RESEARCH

Te-Chun Yang, Hsin-Fan Chao, Li-Shian Shi, Tsu-Chung Chang, Hang-Ching Lin, Wen-Liang Chang (2014) Alkaloids from Coptis chinensis root promote glucose uptake in C2C12 myotubes, Fitoterapia 93 239-244. (IF = 2.34, Integrative and Complementary Medicine, 9/22 = 40%).

Ling-Yih Hsu, Chih-Ying Nien, Wei-Ming Huang, Shou-Che Hsu, and Tsu-Chung Chang* (2014) Synthesis and Protective Effects of Bis{4-[N,N-di- carboxymethyl) amino]-phenoxy}alkane Derivatives on UVA-Induced Production of MMP-1 in Human Skin Fibroblasts, Chem. Pharm. Bull. 62(9) 867–874. (IF = 1.375; Chemistry, Multiple disciplines, 76/148= 51%).

Tzu-Hui Hsu, Shun-Yuan Jiang, Wen-Liang Chang, Richard L. Eckert, Tiffany M. Scharadin, and Tsu-Chung Chang* (2015) Involvement of RARRES3 in the regulation of Wnt proteins acylation and signaling activities in human breast cancer cells, Cell Death and Differentiation, 22, 801–814. (IF = 8.385; Biochemistry and Molecular Biology, 25/291= 8.6%).

Tzu-Hui Hsu and Tsu-Chung Chang* (2015) RARRES3 regulates signal transduction through protein post-translational modifications, Molecular and Cellular Oncology, 2:4, e999512, DOI: 10.1080/ 23723556.2014.999512. （non-Sci）

Chun-Wen Wang, Yu-Chuan Huang, Fang-Na Chan, Shih-Chieh Su, Yu-Han Kuo, Shu-Fen Huang, Mei-Whey Hung, Hang-Chin Lin, Wen-Liang Chang, and Tsu-Chung Chang* (2015) Ginsenoside compound K, a natural triterpene, induces intestinal glucose absorption and Na+/glucose cotransporter 1 gene expression through activation of cAMP Response Element-Binding Protein. Molecular Nutrition & Food Research, 59:670-684. (IF = 4.91; Food Sciences, 3/123= 2.4%).

Shih-Yu Lee, Feng-Yi Lai, Li-Shian Shi, Yu-Ching Chou, I-Chuan Yen, Tsu-Chung Chang* (2015) Rhodiola crenulata extract suppresses hepatic gluconeogenesis via activation of the AMPK pathway. Phytomedicine, 22: 477-486. (IF = 2.877, Integrative and Complementary Medicine, 2/22 = 9.1%).

Pauline Low, Amanda M. Clark, Tz-Chong Chou, Tsu-Chung Chang, Maxwell Reynolds, Stephen J. Ralph (2015) Immunomodulatory activity of Melaleuca alternifolia concentrate (MAC): Inhibition of LPS-induced NF-κB activation and cytokine production in myeloid cell lines. International Immunopharmacology, 26: 257-264. (IF = 2.711; Pharmacology and Pharmacy, 95/256= 37.1%).

Wang CW, Chang WL, Huang YC, Chou FC, Chan FN, Su SC, Huang SF, Ko HH, Ko YL, Lin HC, Chang TC* (2015) An essential role of cAMP response element-binding protein in epidermal growth factor-mediated induction of sodium/glucose cotransporter 1 gene expression and intestinal glucose uptake. Int J Biochem Cell Biol, 64:239-251. (IF = 4.24; Biochemistry and Molecular Biology, 74/291= 25.4%).

Chun-Wen Wang, Shih-Chieh Su, Shu-Fen Huang, Yu-Chuan Huang, Fang-Na Chan, Yu-Han Kuo, Mei-Whey Hung, Hang-Ching Lin, Wen-Liang Chang, and Tsu-Chung Chang* (2015) An Essential Role of cAMP Response Element Binding Protein in Ginsenoside Rg1-Mediated Inhibition of Na+/glucose Cotransporter 1 Gene Expression. Mol Pharmacol, 88:1072–1083. (IF = 4.128; Pharmacology and Pharmacy, 38/254= 15%).

