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Institute of Biology and Anatomy
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Kuo-Hsing MaProfessor      
Kuo-Hsing Ma

Position

Professor

Education

Ph.D., Graduate Institute of Life Sciences, National Defense Medical Center, ROC

M.S., Graduate Institute of Biology and Anatomy, National Defense Medical Center, ROC

B.S., School of Pharmacy, National Defense Medical Center, ROC

Professional Experiences

1. Teaching assistant, Graduate Institute of Biology and Anatomy, National Defense Medical Center, ROC (1994-1996)

2. Lecturer, Graduate Institute of Biology and Anatomy, National Defense Medical Center, ROC (1997-2002)

3. Assistant Professor, Graduate Institute of Biology and Anatomy, National Defense Medical Center, ROC (2003-2008)

4. Associate Professor, Graduate Institute of Biology and Anatomy, National Defense Medical Center, ROC (2009-2011)

5. Associate Professor and Director, Graduate Institute of Biology and Anatomy, National Defense Medical Center, ROC (2011-2012)

6. Professor and Director, Graduate Institute of Biology and Anatomy, National Defense Medical Center, ROC (2012-2013)

Research Interests

1. Neuroimaging

2. Neuronal Stem Cell

3. Parkinson’s Disease

Publications

1. Ma KH*, Huang WS, Kuo YY, Peng CJ, Liou NH, Liu RS, Hwang JJ, Liu JC, Chen HJ, Shiue CY. Validation of 4-[18F]-ADAM as a SERT imaging agent using micro-PET and autoradiography. Neuroimage. 2009 Apr 15;45(3):687-93(IF: 5.463 ; Ranking: 1/14=7.1% ; NEUROIMAGING) (SCI/2015)

2. Ma KH*, Lee JK, Huang SY, Yeh CB, Shen YC, Shen LH, Chen CC, Liu RS, Liu JC, Huang WS. Simultaneous [99mTc]TRODAT-1 and [123I]ADAM brain SPECT in nonhuman primates. Mol Imaging Biol. 2009 Jul-Aug;11(4):253-62(IF: 2.569 ; Ranking: 38/124=30.6% ; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (SCI/2015)

3. Li IH, Huang WS, Yeh CB, Liao MH, Chen CC, Shen LH, Liu JC, Ma KH*. Dual-isotope single-photon emission computed tomography for dopamine and serotonin transporters in normal and Parkinsonian monkey brains. Nuclear Medicine and Biology. 2009 Aug;36(6):605-11(IF: 2.429 ; Ranking:44/124=35.5% ; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (SCI/2015)

4. Huang YS, Cheng SN, Chueh SH, Tsai YL, Liou NH, Guo YW, Liao MH, Shen LH, Chen CC, Liu JC, Ma KH*. Effects of interleukin-15 on neuronal differentiation of neural stem cells. Brain Res. 2009 Dec 22;1304:38-48 (IF: 2.561 ; Ranking:143/256=55.9% ; NEUROSCIENCES) (SCI/2015)

5. Huang SY, Chen HK, Ma KH, Shy MJ, Chen JH, Lin WC, Lu RB. Association of promoter variants of human dopamine transporter gene with schizophrenia in Han Chinese. Schizophr Res. 2010 Jan;116(1):68-74. (IF: 4.453 ; Ranking :25/140=17.9% ; PSYCHIATRY) (SCI/2015)

6. Li IH, Huang WS, Shiue CY, Huang YY, Liu RS, Chyueh SC, Hu SH, Liao MH,Shen LH, Liu JC, Ma KH*.Study on the neuroprotective effect of fluoxetine against MDMA-induced neurotoxicity on the serotonin transporter in rat brain using micro-PET. Neuroimage. 2010 Jan 15;49(2):1259-70. (IF: 5.463 ; Ranking: 1/14=7.1% ; NEUROIMAGING) (SCI/2015)

