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黃世明 Professor

黃世明 Professor      
Shih-Ming Huang

POSITION

Professor

CONTACT

Rm. 7102, 7F., No. 161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City 114, Taiwan (R.O.C.)
(+886)2-8792-3100 ext 18790

E-MAIL

shihming@ndmctsgh.edu.tw

RESEARCH

The study of mechanisms of small molecule drugs in tumorigenesis.
The study of relationship between structures and functions of transcription factor Zac1.

Lu GY, Huang SM, Liu ST, Liu PY, Chou WY and Lin WS (2014) Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genes, The International Journal of Biochemistry and Cell Biology, 47, 83-92 (IF = 4.240; Biochemistry and Molecular Biology, 75/291 =25.8%)

Chan JYH, Chen YC, Liu ST, Chou WY, Ho CL and Huang SM (2014) Characterization of one new mouse p53 variant: loss-of-function and gain-of-function, Journal of Biomedical Science, 21: 40 (co-corresponding author) (IF = 2.736; Medicine, Research & Experimental, 49/124 =39.5%)

Hsu SJ, Huang SM, Chen A, Sun CY, Lin SH, Chen JS, Liu ST and Hsu YJ (2014) Resveratrol increases renal klotho gene expression via the activating transcription factor 3/c-Jun complex-mediated signaling pathway, The International Journal of Biochemistry and Cell Biology, 53, 361-371 (IF = 4.240; Biochemistry and Molecular Biology, 75/291 =25.8%)

Wang WM, Chen JF, Liu ST, Hsu YJ, Liu YC and Huang SM (2014) Biochemical properties of the recurrent LMX1b truncated mutant carried in a Taiwanese family with nail-patella syndrome. British Journal of Dermatology, 171, 356-362 (IF = 4.100; Dermatology, 7/61 =11.5%)

Yang HY, Huang SM, Lu KC, Wu CC, Kang CY, Lin YF, Lin C, Lin FH, Kao SY, Su SL (2014) A Functional Polymorphism in the Promoter Region of TLR3 Is Associated with Susceptibility to End-Stage Renal Disease, American Journal of Nephrology, 40, 31-139 (IF = 2.646; Urology and Nephrology, 21/77=27.3%)

Lu GY, Liu ST, Huang SM, Chang YL and Lin WS (2014) Multiple effects of digoxin on subsets of cancer-associated genes through the alternative splicing pathway, Biochimie, 106, 131-139 (co-corresponding author) (IF = 3.123; Biochemistry and Molecular Biology, 122/291 =41.9%)

Hsu SJ, Huang SM, Lin SH, KA SM, Chen A, Shih MF and Hsu YJ (2014) Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway, Biochemical Journal, 464(2), 221-229 (IF = 4.779; Biochemistry and Molecular Biology, 61/291 =21.0%)

Tang SH, Huang SH, Wu HU, Tsai YT, Chuang MJ, Yu CP, Huang SM, Sun GH, Chang SY, Hsiao PW, Yu DS and Cha TL (2014) Pharmacologic Down-regulation of EZH2 Suppresses Bladder Cancer in Vitro and in Vivo. Oncotarget, 5(21):10342-10355 (IF = 6.627; Oncology, 17/203 =8.4%)

Hsu YJ, Yang SS, Cheng CJ, Liu ST, Huang SM, Chau T, Chu P, Salter DM, Lee HS, Lin SH (2015) Thiazide-sensitive Na+-Cl- cotransporter (NCC) gene inactivation results in increased duodenal Ca2+ absorption, enhanced osteoblast differentiation and elevated bone mineral density, Journal of Bone and Mineral Research, 30(1), 116-127 (IF = 6.589; Endocrinology & Metabolism, 12/124=9.7%)

Chang YL, Gao HW, Chiang CP, Wang WM, Huang SM, Ku CF, Liu GY and Hung HC (2015) Human Mitochondrial NAD(P)+-Dependent Malic Enzyme Participates in Cutaneous Melanoma Progression and Invasion. Journal of Investigative Dermatology, 135, 807-815 (IF = 6.372; Dermatology, 1/61 =1.6%)

Cha TL, Chuang MJ, Tang SH, Wu ST, Sun KH, Chen TT, Sun GH, Chang SY, Yu CP, Ho JY, Huang SM and Yu DS (2015) Emodin Modulates Epigenetic Modifications and Suppresses Bladder Carcinoma Cell Growth, Molecular Carcinogenesis, 54(3):167-77 (IF = 4.770; Oncology, 43/203 =21.2%)

