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謝義興 Professor

謝義興 Professor      
Shieh,Yi-Shing

Position

Professor

Telephone Extension

18501

E-MAIL

ndmcyss@ndmctsgh.edu.tw

Highest Education

PhD in Graduate Institute of Life Sciences, National Defense Medical Center

Experience

1. Chief, Division of Restorative Dentistry, Department of Dentistry, Tri-Service General Hospital
2. Attending Physician, Division of Endodontics, Department of Dentistry, Tri-Service General Hospital

Teaching subjects

Head and neck oncology, oral embryology, oral pathology, oral diagnostics

Specialty

Oral cancer, head and neck oncology, oral embryology, oral pathology

RESEARCH

Shieh,Yi-Shing professior research results in the past 5 years

(* correspondant author)
1. Chien CY, Chen YC, Hsu CC, Chou YT, Shiah SG, Liu SY, Hsieh AC, Yen CY, Lee CH, Shieh YS*. YAP-Dependent BiP Induction Is Involved in Nicotine-Mediated Oral Cancer Malignancy. Cells. 2021;10(8):2080. (IF = 6.600) (本人為責任作者)
2. Chen YC, Chien CY, Hsu CC, Lee CH, Chou YT, Shiah SG, Liu SY, Yen CY, Hsieh AC, Wabitsch M, Shieh YS*. Obesity-associated leptin promotes chemoresistance in colorectal cancer through YAP-dependent AXL upregulation. Am J Cancer Res 2021;11(9):4220-4240. (IF = 6.166) (本人為責任作者)
3. Chu-Yen Chien; Ying-Chen Chen; Chien-Hsing Lee; Jia-Rong Wu; Tsai-Wang Huang; Ren-Yeong Huang; Wan-Chien Cheng; Alexander Cheng-Ting Hsieh; Yi-Shing Shieh*. Dysregulation of the miR-30a/BiP axis by cigarette smoking accelerates oral cancer progression. Cancer Cell Int 2021 (Accepted). (IF = 5.722) (本人為責任作者)
4. Hsu CC, Su YF, Tsai KY, Kuo FC, Chiang CF, Chien CY, Chen YC, Lee CH, Wu YC, Wang K, Liu SY, Shieh YS*. Gamma synuclein is a novel nicotine responsive protein in oral cancer malignancy. Cancer Cell Int. 2020 Jul 10;20:300. (IF = 5.722) (本人為責任作者)
5. Lee KC, Wu YT, Chien WC, Chung CH, Shen CH, Chen LC, Shieh YS*. Osteoporosis and the risk of temporomandibular disorder in chronic obstructive pulmonary disease. J Bone Miner Metab. 2021;39(2):201-211. (IF = 2.626) (本人為責任作者)
6. Lee KC, Wu YT, Chien WC, Chung CH, Chen LC, Shieh YS*. The prevalence of first-onset temporomandibular disorder in low back pain and associated risk factors: A nationwide population-based cohort study with a 15-year follow-up. Medicine (Baltimore). 2020 Jan;99(3):e18686. (IF = 1.889) (本人為責任作者)
7. Hsu CC, Tsai KY, Su YF, Chien CY, Chen YC, Wu YC, Liu SY, Shieh YS*. α7-Nicotine acetylcholine receptor mediated nicotine induced cell survival and cisplatin resistance in oral cancer. Arch Oral Biol. 2020;111:104653. (IF = 2.633) (本人為責任作者)
8. Chen SY, Chiang CF, Chiu KC, Cheng CW, Huang SM, Chen PH, Chen CY, Shieh YS*. Macrophage phenotypes and Gas6/Axl signaling in apical lesions. J Dent Sci. 2019 Sep;14(3):281-287. (IF = 2.080) (本人為責任作者)
9. Lee KC, Wu YT, Chen LC, Shen CH, Chung CH, Chien WC, Shieh YS*. Chronic obstructive pulmonary disease combined with vertebral compression fracture increases the risk of temporomandibular disorder: A population-based cohort study. Medicine (Baltimore). 2019 Sep;98(37):e17162. (IF = 1.889) (本人為責任作者)
10. Su CC, Huang RY, Wu YC, Cheng WC, Chiang HS, Chung MP, Cathy Tsai YW, Chung CH, Shieh YS*. Detection and location of second mesiobuccal canal in permanent maxillary teeth: A cone-beam computed tomography analysis in a Taiwanese population. Arch Oral Biol. 2019 Feb;98:108-114. (IF = 2.633) (本人為責任作者)
11. Yeh HW, Chiang CF, Chen PH, Su CC, Wu YC, Chou L, Huang RY, Liu SY, Shieh YS*. Axl Involved in Mineral Trioxide Aggregate Induces Macrophage Polarization. J Endod. 2018 Oct;44(10):1542-1548. (IF = 4.171) (本人為責任作者)
12. Huang TW, Lin KF, Lee CH, Chang H, Lee SC, Shieh YS*. The role of Thyroid Transcription Factor-1 and Tumor differentiation in Resected Lung Adenocarcinoma. Sci Rep. 2017 Oct 27;7(1):14222. (IF = 4.379) (本人為責任作者)
13. Sua CC, Wu YC, Chung MP, Huang RY, Cheng WC, Cathy Tsai YW, Hsieh CY, Chiang HS, Chen CY, Shieh YS*. Geometric features of second mesiobuccal canal in permanent maxillary first molars: a cone-beam computed tomography study. J Dent Sci 2017; 12(3):241-248. (IF = 2.080) (本人為責任作者)
14. Tsung-I Li, Meng-Ta Chiang, Kuo-Chou Chiu, Ching-Huang Lai, Yi-Shing Shieh*. The association of betel quid, alcohol, and cigarette with salivary gland tumor – a case-control study. J Dent Sci 2017; 12 (2): 151–155. (IF = 2.080) (本人為責任作者)
15. Chang WM, Lin YF, Su CY, Peng HY, Chang YC, Lai TC, Wu GH, Hsu YM, Chi LH, Hsiao JR, Chen CL, Chang JY, Shieh YS*, Hsiao M, Shiah SG. Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2016 Dec 15;76(24):7140-7150. (IF = 12.531) (本人為責任作者)
16. Cheng JC, Chiang MT, Lee CH, Liu SY, Chiu KC, Chou YT, Huang RY, Huang SM, Shieh YS*. γ-Synuclein Expression Is a Malignant Index in Oral Squamous Cell Carcinoma. J Dent Res. 2016 Apr;95(4):439-45. (IF = 6.116) (本人為責任作者)
17. Chung TJ, Hsu KY, Chen JH, Liu JS, Chang HW, Li PF, Huang CL, Shieh YS*, Lee CH. Association of salivary alpha 2-macroglobulin levels and clinical characteristics in type 2 diabetes. J Diabetes Investig. 2016 Mar;7(2):190-6. (IF = 4.232) (本人為責任作者)

