最高學歷
美國喬治城大學
腫瘤生物學博士
學位
美國喬治城大學腫瘤生物學博士 (2014/07-2018/05)
國防醫學院生物化學研究所 (2005/09-2007/06)
國防醫學院藥學系 (2000/08-2004/07)
教授課程
生物化學 (醫、牙、藥) (主帶)
分子生物學 (醫、牙、藥、碩、醫科所)
分子生物學專題討論 (碩)
生物化學專題討論 (碩)
癌症生化學 (碩)
生物化學研究技術 (碩)
生物醫學論文表述與寫作 (藥理所)
研究興趣
探討絲胺酸蛋白酶活性於惡性淋巴腫瘤抗藥性之影響
探討惡性淋巴腫瘤對CD19嵌合抗原受體T細胞(CAR-T)產生抗性之機制
研究生物資訊分析結果於臨床疾病之應用
研究計畫
2022
MOST-111-2314-B-016 -019 -MY3 開發可局部釋放標靶絲胺酸蛋白酶奈米抗體之嵌合抗原受體T細胞於惡性淋巴癌治療
2021
MOST-110-2314-B-016-056- 以M2巨噬細胞與絲胺酸蛋白酶於淋巴癌腫瘤微環境之表達作為化療抗藥性與治療預後評估指標 III (共同主持)
2020
MOST-109-2320-B-016-004- 探討絲胺酸蛋白酶於惡性淋巴癌之抗凋亡角色並發展具雙重效果之化療藥物承載單株抗體治療策略II
MOST-109-2314-B-016-050- 以M2巨噬細胞與絲胺酸蛋白酶於淋巴癌腫瘤微環境之表達作為化療抗藥性與治療預後評估指標 II (共同主持)
2019
MOST-108-2311-B-016-001- 探討絲胺酸蛋白酶於惡性淋巴癌之抗凋亡角色並發展具雙重效果之化療藥物承載單株抗體治療策略
MOST-108-2314-B-016 -036-以M2巨噬細胞與絲胺酸蛋白酶於淋巴癌腫瘤微環境之表達作為化療抗藥性與治療預後評估指標 (共同主持)
MOST-108-2314-B-016-047-MY3 微核醣核酸-424/322可藉由調節鈣調磷酸酶/活化T細胞核因子與纖維細胞變間質型細胞轉換及增生等路徑改善心肌肥大以及心臟重塑 (共同主持)
研究論文
2019以前
1. Ching-Hsiung Lin, Yi-Min Hsiao, Chu-Chyn Ou, Yu-Wen Lin, Yi-Lin Chiu*, Ko-Huang Lue, Jan-Gowth Chang, Jiunn-Liang Ko; GMI, a Ganoderma Immunomodulatory Protein, Down-regulates Tumor Necrosis Factor α-Induced Expression of Matrix Metalloproteinase 9 via NF-κB Pathway in Human Alveolar Epithelial A549 Cells; Journal of agricultural and food chemistry 2010 Oct.; 58(22):12014-12021 (IF = 5.895; Agriculture, Multidisciplinary, 8/84 = 9.52%)
2. YC Chen, J YH Chan, YL Chiu*, ST Liu, G Lozano, SL Wang, CL Ho, SM Huang; Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis; Cell death and differentiation 2013 Feb.; 20(5), 732-743 (IF = 15.828; Biochemistry & Molecular biology, 12/297 = 4.04%)
3. Hui Chen Su, Yan A Liang, Ying-Jung J Lai, Yi-Lin Chiu*, Robert B Barndt, Frank Shiao, Hsiang-Hua D Chang, Dajun D Lu, Nanxi Huang, Chun-Che Tseng, Jehng-Kang Wang, Ming-Shyue Lee, Michael D Johnson, Shih-Ming Huang, Chen-Yong Lin; Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner. PLoS ONE 2016 Dec.; 11(12): e0167894 (IF = 3.752; Multidisciplinary sciences, 29/73 = 39.73%)
4. Shiao-Pieng Lee, Chen-Yu Kao, Shun-Cheng Chang, Yi-Lin Chiu*, Yen-Ju Chen, Ming-Hsing G Chen, Chun-Chia Chang, Yu-Wen Lin, Chien-Ping Chiang, Jehng-Kang Wang, Chen-Yong Lin, Michael D Johnson; Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin. PLoS ONE 2018 Feb.; 13(2):e0192632 (IF = 3.752; Multidisciplinary sciences, 29/73 = 39.73%)
5. Yi-Lin Chiu*, Yi-Ying Wu, Robert B. Barndt, Yee Hui Yeo, Yu-Wen Lin, Hou-Ping Sytwo, Huan-Cheng Liu, Yuan Xu, Bailing Jia, Jehng-Kang Wang, Michael D. Johnson, and Chen-Yong Lin; Aberrant regulation favors matriptase proteolysis in neoplastic B-cells that co-express HAI-2. Journal of Enzyme Inhibition and Medicinal Chemistry 2019 Jan.; 34(1):692-702 (IF= 5.756; Chemistry, medicinal, 13/63 = 20.63%)(第一作者)