Chiou HY, Lai WK, Huang LC, Huang SM, Chueh SH, Ma HI and Hueng DY (2015) Valproic acid induced apoptosis and promoted radiosensitization in meningioma stem-like cells, Oncotarget, 6(12):9959-69 (IF = 6.627; Oncology, 17/203 =8.4%)

Chiu KC, Lee CH, Li SY, Chou YT, Huang RY, Huang SM and Shieh YS (2015) Polarization of tumor-associated macrophages and Gas6/Axl signaling in oral squamous cell carcinoma. Oral Oncology, 51(7):683-689. (IF = 3.029; Dental, 5/83 =6.0%)

Hsu YJ, Hsu SC, Huang SM, Lee HS, Lin SH, Tsai CS, Shih CC and Lin CY. (2015) Hyperphosphatemia induces protective autophagy in endothelial cells through the inhibition of Akt/mTOR signaling. Journal of Vascular Surgery, 62(1):210-221. (IF = 3.021; Suergy, 33/198 =16.7%)

Lin CY, Hsu YJ, Hsu SC, Chen Y, Lee HS, Lin SH, Huang SM, Tsai CS and Shih CC (2015) CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia. Journal of Molecular and Cellular Cardiology, 85, 249-261 (IF =4.66; Cardiology, 19/123 =15.4%)

Tsai YT, Chuang MJ, Tang SH, Wu ST, Chen YC, Sun GH, Hsiao PW, Huang SM, Lee HJ, Yu CP, Ho JY, Lin HK, Chen MR, Lin CC, Chang SY, Lin VC, Yu DS, Cha TL (2015) Novel Cancer Therapeutics with Allosteric Modulation of The Mitochondrial C-Raf/DAPK Complex by Raf Inhibitor Combination Therapy. Cancer Research, 75(17):3568-82 (IF = 9.329; Oncology, 11/211 =5.2%)

Hung CT, Huang SM, Cheng HC, Liu ST, Chang YL, Liu YC and Wang WM (2015) The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes. Journal of Dermatological Science, 79, 262-267 (IF = 3.419; Dermatology, 10/63 =15.9%)

Liu ST, Huang SM, HO CL, LC Yen, Huang CJ, Lin WS and Chan JYH (2015) The role of myogenin in doxorubicin-induced cardiotoxicity in rat H9c2 cardiomyocytes, Oncotarget, 6(35):37443-37457 (IF = 6.359; Oncotarget, 21/211 =9.9%)

Chu YW, Liu ST, Cheng HC, Huang SM, Chang YL, Chiang CP, Liu YC and Wang WM (2015) Opposing effects of Zac1 and curcumin on AP-1-regulated expressions of S100A7. PLOS ONE, 10(12):e0144175 (co-coresponding author) (IF = 3.324; Multidisciplinary Sciences, 9/57 =15.8%)

Cheng JC, Chiang MT, Lee CH, Liu SY, Chiu KC, Chou YT, Huang RY, Huang SM, and Shieh YS (2016) -Synuclein expression is a malignant index in oral squamous cell carcinoma. Journal of Dental Research, 95(4):439-45. (IF = 4.602; Dentistry, Oral Surgery & Medicine, 2/91 =2.2%)

Cheng CP, Huang LC, Chang YL, Hsieh CH, Huang SM, and Hueng DY (2016) The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas, Oncotarget, 7(27 ):41460-41472 (co-corresponding author) (IF = 5.008; Oncology, 36/213=16.9%)

Yeh CB, Weng SJ, Chang KW, Chan JY, Huang SM, Chu TH, Wei NK, Ma HS, Cheng JT, Ma KH, Chen TH, and Shyu JF (2016) Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activity, Osteoporosis International, 27(11):3355-3364. (IF = 3.455; Endocriologly & Metabolism, 45/133 =33.8%)

Chen YJ, Lin CL, Li CR, Huang SM, Chan JY, Fang WH, Chen WL (2016) Associations among integrated psychoneuroimmunological factors and metabolic syndrome. Psychoneuroendocrinology, 74:342-349. (IF = 4.704; Endocriologly & Metabolism, 23/133 =17.3%)