其他作者
1. Tsai YC, Huang RY, Cheng CD, Cheng WC, Cochran DL, Nguyen TT, Shieh YS, Lin FG, Sung CE. Risk assessment of labial bone perforation in the anterior mandibular region: a virtual immediate implant placement study. Int J Implant Dent. 2021 Jul 26;7(1):68.
2. Chen SH, Huang RY, Huang LG, Weng PW, Chung CH, Cheng CD, Chen MC, Chiang HS, Sung CE, Tsai YC, Shieh YS, Cheng WC. A bibliometric analysis of top 100 most-cited articles in dentistry with author(s) affiliated with Taiwan institutes. J Chin Med Assoc. 2021 Aug 1;84(8):799-807.
3. Lee WC, Shieh YS, Liao YF, Lee CH, Huang CS. Long-term maxillary anteroposterior changes following maxillary protraction with or without expansion: A meta-analysis and meta-regression. PLoS One. 2021 Feb 22;16(2):e0247027.
4. Lee WC, Shieh YS, Liao YF, Lee CH, Huang CS. Long-term maxillary three dimensional changes following maxillary protraction with or without expansion: A systematic review and meta-analysis. J Dent Sci. 2021 Jan;16(1):168-177.
5. Chiang HS, Tsai YC, Huang RY, Weng PW, Mau LP, Nguyen TT, Cochran DL, Sung CE, Chung CH, Shieh YS, Cheng WC. Citation Characteristics of H-Classics Articles in Implant Dentistry: A Citation Analysis Using H-Classics Method. Int J Oral Maxillofac Implants. 2020 Sep/Oct;35(5):900-909.
6. Su SC, Chiang CF, Hsieh CH, Lu GH, Liu JS, Shieh YS, Hung YJ, Lee CH. Growth arrest-specific 6 modulates adiponectin expression and insulin resistance in adipose tissue. J Diabetes Investig. 2021 Apr;12(4):485-492.
7. Peng HY, Hsiao JR, Chou ST, Hsu YM, Wu GH, Shieh YS, Shiah SG. MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking. Neoplasia. 2020 Nov;22(11):554-565.
8. Wu YC, Su WS, Mau LP, Cheng WC, Weng PW, Tsai YC, Su CC, Chiang HS, Lin J, Shieh YS, Huang RY. Association between the presence of distolingual root in mandibular first molars and the presence of C-shaped mandibular second molars: a CBCT study in a Taiwanese population. Quintessence Int. 2020;51(10):798-807.
9. Chang TY, Hong G, Paganelli C, Phantumvanit P, Chang WJ, Shieh YS, Hsu ML. Innovation of dental education during COVID-19 pandemic. J Dent Sci. 2021 Jan;16(1):15-20.
10. Chen YY, Huang YJ, Huang HK, Chang H, Lee SC, Shieh YS, Huang TW. The prognostic factors of recurrence and survival in female patients with lung adenocarcinoma and breast cancer. J Cancer Res Clin Oncol. 2020 May;146(5):1299-1306.
11. Peng HY, Hsiao JR, Chou ST, Hsu YM, Wu GH, Shieh YS, Shiah SG. MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking. Neoplasia. 2020 Sep 19;22(11):554-565.
12. Su SC, Chiang CF, Hsieh CH, Lu GH, Liu JS, Shieh YS, Hung YJ, Lee CH Growth Arrest-Specific 6 Modulates Adiponectin Expression and Insulin Resistance in Adipose Tissue.J Diabetes Investig. 2020 Sep 24. doi: 10.1111/jdi.13412.
13. Chang TY, Hong G, Paganelli C, Phantumvanit P, Chang WJ, Shieh YS, Hsu ML. Innovation of dental education during COVID-19 pandemic. J Dent Sci. 2020 Aug 19. doi: 10.1016/j.jds.2020.07.011.
