E-MAIL
shuyilin@mail.ndmctsgh.edu.tw
經歷Experience
國防醫學院藥學系助理教授 (2024/05-present)
國防醫學院藥學系講師 (2018/08-2024/04)
國防醫學院藥學系兼任講師 (2016/08-2018/08)
國軍花蓮總醫院藥師、採購官 (2018/01-2018/08)
三軍衛材供應處衛材補給官、採購官、庫長 (2012/07-2017/12)
2024/05–present Assistant professor, School of Pharmacy, National Defense Medical Center
2018/08–2024/04 Lecturer, School of Pharmacy, National Defense Medical Center
2016/08–2018/08 Adjunct lecturer, School of Pharmacy, National Defense Medical Center
2018/01–2018/08 Pharmacist, Hualien Armed Forces General Hospital
2012/07–2017/12 Military service, Armed Forces Medical Supplies Office
專長學科 Research Interest
合成生物學，天然物化學
Synthetic biology, Natural product chemistry
實驗室簡介 Short Biography
天然物具有各種生物活性且結構多樣，所以在臨床應用上有不同的藥理與治療潛力，是新藥開發中非常重要的來源，許多藥物都是由天然物直接或衍生發展而來。近年，隨著基因定序技術、生物資訊學與合成生物學等領域的快速進步，使天然物得以從基因與蛋白質層面進行相關研究。
目前本實驗室主要利用基因體探勘與真菌異源表達的方式，探索真菌生物合成基因簇產生的天然物及其生物合成途徑，並進行相關藥理活性的篩選。另外我們也以活性測試為導向進行活性天然物的分離純化與結構鑑定。
Natural products possess various biological activities and structural diversity, hence they hold different pharmacological and therapeutic potentials in clinical applications. They are important sources in the development of new drug, as many medications are directly derived from or inspired by these compounds. In recent years, rapid advancements in fields such as gene sequencing, bioinformatics, and synthetic biology have enabled a deeper understanding of natural products at the genetic and protein levels.
Currently, our research primarily utilizes genome mining and heterologous expression in fungi to explore natural products produced by fungal biosynthetic gene clusters and their biosynthetic pathways. We also conduct screening for relevant pharmacological activities. Additionally, we focus on the discovery of bioactive natural products guided by bioactivity assays.
著作 Publications
(Star-sign*: correspondent)
1. Shu-Yi Lin, Meng-Ren Wang, Shih-Jiuan Chiu, Chien-Yu Lin, and Teh-Min Hu*. S-Nitrosothiols (SNO) as light-responsive molecular activators for post-synthesis fluorescence augmentation in fluorophore-loaded nanospheres. Journal of Materials Chemistry B. 2018, 6(1): 153–164. (IF = 7.0; Materials Science, Biomaterials, 10/45 = 22.22%)
2. Chris Rabot, Yuhao Chen, Shu-Yi Lin, Ben Miller, Yi-Ming Chiang, C. Elizabeth Oakley, Berl R. Oakley, Clay C. C. Wang*, and Travis J. Williams*. Polystyrene upcycling into fungal natural products and a biocontrol agent. Journal of the American Chemical Society. 2023, 145(9): 5222-5230. (IF = 15.0; Chemistry, Multidisciplinary, 17/178 = 9.55%)
3. Shu-Yi Lin, C. Elizabeth Oakley, Cory B. Jenkinson, Yi-Ming Chiang, Ching-Kuo Lee, Christopher G. Jones, Paul M. Seidler, Hosea M. Nelson, Richard B. Todd, Clay C. C. Wang*, and Berl R. Oakley*. A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathway. Chemical Science. 2023, 14(40): 10983–11284. (IF = 8.4; Chemistry, Multidisciplinary, 32/178 = 17.98%)
專利 Patent
1. Swati Bijlani, Chris Rabot, Yuhao Chen, Shu-Yi Lin, Ben Miller, Yi-Ming Chiang, Clay C. C. Wang, and Travis J. Williams. Conversion of Waste Plastics to High-Value Metabolites. 2022, USC-0336PUSP.
2. Chris Rabot, Yuhao Chen, Shu-Yi Lin, Ben Miller, Yi-Ming Chiang, Clay C. C. Wang, and Travis J. Williams. Polystyrene upcycling into fungal natural products and a biocontrol agent. 2023, USC-0343PRV.
會議論文 Conference Papers
1. Shu-Yi Lin, C. Elizabeth Oakley, Cory B. Jenkinson, Yi-Ming Chiang, Ching-Kuo Lee, Christopher G. Jones, Paul M. Seidler, Hosea M. Nelson, Richard B. Todd, Clay C. C. Wang, and Berl R. Oakley. A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters in Aspergillus fumigatus. AAPS Moving Targets Conference, Los Angeles, USA, Aug. 2023. (Winner of the 2023 Young Investigator Award)