Su HC, Liang YA, Lai YJ, Chiu YL, Barndt RB, Shiao F, Chang HD, Lu DD, Huang N, Tseng CC, Wang JK, Lee MS, Johnson MD, Huang SM, and Lin CY (2016) Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled manner, PLOS ONE, 11(12):e0167894 (co-corresponding author) (IF = 2.806; Multidisciplinary Sciences, 15/64 =22.7%)

Hsu YJ, Hsu SC, Hsu CP, Chen YH, Chang YL, Sadoshima J, Huang SM, Tsai CS, and Lin CY (2017) Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model. International Journal of Cardiology, 228:543-552. (IF = 6.189; Cardiac & Cardiovascular Systems, 16/126 =12.3%)

Chen SJ, Kao YH, Jing L, Chuang, YP, Wu WL. Liu ST, Huang SM, Lai JH, Ho LJ, Tsai MC, and Lin CS (2017) Epigallocatechin-3-gallate Reduces Scavenger Receptor A Expression and Foam Cell Formation in Human Macrophages, Journal of Agricultural and Food Chemistry, 65(15):3141-3150 (IF=3.154; Multidisciplinary Agriculture, 2/56 =2.7%)

Shiu TY, Shih YL, Feng AC, Lin HH, Huang SM, Huang TY, Hsieh CB, Chang WK, and Hsieh TY (2017) HCV core inhibits hepatocellular carcinoma cell replicative senescence through downregulating microRNA-138 expression. Journal of Molecular Medicine, 95(6):629-639 (IF=4.686; Genetics & Heredity, 27/167 =15.9%)

Chung MH, Wang YW, Chang YL, Huang SM, and Lin WS (2017) Risk of Cancer in Patients with Heart Failure Who Use Digoxin: A 10-Year Follow-Up Study and Cell-Based Verification, Oncotarget, 8(27):44203-44216 (IF = 5.168; Oncology, 44/217=20.3%)

Lai XM, Liu SY, Tsai YT, Sun GH, Chang SY, Huang SM, and Cha TL (2017) HAF Mediates the Evasive Resistance of Anti-angiogenesis TKI through Disrupting HIF-1a and HIF-2a Balance in Renal Cell Carcinoma, Oncotarget, 8(30):49713-49724 (co-corresponding author) (IF = 5.168; Oncology, 44/217=20.3%)

Chu YW, Liu ST, Yang YL, Huang SM, and Wang WM (2017) The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes. Journal of Biomedical Science, 24(1):55. (co-corresponding author) (IF = 2.799; Medicine, Research & Experimental, 51/128=39.5%)

Chen WL, Huang AF, Huang SM, Ho CL, Chang YL, and Chan YH (2017) CD164 promotes lung tumor-initiation cells with stem cell activity and determines tumor growth and drug resistance via Akt/mTOR signaling. Oncotarget, 8(33):54115-54135 (IF = 5.168; Oncology, 44/217=20.3%)

Lu JW, Hsieh PS, Lin CC, Hu MK, Huang SM, Wang YM, Liang CY, Gong Z, and Ho YJ (2017) Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus. Biochemical and Biophysical Research Communications, 491:595-602 (IF = 2.466; Biochemistry & Molecular Biology, 95/290 =56.4%)

Chang YL, Huang LC, Chen YC, Wang YW, Heung DY, and Huang SM (2017) The synergy effects of valproic acid and fluvastatin on apoptosis induction in glioblastomas multiforme cell lines, International Journal of Biochemistry and Cell Biology, 92:155-163 (co-corresponding author) (IF = 3.505; Biochemistry & Molecular Biology, 95/290 =32.6%)

Tseng MH, Huang SM, Lo FS, Huang JL, Cheng CJ, Lee HJ, and Lin SH (2017) Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with Alopecia. Scientific Reports, 7:15337

Chang YL, Hsu YJ, Chen Y, Wang YW, and Huang SM (2017) Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines, Oncotarget, 8;101461-101474 (co-corresponding author) (IF = 5.168; Oncology, 44/217=20.3%)

Lee CH, Su SC, Chiang CF, Chien CY, Hsu CC, Yu TY, Huang SM, Shieh YS, Kao HW, Tsai CS, Hung YJ and Lin CY (2017) Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1, Oncotarget, 8(66):110039-110051 (IF = 5.168; Oncology, 44/217=20.3%)

