醫學科學研究所 Graduate Institute of Medical Sciences

::: 專任教師

楊松昇 副教授

楊松昇 副教授      






(02) 8792-3100 ext 88099







研究專長: 分子生物、基因工程、醫學遺傳學






Hsu YJ1, Yang SS, Cheng CJ, Liu ST, Huang SM, Chau T, Chu P, Salter DM, Lee HS, Lin SH.Thiazide-Sensitive Na(+) -Cl(-) Cotransporter (NCC) Gene Inactivation Results in Increased Duodenal Ca(2+) Absorption, Enhanced Osteoblast Differentiation and Elevated Bone Mineral Density.. J Bone Miner Res. 2015 Jan;30(1):116-27

Chiu JJ, Chien S. Effects of disturbed flow on vascular endothelium : Pathophysiological basis and clinical perspectives. Physiol Rev. 2011,91:1-61.

Yang SS, Fang YW, Tseng MH, Chu PY, Yu IS, Wu HC, Lin SW, Chau T, Uchida S, Sasaki S, Lin YF, Sytwu HK, Lin SH*. Phosphorylation Regulates NCC Stability and Transporter Activity In Vivo. J Am Soc Nephrol. 2013 24(10):1587-97

Lin SH, Yu IS, Jiang ST , Lin SW, Chu P, Chen Ann , Sytwu HK, Sohara E, Uchida S, Sasaki S, Yang SS (correspondence) Impaired phosphorylation of Na-K-2Cl cotransporter by OSR1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A 2011 108(42):17538-43 ( NSC 98-2314-B-016-002- MY2; NSC 98-2314-B-016-002- MY2)

Algharabli J, Kintner D, Wang Q, Begum G, Clark P, Currie C, Lee H, Yang SS, Lin SH, Kahle K, Kuo J , and Sun D. Inhibition of Na+-K+-2Cl− cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells. Am J Physiol 2011 (under revision)

Ka SM, Hsieh TT, Lin SH, Yang SS, Wu CC, Sytwu HK, Chen A.Decoy receptor 3 inhibits renal mononuclear leukocyte infiltration and apoptosis and prevents progression of IgA nephropathy in mice. 2011 Sep 7. [Epub ahead of print]

Sung CC, Cheng CJ, Lo YF, Lin MS, Yang SS, Hsu YC, Lin SH. Genotype and Phenotype Analysis of Patients with Sporadic Periodic Paralysis. Am J Med Sci. 2011 Aug 11. [Epub ahead of print]

Chen CC, Wu HC, Hsu YJ, Cheng CJ, Yang SS, Chu P, Lin SH. Hypocalciuria in patients with Gitelman’s syndrome: Role of Hypomagnesemia. Acta Nephrologica, 2011, 25(2) , 70-76.

Cheng CJ, Lin SH, Lo YF, Yang SS, Hsu YJ, Cannon SC, Huang CL. Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis. J Biol Chem. 2011 Aug 5;286(31):27425-35

Yang SS, Lin SH. WNK-SPAK/OSR1-N(K)CC signaling in the kidney. J Med Sci 2011, 31(4),145-155,

Tsai PY; Ka SM, Chang JM, PhD; Chen HC, Shui HA, Li CY, Hua K, Chang WL, Huang JJ; Yang SS, Chen Ann, Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation. Free Radical Biology & Medicine 2011, 51(3):744-54

Lo YF, Yang SS, Seki G, Yamada H, Horita S, Yamazaki O, Fujita T, Usui T, Tsai JD, Yu IS, Lin SW, Lin SH. Severe Metabolic Acidosis Causes Early Lethality in NBC1 W516X Knock-in Mice as a Model of Human Isolated Proximal Renal Tubular Acidosis. Kidney Int 2011 79(7):730-41) (NSC 96-2628-B-016-003- MY3)

Lo YF, Nozu K, Iijima K, Morishita T, Huang CC, Yang SS, Sytwu HK, Fang YW, Tseng MH, Lin SH. Recurrent Deep Intronic Mutations in the SLC12A3 Gene Responsible for Gitelman's Syndrome. Clin J Am Soc Nephrol. 2011 6(3):630-9 ( NSC 98-2314-B-016-002- MY2)

Lin SH, Yang SS, Chau T. A Practical Approach to Genetic Hypokalemia: Electrolyte Blood Press. 2010, 8(1): 38–50.

