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醫學科學研究所 Graduate Institute of Medical Sciences
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::: 專任教師

張心儀 助理教授

張心儀 助理教授      

現職

國防醫學院醫學科學研究所助理教授
台灣蛋白體學會理事

學位

國立臺灣大學細胞與分子細胞生物學博士
國立臺灣大學細胞與分子細胞生物學碩士
國立臺灣師範大學生命科學學士

聯絡分機

(02) 8792-3100 ext 18525

E-MAIL

hsinyi.chang@mail.ndmctsgh.edu.tw
hsinyi.chang.ndmc@gmail.com

經歷

臺北醫學大學助理教授 (2019-2021)
日本京都大學助理教授 (2017-2019)
日本京都大學博士後研究員 (2015-2017)
國立台灣大學博士後研究員 (2013-2015)

研究方向

Our laboratory studies fundamental biological questions by mass spectrometry-driven proteomics and metabolomics, including quantitative proteomics, post-translational modifications (PTMs), protein-protein interactome, subcellular proteomics, and targeted/untargeted metabolomics. Currently, our research interest is to map the scope of the critical molecules and post-translational modifications for determining the thermogenesis process in white adipocytes. We are also interested in solving the reprogramming circuits accounting for cancer development. We apply multiomics approaches, e.g. pharmacogenomics for drug repurposition, phosphoproteomics to delineate signal transduction, proteomics methods to discover biomarkers, quantify protein expression profiles, determine protein-protein interaction, and identify bona fide drug targets. This leads our research integrates multi-layer omic data toward translational medicine.