7. Huang YY, Ma KH, Tseng TW, Chou TK, Ng H, Mirsalis JC, Fu YK, Chu TC,Huang WS, Shiue CY. Biodistribution, toxicity and radiation dosimetry studies of the serotonin transporter radioligand 4-[18F]-ADAM in rats and monkeys. Eur J Nucl Med Mol Imaging. 2010 Mar;37(3):545-55. (IF: 5.537 ; Ranking: 6/124=4.8% ; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (SCI/2015)

8. Chin TY, Kao CH, Wang HY, Huang WP, Ma KH, Chueh SH. Inhibition of the mammalian target of rapamycin promotes cyclic AMP-induced differentiation of NG108-15 cells. Autophagy. 2010 Nov 16;6(8):1139-56. (IF:9.108 ; Ranking:19/187=10.2% ; CELL BIOLOGY) (SCI/2015)

9. Ho PS, Shih MC, Ma KH, Huang WS, Ho KK, Yen CH, Lu RB, Huang SY. Availability of the serotonin transporter in patients with alcohol dependence. World J Biol Psychia. 2011 Mar; 12(2):134-42. (IF: 4.159 ; Ranking:29/140=20.7% ; PSYCHIATRY) (SCI/2015)

10. Wang MT, Lian PW, Yeh CB, Yen CH, Ma KH, Chan AL. Incidence, prescription patterns, and determinants of antipsychotic use in patients with Parkinson's disease. Mov Disord. 2011 Aug 1;26(9):1663-9. (IF: 6.010; Ranking:14/192=7.2% ; CLINICAL NEUROLOGY) (SCI/2015)

11. Chang CY, Ma KH, Wang JK, Tung YL, Chueh SH. Inhibition of protein kinase C promotes differentiation of neuroblastoma × glioma NG108-15 hybrid cells. Eur J Neurosci. 2011 Oct;34(7):1074-84. (IF: 2.975 ; Ranking: 114/256 =44.5%; NEUROSCIENCES) (SCI/2015)

12. Huang YS, Cheng CY, Chueh SH, Hueng DY,Huang YF, Chu CM, Wu ST, Tai MC,Liang CM, Liao MH, Chen CC, Shen LH, Ma KH*. Involvement of SHP2 infocal adhesion, migration and differentiation of neural stem cells. BRAIN & DEVELOPMENT . 2012 Sep;34(8):674-84. (IF: 1.785 ; Ranking: 125/192=65.1% ; CLINICAL NEUROLOGY) (SCI/2015)

13. Chen YA , Huang WS, Lin YS, Cheng CY , Liu RS, Wang SJ , Li IH, Huang SY, Shiue CY, Ma KH*. Characterization of 4-[18F]-ADAM as an imaging agent for SERT in non-human primate brain using PET: a dynamic study. Nucl Med Biol. 2012 Feb;39(2):279-85. (IF: 2.429 ; Ranking:44/124=35.5% ; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (SCI/2015)

14. Yeh CB, Huang WS, Lo MC, Chang CJ, Ma KH, Shyu JF. The rCBF brain mapping in adolescent ADHD comorbid developmental coordination disorder and its changes after MPH challenging. Eur J Paediatr Neurol. 2012 Nov; 16(6):613-8. (IF: 1.923 ; Ranking: 40/120=33.3% ; PEDIATRICS ) (SCI/2015)

15. Huang YY, Huang WS, Ma KH, Chou TK, Kuo YY, Cheng CY, Shiue CY. Synthesis and comparison of 4-[18F]F-ADAM, 2-[18F]F-ADAM, N-Desmethyl-4-[18F]F-ADAM and [18F]F-AFM as serotonin transporter imaging agents. Appl Radiat Isotopes. 2012 Oct; 70(10):2298-307. (IF: 1.136 ; Ranking: 14/32=43.8% ; NUCLEAR SCIENCE & TECHNOLOGY ) (SCI/2015)