2020
6. Yi-Lin Chiu*, Wei-Che Tsai, Chih-Hsien Wu, Chun-Hsien Wu, Cheng-Chung Cheng, Wei-Shing Lin, Tsung-Neng Tsai, Lian-Shan Wu; Ginkgo biloba Induces Thrombomodulin Expression and Tissue-Type Plasminogen Activator Secretion via the Activation of Kruppel-Like Factor 2 within Endothelial Cells. American Journal of Chinese Medicine 2020, Feb.; 48(2):357-372. (IF = 6.005; Integrative & Complementary medicine, 2/30= 6.67%)(第一作者)
7. Fu-Kai Chuang, Ching-Len Liao, Ming-Kuan Hu, Yi-Lin Chiu*, An-Rong Lee, Shih-Ming Huang, Yu-Lung Chiu, Pei-Ling Tsai, Bo-Cyuan Su, Tsung-Hsien, Chang, Chang-Chi Lin, Chih-Chin Shih, Li-Chen Yen; Antiviral activity of compound L3 against dengue and Zika virus in vitro and in vivo; International Journal of Molecular Sciences 2020 Jun.; 21(11):4050. (IF = 6.208; Biochemistry & Molecular Biology, 69/296 = 23.31%)
8. Shih-Hung Tsai, Lung-An Hsu, Hsiao-Ya Tsai, Yung-Hsin Yeh, Cheng-Yo Lu, Po-Chuan Chen, Jen-Chun Wang, Yi-Lin Chiu*, Chih-Yuan Lin, Yu-Juei Hsu; Aldehyde dehydrogenase 2 protects against abdominal aortic aneurysm formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of vascular smooth muscle cells; FASEB journal 2020 Jul.; 34(7):9498-9511 (IF = 5.834; Biology, 16/94 = 17.02%)
9. Bailing Jia, Hamishi A. Thompson, Robert B. Barndt, Yi-Lin Chiu*, Mon-Juan Lee, See-Chi Lee, Jehng-Kang Wang, Hung-Jen Tang, Michael D. Johnson and Chen-Yong Lin; Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation. Human cell 2020 Jul.; 33(3):459-469 (IF = 4.374; Cell biology, 107/194 = 55.15%)
10. Yi-Ying Wu, Sheng-Huei Wang, Chih-Hsien Wu, Li-Chen Yen, Hsing-Fan Lai, Ching-Liang Ho, Yi-Lin Chiu*; In silico immune infiltration profiling combined with functional enrichment analysis reveals a potential role for naïve B cells as a trigger for severe immune responses in the lungs of COVID-19 patients. PLoS ONE 2020 Dec.; 15(12): e0242900 (IF = 3.752; Multidisciplinary sciences, 29/73 = 39.73%) (責任作者)
11. Hui-Chen Su, Sheng-Cheng Wu, Li-Chen Yen, Li-Kang Chiao, Jehng-Kang Wang, Yi-Lin Chiu*, Ching-Liang Ho, Shih-Ming Huang; Gene Expression Profiling Identifies the Role of Zac1 in Cervical Cancer Metastasis; Scientific Reports 2020 Dec.; 10(1):11837 (IF = 4.996; Multidisciplinary Sciences, 19/134= 14.18%)(共同責任作者)
12. Hsuan-Wei Chen, Yi-Lin Chiu*, Tsai-Yuan Hsieh, Peng-Jen Chen, Tien-Yu Huang, Hsuan-Hwai Lin, Yu-Lueng Shih, Jung-Chun Lin; Relationships Between Vitamin D Status and Cytokine: Results from Interferon-Based Therapy in Non-Cirrhotic, Treatment-Naïve Patients with Chronic Hepatitis C Infection. Journal of Inflammation Research 2020 Dec 29; (13):1207-1218 (IF = 6.922; Immunology, 35/162 = 21.30%)
