最高學歷

美國南加州大學
生化及分子生物博士

研究興趣

探討小分子藥物抑制癌症生成之作用機轉
The study of mechanisms of small molecule drugs in tumorigenesis.

探討Zac1轉錄因子結構及功能之關聯性
The study of relationship between structures and functions of transcription factor Zac1

研究論文

Lu GY, Huang SM, Liu ST, Liu PY, Chou WY and Lin WS (2014) Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genes, The International Journal of Biochemistry and Cell Biology, 47, 83-92 (IF = 4.240; Biochemistry and Molecular Biology, 75/291 =25.8%)

Chan JYH, Chen YC, Liu ST, Chou WY, Ho CL and Huang SM (2014) Characterization of one new mouse p53 variant: loss-of-function and gain-of-function, Journal of Biomedical Science, 21: 40 (co-corresponding author) (IF = 2.736; Medicine, Research & Experimental, 49/124 =39.5%)

Hsu SJ, Huang SM, Chen A, Sun CY, Lin SH, Chen JS, Liu ST and Hsu YJ (2014) Resveratrol increases renal klotho gene expression via the activating transcription factor 3/c-Jun complex-mediated signaling pathway, The International Journal of Biochemistry and Cell Biology, 53, 361-371 (IF = 4.240; Biochemistry and Molecular Biology, 75/291 =25.8%)

Wang WM, Chen JF, Liu ST, Hsu YJ, Liu YC and Huang SM (2014) Biochemical properties of the recurrent LMX1b truncated mutant carried in a Taiwanese family with nail-patella syndrome. British Journal of Dermatology, 171, 356-362 (IF = 4.100; Dermatology, 7/61 =11.5%)

Yang HY, Huang SM, Lu KC, Wu CC, Kang CY, Lin YF, Lin C, Lin FH, Kao SY, Su SL (2014) A Functional Polymorphism in the Promoter Region of TLR3 Is Associated with Susceptibility to End-Stage Renal Disease, American Journal of Nephrology, 40, 31-139 (IF = 2.646; Urology and Nephrology, 21/77=27.3%)

Lu GY, Liu ST, Huang SM, Chang YL and Lin WS (2014) Multiple effects of digoxin on subsets of cancer-associated genes through the alternative splicing pathway, Biochimie, 106, 131-139 (co-corresponding author) (IF = 3.123; Biochemistry and Molecular Biology, 122/291 =41.9%)

Hsu SJ, Huang SM, Lin SH, KA SM, Chen A, Shih MF and Hsu YJ (2014) Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway, Biochemical Journal, 464(2), 221-229 (IF = 4.779; Biochemistry and Molecular Biology, 61/291 =21.0%)

Tang SH, Huang SH, Wu HU, Tsai YT, Chuang MJ, Yu CP, Huang SM, Sun GH, Chang SY, Hsiao PW, Yu DS and Cha TL (2014) Pharmacologic Down-regulation of EZH2 Suppresses Bladder Cancer in Vitro and in Vivo. Oncotarget, 5(21):10342-10355 (IF = 6.627; Oncology, 17/203 =8.4%)

Hsu YJ, Yang SS, Cheng CJ, Liu ST, Huang SM, Chau T, Chu P, Salter DM, Lee HS, Lin SH (2015) Thiazide-sensitive Na+-Cl- cotransporter (NCC) gene inactivation results in increased duodenal Ca2+ absorption, enhanced osteoblast differentiation and elevated bone mineral density, Journal of Bone and Mineral Research, 30(1), 116-127 (IF = 6.589; Endocrinology & Metabolism, 12/124=9.7%)

Chang YL, Gao HW, Chiang CP, Wang WM, Huang SM, Ku CF, Liu GY and Hung HC (2015) Human Mitochondrial NAD(P)+-Dependent Malic Enzyme Participates in Cutaneous Melanoma Progression and Invasion. Journal of Investigative Dermatology, 135, 807-815 (IF = 6.372; Dermatology, 1/61 =1.6%)

Cha TL, Chuang MJ, Tang SH, Wu ST, Sun KH, Chen TT, Sun GH, Chang SY, Yu CP, Ho JY, Huang SM and Yu DS (2015) Emodin Modulates Epigenetic Modifications and Suppresses Bladder Carcinoma Cell Growth, Molecular Carcinogenesis, 54(3):167-77 (IF = 4.770; Oncology, 43/203 =21.2%)