16. Pao LH*, Lu SW, Sun GG, Chiou SH, Ma KH. Three Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior, the HPA axis, and proliferation of hippocampal precursor cell in vivo. J Ethnopharmacol. 2012 Nov 21; 144(2):261-9. (IF: 3.055, Ranking: 2/24=8.3% ; INTEGRATIVE & COMPLEMENTARY MEDICINE) (SCI/2015)

17. Huang WS, Huang SY, Ho PS, Ma KH, Huang YY, Yeh CB, Liu RS, Cheng CY, Shiue CY. PET imaging of the brain serotonin transporters (SERT) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) in humans: a preliminary study. Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):115-24. (IF: 5.337 ; Ranking: 6/124=4.8% ; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (SCI/2015)

18. Weng SJ, Shiue CY, Huang WS, Cheng CY, Huang SY, Li IH, Tao CC, Chou TK, Liao MH, Chang YP, Ma KH*. PET imaging of serotonin transporters with 4-[18F]-ADAM in a Parkinsonian rat model. Cell Transplant. 2013;22(7):1295-305. (IF: 3.427 ; Ranking: 34/124=27.4% ; MEDICINE, RESEARCH & EXPERIMENTAL) (SCI/2015)

19. Ho PS, Ho KK, Huang WS, Yen CH, Shih MC, Shen LH, Ma KH, Huang SY. Association study of serotonin transporter availability and SLC6A4 gene polymorphisms in patients with major depression. Psychiatry Research-Neuroimaging. 2013 Jun 30;212(3):216-22. (IF: 2.477 ; Ranking: 61/140=43.6% ; PSYCHIATRY) (SCI/2015)

20. Kang HH, Wang CH, Chen HC, Li IH, Cheng CY, Liu RS, Huang WS, Shiue CY, Ma KH*. Investigating the effects of noise-induced hearing loss on serotonin transporters in rat brain using 4-[18F]-ADAM/small animal PET. NeuroImage. 2013 Jul 15;75:262-9. (IF: 5.463 ; Ranking: 1/14=7.1% ; NEUROIMAGING) (SCI/2015)

21. Huang YS, Li IH, Chueh SH, Hueng DY, Tai MC, Liang CM, Lien SB, Sytwu HK, Ma KH*. Mesenchymal stem cells from rat olfactory bulbs can differentiate into cells with cardiomyocyte characteristics. J Tissue Eng Regen Med. 2015 December ; Volume 9, Issue 12, pages E191–E201 (IF: 4.710 ; Ranking: 5/76=6.5% ; ENGINEERING, BIOMEDICAL) (SCI/2015)

22. Chien CS*, Ma KH*, Lee HS, Liu PS, Li YH, Huang YS, Chueh SH. Dual effect of capsaicin on cell death in human osteosarcoma G292 cells. Eur J Pharmacol. 2013 Oct 15;718(1-3):350-60. (IF: 2.730 ; Ranking: 91/253=35.9% ; PHARMACOLOGY & PHARMACY) (SCI/2015) *Co-first author

23. Liu KC, Yo YT, Huang RL, Wang YC, Liao YP, Huang TS, Chao TK, Lin CK, Weng SJ, Ma KH, Chang CC, Yu MH, Lai HC. Ovarian cancer stem-like cells show induced translineage - differentiation capacity and are suppressed by alkaline phosphatase inhibitor. Oncotarget. 2013 Nov 16. [Epub ahead of print] (IF: 5.008 ; Ranking: 36/213=16.9% ; ONCOLOGY) (SCI/2015)

24. Lin YH, Fu KY, Hong PD, Ma H, Liou NH, Ma KH, Liu JC, Huang KL, Dai LG, Chang SC, Yi-Hsin Chan J, Chen SG, Chen TM, Dai NT. The effects of microenvironment on wound healing by keratinocytes derived from mesenchymal stem cells. Ann Plas Surg. 2013 Dec; 71 Suppl 1:S67-74. (IF: 1.535 ; Ranking: 103/199=51.8% ; SURGERY) (SCI/2015)