2021
13. Ching-Wei Ho, Yun-Chen Chung, Yi-Lin Chiu*, Lan-Shin Wang; The bHLH transcription factor E protein negatively regulates endoreplication in the salivary gland cells. Journal of Medical Science 2021 Jan 41:29-37 (國防醫學期刊)
14. Hsuan-Wei Chen, Jung-Chun Lin, Ying-Hsuen Wu, and Yi-Lin Chiu*; Risk of non-alcoholic fatty liver disease in xanthelasma palpebrarum. Journal of Inflammation Research 2021 Jan.; 14:1891-1899 (IF = 6.922; Immunology, 35/162 = 21.30%)(共同責任作者)
15. Yuan-Yuei Chen, Yi-Lin Chiu*, Tung-Wei Kao, Tao-Chun Peng, Hui-Fang Yang and Wei-Liang Chen; Cross-sectional associations among P3NP, HtrA, Hsp70, Apelin and Sarcopenia in Taiwanese Population. BMC Geriatrics 2021 Mar 20; (2021) 21:192 (IF = 4.076; Gerontology, 10/37 = 27.03%)
16. Yuan-Yuei Chen, Tung-Wei Kao, Yi-Lin Chiu*, Tao-Chun Peng, Hui-Fang Yang, and Wei-Liang Chen; Association between Interleukin-12 and Sarcopenia. Journal of Inflammation Research 2021 May; 14:2019-2029 (IF = 6.922; Immunology, 35/162 = 21.30%)
17. Chin-Li Chen, En Meng, Sheng-Tang Wu, Hsing-Fan Lai, Yi-Shan Lu, Ming-Hsin Yang, Chih-Wei Tsao, Chien-Chang Kao, and Yi-Lin Chiu*; Targeting S1PR1 may results in enhanced migration of cancer cells in bladder carcinoma; Cancers 2021 Sep.; 13(17), 4474 (IF = 6.575; Oncology, 60/245 = 24.49%)(責任作者)
18. Yi-Ying Wu, Hsing-Fan Lai, Tzu-Chuan Huang, Yu-Guang Chen, Ren-Hua Ye, Ping-Ying Chang, Shiue-Wei Lai, Yeu-Chin Chen, Cho-Hao Lee, Wei-Nung Liu, Ming-Shen Dai, Jia-Hong Chen, Ching-Liang Ho, and Yi-Lin Chiu*; Aberrantly reduced expression of miR-342-5P contributes to CCND1-associated chronic myeloid leukemia progression and imatinib resistance; Cell Death & Disease, 2021 Oct.; 12:908 (IF = 9.705, Cell Biology, 35/194= 18.04%)(責任作者)
19. Shou-En Wu, Yi-Lin Chiu*, Tung-Wei Kao, and Wei-Liang Chen; Elevated level of the soluble receptor for advanced glycation end-products involved in sarcopenia: an observational study; BMC Geriatrics 2021; 21:531 (IF = 4.076; Gerontology, 10/37 = 27.03%)
20. Chih-Hsien Wu, Yi-Lin Chiu*, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai; Cilostazol induces eNOS and TM expression via activation with Sirtuin 1/Krüppel-like factor 2 pathway in endothelial cells; International Journal of Molecular Sciences 2021 Oct 22; (19):10287 (IF = 6.208; Biochemistry & Molecular Biology, 69/296 = 23.31%)
