學歷

國防醫學院牙醫系
國防醫學院醫科所博士

經歷

國防醫學院牙醫學系教授
三軍總醫院家牙暨口腔診斷科主任
三軍總醫院口腔顎面外科主任

主要授課內容

口腔顎面外科學、口腔解剖學、牙科放射線學、牙科麻醉學 、 牙科植體學、口腔腫瘤學。

主要研究方向

口腔顎顏面外科學、口腔腫瘤學
口腔癌之中草藥、標靶、基因、免疫治療

研究成果

最近5年已出版(SCI)之著作：
(SCI) Chin-Shan Kuo, Cheng-Yu Yang, Chih-Kung Lin, Gu-Jiun Lin, Huey-Kang Sytwu, Yuan-Wu Chen(Corresponding Author)＊.Triptolide suppresses oral cancer cell PD-L1 expression in the interferon-γ-modulated microenvironment in vitro, in vivo, and in clinical patients. BIOMEDICINE & PHARMACOTHERAPY (2020) Ranking 42/271=15% Impact Factor:4.545

(SCI)Tien-En Chiang, Yu-Chun Lin, Chi-Tsung Wu, Cheng-Yu Yang, Sheng-Tang Wu, Yuan-Wu Chen (2020). Comparison of the accuracy of diagnoses of oral potentially malignant disorders with dysplasia by a general dental clinician and a specialist using the Taiwanese Nationwide Oral Mucosal Screening Program.
PLOS ONE (2020) Ranking 27/71=38% Impact Factor:2.740

(SCI) Yuan-Wu Chen, Meng-Yen Chen, Dar-Jen Hsieh, Srinivasan Periasamy, Ko-Chung Yen, Chao-Tang Chuang, Hung-Chou Wang, Fan-Wei Tseng, Jer-Cheng Kuo, Hua-Hong Chien (2020). Evaluating the bone-regenerative role of the decellularized porcine bone xenograft in a canine extraction socket model. Clinical and Experimental Dental Research本人為第一作者.

(SCI) Cheng-Yu Yang, Chang-Huei Tsao, Cheng-Chih Hsieh, Chih-Kung Lin, Chun-Shu Lin, Yu-Hsuan Li, Wei-Chin Chang, Jen-Chen Cheng, Gu-Jiun Lin, Huey-Kang Sytwu, Yin-Lai Wang, Yuan-Wu Chen (2020). Downregulation of Jumonji-C domaincontaining protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model. PLOS ONE Ranking 27/71=38% Impact Factor:2.740

(SCI) Chang WC, Chang CF, Li YH, Yang CY, Su RY, Lin CK, Chen YW (2019). A histopathological evaluation and potential prognostic implications of oral squamous cell carcinoma with adverse features. Oral Oncol (Ranking 6/91=7% Impact Factor:3.979)(本人為通訊作者).

(SCI) Cheng-Yu Yang, Chih-Kung Lin, Cheng-Chih Hsieh, Chang-Huei Tsao, Chun-Shu Lin, Bo Peng, Yen-Tzu Chen, Chun-Chieh Ting, Wei-Chin Chang, Gu-Jiun Lin, Huey-Kang Sytwu, Yuan-Wu Chen (Corresponding Author) ＊. Triptolide exerts anti-oral cancer effects by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model.Head & Neck (2018) 2016 Ranking 1/42= 2.4% (投稿與Revised 2) Impact Factor: 3.376 (本人為單一責任作者)

(SCI) Yang CY, Hsieh CC, Lin CK, Lin CS, Peng B, Lin GJ, Sytwu HK, Chang WL, Chen YW (Corresponding Author) ＊.BMC Complement Altern Med. (2017) Dec 29;17(1):555. (2017 Ranking 8/27=29.6%)Impact Factor: 2.109 (本人為單一責任作者)

(SCI) Cheng-Yu Yang, Chih-Kung Lin, Chang-Huei Tsao, Cheng-Chih Hsieh, Gu- Jiun Lin, Kuo-Hsing Ma, Yi-Shing Shieh, Huey-Kang Sytwu, Yuan-Wu Chen＊. (Corresponding Author) Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models. Oncotarget. 2017 May 16;8(20):33756-33769. (投稿與接受時為SCI IF:5.168) (Received: June 16, 2016 Accepted: March 08, 2017 Published: April 04, 2017) impact factor: 5.168(本人為單一責任作者)

(SCI)Yang CY, Lin CK, Lin GJ, Hsieh CC, Huang SH, Ma KH, Shieh YS, Sytwu HK, Chen YW＊(Corresponding Author). (2016) Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells. Clin Oral Investig. 2016 Apr 13. (2017Ranking 19/91=20.8%) Impact Factor: 2.386 (本人為單一責任作者)

(SCI) Yu-Hsuan Li, Wei-Chin Chang, Tien-En Chiang, Chiun-Shu Lin, Chen YW (Corresponding Author) ＊Mouth-opening device as a treatment modality in trismus patients with head and neck cancer and oral submucous fibrosis: A prospective study Clin Oral Investig. 2018. (2017Ranking 19/91=20.8%) Impact Factor: 2.386 (本人為單一責任作者)

(SCI) Chang WC, Lin CS, Yang CY, Lin CK, Chen YW (Corresponding Author) ＊. Lymph node density as a prognostic predictor in patients with betel nut-related oral squamous cell carcinoma. Clin Oral Investig. 2017 Oct 17. (2017Ranking 19/91=20.8%) Impact Factor: 2.386 (本人為單一責任作者)

(SCI)Tsai PT, Shieh YS, Wu CT, Lee SP, Chen YW＊(Corresponding Author). (2016) Buccal Mucosa Elasticity Influences Surgical Margin Determination in Buccal Carcinoma Resection. J Oral Maxillofac Surg. 2016 Sep;74(9):1900.e1-7. (本人為單一責任作者)

(SCI) Tien-En Chiang, Yu-Chun Lin, Yu-Hsuan Li, Chi-Tsung Wu, Chin-Shan Kuo, Yuan-Wu Chen＊(Corresponding Author).(2018) Comparative evaluation of autofluorescence imaging and histopathological investigation for oral potentially malignant disorders in Taiwan Clin Oral Investig. 2018 Oct . (2017Ranking 19/91=20.8%) Impact Factor: 2.386 (本人為單一責任作者)