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::: Chair Professor

植田 弘師 Chair Professor

植田 弘師 Chair Professor      
Hiroshi Ueda


National Defense Medical Center/Chair Professor


1976 Japan_Kyoto University_Ph.D. (Pharmaceutical Sciences)
1978 Japan_Kyoto University_Master.D. (Pharmaceutical Sciences)
1981 Japan_Kyoto University_Bachelor D. (Pharmaceutical Sciences)




1981-1983 Japan_Yokohama City University Medical School/Assistant Professor
1983-1991 Japan_Kyoto University Graduate School of Pharmaceutical Sciences/ Assistant Professor
1991-1996 Japan_Yokohama City University Medical School/Associate Professor
1996-2019 Japan_Nagasaki University Graduate School of Biomedical Science/Chairman and Professor
2017-2018 Canada/ McGill University/Visiting Professor
2017-2019 Japan_Kyoto University Graduate School of Pharmaceutical Sciences/ Adjunct Professor
2017-2019 Japan_Kyoto Prefectural University/Visiting Professor
2019-2021 Japan_Kyoto University Graduate School of Pharmaceutical Sciences/Researcher
2019.05.30 Japan_Nagasaki University/Emeritus Professor
2019~ Japan_Research Institute for Production Development/Advisor and Principal Investigator
2022~ National Defense Medical Center/Chair Professor



Specialized Fields

1. Mechanisms of Chronic Pain
2. Mechanisms of Endogenous Neuroprotective System
3. Pain-related Brain-Immune Functional Network


1981 Prize of Encouragement from the Society for Japanese Pharmaceutical Sciences
1986 The Pharmacological Society of Japan Award for Young Scientists
2019 The Pharmaceutical Society of Japan Award
2022 Gayle A.Olson & Richard D Olson Prize 2020

Selected Original Papers (in total 243)

1. Neyama H, Nishiyori M, Yilong Cui YL, Watanabe Y, Hiroshi Ueda H. Lysophosphatidic acid receptor type-1 mediates brain activation in micro-positron emission tomography analysis in a fibromyalgia-like mouse model. Eur J Neurosci. 2022 in press (DOI: 10.1111/ejn.15729)

2. Matsunaga H, Halder SK, Ueda H. Annexin A2 Flop-Out Mediates the Non-Vesicular Release of DAMPs/Alarmins from C6 Glioma Cells Induced by Serum-Free Conditions. Cells. 10 (3): 567, 2021

3. Ueda H, Dozono N, Tanaka K, Kaneko S, Neyama H, Uchida H. Allodynia by Splenocytes From Mice With Acid-Induced Fibromyalgia-Like Generalized Pain and Its Sexual Dimorphic Regulation by Brain Microglia. Front Neurosci. 14: 600166, 2020

4. Ueda H, Neyama H, Matsushita Y. Lysophosphatidic Acid Receptor 1- and 3-Mediated Hyperalgesia and Hypoalgesia in Diabetic Neuropathic Pain Models in Mice. Cells. 9: E1906, 2020

5. Neyama H, Dozono N, Uchida H, Ueda H. Mirtazapine, an α2 antagonist-type antidepressant reverses pain and lack of morphine analgesia in fibromyalgia-like mouse models. J Pharmacol Exp Ther. 375: 1-9, 2020

6. Neyama H, Dozono N, Ueda H. NR2A-NMDA receptor blockade reverses the lack of morphine analgesia without affecting chronic pain status in fibromyalgia-like mouse model. J Pharmacol Exp Ther. 373: 103-112, 2020

7. Xie K, Masuho I, Shih CC, Cao Y, Sasaki K,Lai CW, Han PL, Ueda H, Dessauer CW, Ehrlich ME, Xu B, Willardson BM, Martemyanov KA: Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling. eLIFE. 4: e10451, 2015

8. Jia N, Nakazawa Y, Guo C, Shimada M, Sethi M, Takahashi Y, Ueda H, Nagayama Y ,Ogi T: A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents. Nature Protoc. 10(1): 12-24, 2014

9. Uchida H, Ma L, Ueda H: Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain. J of Neuroscience. 30(13): 4806-4814, 2010

10. Ueda H, Fujita R, Yoshida A, Matsunaga H, Ueda M: Identification of prothymosin-α 1, the necrosis-apoptosis switch molecule in cortical neuronal cultures. J Cell Biol. 176(6): 853-862, 2007

11. Inoue M, Rashid MH, Fujita R, Contos JJ, Chun J, Ueda H: Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nature Med. 10(7): 712-718, 2004

12. Inoue M, Kobayashi M, Kozaki S, Zimmer A, Ueda H: Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice. Proc. Natl. Acad. Sci. USA. 95(18): 10949-10953, 1998

Selected Review Articles (in total 28)

1. Ueda H: Review of kyotorphin research: a mysterious opioid analgesic dipeptide and its molecular, physiological, and pharmacological characteristics. Front Med Technol. 3. 662697, 2021

2. Gazerani P, Aloisi AM, Ueda H: Editorial: Differences in Pain Biology, Perception, and Coping Strategies: Towards Sex and Gender Specific Treatments. Front Neurosci. 15: 697285, 2021

3. Ueda H: Ueda H: Pathogenic mechanisms of lipid mediator lysophosphatidic acid in chronic pain. Prog Lipid Res. 81: 101079, 2021

4. Ueda H. LPA receptor signaling as a therapeutic target for radical treatment of neuropathic pain and fibromyalgia. Pain Manag. 10: 43-53, 2020

5. Ueda H: Lysophosphatidic acid signaling is the definitive mechanism underlying neuropathic pain. PAIN 158: 55-65, 2017

6. Ueda H, Uchida H: Epigenetic Modification in Neuropathic Pain. Curr Pharm Des.
21(7): 849-67, 2015

7. Ueda H: Prothymosin α and cell death mode switch, a novel target for the prevention of cerebral ischemia-induced damage. Pharmacol Ther. 123(3): 323-333, 2009

8. Ueda H: Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms. Pharmacol Ther. 109(1-2): 57-77, 2006

  • Update Date:2022-06-30