Chiou HY, Lai WK, Huang LC, Huang SM, Chueh SH, Ma HI and Hueng DY (2015) Valproic acid induced apoptosis and promoted radiosensitization in meningioma stem-like cells, Oncotarget, 6(12):9959-69 (IF = 6.627; Oncology, 17/203 =8.4%)

Chiu KC, Lee CH, Li SY, Chou YT, Huang RY, Huang SM and Shieh YS (2015) Polarization of tumor-associated macrophages and Gas6/Axl signaling in oral squamous cell carcinoma. Oral Oncology, 51(7):683-689. (IF = 3.029; Dental, 5/83 =6.0%)

Hsu YJ, Hsu SC, Huang SM, Lee HS, Lin SH, Tsai CS, Shih CC and Lin CY. (2015) Hyperphosphatemia induces protective autophagy in endothelial cells through the inhibition of Akt/mTOR signaling. Journal of Vascular Surgery, 62(1):210-221. (IF = 3.021; Suergy, 33/198 =16.7%)

Lin CY, Hsu YJ, Hsu SC, Chen Y, Lee HS, Lin SH, Huang SM, Tsai CS and Shih CC (2015) CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia. Journal of Molecular and Cellular Cardiology, 85, 249-261 (IF =4.66; Cardiology, 19/123 =15.4%)

Tsai YT, Chuang MJ, Tang SH, Wu ST, Chen YC, Sun GH, Hsiao PW, Huang SM, Lee HJ, Yu CP, Ho JY, Lin HK, Chen MR, Lin CC, Chang SY, Lin VC, Yu DS, Cha TL (2015) Novel Cancer Therapeutics with Allosteric Modulation of The Mitochondrial C-Raf/DAPK Complex by Raf Inhibitor Combination Therapy. Cancer Research, 75(17):3568-82 (IF = 9.329; Oncology, 11/211 =5.2%)

Hung CT, Huang SM, Cheng HC, Liu ST, Chang YL, Liu YC and Wang WM (2015) The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes. Journal of Dermatological Science, 79, 262-267 (IF = 3.419; Dermatology, 10/63 =15.9%)

Liu ST, Huang SM, HO CL, LC Yen, Huang CJ, Lin WS and Chan JYH (2015) The role of myogenin in doxorubicin-induced cardiotoxicity in rat H9c2 cardiomyocytes, Oncotarget, 6(35):37443-37457 (IF = 6.359; Oncotarget, 21/211 =9.9%)

Chu YW, Liu ST, Cheng HC, Huang SM, Chang YL, Chiang CP, Liu YC and Wang WM (2015) Opposing effects of Zac1 and curcumin on AP-1-regulated expressions of S100A7. PLOS ONE, 10(12):e0144175 (co-coresponding author) (IF = 3.324; Multidisciplinary Sciences, 9/57 =15.8%)

Cheng JC, Chiang MT, Lee CH, Liu SY, Chiu KC, Chou YT, Huang RY, Huang SM, and Shieh YS (2016) -Synuclein expression is a malignant index in oral squamous cell carcinoma. Journal of Dental Research, 95(4):439-45. (IF = 4.602; Dentistry, Oral Surgery & Medicine, 2/91 =2.2%)

Cheng CP, Huang LC, Chang YL, Hsieh CH, Huang SM, and Hueng DY (2016) The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas, Oncotarget, 7(27 ):41460-41472 (co-corresponding author) (IF = 5.008; Oncology, 36/213=16.9%)

Yeh CB, Weng SJ, Chang KW, Chan JY, Huang SM, Chu TH, Wei NK, Ma HS, Cheng JT, Ma KH, Chen TH, and Shyu JF (2016) Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activity, Osteoporosis International, 27(11):3355-3364. (IF = 3.455; Endocriologly & Metabolism, 45/133 =33.8%)

Chen YJ, Lin CL, Li CR, Huang SM, Chan JY, Fang WH, Chen WL (2016) Associations among integrated psychoneuroimmunological factors and metabolic syndrome. Psychoneuroendocrinology, 74:342-349. (IF = 4.704; Endocriologly & Metabolism, 23/133 =17.3%)