25. Chen YW, Lin GJ, Hueng DY, Huang SH, Chia WT, Shieh YS, Ma KH, Sytwu HK. Enhanced anti-tumor activity of triptolide in combination with irradiation for the treatment of oral cancer. Planta Med. 2014 Mar;80(4):255-61. Epub 2014 Feb 7 (IF: 1.99 ; Ranking: 70/209=33.5% ; PLANT SCIENCES) (SCI/2015)

26. Wang YW, Liou NH, Cherng JH, Chang SJ, Ma KH, Fu E, Liu JC, Dai NT. siRNA-Targeting Transforming Growth Factor-β Type I Receptor Reduces Wound Scarring and Extracellular Matrix Deposition of Scar Tissue. J Invest Dermatol. 2014 Jul;134(7):2016-25. Epub 2014 Feb 13. (IF: 6.915 ; Ranking: 1/61=1.63% ; DERMATOLOGY) (SCI/2015)

27. Liang CM, Weng SJ, Tsai TH, Li IH, Lu PH, Ma KH, Tai MC, Chen JT, Cheng CY, Huang YS. Neurotrophic and neuroprotective potential of human limbus-derived mesenchymal stromal cells. Cytotherapy. 2014 Jul 2. pii: S1465-3249(14)00633-1. (IF: 3.625 ; Ranking: 38/161=23.6% ; BIOTECHNOLOGY & APPLIED MICROBIOLOGY) (SCI/2015)

28. Chen YW, Huang HS, Shieh YS, Ma KH, Huang SH, Hueng DY, Sytwu HK, Lin GJ. A Novel Compound NSC745885 Exerts an Anti-Tumor Effect on Tongue Cancer SAS Cells In Vitro and In Vivo. PLoS One. 2014 Aug 15;9(8):e104703. (IF: 3.057 ; Ranking: 11/63=16.7% ; MULTIDISCIPLINARY SCIENCES) (SCI/2015)

29. Su WF, Liu SC, Wang SD, Su WY, Ma KH, Huang TT. Nerve branches to the posterior cricoarytenoid muscle may complicate the laryngeal reinnervation procedure. Laryngoscope. 2015 Feb;125(2):419-23. doi: 10.1002/lary.24944. Epub 2014 Sep 30. (IF: 2.272 ; Ranking: 9/43=20.9% ; OTORHINOLARYNGOLOGY) (SCI/2015)

30. Liang CS, Ho PS, Yen CH, Yeh YW, Kuo SC, Huang CC, Chen CY, Shih MC, Ma KH, Huang SY. Reduced striatal dopamine transporter density associated with working memory deficits in opioid-dependent male subjects: a SPECT study. Addiction Biology. 2014 Dec 1. doi: 10.1111/adb.12203. [Epub ahead of print] (IF: 4.547 ; Ranking: 2/18=11.1% ; SUBSTANCE ABUSE) (SCI/2015)

31. Yeh YW, Ho PS, Chen CY, Kuo SC, Liang CS, Ma KH, Shiue CY, Huang WS, Cheng CY, Wang TY, Lu RB, Huang SY. Incongruent Reduction of Serotonin Transporter Associated with Suicide Attempts in Patie. Int J Neuropsychoph. 2014 Oct 31;18(3). (IF: 4.333 ; Ranking: 39/253=15.4% ; PHARMACOLOGY & PHARMACY) (SCI/2015)

32. Li IH, Ma KH, Weng SJ, Huang SS, Liang CM, Huang YS. Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons. PLoS One. 2014 Dec 31;9(12) (IF: 3.057 ; Ranking: 11/63=16.7% ; MULTIDISCIPLINARY SCIENCES) (SCI/2015)

