Education and Training
2011-2014 Postdoctoral Research Scientist, advised by Stuart Firestein
Department of Biological Sciences, Columbia University
2005-2011 PhD, advised by Donald Wilson, Cellular and Behavioral Neurobiology
University of Oklahoma, Norman, Oklahoma, USA
2002-2004 Master of Science in Applied Cognition and Neuroscience
University of Texas at Dallas, Richardson, Texas, USA
1995-1999 Bachelor of Science in Agriculture, Department of Entomology
National Taiwan University, Taipei City, Taiwan
Academic Position
2015-present Assistant Professor, Graduate Institute of Life Sciences
National Defense Medical Center, Taipei, Taiwan
Research Interests
My laboratory is studying mammalian olfactory system with a focus on the olfactory cortex.
We use rodents (rats and mice) and the non-human primate (Rhesus monkeys) as the model systems.
Current interests include:
1. Organization of olfactory cortex and central olfactory circuit of the brain.
2. Olfactory perception and odor-induced emotion.
3. Olfactory disfunction and neurodegenerative diseases.
Recent Publications
1. Chen, H.L., Chen, C.F.F.*, Huang, H.B. Distinct age-specific effects on olfactory associative learning in C57BL/6 substrains. Frontiers in Behavioral Neuroscience. 2022. February 2. https://doi.org/10.3389/fnbeh.2022.808978 *Corresponding author.
2. Shabangu, T., Chen, H.L., Zhuang, Z.H., Pierani, A., Chen, C.F.F.*, Chou, S.J. Specific contribution of neurons from the Dbx1 lineage to the piriform cortex. Scientific Reports. 2021. April 16;11(1):8349. *co-corresponding author.
3. Weng, S.J.*, Chen, C.F.F.*, Huang, Y.S., Chiu, C.H., Wu, S.C., Lin, C.Y., Chueh, S.H., Cheng, C.Y., Ma, H.H. Olfactory ensheathing cells improve the survival of porcine neural xenografts in a Parkinsonian rat model. Xenotransplantation. 2019 Nov 28; e12569. *equal contribution.
4. Jhao, Y.T., Chiu, C.H., Chen, C.F.F., Chou, T.K., Lin, Y.W., Ju, Y.T., Wu, S.C., Yan, R.F., Shiue, C.Y., Chueh, S.H., Halldin, C., Cheng, C.Y., Ma, K.H.. The effect of Sertoli cells on xenotransplantation and allotransplantation of ventral mesencephalic tissue in a rat model of Parkinson’s disease. Cells. 2019. Nov 11;8(11) 1420
5. Li, I.H., Shih, J.H., Jhao, Y.T., Chen, H.C., Chiu, C.H., Chen, C.F.F., Huang, Y.S., Shiue, C.Y., Ma, K.H. Regulation of Noise-Induced loss of serotonin transporters with resveratrol in a rat model using 4-[18F]-ADAM/small-animal positron emission tomography. Molecules. 2019. Apr 5;24(7)
6. Ma, K.H., Liu, T.T., Weng, S.J., Chen, C.F., Liao, M.H., Chang, K.W., Sung, C.C., Hsu, T.H., Huang, W.S., Cheng, C.Y. Effects of dextromethorphan on MDMA-induced serotonergic aberration in the brains of non-human primates using [123I]-ADAM/SPECT. Scientific Reports. 2016 Dec 12;6:38695.
7. Shih, J.H., Ma, K.H., Chen, C.F., Cheng, C.Y., Pao, L.H., Weng, S.J., Huang, Y.S., Shiue, C.Y., Yeh, M.K., Li, I.H. Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[18F]-ADAM/small-animal PET study. European Neuropsychopharmacology. 2016. 26 92-104.
8. Chen, C.F., Zou, D.J., Altomare, C.G., Xu, L., Greer, C.A., and Firestein, S.J. Non-sensory target-dependent organization of piriform cortex. PNAS. 2014. 111(47) 16931-6.
9. Chen, C.F., Barnes, D.C. and Wilson, D.A. Generalized versus stimulus-specialized fear differentially modifies stimulus encoding in primary sensory cortex of awake rats. Journal of Neurophysiology. 2011. 106(6) 3136-44.
10. Wilson, D.A., Bell, H., Chen, C.F. Olfactory perceptual learning. Encyclopedic Reference of Neuroscience, Springer, 2009.
11. Rennaker, R.L., Chen, C.F., Ruyle, A.M., Sloan, A.M. and Wilson, D.A. Spatial and temporal distribution of odorant-evoked activity in the piriform cortex. Journal of Neuroscience. 2007. 27(7) 1534 - 42.