Su HC, Liang YA, Lai YJ, Chiu YL, Barndt RB, Shiao F, Chang HD, Lu DD, Huang N, Tseng CC, Wang JK, Lee MS, Johnson MD, Huang SM, and Lin CY (2016) Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled manner, PLOS ONE, 11(12):e0167894 (co-corresponding author) (IF = 2.806; Multidisciplinary Sciences, 15/64 =22.7%)

Hsu YJ, Hsu SC, Hsu CP, Chen YH, Chang YL, Sadoshima J, Huang SM, Tsai CS, and Lin CY (2017) Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model. International Journal of Cardiology, 228:543-552. (IF = 6.189; Cardiac & Cardiovascular Systems, 16/126 =12.3%)

Chen SJ, Kao YH, Jing L, Chuang, YP, Wu WL. Liu ST, Huang SM, Lai JH, Ho LJ, Tsai MC, and Lin CS (2017) Epigallocatechin-3-gallate Reduces Scavenger Receptor A Expression and Foam Cell Formation in Human Macrophages, Journal of Agricultural and Food Chemistry, 65(15):3141-3150 (IF=3.154; Multidisciplinary Agriculture, 2/56 =2.7%)

Shiu TY, Shih YL, Feng AC, Lin HH, Huang SM, Huang TY, Hsieh CB, Chang WK, and Hsieh TY (2017) HCV core inhibits hepatocellular carcinoma cell replicative senescence through downregulating microRNA-138 expression. Journal of Molecular Medicine, 95(6):629-639 (IF=4.686; Genetics & Heredity, 27/167 =15.9%)

Chung MH, Wang YW, Chang YL, Huang SM, and Lin WS (2017) Risk of Cancer in Patients with Heart Failure Who Use Digoxin: A 10-Year Follow-Up Study and Cell-Based Verification, Oncotarget, 8(27):44203-44216 (IF = 5.168; Oncology, 44/217=20.3%)

Lai XM, Liu SY, Tsai YT, Sun GH, Chang SY, Huang SM, and Cha TL (2017) HAF Mediates the Evasive Resistance of Anti-angiogenesis TKI through Disrupting HIF-1a and HIF-2a Balance in Renal Cell Carcinoma, Oncotarget, 8(30):49713-49724 (co-corresponding author) (IF = 5.168; Oncology, 44/217=20.3%)

Chu YW, Liu ST, Yang YL, Huang SM, and Wang WM (2017) The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes. Journal of Biomedical Science, 24(1):55. (co-corresponding author) (IF = 2.799; Medicine, Research & Experimental, 51/128=39.5%)

Chen WL, Huang AF, Huang SM, Ho CL, Chang YL, and Chan YH (2017) CD164 promotes lung tumor-initiation cells with stem cell activity and determines tumor growth and drug resistance via Akt/mTOR signaling. Oncotarget, 8(33):54115-54135 (IF = 5.168; Oncology, 44/217=20.3%)

Lu JW, Hsieh PS, Lin CC, Hu MK, Huang SM, Wang YM, Liang CY, Gong Z, and Ho YJ (2017) Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus. Biochemical and Biophysical Research Communications, 491:595-602 (IF = 2.466; Biochemistry & Molecular Biology, 95/290 =56.4%)

Chang YL, Huang LC, Chen YC, Wang YW, Heung DY, and Huang SM (2017) The synergy effects of valproic acid and fluvastatin on apoptosis induction in glioblastomas multiforme cell lines, International Journal of Biochemistry and Cell Biology, 92:155-163 (co-corresponding author) (IF = 3.505; Biochemistry & Molecular Biology, 95/290 =32.6%)

Tseng MH, Huang SM, Lo FS, Huang JL, Cheng CJ, Lee HJ, and Lin SH (2017) Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with Alopecia. Scientific Reports, 7:15337

Chang YL, Hsu YJ, Chen Y, Wang YW, and Huang SM (2017) Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines, Oncotarget, 8;101461-101474 (co-corresponding author) (IF = 5.168; Oncology, 44/217=20.3%)

Lee CH, Su SC, Chiang CF, Chien CY, Hsu CC, Yu TY, Huang SM, Shieh YS, Kao HW, Tsai CS, Hung YJ and Lin CY (2017) Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1, Oncotarget, 8(66):110039-110051 (IF = 5.168; Oncology, 44/217=20.3%)

