E-MAIL

ndmcyss@ndmctsgh.edu.tw

學歷

美國國家衛生研究院 訪問學者

國家衛生研究院 博士後研究

國防醫學院 生科所 博士

國防醫學院 牙醫學系 學士

經歷

中華牙醫學會 理事長 (106.11-108.10)

國防醫學院 牙醫學系 系主任 (100.8-106.9)

國防醫學院 牙醫科學研究所 所長 (100.8-106.9

三軍總醫院 牙科部 部主任  (100.8-106.9

主要授課內容

牙體復形學、頭頸腫瘤學、口腔診斷學

主要研究內容

Tumor biology: tumor microenvironment and cancer progression

Epigenetics: signal transduction and gene regulation

Inflammation and oral health: DM and oral diseases\

AI and 3D printing: clinical application

研究成果

謝義興教授近5年研究成果

1. Su YF, Lin CH, Shen PC, Chuang SE, Dai YH, Huang TW, Lin CY, Hung YJ, Shieh YS*.MiR-34a functions as a tumor suppressor in oral cancer through the inhibition of the Axl/Akt/GSK-3β pathway. J Dent Sci (In Press. Available online 25 August 2023) (本人為責任作者)

2. Su YF, Lin CH, Shen PC, Huang WY, Hung YJ, Huang TW, Dai YH, Lin CY, Shieh YS*.Nuclear translocation of Axl contributes to the malignancy of oral cancer cells. J Dent Sci (In Press. Available online 29 August 2023) (本人為責任作者)

3. Chao YC, Chen PH, Su WS, Yeh HW, Su CC, Wu YC, Chiang HS, Jhou HJ, Shieh YS*. Effectiveness of different root-end filling materials in modern surgical endodontic treatment: A systematic review and network meta-analysis. J Dent Sci. 2022;17(4):1731-1743. (本人為責任作者)

4. Hsu CT, Hsu SC, Huang SK, Lee CL, Shieh YS*. Air quality in a hospital dental department. J Dent Sci. 2022;17(3):1350-1355.

5. Chien CY, Chen YC, Hsu CC, Chou YT, Shiah SG, Liu SY, Hsieh AC, Yen CY, Lee CH, Shieh YS*. YAP-Dependent BiP Induction Is Involved in Nicotine-Mediated Oral Cancer Malignancy. Cells. 2021;10(8):2080. (本人為責任作者)

6. Chen YC, Chien CY, Hsu CC, Lee CH, Chou YT, Shiah SG, Liu SY, Yen CY, Hsieh AC, Wabitsch M, Shieh YS*. Obesity-associated leptin promotes chemoresistance in colorectal cancer through YAP-dependent AXL upregulation. Am J Cancer Res 2021;11(9):4220-4240. (本人為責任作者)

7. Chu-Yen Chien; Ying-Chen Chen; Chien-Hsing Lee; Jia-Rong Wu; Tsai-Wang Huang; Ren-Yeong Huang; Wan-Chien Cheng; Alexander Cheng-Ting Hsieh; Yi-Shing Shieh*. Dysregulation of the miR-30a/BiP axis by cigarette smoking accelerates oral cancer progression. Cancer Cell Int. 2021 Oct 30;21(1):578.. (本人為責任作者)

8. Hsu CC, Su YF, Tsai KY, Kuo FC, Chiang CF, Chien CY, Chen YC, Lee CH, Wu YC, Wang K, Liu SY, Shieh YS*. Gamma synuclein is a novel nicotine responsive protein in oral cancer malignancy. Cancer Cell Int. 2020 Jul 10;20:300. (本人為責任作者)

9. Lee KC, Wu YT, Chien WC, Chung CH, Shen CH, Chen LC, Shieh YS*. Osteoporosis and the risk of temporomandibular disorder in chronic obstructive pulmonary disease. J Bone Miner Metab. 2021;39(2):201-211. (本人為責任作者)