21. Chih-Hsien Wu, Hsuan-Hwai Lin, Yi-Ying Wu, Yi-Lin Chiu*, Li-Yen Huang, Cheng-Chung Cheng, Chung-Chi Yang, and Tsung-Neng Tsai; Generation of beating cardiomyocytes from human gastric fibroblast cells; Biomedicines 2021 Oct 29; 9:1565 (IF = 6.081; Medicines, Research & Experimental, 32/140 = 22.86%)
22. Chiao-Pei Cheng, Shu-Ting Liu, Yi-Lin Chiu*, Shih-Ming Huang and Ching-Liang Ho; The inhibitory effects of 6-thioguanine and 6- mercaptopurine on the USP2a target fatty acid synthase in human submaxillary carcinoma cells; Frontiers in Oncology 2021 Dec 10; 11:749661 (IF = 6.244; Oncology, 62/242 = 25.62%)
23. Hsiao-Ya Tsai, PhD, Jen-Chun Wang, MD, Yu-Juei Hsu, MD, PhD, Yi-Lin Chiu, PhD*, Chih-Yuan Lin, MD, PhD, Cheng-Yo Lu, Shih-Hung Tsai, MD, PhD; miR-424/322 protects against abdominal aortic aneurysm formation by modulating the Smad2/3/Runt-related transcription factor 2 axis; Molecular Therapy-Nucleic Acid 2021 Dec; 27:656-669 (IF = 10.183; MEDICINE, RESEARCH & EXPERIMENTAL, 12/195 = 6.15%)
2022
24. Ying-Hsuen Wu, Yi-Lin Chiu*, Jung-Chun Lin, Hsuan-Wei Chen; New insights into sex differences in primary biliary cholangitis. Gender difference in primary biliary cholangitis; Journal of the Pakistan Medical Association 2022 May, 72(5):896-900 (IF= 1.002; MEDICINE, GENERAL & INTERNAL, 214/329 = 65.04%)
25. Hsiu-Lung Fan, Shu-Ting Liu, Yung-Lung Chang, Yilin Chiu*, Shih-Ming Huang, Teng-Wei Chen; In Vitro Cell Density Determines the Sensitivity of Hepatocarcinoma Cells to Ascorbate; Frontiers in Oncology 2022 May 23, 12:843742 (IF = 6.244; Oncology, 62/242 = 25.62%)
26. Shou-En Wu, Ju-Chun Hsu, Yung-Lung Chang, Hsiao-Chi Chuang, Yi-Lin Chiu*, Wei-Liang Chen; Benzo[a]pyrene exposure in muscle triggers sarcopenia through aryl hydrocarbon receptor-mediated reactive oxygen species production; Ecotoxicology and Environmental Safety 2022 Jul; 239(1):113599 (IF = 7.129; Toxicology, 7/94 = 7.45% )
27. Yi-Lin Chiu*, Yi-Ying Wu, Robert B. Barndt, Yu-Wen Lin, Hou-Ping Sytwo, Amy Cheng, Kacy Yang, Khee-Siang Chan, Jehng-Kang Wang, Michael D. Johnson, and Chen-Yong Lin; Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity. Genes & Diseases 2022 Aug.; 9(4)1049-1061 (IF = 7.243; Genetics & Heredity, 20/175 = 11.43%)(第一作者)
28. Wei-Hung Chan, Yu-Juei Hsu, Chiao-Pei Cheng, Kuan-Nien Chou, Chin-Li Chen, Shih-Ming Huang, Wei-Chih Kan, Yi-Lin Chiu*; Assessing the global impact on the mouse kidney after traumatic brain injury: a transcriptomic study; Journal of Inflammation Research 2022 Aug.; 15:4833-4851 (IF = 6.922; Immunology, 35/162 = 21.30%)(共同責任作者)