Chin LH, Hsu YJ, Hsu SC, Chen YH, Chang YL Huang SM, Tsai CS and Lin CY (2017) The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease, Oncotarget, 8(69):113303-113317 (IF = 5.168; Oncology, 44/217=20.3%)

Hsu YJ, Hsu SC, Chang YL, Huang SM, Shih CC, Tsai CS, and Lin CY (2018) Indoxyl sulfate upregulates the cannabinoid type 1 receptor gene via an ATF3/c-Jun complex-mediated signaling pathway in the model of uremic cardiomyopathy, International Journal of Cardiology, 252:128-135 (IF = 6.189; Cardiac & Cardiovascular Systems, 16/126 =12.3%)

Chang YL, Liu ST, Wang YW, Lin WS, and Huang SM (2018) Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224, Oncotarget, 9(17):13390-13406 (co-corresponding author) (IF = 5.168; Oncology, 44/217=20.3%)

Kuo CL, Liu ST, Chang YL, Wu CC and Huang SM (2018) Zac1 regulates IL-11 expression in osteoarthritis, Oncotarget, 9(65):32478-32495 (corresponding author) (IF = 5.168; Oncology, 44/217=20.3%)

Hsieh Li SM, Liu ST, Chang YL, Ho CL and Huang SM (2018) Metformin Causes Cancer Cell Death mediated through downregulation of p53-dependent differentiated embryo chondrocyte 1, Journal of Biomedical Science, 25:81 (co-corresponding author) (IF = 3.466; Medicine, Research & Experimental, 46/133=36.2%)

Syu WZ, Chen SG, Chan, JY, Wang CH, Dai NT, Huang SM (2019) The Potential of Acellular Dermal Matrix Combined With Neural Stem Cells Induced From Human Adipose-Derived Stem Cells in Nerve Tissue Engineering. Annals of Plastic Surgery, 82, S108-S118 (IF =1.536; Surgery, 117/200=58.5%)

Wu LW, Chen WL, Huang SM, Chan JY (2019) Platelet-derived growth factor-AA is a substantial factor in the ability of adipose-derived stem cells and endothelial progenitor cells to enhance wound healing. FASEB J, 33(2), 2388-2395 (IF = 5.595; Biology, 8/85=8.8%)

Wang CC, Hueng DY, Huang AF, Chen WL, Huang SM, and Chan JYH (2019) CD164 Regulates Proliferation, Progression, and Invasion of human glioblastoma cells, Oncotarget, 10(21):2041-2054 (co-corresponding author)

Lin CK, Liu ST, Chang CC, and Huang SM (2019) Regulatory mechanisms of fluvastatin and lovastatin for the p21 induction in human cervical cancer cells, Plos ONE, 14(4):e0214408 (co-corresponding author) (IF = 2.776; Multidisciplinary Sciences, 24/69=34.78%)

Tseng MH, Tsai JD, Tsai IJ, Huang SM, Huang JL, Fan WL, Lee HJ, Wu TW, Lin SH. (2019) Whole-Exome Sequencing Detects Mutations in Pediatric Patients with Atypical Hemolytic Uremic Syndrome in Taiwan. Clinica Chimica Acta, 494:143-150(IF = 2.735; Clinical Laboratory Technology, 8/29=27.59%)

Tsai YC, Lin YC, Huang CC, Villaflores OB, Wu TY, Huang SM, and Chin TY (2019) Hericium erinaceus mycelium and its isolated compound, Erinacine A, ameliorate high-fat high-sucrose diet–induced metabolic dysfunction and spatial learning deficits in aging mice. Journal of Medicinal Food, 22, 469-478 (co-corresponding author) (IF = 2.020; Food Secience and Technology, 60/135=44.44%)

Kuo CL, Hsieh Li SM, Liang SY, Liu ST, Wang WM, Yen LC, and Huang SM (2019) The antitumor properties of metformin and phenformin reflect their ability to inhibit the actions of differentiated embryo chondrocyte 1, Cancer Management and Research, 11:6567-6579 (co-corresponding author) (IF = 2.243; Oncology, 167/229=72.92%)

Syu WZ, Hueng DY, Chen WL, Chan JYH, Chen SG, and Huang SM (2019) Adipose-derived neural stem cells combined with acellular dermal matrix as a neural conduit enhances peripheral nerve repair, Cell Transplantation, in press (co-corresponding author) (IF = 3.477; Medicine, Research and Experimental, 54/136=39.7%)