33. Yeh CH*, Ma KH*, Liu PS, Kuo JK, Chueh SH. Baicalein decreases hydrogen peroxide-induced damage to NG108-15 cells via upregulation of Nrf2. J Cell Physiol. 2015 Aug;230(8):1840-51. (IF: 4.155 ; Ranking: 12/83=14.5% ; PHYSIOLOGY) (SCI/2015) *Co-first author

34. Yeh YW, Ho PS, Kuo SC, Chen CY, Liang CS, Yen CH, Huang CC, Ma KH, Shiue CY, Huang WS, Shyu JF, Wan FJ, Lu RB, Huang SY. Disproportionate reduction of serotonin transporter may predict the response and adherence to antidepressants in patients with major depressive disorder: a positron emission tomography study with 4-[18F]-ADAM. Int J Neuropsychoph. 2015 Jan 7;18(7). (IF: 4.333 ; Ranking: 39/253=15.4% ; PHARMACOLOGY & PHARMACY) (SCI/2015)

35. Dai NT, Fan GY, Liou NH, Wang YW, Fu KY, Ma KH, Liu JC, Chang SC, Huang KL, Dai LG, Chen SG, Chen TM. Histochemical and Functional Improvement of Adipose-Derived Stem Cell-Based Tissue-Engineered Cartilage by Hyperbaric Oxygen/Air Treatment in a Rabbit Articular Defect Model. Ann Plas Surg. 2015 May;74 Suppl 2:S139-45. (IF: 1.535 ; Ranking: 103/199=51.8% ; SURGERY) (SCI/2015)

36. Chiu CH, Li IH, Weng SJ, Huang YS, Wu SC, Chou TK, Huang WS, Liao MH, Shiue CY, Cheng CY, Ma KH*. PET imaging of serotonin transporters with 4-[18F]-ADAM in a Parkinsonian rat model with porcine neural xenografts. Cell Transplant. 2016;25(2):301-11. (IF: 3.427 ; Ranking: 34/124=27.4% ; MEDICINE, RESEARCH & EXPERIMENTAL) (SCI/2015)

37. Chuang-Hsin Chiu, Tiing-Yee Siow, Shao-Ju Weng, Yi-Hua Hsu, Yuahn-Sieh Huang, Kang-Wei Chang, Cheng-Yi Cheng**, Kuo-Hsing Ma*. Effect of MDMA-Induced Axotomy on the Dorsal Raphe Forebrain Tract in Rats: An In Vivo Manganese-Enhanced Magnetic Resonance Imaging Study. PLoS One. 2015; 10(9): e0138431. (IF: 3.057 ; Ranking: 11/63=16.7% ; MULTIDISCIPLINARY SCIENCES) (SCI/2015)

38. Shao-Ju Weng , I-Hsun Li, Yuahn-Sieh Huang, Sheau-Huei Chueh, Ta-Kai Chou, San-Yuan Huang, Chyng-Yann Shiue , Cheng-Yi Cheng* , Kuo-Hsing Ma*. KA-bridged transplantation of mesencephalic tissue and olfactory ensheathing cells in a Parkinsonian rat model. J Tissue Eng Regen Med. 2015 Oct 29. doi: 10.1002/term.2098. [Epub ahead of print] (IF: 4.710 ; Ranking: 5/76=6.5% ; ENGINEERING, BIOMEDICAL) (SCI/2015)

39. Shih JH, Ma KH, Chen CF, Cheng CY, Pao LH, Weng SJ, Huang YS, Shiue CY, Yeh MK, Li IH. Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[18F]-ADAM/small-animal PET study. Eur Neuropsychopharmacol. 2015 Nov 14. pii: S0924-977X(15)00351-X. doi: 10.1016/j.euroneuro.2015.11.001. [Epub ahead of print] (IF: 4.409 ; Ranking: 35/253=13.8% ; PHARMACOLOGY & PHARMACY) (SCI/2015)

