最高學歷

英國牛津大學
分子科學中心博士

研究興趣

蛋白質結構與功能、分子酶學及由蛋白質結構設計新穎藥物研究

研究論文

Yin, F. Y., Chen, Y. H., Yu, C. M., Pon, Y. C. and Lee, H. J.* (2007) Kinetic refolding barrier of guanidinium chloride denatured goose d-crystallin leads to regular aggregate formation. Biophys. J. 93, 1235-1245. ( IF = 4.683; Biophysics, 9/70 = 12.9% )

Lin, C. H., Peng, Y. H., Coumar, M. S., Chittimalla, S. K., Liao, C. C., Lyn, P. C.,Huang, C. C., Lien, T. W., Lin, W. H., Hsu, J. T. A., Cheng, J. H., Chen, X., Wu, J. S., Chao, Y. S., Lee, H. J., Juo, C. G., Wu, S. Y., and Hsieh, H. P. (2009) Design and Structural Analysis of Novel Pharmacophores for Potent and Selective Peroxisome Proliferator-activated Receptor γ Agonists. J. Med. Chem.52, 2618-2622. ( IF = 4.898; Chemistry, Medicinal, 3/40 = 7.5%)

Huang, C. W., Tseng, C. C., Chen, Y. H., Chen, Y. H., Chou, W. Y. and Lee, H. J.* (2009) Substitution of residues at the double dimer interface affects the stability and oligomerization of goose d-crystallin. FEBS J. 276, 5126-5136. ( IF = 3.139; Biochemistry & Molecular Biology, 105/276 = 38%)

Huang, C. W. and Lee, H. J.* (2009) Role of Glu367 in the quaternary structure of goose d-crystallin. J. Med. Sci. 29, 315-318.

Huang, C. W., Chen, Y. H., Chen, Y. H., Tsai, Y. C. and Lee, H. J.* (2009) The interaction of Glu294 at the subunit interface is important for the activity and stability of goose d-crystallin. Mol. Vis. 15, 2358-2363. ( IF = 2.464; Ophthalmology, 14/48 = 29%)

Chen, Y. H., Lee, M. T., Cheng, Y. W., Chou, W. Y., Yu, C. M., and Lee, H. J.* (2011) Distinct interactions of aA-crystallin with homologous substrate proteins, d-crystallin and argininosuccinate lyase, under thermal stress. Biochimie 93, 314-320. (IF = 3.897; Biochemistry & Molecular Biology, 78/283 = 27.6%)

Chang, Y. L., Lee, H. J., Liu, S. T., Lin, Y. S., Chen, T. C., Hsieh, T. Y., Huang, H. S., and Huang, S. M. (2011) Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin. Int. J. Biochem. Cell Biol. 43, 1720-1728 (IF = 4.956; Biochemistry & Molecular Biology, 58/286 = 20.3 %)

Wei, Y. Y., Huang, C. W., Chou, W. Y., Lee, H. J.* (2012) α-Crystallin protects human arginosuccinate lyase activity under freeze-thaw conditions. Biochimie 94, 566-573.

Hsu, T. H., Chu, C. C., Hung, M. W. Lee, H. J., Hsu, H. J., Chang, T. C. (2013) Caffeic acid phenethyl ester induces E2F-1-mediated growth inhibition and cell cycle arrest in human cervical cancer cells. FEBS J. 280: 2581–2593.

Chi-Ching Hwang, Yi-Hsun Chang; Hwei-Jen Lee; Tzu-Pin Wang; Yu-Mei Su; Hsin-Wei Chen; Po-Huang Liang (2013) The catalytic roles of P185 and T188 and substrate-binding loop flexibility in 3α-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosterone. PLos ONE 8 (5), e63594.

Jang-Foung Lin, Yung-Lin Sheih, Tsu-Chung Chang, Ni-Yuan Chang, Chiung-Wen Chang, Chia-Pei Shen, and Hwei-Jen Lee* (2013) The interactions in the carboxyl terminus of human 4-hydroxyphenylpyruvate dioxygenase are critical to mediate the conformation of the final helix and the tail to shield the active site for catalysis. PLos ONE 8(8), e69733.

Tsai YT, Chuang MJ, Tang SH, Wu ST, Chen YC, Sun GH, Hsiao PW, Huang SM, Lee HJ, Yu CP, Ho JY, Lin HK, Chen MR, Lin CC, Chang SY, Lin VC, Yu DS, Cha TL. (2015) Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf-DAPK Complex by Raf Inhibitor Combination Therapy. Cancer Res. Sep 1;75(17):3568-82. (IF = 9.329; Oncology, 11/211 =5.2%)

Chih-Wei Huang, Hui-Chen Lin, Chi-Yuan Chou, Wei-Chuo Kao, Wei-Yuan Chou and Hwei-Jen Lee* (2015) Lys-315 at the interfaces of diagonal subunits of δ-crystallin plays a critical role in the reversibility of folding and subunit assembly. PLos ONE 11(1), e145957. (IF= 3.73; Multidisciplinary Sciences, 7/56 = 12.5%）

Li-Chen Yen, Jia-Teh Liao, Hwei-Jen Lee, Wei-Yuan Chou, Chun-Wei Chen, Yi-Ling Lin, and Ching-Len Liao (2016) The C-Terminus of the Core β-Ladder domain in Japanese Encephalitis Virus Nonstructural Protein 1 Is Flexible for Accommodation of Heterologous Epitope Fusion. J. Virol. 90(3), 1178-1189. (IF=4.439; Virology, 7/33 = 21.2%)

Chih-Wei Huang, Hsiu-Chen Liu, Chia-Pei Shen, Yi-Tong Chen, Sung-Jai Lee, Matthew D. Lloyd, and Hwei-Jen Lee* (2016) The different catalytic roles of the metal binding ligands in human 4-hydroxyphenylpyruvate dioxygenase. Biochem. J. 473 (9), 1179-1189. (IF= 4.396; Biochemistry & Molecular Biology, 67/290 = 23%）

Chang Hung, Chang Cheng-Yi, Lee Hwei-Jen, Chou Ching-Yu, Chou Tz-Chong (2018) Magnolol ameliorates pneumonectomy and monocrotaline-induced pulmonary arterial hypertension in rats through inhibition of angiotensin II and endothelin-1 expression. Phytomedicine 51, 205-213. (IF=3.186; Plant science, 34/223 = 15.2%)

An-Ning Feng, Chih-Wei Huang, Chi-Huei Lin, Yung-Lung Chang, Meng-Yuan Ni and Hwei-Jen Lee*(2020) Role of the N-terminus in human 4-hydroxyphenylpyruvate dioxygenase activity. J. Biochem. 167(3),315-322.