, 10/61 = 15.6%)