29. Hiong-Ping Hii, Whai-Zer Lo, Yung-Hui Fu , Ming-Hua Chen, Chia-Ching Shih, Cheng-Ming Tsao, Shuk-Man Ka, Yi-Lin Chiu*, Chin-Chen Wu, and Chih-Chin Shih; Improvement in heat stress-induced multiple organ dysfunction and intestinal damage through protection of intestinal goblet cells from prostaglandin E1 analogue misoprostol; Life sciences 2022 Oct.; 310(2022)121039 (IF = 6.78; PHARMACOLOGY & PHARMACY, 36/279 =12.90%)
2023
30. Chih-Chin Shih, Wei-Chieh Liao, Hung-Yen Ke, Chia-Wen Kuo, Cheng-Ming Tsao, Wen-Chiuan Tsai, Yi-Lin Chiu*, Hsieh-Chou Huang, Chin-Chen Wu; Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke; Biomedicine & Pharmacotherapy 2023 May; (161) 114565 ((IF = 7.419; PHARMACOLOGY & PHARMACY, 26/279 = 9.32%)
31. Shao-Wei Feng, Zih-Syuan Wu, Yi-Lin Chiu*, Shih-Ming Huang; Exploring the functional roles of telomere maintenance 2 in the tumorigenesis of Glioblastoma multiforme and drug responsiveness to temozolomide; International Journal of Molecular Sciences 2023 May 25; 24(11):9256 (IF = 6.208; Biochemistry & Molecular Biology, 69/296 = 23.31%)
32. Sheng-Cheng Wu, Shiue-Wei Lai, Xin-Jie Lu, Hsing-Fan Lai, Yu-Guang Chen, Po-Huang Chen, Ching-Liang Ho, Yi-Ying Wu and Yi-Lin Chiu*; Profiling of miRNAs and their interfering targets in peripheral blood mononuclear cells from patients with chronic myeloid leukemia; Frontiers in Oncology 2023 Jul 5; 13:1173970 (IF = 5.738; Oncology, 78/245 = 31.83%) (共同責任作者)
33. Po-Shun Hsu, Shu-Ting Liu, Yi-Lin Chiu, Chien-Sung Tsai; The functional role of myogenin in cardiomyoblast H9c2 cells treated with high glucose and palmitic acid: insights into no-rejection heart transplantation; International Journal of Molecular Sciences 2023 Aug 22; 24(17):13031(IF = 5.6; Biochemistry & Molecular Biology, 66/285 = 23.16%)
34. Xin-Jie Lu, Hsing-Fan Lai, Sheng-Cheng Wu, Chin-Li Chen, and Yi-Lin Chiu; Elucidating the Associated Biological Function and Clinical Significance of RHOJ Expression in Urothelial Carcinoma; International Journal of Molecular Sciences 2023 Sep 14; 24(18):14081 (IF = 5.6; Biochemistry & Molecular Biology, 66/285 = 23.16%)(共同責任作者)
2024
35. Wei-Hung Chan, Shih-Ming Huang, Yi-Lin Chiu; Pulmonary Effects of Traumatic Brain Injury in Mice: A Gene Set Enrichment Analysis; International Journal of Molecular Sciences 2024 Mar 5; 25(5):3018 (IF = 5.6; Biochemistry & Molecular Biology, 66/285 = 23.16%)(責任作者)
36. Chia-Ning Fan, Tsung-Neng Tsai, Xin-Jie Lu, Hsing-Fan Lai, Chun-Hua Wang, Yi-Lin Chiu; Transcriptomic Analysis Reveals Cilostazol's Role in Ameliorating Cardiovascular Disease: Inhibition of Monocyte-to-Macrophage Differentiation and Reduction of Endothelial Cell Reactive Oxygen Species Production; Heliyon 2024 Apr 3; 10(7):E29194 (IF = 4.0; MULTIDISCIPLINARY SCIENCES, 34/134 = 25.3%)(責任作者)