Chien-Liang Chao, Hui-Chi Huang, Hang-Ching Lin, Tsu-Chung Chang*, and Wen-Liang Chang (2016) Sesquiterpenes from Baizhu Stimulate Glucose Uptake by Activation of AMPK and PI3K, Am J Chin Med, 44: 963-979.(IF = 2.96; Alternative and complementary medicine, 3/24 = 12. 5%)

Kuen-Tze Lin, Shih-Wei Hsu, Feng-Yi Lai, Tsu-Chung Chang, Li-Shian Shi and Shih-Yu Lee (2016) Rhodiola crenulata extract regulates hepatic glycogen and lipid metabolism via activation of the AMPK pathway. BMC Complement Altern Med, 16:127, DOI 10.1186/s12906-016-1108-y. (IF = 2.94; Alternative and complementary medicine, 4/24 = 16. 7%)

Hsu, S.-W.; Chang, T.-C.; Wu, Y.-K.; Lin, K.-T.; Shi, L.-S.; Lee, S.-Y* (2017). Rhodiola crenulata extract counteracts the effect of hypobaric hypoxia in rat heart via redirection of the nitric oxide and arginase 1 pathway. BMC Complement Altern Med, 17:29, doi: 10.1186/s12906-016-1524-z. (SCI, IF = 2.29; Alternative and complementary medicine, 6/26 = 23.1%)

Li-Yen Huang, I-Chuan Yen, Wei-Cheng Tsai, Blerina Ahmetaj-Shala, Tsu-Chung Chang, Chien-Sung Tsai and Shih-Yu Lee* (2017). Rhodiola crenulata Attenuates High Glucose Induced Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells. Am J Chin Med, 45:1-16. (SCI, IF = 3.22; Alternative and complementary medicine, 3/26 = 11.5%)

Shih-Yu Lee, Wei-Cheng Tsai, Jung-Chun Lin, Blerina Ahmetaj-Shala, Su-Feng Huang, Wen-Liang Chang and Tsu-Chung Chang* (2017) Astragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway, Scientific Reports, 7: 12302, DOI:10.1038/s41598-017-12435-y. (SCI, IF = 4.26; Multidisciplinary sciences, 10/64= 15.6%)

Shih-Yu Lee, Po-Yu Chen, Jung-Chun Lin, Nicholas S. Kirkby, Ching-Huei Ou and Tsu-Chung Chang* (2017) Melaleuca alternifolia concentrate induces heme oxygenase-1 expression in murine RAW264.7 cells through activation of the Nrf2-ARE pathway, Am J Chin Med, 45:1631-1648. doi: 10.1142/S0192415X17500884. (SCI, IF = 3.22; Alternative and complementary medicine, 3/26 = 11.5%)

Shih-Yu Lee, Wen-Liang Chang, Zhi-Xiang Li, Nicholas S Kirkby, Wei-Cheng Tsai, Shu-Fen Huang, Ching-Huei Ou, Tsu-Chung Chang*. (2018) Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo. Phytomedicine, 38: 183-191. (SCI, IF = 3.53, Alternative and complementary medicine, 2/26 = 7.7%).

Kuen-Tze Lin, Tsu-Chung Chang, Feng-Yi Lai, Chun-Shu Lin, Hsing-Lung Chao, Shih-Yu Lee* (2018, Feb). Rhodiola crenulata attenuates gamma-ray induced cellular injury via modulation of oxidative stress in human skin cells. Am J Chin Med, 46:175-190, DOI: 10.1142/S0192415X18500106, (SCI, IF=3.22, Alternative and complementary medicine, 3/26=11.5%)

Pi-Kai Chang, I-Chuan Yen, Wei-Cheng Tsai, Tsu-Chung Chang, Shih-Yu Lee* (2018). Protective effects of Rhodiola crenulata extract on hypoxia-induced endothelial damage via regulation of AMPK and ERK pathways. International Journal of Molecular Sciences, 19(8), 2286. https://doi.org/10.3390/ijms19082286.

PATENT

US patent: Use of lanostane and poria extract in treating diabetes。Inventor: Hang-Ching Lin, Yu-Chuan Huang, Tsu-Chung Chang, Wen-Liang Chang。Date of patent: July 21, 2015，Patent Number: US 9,084,798 B2。

ROC patent: 用於促進傷口癒合之醫藥組成物及其用途。發明人: 曾卉菱; 張自忠；張溫良；曾宛平；曾泰霖；郭盈妤。Date of patent: 中華民國 105 (2016) 年04 月01 日。證書號數：I527583。

US patent: Pharmaceutical composition and extract of poria for enhancing uptake of nutrients。Inventor: Hang-Ching Lin, Tsu-Chung Chang, Wen-Liang Chang, Yi-Yang Song。Date of patent: September 12, 2017，Patent Number: US 9,757,392 B2。

ROC patent: 牛樟芝化合物用於製備促進毛髮增生組合物之用途。發明人: 張自忠；張溫良；曾卉菱；曾宛平；曾泰霖；郭盈妤。Date of patent: 中華民國 107 (2018) 年06 月11 日。證書號數：I626053。

ROC patent: Uses of osmanthus fragrans extracts for manufactureing a composition for enhancing hair growth and a composition for wound healing。Inventor: CHANG, WEN-LIANG；CHANG, TSU-CHUNG；SHI, LI-SHIAN； YANG, YUAN。Date of patent: 中華民國107 (2018) 年09 月11 日。證書號數：I634896。