Chen SY, Chiang CF, Chiu KC, Cheng CW, Huang SM, Chen PH, Chen CY, Shieh YS (2019) Macrophage phenotypes and Gas6/Axl signaling in apical lesions, Journal of Dental Sciences, 14, 281-287. (IF = 0.798; Dentistry, Oral Surgery & Medicine, 83/91=91.2%)

Chen YJ, Huang SM, Tai MC, Chen JT, Liang CM (2019) Glucosamine Impedes Transforming Growth Factor 1-mediated Corneal Fibroblast Differentiation by Targeting Krüppel-like Factor 4, Journal of Biomedical Science, 26:72 (IF = 5.203; Medicine, Research & Experimental, 20/136=14.7%)

Chen SJ, Tsui PF, Chuang YP, Chiang DML, LWC Chen, Liu ST, Lin FY, Huang SM, Lin SH, Wu WL, Tsai MC, Lin CS (2019) Carvedilol Ameliorates Experimental Atherosclerosis by Regulating Cholesterol Efflux and Exosome Functions, International Journal of Molecular Sciences, 20, 5202 (IF = 4.183; Biochemistry & Molecular Biology, 78/299=26.08%)

Chen SY, Liu ST, Lin WR, Lin CK, Huang SM (2019) The mechanisms underlying the cytotoxic effects of copper via differentiated embryonic chondrocyte 1, International Journal of Molecular Sciences, 20, 5225 (co-corresponding author) (IF = 4.183; Biochemistry & Molecular Biology, 78/299=26.08%)

Chuang FK, Huang SM, Liao CL, Lee AR, Lien SP, Chiu Y, Chang TH, Tsai PL, Lin RJ, Shih C, Tsai YJ, Lin GJ, and Yen LC (2020) Anti-inflammatory compound shows therapeutic safety and efficacy against flavivirus infection, Antimicrobial Agents and Chemotherapy, 64(1):e00941-19 (IF = 4.715; Pharnacology and Pharmacy, 27/267=10.1%)

Chen YJ, Huang SM, Tai MC, Chen JT, Lee AN, Huang RY, Liang CM (2020) The anti-fibrotic and anti-inflammatory effects of 2,4-Diamino-5-(1-hydroxynaphthalen-2-yl)-5H-chromeno[2,3-b] pyriine-3-carbonitrile in corneal fibroblasts, Pharmacological Reports, 72(1), 115-125 (IF = 2.761; Pharnacology and Pharmacy, 119/267=44.6%)

Ke HY, Chin LH, Tsai CS, Lin FZ, Chen YH, Chang YL, Huang SM, Chen YC, Lin CY (2020) Cardiac Calcium Dysreg ulation in Mice With Chronic Kidney Disease. Journal of cellular and Molecular Medicine, 24:3669-3677 (IF =4.658; Medicine, Research and Experimental, 31/136=22.79%)

Chuang FK, Liao CL, Hu MK, Chiu RL, Lee AR, Huang SM, Chiu YL, Tsai PL, Su BC, Chang TH, Lin CC, Shih CC, and Yen LC (2020) Antiviral Activity of Compound L3 against Dengue and Zika Viruses In Vitro and In Vivo, International Journal of Molecular Sciences, 21:4050 (IF = 4.183; Biochemistry & Molecular Biology, 78/299=26.08%)

Yang HY, Lin FZ, Yang HW, Yu PL, Huang SM, Chen YC, Tsai CS, Lin CY (2020) The effect of Sirt1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytes. Journal of cellular and Molecular Medicine, 24:6762–6772 (IF =4.658; Medicine, Research and Experimental, 31/136=22.79%)

Su HC, Wu SC, Yen LC, Chiao LK, Wang JK, Chiu YL, Ho CL, and Huang SM (2020) Gene expression profiling identifies the role of Zac1 in cervical cancer metastasis. Scientific Reports, 10:11837 (co-corresponding author) (IF =3.998; Multidisciplinary Sciences, 17/71=23.239%)

Wu TM, Liu ST, Chen SY, Chen GS, Wu CC, Huang SM (2020) Mechanisms and applications of the anti-cancer effect of pharmacological ascorbic acid, Frontiers in Oncology, 10:1483 (co-corresponding author) (IF = 4.848; Oncology, 69/224=28.074%)