Chin LH, Hsu YJ, Hsu SC, Chen YH, Chang YL Huang SM, Tsai CS and Lin CY (2017) The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease, Oncotarget, 8(69):113303-113317 (IF = 5.168; Oncology, 44/217=20.3%)

Hsu YJ, Hsu SC, Chang YL, Huang SM, Shih CC, Tsai CS, and Lin CY (2018) Indoxyl sulfate upregulates the cannabinoid type 1 receptor gene via an ATF3/c-Jun complex-mediated signaling pathway in the model of uremic cardiomyopathy, International Journal of Cardiology, 252:128-135 (IF = 6.189; Cardiac & Cardiovascular Systems, 16/126 =12.3%)

Chang YL, Liu ST, Wang YW, Lin WS, and Huang SM (2018) Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224, Oncotarget, 9(17):13390-13406 (co-corresponding author) (IF = 5.168; Oncology, 44/217=20.3%)

Kuo CL, Liu ST, Chang YL, Wu CC and Huang SM (2018) Zac1 regulates IL-11 expression in osteoarthritis, Oncotarget, 9(65):32478-32495 (corresponding author) (IF = 5.168; Oncology, 44/217=20.3%)

Hsieh Li SM, Liu ST, Chang YL, Ho CL and Huang SM (2018) Metformin Causes Cancer Cell Death mediated through downregulation of p53-dependent differentiated embryo chondrocyte 1, Journal of Biomedical Science, 25:81 (co-corresponding author) (IF = 3.466; Medicine, Research & Experimental, 46/133=36.2%)

Syu WZ, Chen SG, Chan, JY, Wang CH, Dai NT, Huang SM (2019) The Potential of Acellular Dermal Matrix Combined With Neural Stem Cells Induced From Human Adipose-Derived Stem Cells in Nerve Tissue Engineering. Annals of Plastic Surgery, 82, S108-S118 (IF =1.536; Surgery, 117/200=58.5%)

Wu LW, Chen WL, Huang SM, Chan JY (2019) Platelet-derived growth factor-AA is a substantial factor in the ability of adipose-derived stem cells and endothelial progenitor cells to enhance wound healing. FASEB J, 33(2), 2388-2395 (IF = 5.595; Biology, 8/85=8.8%)

Wang CC, Hueng DY, Huang AF, Chen WL, Huang SM, and Chan JYH (2019) CD164 Regulates Proliferation, Progression, and Invasion of human glioblastoma cells, Oncotarget, 10(21):2041-2054 (co-corresponding author)

Lin CK, Liu ST, Chang CC, and Huang SM (2019) Regulatory mechanisms of fluvastatin and lovastatin for the p21 induction in human cervical cancer cells, Plos ONE, 14(4):e0214408 (co-corresponding author) (IF = 2.776; Multidisciplinary Sciences, 24/69=34.78%)

Tseng MH, Tsai JD, Tsai IJ, Huang SM, Huang JL, Fan WL, Lee HJ, Wu TW, Lin SH. (2019) Whole-Exome Sequencing Detects Mutations in Pediatric Patients with Atypical Hemolytic Uremic Syndrome in Taiwan. Clinica Chimica Acta, 494:143-150(IF = 2.735; Clinical Laboratory Technology, 8/29=27.59%)

Tsai YC, Lin YC, Huang CC, Villaflores OB, Wu TY, Huang SM, and Chin TY (2019) Hericium erinaceus mycelium and its isolated compound, Erinacine A, ameliorate high-fat high-sucrose diet–induced metabolic dysfunction and spatial learning deficits in aging mice. Journal of Medicinal Food, 22, 469-478 (co-corresponding author) (IF = 2.020; Food Secience and Technology, 60/135=44.44%)

Kuo CL, Hsieh Li SM, Liang SY, Liu ST, Wang WM, Yen LC, and Huang SM (2019) The antitumor properties of metformin and phenformin reflect their ability to inhibit the actions of differentiated embryo chondrocyte 1, Cancer Management and Research, 11:6567-6579 (co-corresponding author) (IF = 2.243; Oncology, 167/229=72.92%)

Syu WZ, Hueng DY, Chen WL, Chan JYH, Chen SG, and Huang SM (2019) Adipose-derived neural stem cells combined with acellular dermal matrix as a neural conduit enhances peripheral nerve repair, Cell Transplantation, in press (co-corresponding author) (IF = 3.477; Medicine, Research and Experimental, 54/136=39.7%)

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  • Update Date:2019-10-03