10. Lee KC, Wu YT, Chien WC, Chung CH, Chen LC, Shieh YS*. The prevalence of first-onset temporomandibular disorder in low back pain and associated risk factors: A nationwide population-based cohort study with a 15-year follow-up. Medicine (Baltimore). 2020 Jan;99(3):e18686. (本人為責任作者)

11. Hsu CC, Tsai KY, Su YF, Chien CY, Chen YC, Wu YC, Liu SY, Shieh YS*. α7-Nicotine acetylcholine receptor mediated nicotine induced cell survival and cisplatin resistance in oral cancer. Arch Oral Biol. 2020;111:104653. (本人為責任作者)

12. Chen SY, Chiang CF, Chiu KC, Cheng CW, Huang SM, Chen PH, Chen CY, Shieh YS*. Macrophage phenotypes and Gas6/Axl signaling in apical lesions. J Dent Sci. 2019 Sep;14(3):281-287. (本人為責任作者)

13. Lee KC, Wu YT, Chen LC, Shen CH, Chung CH, Chien WC, Shieh YS*. Chronic obstructive pulmonary disease combined with vertebral compression fracture increases the risk of temporomandibular disorder: A population-based cohort study. Medicine (Baltimore). 2019 Sep;98(37):e17162. (本人為責任作者)

14. Su CC, Huang RY, Wu YC, Cheng WC, Chiang HS, Chung MP, Cathy Tsai YW, Chung CH, Shieh YS*. Detection and location of second mesiobuccal canal in permanent maxillary teeth: A cone-beam computed tomography analysis in a Taiwanese population. Arch Oral Biol. 2019 Feb;98:108-114. (本人為責任作者)

15. Yeh HW, Chiang CF, Chen PH, Su CC, Wu YC, Chou L, Huang RY, Liu SY, Shieh YS*. Axl Involved in Mineral Trioxide Aggregate Induces Macrophage Polarization. J Endod. 2018 Oct;44(10):1542-1548. (本人為責任作者)

16. Huang TW, Lin KF, Lee CH, Chang H, Lee SC, Shieh YS*. The role of Thyroid Transcription Factor-1 and Tumor differentiation in Resected Lung Adenocarcinoma. Sci Rep. 2017 Oct 27;7(1):14222. (本人為責任作者)

17. Sua CC, Wu YC, Chung MP, Huang RY, Cheng WC, Cathy Tsai YW, Hsieh CY, Chiang HS, Chen CY, Shieh YS*. Geometric features of second mesiobuccal canal in permanent maxillary first molars: a cone-beam computed tomography study. J Dent Sci 2017; 12(3):241-248. (本人為責任作者)

18. Tsung-I Li, Meng-Ta Chiang, Kuo-Chou Chiu, Ching-Huang Lai, Yi-Shing Shieh*. The association of betel quid, alcohol, and cigarette with salivary gland tumor – a case-control study. J Dent Sci 2017; 12 (2): 151–155. (本人為責任作者)

19. Chang WM, Lin YF, Su CY, Peng HY, Chang YC, Lai TC, Wu GH, Hsu YM, Chi LH, Hsiao JR, Chen CL, Chang JY, Shieh YS*, Hsiao M, Shiah SG. Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2016 Dec 15;76(24):7140-7150. (本人為責任作者)

20. Cheng JC, Chiang MT, Lee CH, Liu SY, Chiu KC, Chou YT, Huang RY, Huang SM, Shieh YS*. γ-Synuclein Expression Is a Malignant Index in Oral Squamous Cell Carcinoma. J Dent Res. 2016 Apr;95(4):439-45. (本人為責任作者)

21. Chung TJ, Hsu KY, Chen JH, Liu JS, Chang HW, Li PF, Huang CL, Shieh YS*, Lee CH. Association of salivary alpha 2-macroglobulin levels and clinical characteristics in type 2 diabetes. J Diabetes Investig. 2016 Mar;7(2):190-6. (本人為責任作者)

榮譽及獎項

1. 2023指導學生參加Asia Pacific Dental Students Association (APDSA)壁報論文競賽第一名