40. Li IH, Ma KH, Kao TJ, Lin YY, Weng SJ, Yen TY, Chen LC, Huang YS. Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity. Neurotoxicology. 2015 Nov 21;52:114-126. doi: 10.1016/j.neuro.2015.11.009. [Epub ahead of print] (IF: 2.738 ; Ranking: 32/90=35.6% ; TOXICOLOGY) (SCI/2015)

41. Huang KF, Ma KH*, Liu PS, Chen BW, Chueh SH. Baicalein increases keratin 1 and 10 expression in HaCaT keratinocytes via TRPV4 receptor activation. Exp Dermatol. 2016 Apr 6. doi: 10.1111/exd.13024. [Epub ahead of print] (IF: 2.675 ; Ranking: 11/61=18% ; DERMATOLOGY) (SCI/2015) *Co-first author

42. Yeh CB, Weng SJ, Chang KW, Chan JY, Huang SM, Chu TH, Wei NK, Ma HS, Cheng JT, Ma KH, Chen TH, Shyu JF. Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activity. Osteoporos Int. 2016 Jun 3. [Epub ahead of print] (IF: 3.445 ; Ranking: 45/131=33.9% ; ENDOCRINOLOGY & METABOLISM) (SCI/2015)

43. Yen CH, Shih MC, Cheng CY, Ma KH, Lu RB, Huang SY. Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence. Medicine (Baltimore). 2016 Aug;95(33):e4048. (IF: 1.206 ; Ranking: 77/151=51% ; MEDICINE, GENERAL & INTERNAL) (SCI/2015)

44. Ya-Yao Huang, Cheng-Yi Cheng, Wen-Sheng Huang, Kuo-Hsing Ma, Ta-Wei Tseng, Ta-Kai Chou, Yiyun Huang and Chyng-Yann Shiue. Erratum to: Toxicity and radiation dosimetry studies of the serotonin transporter radioligand [18F]AFM in rats and monkeys. EJNMMI Res. 2016 Dec;6(1):66. doi: 10.1186/s13550-016-0222-7. Epub 2016 Sep 6. (IF: 1.761 ; Ranking: 69/124=55.6% ; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING) (SCI/2015)

45. Kuo-Hsing Ma, Tsung Ta Liu, Shao-Ju Weng, Chien Fu F. Chen, Yuahn Sieh Huang, Sheau-Huei Chueh, Mei Hsiu Liao, Kang Wei Chang, Chi Chang Sung, Te Hung Hsu, Wen-Sheng Huang, and Cheng-Yi Cheng. Effects of dextromethorphan on MDMA-induced serotonergic aberration in the brains of non-human primates using [123I]-ADAM/SPECT. Scientific Reports. Accepted. (IF: 5.228 ; Ranking: 7/63=11.1% ; MULTIDISCIPLINARY SCIENCES) (SCI/2015)

Laboratory Description

Our researches focus on neuroimaging, therapeutic strategies of Parkinson’s disease, and effects of drug addiction in central nerve system (CNS). The main facilities and techniques of our laboratory are the animal-positron emission tomography (animal-PET), behavior analysis (rotation behavioral test, open-field test. and the test of radial arm maze), immunohistochemistry, and neurotransplanation. Our therapeutic strategies of Parkinson’s disease are the allograft, xenograft and KA-bridged transplantation to restore the brain dopaminergic and serotonergic systems. We have also established the preclinical screening platform for evaluating the candidate drugs which may exert the neuroprotective effects against addictive drug or hear loss using animal-positron emission tomography (animal-PET).

We have published several articles in the famous SCI journals such as Neuroimage, Cell transplantation, Nuclear medicine and biology, etc. we also participate the annual conferences such as the European Association of Nuclear Medicine (EANM) and Society of Nuclear Medicine and Molecular Imaging (SNMMI).

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  • Update Date:2021-10-25