研究論文

1. Hsin-Yuan Chen, Wen-Pin Cheng, Yi-Fen Chiang, Yong-Han Hong, Mohamed Ali, Tsui-Chin Huang, Kai-Lee Wang, Tzong-Ming Shieh, Hsin-Yi Chang, Shih-Min Hsia. (2021) Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE). Int. J. Mol. Sci. 22:8268.
2. Tsui-Chin Huang, Kuan-Chieh Peng, Tzu-Ting Kuo, Li-Chun Lin, Bai-Chia Liu, Shu-Ping Ye, Chien-Chou Chu, Shih-Min Hsia, Hsin-Yi Chang*. (2021) Predicting Agents That Can Overcome 5-FU Resistance in Colorectal Cancers via Pharmacogenomic Analysis. Biomedicines. 9:882.
3. Hsin-Yuan Chen, Yi-Fen Chiang, Kai-Lee Wang, Tsui-Chin Huang, Mohamed Ali, Tzong-Ming Shieh, Hsin-Yi Chang, Yong-Han Hong, Shih-Min Hsia. (2021) Rice Husk Silica Liquid Protects Pancreatic β Cells from Streptozotocin-Induced Oxidative Damage. Antioxidants. 10:1080.
4. Guan-Wen Chen, Yi-An Chen, Hsin-Yi Chang, Tsui-Chin Huang, Tai-Yuan Chen. (2021) Combined impact of high-pressure processing and slightly acidic electrolysed water on Listeria monocytogenes proteomes. Food Research International. 147:110494.
5. Yi-Fen Chiang, Chih-Hung Tsai, Hsin-Yuan Chen, Kai-Lee Wang, Hsin-Yi Chang, Yun-Ju Huang, Yong-Han Hong, Mohamed Ali, Tzong-Ming Shieh, Tsui-Chin Huang, Ching-I Lin, Shih-Min Hsia. (2021) Protective Effects of Fucoxanthin on Hydrogen Peroxide-Induced Calcification of Heart Valve Interstitial Cells. Mar. Drugs. 19(6):307.
6. Ching-Feng Chiu, Hsin-Yi Chang, Chun-Yine Huang, Chen-Zou Mau, Tzu-Ting Kuo, Hsiu-Chuan Lee, Shih-Yi Huang. (2021) Betulinic Acid Affects the Energy-Related Proteomic Profiling in Pancreatic Ductal Adenocarcinoma Cells. Molecules. 26(9): 2482.
7. Tzu-Ting Kuo*, Hsin-Yi Chang*, Tai-Yuan Chen, Bai-Chia Liu, Hsin-Yi Chen, Yuan-Chin Hsiung, Shih-Min Hsia, Chun-Ju Chang#, Tsui-Chin Huang#. (2020) Melissa officinalis Extract Induces Apoptosis and Inhibits Migration in Human Colorectal Cancer Cells. ACS Omega. 5(49):31792.
8. Chih-Hsiang Chang, Hsin-Yi Chang, Juri Rappsilber, Yasushi Ishihama. (2020) Isolation of acetylated and unmodified protein N-terminal peptides by strong cation exchange chromatographic separation of TrypN-digested peptides. Mol Cell Proteomics. mcp.TIR120.002148.
9. Titus Ime Ekanem, Wei-Lun Tsai, Yi-Hsuan Lin, Wan-Qian Tan, Hsin-Yi Chang, Tsui-Chin Huang, Hsin-Yi Chen, Kuen-Haur Lee. (2020) Identification of the Effects of Aspirin and Sulindac Sulfide on the Inhibition of HMGA2-Mediated Oncogenic Capacities in Colorectal Cancer. Molecules. 25(17):3826.
10. Akihiro Matsumoto, Yuki Takahashi, Hsin-Yi Chang, Yi-Wen Wu, Aki Yamamoto, Yasushi Ishihama, Yoshinobu Takakura. (2020) Blood concentrations of small extracellular vesicles are determined by a balance between abundant secretion and rapid clearance. Journal of Extracellular Vesicles. 9(1): 1696517.
11. Kazuki Tajima, Kenji Ikeda, Hsin-Yi Chang, Chih-Hsiang Chang, Takeshi Yoneshiro, Yasuo Oguri, Heejin Jun, Jun Wu, Yasushi Ishihama, Shingo Kajimura. (2019) Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Nature Metabolism. 1:886-898.
12. Li-Chun Lin*, Tzu-Ting Kuo*, Hsin-Yi Chang, Wen-Shan Liu, Shih-Min Hsia, Tsui-Chin Huang. (2018) Manzamine A Exerts Anticancer Activity against Human Colorectal Cancer Cells. Marine Drugs. 16(8): 252. *Equal contribution.
13. Jean-Michel Fustin#, Rika Kojima*, Kakeru Itoh*, Hsin-Yi Chang*, Shiqi Ye*, Bowen Zhuang, Asami Oji, Shingo Gibo, Rajesh Narasimamurthy, David M. Virshup, Gen Kurosawa, Ichiro Manabe, Yasushi Ishihama, Masahito Ikawa, Hitoshi Okamura#. (2018) Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock. Proceedings of the National Academy of Sciences, USA. 115:5980-5985. *Equal contribution.
14. Hsin-Yi Chang*, Shu-Ping Ye*, Shiow-Lin Pan, Tzu-Ting Kuo, Bia Chia Liu, Yi-Lin Chen, Tsui-Chin Huang#. (2017) Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer. Theranostics. 7(16):3889-3900. *Equal contribution.