Yang SS, Lo YF, Yu IS, Lin SW, Chang TH, Hsu YJ, Chao TK, Sytwu HK, Uchida S, Sasaki S and Lin SH. Generation and analysis of the thiazide-sensitive Na+-Cl- cotransporter S707X knockin mice as a model of Gitelman’s syndrome. Hum Mutat. 2010; 31(12) 1304-1315, (NSC 95-2314-B-016-060-MY2; NSC-98-2314-B-016-002-MY2)

Yang SS, Lo YF, Wu CC, Lin SW, Yeh CJ, Chu P, Sytwu HK, Uchida S, Sasaki S, Lin SH. SPAK knockout mice manifest Gitelman’s syndrome and impaired vasoconstriction. J Am Soc Nephrol. 2010, 21; 1868-1877 (NSC 96-2314-B-016-052-MY2; NSC 98-2314-B- 016-003-MY3)

Yang SS, Hsu YJ, Chiga M, Rai T, Uchida S, Sasaki S, Lin SH, Molecular Mechanisms for Hypercalciuria in Pseudohypoaldosteronism Type II –Causing WNK4 Knockin Mice. Endocrinology, 2010, 151(4):1829-1836 (SCI) (NSC-96- 2314-B-016-052-MY2)

Sun MT, Yang SS, Juan CJ, Lin SH Symmetrical brain calcifications. Am J Med, 2010, 123(2): 131-133 (SCI)

Shiang JC, Cheng CJ, Tsai MK, Hung YJ, Hsu YJ, Yang SS, Chu SJ, Lin SH. Therapeutic analysis in Chinese patients with thyrotoxic periodic paralysis over 6 years. Eur J Endocrinol. 2009, 161(6):911-6. (SCI)

Yan MT, Yang SS, Chu HY, Lin SH. Ataxia associated with spurious hyperchloremia: the one behind the scene Am J Emerg Med. 2009 Jul;27(6):752.e1-3. (SCI)

Lin CM, Tsai JD, Lo YF, Yan MT, Yang SS, Lin SH Chronic renal failure in a boy with classic Bartter's syndrome due to a novel mutation in CLCNKB coding for the chloride channel Eur J Pediatr. 2009168(9):1129-33.

Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S. Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion, and lowers blood pressure. Hum Mol Genet. 2009 Oct 15;18(20):3978-86

Yu-Juei Hsu, Sung-Sen Yang, Nain-Feng Chu, Huey-Kang Sytwu, Chih-Jen Cheng and Shih-Hua Lin Heterozygous mutations of the sodium chloride cotransporter in Chinese children: prevalence and association with blood pressure Nephrol Dial Transplant. 2009, 24(4):1170-5 (SCI) (NSC 96-2314 -B-016-037)

Motoko Chiga, Tatemitsu Rai, Sung-Sen Yang, Akihito Ohta, Toichiro Takizawa, Sei Sasaki, Shinichi Uchida. Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int 2008; 74(11):1403-1409 (SCI)

Sung-Sen Yang, Shih-Hua Lin, Chou-Long Huang, Role of WNK kinases in Blood Pressure Control. Current Hypertension Reviews 2008;4(3):161-166 (Review) (SCI)

Chou-Long Huang, Sung-Sen Yang, Shih-Hua Lin Mechanism of regulation of renal ion transport by WNK kinases. Current Opinion in Nephrology and Hypertension 2008; 17(5):519-25. (Review) (SCI)

Sung-Sen Yang, Tetsuji Morimoto, Tatemitsu Rai, Motoko Chiga, Eisei Sohara, Mayuko Ohno, Keiko Uchida, Shih-Hua Lin, Tetsuo Moriguchi, Hiroshi Shibuya, Yoshiaki Kondo, Sei Sasaki, Shinichi Uchida Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4D561A/+ knock-in mouse model. Cell Metabolism 2007; 5(5):331-44 (FEATURED ARTICLE in this issue)

Chih-Jen Cheng; Jen-Chuan Shiang; Yu-Juei Hsu; Sung-Sen Yang; Shih-Hua Lin Hypocalciuria in Patients with Gitelman’s Syndrome: Role of the Blood Volume. Am J Kidney Dis 2007; 49(5): 693-700.(SCI)

Akihito Ohta; Sung-Sen Yang; Tatemitsu Rai; Motoko Chiga; Sei Sasaki, Shinichi Uchida Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells. Biochem Biophys Res Commun. 2006;349(2):804-8. (SCI)

Eisei Sohara; Tatemitsu Rai; Sung-Sen Yang; Keiko Uchida, Kosak Nitta; Shigeru Horita; Mayuko Ohno; Akihiro Harada; Sei Sasaki, Shinichi Uchida Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation.Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14217-22. (SCI)

Kozue Yamauchi; Sung-Sen Yang; Akihito Ohta; Eisei Sohara; Tatemitsu Rai; Sei Sasaki, Shinichi Uchida Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice Biochem. Biophys. Res. Commun.2005: 332(3); 750-755.