14. Wu YC, Su WS, Mau LP, Cheng WC, Weng PW, Tsai YC, Su CC, Chiang HS, Lin J, Shieh YS, Huang RY. Association between the presence of distolingual root in mandibular first molars and the presence of C-shaped mandibular second molars: a CBCT study in a Taiwanese population. Quintessence Int. 2020 Sep 18:2-12.
15. Su SC, Hung YJ, Huang CL, Shieh YS, Chien CY, Chiang CF, Liu JS, Lu CH, Hsieh CH, Lin CM, Lee CH. Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways. J Biomed Sci. 2019 Sep 6;26(1):68.
16. Li YH, Lu CH, Lin FH, Su SC, Liu JS, Hsieh CH, Hung YJ, Shieh YS, Lee CH. Plasma Growth Arrest-Specific 6 Protein and Genetic Variations in the GAS6 Gene in Patients with Metabolic Syndrome. Metab Syndr Relat Disord. 2019 Feb;17(1):22-28.
17. Lin SC, Chung CH, Chung CH, Kuo MH, Hsieh CH, Chiu YF, Shieh YS, Chou YT, Wu CW. OCT4B mediates hypoxia-induced cancer dissemination. Oncogene. 2018 Sep 12. doi: 10.1038/s41388-018-0487-6.
18. Lee CH, Su SC, Chiang CF, Chien CY, Hsu CC, Yu TY, Huang SM, Shieh YS, Kao HW, Tsai CS, Hung YJ, Lin CY. Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1. Oncotarget. 2017 Nov 10;8(66):110039-110051.
19. Lee CH, Shieh YS, Tsai CS, Hung YJ, Tsai YT, Lin CY. Plasma Concentrations Predict Aortic Expression of Growth-Arrest-Specific Protein 6 in Patients Undergoing Coronary Artery Bypass Grafting. PLoS One. 2017 Apr 24;12(4):e0175754.
20. Yang CY, Lin CK, Tsao CH, Hsieh CC, Lin GJ, Ma KH, Shieh YS, Sytwu HK, Chen YW. Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models. Oncotarget. 2017;8(20):33756-33769.
21. Chang WM, Lin YF, Su CY, Peng HY, Chang YC, Hsiao JR, Chen CL, Chang JY, Shieh YS, Hsiao M, Shiah SG. Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation. Sci Rep. 2017;7:41131.
22. Tsai PT, Shieh YS, Wu CT, Lee SP, Chen YW. Buccal Mucosa Elasticity Influences Surgical Margin Determination in Buccal Carcinoma Resection. J Oral Maxillofac Surg. 2016 Sep;74(9):1900.e1-7.
23. Yang CY, Lin CK, Lin GJ, Hsieh CC, Huang SH, Ma KH, Shieh YS, Sytwu HK, Chen YW. Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells. Clin Oral Investig. 2017 Jan;21(1):419-427.
24. Shiah SG, Shieh YS, Chang JY. The Role of Wnt Signaling in Squamous Cell Carcinoma. J Dent Res. 2016 Feb;95(2):129-34.

Honors and awards

1. 2021年研究倫文獲頒三軍總醫院研究論著優異獎
2. 2021年牙醫學系80周年系慶教育學術特殊貢獻獎
3. 2020年度獲得國家新創獎(17th National Innovation Award).
4. 2020年度獲得牙醫師公會全聯會金質獎
5. 2020年獲刊登錄於台灣生物科技與醫學名人錄
6. 指導研究生榮獲2020年第47屆國軍軍醫學術研討會研究生論文競賽牙醫組組第一名。
7. 指導研究生榮獲2020年第47屆國軍軍醫學術研討會研究生論文競賽研究生組第一名。
8. 2020年J Dent Sci Outstanding Article Award傑出文章獎指導教授。
9. 指導研究生榮獲2019年第46屆國軍軍醫學術研討會論文海報展示競賽內科組第一名
10. 2018年獲頒牙醫師公會全國聯合會優等學術研究獎
11. 2017年獲軍總醫院研究論文引用次數評比全院第三名
12. 2016年獲頒國防部優良教師
13. 2016研究倫文獲頒三軍總醫院研究論著優異獎
14. 2015年教學牙醫師公會全國聯合會優良教師

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  • Update Date:2019-09-23