15. Chia-Lang Hsu, Hsin-Yi Chang, Jen-Yun Chang, Wen-Ming Hsu, Hsuan-Cheng Huang, and Hsueh-Fen Juan. (2016) Unveiling MYCN regulatory networks in neuroblastoma via integrative analysis of heterogeneous genomics data. Oncotarget. 7(24): 36293-36310.
16. Kosaku Shinoda, Kana Ohyama, Yutaka Hasegawa, Hsin-Yi Chang, Mayu Ogura, Ayaka Sato, Haemin Hong, Takashi Hosono, Louis Z. Sharp, David W. Scheel, Mark Graham, Yasushi Ishihama, and Shingo Kajimura#. (2015) Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. Cell Metabolism. 22(6):997-1088.
17. Hsin-Yi Chang, Ming-Hua Li, Tsui-Chin Huang, Chia-Lang Hsu, Shang-Ru Tsai, Si-Chen Lee#, Hsuan-Cheng Huang#, and Hsueh-Fen Juan#. (2015) Quantitative proteomics reveals middle infrared radiation-interfered networks in breast cancer cells. Journal of Proteome Research. 14(2):1250-62.
18. Hsin-Yi Chang, Tsui-Chin Huang, Nan-Ning Chen, Hsuan-Cheng Huang#, and Hsueh-Fen# Juan. (2014) Combination Therapy Targeting Ectopic ATP Synthase and 26S Proteasome Induces ER Stress in Breast Cancer Cells. Cell Death & Disease. 5:e1540.
19. Wei-Jan Huang, Yen-An Tang, Mei-Yu Chen, Ying-Jan Wang, Fu-Han Hu, Tseng-Wei Wang, Shi-Wei Chao, Hui-Wen Chiu, Ya-Ling Yeh, Hsin-Yi Chang, Hsueh-Fen Juan, Pinpin Lin, Yi-Ching Wang#. (2014) A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies. Cancer Letters. 46(1):84-93.
20. Hsin-Yi Chang*, Meng-Her Shih*, Hsuan-Cheng Huang, Shang-Ru Tsai, Hsueh-Fen Juan#, and Si-Chen Lee#. (2013) Middle Infrared Radiation Induces G2/M Cell Cycle Arrest in A549 Lung Cancer Cells. PLoS One. 8(1):e54117. *Equal contribution.
21. Hsin-Yi Chang, Hsuan-Cheng Huang, Tsui-Chin Huang, Pan-Chyr Yang#, Yi-Ching Wang#, Hsueh-Fen Juan#. (2013) Flow Cytometric Detection of Mitochondrial Membrane Potential. Bio-protocol. 3(8):e430.
22. Hsin-Yi Chang, Hsuan-Cheng Huang, Tsui-Chin Huang, Pan-Chyr Yang#, Yi-Ching Wang#, Hsueh-Fen Juan#. (2013) Flow Cytometric Detection of Reactive Oxygen Species. Bio-protocol. 3(8):e431.
23. Hsin-Yi Chang, Hsuan-Cheng Huang, Tsui-Chin Huang, Pan-Chyr Yang#, Yi-Ching Wang#, Hsueh-Fen Juan#. (2012) Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response. Cancer Research. 72(18):4696-706.
24. Ming-Wei Chang, Jem-Mau Lo, Hsueh-Fen Juan, Hsin-Yi Chang, Chun-Yu Chuang#. (2012) Combination of RGD compound and low-dose paclitaxel induces apoptosis in human glioblastoma cells. PLoS One. 2012;7(5):e37935.
25. Shang-Ru Tsai, Tsui-Chin Huang, Chia-Ming Liang, Hsin-Yi Chang, Yi-Tsung Chang, Hsuan-Cheng Huang, Hsueh-Fen Juan#, Si-Chen Lee#. (2011) The effect of narrow bandwidth infrared radiation on the growth of Escherichia coli. Applied Physics Letters. 99:163704.
26. Tsui-Chin Huang, Hsin-Yi Chang, Cheng-Yu Chen, Pei-Yi Wu, Hsinyu Lee, Yung-Feng Liao, Wen-Ming Hsu#, Hsuan-Cheng Huang#, Hsueh-Fen Juan#. (2011) Silencing of miR-124 induces neuroblastoma cell differentiation, cell cycle arrest and apoptosis through promoting AHR. FEBS Letters. 585(22): 3582-3586.
27. Chiung-Mei Chen, Chih-Hsin Lin, Hsueh-Fen Juan, Fen-Ju Hu, Ya-Chin Hsiao, Hsin-Yi Chang, Chih-Ying Chao, I-Cheng Chen, Li-Ching Lee, Tsu-Wei Wang, Ya-Tang Chen, Yi-Tsun Chen, Guey-Jen Lee-Chen, Yih-Ru Wu#. (2011) ATP13A2 variability in Taiwanese Parkinson's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 156B:720-729.
28. Tsui-Chin Huang*, Hsin-Yi Chang*, Chun-Hua Hsu, Wen-Hung Kuo, King-Jen Chang and Hsueh-Fen Juan#. (2008) Targeting Therapy on Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B. Journal of Proteome Research. 7:1433-1444. *Equal contribution.
29. Tsui-Chin Huang, Hsuan-Cheng Huang, Chih-Chin Chang, Hsin-Yi Chang, Chern-Han Ou, Chun-Hua Hsu, Shui-Tein Chen, Hsueh-Fen Juan#. (2007) An Apoptosis-related Gene Network Induced by Novel Compound-cRGD in Human Breast Cancer Cells. FEBS Letters. 581:3517-3522.

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  • 更新日期:2020-11-27