Sung-Sen Yang, Kozue Yamauchi, Tatemitsu Rai, Atsushi Hiyama, Eisei Sohara, Tatsunori Suzuki, Tomohiro Itoh, Shin Suda, Sei Sasaki, and Shinichi Uchida Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells Biochem. Biophys. Res. Commun.2005: 330(2); 410-414 (SCI) (Figure on Cover Page)

Feng-Chen Liu, Chiu-An Chen, Sung-Sen Yang, Shih-Hua Lin Acupuncture therapy rapidly terminates intractable hiccups complicating acute myocardial infarction South Med J. 2005 ;98(3):385-387(SCI)

Shih-Hua Lin, Jen-Chuan Shiang, Che-Chung Huang, Sung-Sen Yang, Yu-Juei Hsu, Chih-Jen Cheng, Phenotype and Genotype Analysis in Chinese Patients with Gitelman’s Syndrome. J Clin Endocr Metab 2005: 90 (5); 2500-7 (SCI) (NSC 93-2314-B-016-031)

Yu-Juei Hsu, Tom Chau, Sung-Sen Yang, Weng-Sheng Tsai, Shih-Hua Lin. Rathke’s cleft cyst presenting with hyponatremia and transient central diabetes insipidus . Acat Neueol Scand 2003, 107(5); 382-385. (SCI)

Shih-Hua Lin, Sung-Sen Yang, Tom Chau, Mitchell L Healperin. An unusual cause of hypokalemic paralysis : Chronic licorice ingestion. Am J Med Sci 2003, 325(3); 153-6. (SCI)

Chong-Hin Chou, Tom Chau, Sung-Sen Yang, Shih-Hua Lin. Acute hyponatreima and renal failure following percutaneous nephrolithotomy. Clin Nephrol 2003, 59(3); 237-238. (SCI)

Sung-Sen Yang, Tom Chau, Ming-Shen Dai, Shih-Hua Lin. Steroid-induced tumor lysis syndrome in a patient with prelukemia. Clin Nephrol 2003, 59(3); 201-205. (SCI)

Sung-Sen Yang, Shih-Hua Lin, Pauling Chu, San-Chiang Wu, Chia-Chou Wu, Weng-Sheng, Tsai, Yuh-Feng Lin. The effect of low-dose deferoxamine on anemia in iron-overloaded hemodilaysis patients. J Med Sci 2002; 22(6); 283-288. (ISSN) (in English)

Sung-Sen Yang, Shih-Hua Lin, Weng-Sheng Tsai, Jih-Guang Juang, Yuh-Feng Lin. Evaluation of metabolic acidosis in chronic hemodialysis patients. J Med Sci 2002; 22(4); 149-154. (ISSN) (in English)

Shih-Hua Lin, Tom Chau, Chia-Chao Wu, Sung –Sen Yang. Osmotic demyelination syndrome following correction of chronic hyponatremia with normal saline. Am J Med Sci 2002;323(5); 259-262. (SCI)

Sung-Sen Yang, Pauling Chu, Yuh-Feng Lin, An Chen, Shih-Hua Lin. Aristolochic acid-induced Fanconi’s syndrome and nephropathy presenting as hypokalemic paralysis. Am J Kidney Dis 2002; 39(3): E14 , 1-5. (SCI)

Sung-Sen Yang, Pauling Chu, Mei-Shang Lin, An Chen, Yuh-Feng Lin. Two clinical variants of Chinese-herb nephrophathy : Case reports and review of the literature. J Med Sci 2001; 21(4): 217-224. (ISSN) (in English)

Giou-Teng Yiang , Kai-Jen Ho, Chia-Chao Wu, Sung-Sen Yang, Jin-Guang Juang, Shih-Hua Lin. Milk-alkali syndrome caused by chewing betal nuts. J Med Sci 2000; 20(8): 429-434. (ISSN) (in English)

  • 更新日期:2020-11-27