Tseng MH, Huang SM, Huang JL, Fan WL, Konrad M, Shaw SW, Lien R, Chien HP, Ding JJ, Wu TW, Tsai JD, Tian YC, Lee HJ, Cheng PJ, Hsu JF, Lin SH (2020) Autosomal Recessive Renal Tubular Dysgenesis Caused by a Founder Mutation of Angiotensinogen. Kidney Int Rep. 20;5(11):2042-2051. (IF =3.336; Urology & Nephrology, 20/851=22.941%)

Chung LH, Liu ST, Huang SM, Lee HS, Salter DM, Hsu YJ (2020) Hyperphosphatemia induces muscle wasting and suppresses myogenic differentiation by increasing oxidative stress and activating Nrf2 signaling, Aging-US, 12(21):21446-21468. (IF =4.831; Geriatric & Gerontology, 7/51=22.745%)

Li YF, Tsai WC, Chou CH, Huang LC, Huang SM, Hueng DY, Tsai CK (2020) CKAP2L knockdown exerts antitumor effects by increasing miR-4496 in glioblastoma cell lines, International Journal of Molecular Sciences, 22:197 (IF =4.658; Medicine, Research and Experimental, 31/136=22.79%)

Tseng MH, Fan WL, Liu H, Yang CY, Ding JJ, Lee HJ, Huang SM, Lin SH, Huang JL (2021) Complement Factor I Mutation May Contribute to Development of Thrombotic Microangiopathy in Lupus Nephritis, Frontiers in Medicine, 7:621209 (IF =5.01; Medicine, General & Internal, 28/169=16.27%)

Lu DD, Gu Y, Li SWA, Barndt RJ, Huang SM, Wang JK, Su HC, Johnson MD, Lin CY (2021) Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes, Human Cell, 34(3):771-784 (IF =4.174; Cell Biology, 111/195=56.92%)

Lin CK, Liu ST, Wu ZS, Wang YC, Huang SM (2021) Mechanisms of cisplatin in combination with repurposed drugs against human endometrial carcinoma cells, Life-Basel, 11, 160 (IF =3.817; Biology, 27/93=29.03%)

Chen SY, Chang YL, Liu ST, Chen GS, Lee SP, and Huang SM (2021) Differential Cytotoxicity Mechanisms of Copper Complexed with Disulfiram in Oral Cancer Cells, International Journal of Molecular Sciences, 22:3711 (co-corresponding author) (IF = 5.923; Biochemistry & Molecular Biology, 67/297=22.56%)

Tseng MH, Huang SM, Konrad M, Huang JL, Shaw SW, Tian YC, Chueh HY, Fan WL, Wu TW, Ding JJ, Chiang MC, Lin SH (2021) Effect of Hydrocortisone on Angiotensionogen (AGT) Mutation–Causing Autosomal Recessive Renal Tubular Dysgenesis, Cells, 10:782. (IF = 6.60; Cell Biology, 53/195=27.18%)

Chen SY, Tsuneyama K, Yen MH, Lee JT, Chen JL, Huang SM (2021) Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancer, Scientific Reports, 11:12033 (IF = 4.379; Multidisciplinary Sciences, 17/73=23.29%)

Luo SM, Wu YP, Huang LC, Huang SM, and Hueng DY (2021) The anti-cancer effect of four curcumin analogues on human glioma cells, OncoTargets and Therapy, 4:4345-4359. (IF = 4.147; Oncology, 121/242=50%)

Kao Y, Tsai WC, Chen S, Hsu SY, Huang LC, Chang CJ, Huang SM, Hueng DY (2021) Shugosin 2 is a biomarker for pathological grading and survival prediction in patients with gliomas, Scientific Reports 11(1):18541. (IF = 4.996; Multidisciplinary Sciences, 19/73=26%)

Yang HW, Lin CY, Lin FZ, Yu PL, Huang SM, Chen YC, Tsai CS, Yang HY (2021) Phosphodiesterase-1 inhibitor modulates Ca2+ regulation in sirtuin 1-deficient mouse cardiomyocytes, European Journal of Pharmacology, 910:174498. (IF = 5.195; Pharmacology & Pharmacy, 71/279=25.44%)

Tang CT, Li YF, Chou CH, Huang LC, Huang SM, Hueng DY, Tsai CK, Chen YH (2021) GRPEL2 Knockdown Exerts Redox Regulation in Glioblastoma, International Journal of Molecular Sciences, 22(23):12705. (IF = 6.208; Biochemistry & Molecular Biology, 69/296=23.3%)

Tsai DJ, Fang WH, Wu LW, Tai MC, Kao CC, Huang SM, Chen WT, Hsiao PJ, Chiu CC, Su W, Wu CC, Su SL (2021) The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation, Frontiers in Endocrinology (Lausanne), 12:730686. (IF = 6.055; Endocrinology & Metabolism, 33/146=22.6%)

Cheng CP, Liu ST, Chiu YL, HO CL, and Huang SM (2021) The inhibitory effects of 6-thioguanine and 6-mercaptopurine on USP2a target fatty acid synthase for antitumor functions, Frontiers in Oncology, 11:749661 (co-corresponding author) (IF = 5.738; Oncology, 78/245=31.83%)

Huang N, Barndt RB, Lu DD, Wang QC, Huang SM, Wang JK, Chang PY, Chen CY, Hu JM, Su HC, Johnson MD, Lin CY (2022) The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2, Human Cell, 35, 163-172. (IF = 4.374; Cell Biology, 107/197=55.15%)

Wu ZS, Huang SM, Wang YC (2022) Palmitate Enhances the Efficacy of Cisplatin and Doxorubicin against Human Endometrial Carcinoma Cells, International Journal of Molecular Sciences, 23:80. (IF = 6.208; Biochemistry & Molecular Biology, 69/296=23.3%)

Huang YH, Sue SH, Wu ZS, Huang SM, Lee SY, Wu ZF (2022) Antitumorigenic Effect of Tramadol and Synergistic Effect with Doxorubicin in Human Breast Cancer Cells, Frontiers in Oncology, 12:811716 (IF = 5.738; Oncology, 78/245=31.83%)

Yang HY, Chen JY, Huo YN, Yu PL, Lin PZ, Hsu SC, Huang SM, Tsai CS, Lin CY (2022) The role of sirtuin 1 in palmitic acid-induced endoplasmic reticulum stress in cardiac myoblasts, Life, 12:182 (IF = 3.251; Biology, 39/94=41.48%)

Lin CJ, Liu ST, Yang RC, Wang LH, Tsai CC, Chen TW, Huang SM (2022) Anticancer Effects of Taraxacum via Cell Cycle Arrest, Necrosis, Apoptosis, and Endoplasmic Reticulum Stress, American Journal of Chinese Medicine, 50(2), 569-587 (co-corresponding author) (IF = 6.005; Integrative & Complementary Medicine, 2/30=6.67%)

Kao Y, Huang LC, Hsu SY, Huang SM, Hueng DY (2022) Repurposing disulfiram and copper for treating meningioma, Biomedicines, 10, 887 (IF = 4.757; Biochemistry & Molecular Biology, 121/296=40.87%)

Fan HL, Liu ST, Chang YL, Chiu YL, Huang SM, Chen TW (2022) In vitro cell density determines the sensitivity of hepatocarcinoma cells to ascrobate, Frontiers in Oncology, 12:843742 (IF = 5.738; Oncology, 78/245=31.83%)

Lin CM, Sung CC, Yang SS, Chen YC, Huang SM, Lin SH (2022) Generation and analysis of pseudohypoaldosteronism type II knock-in mice caused by a nonsense KLHL3 mutation in the Kelch domain, FASEB J, 36(6):e22363 (IF = 5.834; Biology, 16/94=17.02%)

Hu JM, Chang YL, Hsieh CC, Huang SM (2022) The synergistic cytotoxic effects of GW5074 and sorafenib by impacting mitochondrial functions in human colorectal cancer cell lines, Frontiers in Oncology, 12:925653 (corresponding author) (IF = 5.738; Oncology, 78/245=31.83%)

Feng SW, Chang PC, Chen HY, Hueng DY, Li YF, Huang SM (2022) Exploring the mechanism of adjuvant treatment of glioblastoma using temozolomide and metformin, International Journal of Molecular Sciences, 23:8171 (co-corresponding author) (IF = 6.208; Biochemistry & Molecular Biology, 69/296=23.3%)