學位

印第安那大學 生命科學博士

研究興趣

建立人類解毒酶系統之遺傳學、化學與分子生物學之研究、酒精代謝酶基因型與酒癮、酒精藥物動力學研究

研究論文

Yin, S.-J., Lee, S.-L., Yao, C.-T. and Lai, C.-L. (2007) Functional roles of alcohol dehydrogenases in human ethanol metabolism, in “Enzymology and Molecular Biology of Carbonyl Metabolism 13,” H. Weiner, E. Maser, R. Lindahl, and B. V. Plapp eds., Purdue University Press, West Lafayette, pp. 134–143.
Yin, S.-J. and Peng, G.-S. (2007) Acetaldehyde, polymorphisms and cardiovascular system, in “Acetaldehyde-related Pathology: Bridging the Trans-disciplinary Divide,” (Novartis Foundation Symposia 285), D. J. Chadwick and J. Goode, eds., John Wiley & Sons Ltd., Chichester, UK, pp. 52–63; Discussion, pp. 63–68.
Peng, G.-S., Yin, S.-J., Cheng, C.-A., Chiu, S.-W., Lee, J.-T., Lin, W.-W., Lin, J.-C. and Hsu, Y.-D. (2007) Increased risk of cerebral haemorrhage in Chinese male heavy drinkers with mild liver disorder. Cerebrovasc. Dis. 23:309–314. ( IF = 2.319; Clinical Neurology, 52/148 = 35.1%)
Peng, G.-S., Chen, Y.-C., Tsao, T.-P., Wang, M.-F. and Yin, S.-J. (2007) Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet. Genomics17:845–855. ( IF = 5.775; Pharmacology & Pharmacy, 13/205 = 6.3% )
Ching, C.-C. and Yin, S.-J. (2008) Alcohol abuse and related factors in Asia. Int. Rev. Psychiatry 20: 425–433.
Peng, G.-S. and Yin, S.-J. (2009) Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. Hum. Genomics 3:121–127.
Chen, Y.-C, Peng, G.-S., Wang, M.-F., Taso, T.-P. and Yin, S.-J. (2009) Polymorphism of ethanol-metabolism genes and alcoholism: Correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences. Chem. Biol. Interact.178:2–7. ( IF = 3.090; Toxicology, 11/73 = 15.1% )
Wang, M-F., Han, C.-L. and Yin, S.-J. (2009) Substrate specificity of human and yeast aldehyde dehydrogenases. Chem. Biol. Interact.178:36–39. ( IF = 3.090；Toxicology, 11/73 = 15.1% )
Chiang, C.-P., Wu, C.-W., Lee, S.-P., Chung, C.-C., Wang, C.-W., Lee, S.-L., Nieh, S. and Yin, S.-J. (2009) Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: Implications for pathogenesis of alcohol-induced pancreatic injury. Alcohol. Clin. Exp. Res. 33:1059–1068, 2009. ( IF = 3.175; Substance Abuse, 3/10 = 30% )
Chen, Y.-C., Peng, G.-S., Tsao, T.-P., Wang, M.-F., Lu, R.-B. and Yin, S.-J. (2009) Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet. Genomics, 19:588–599. ( IF = 5.775; Pharmacology & Pharmacy, 13/205 = 6.3% )
Yao, C.-T., Lai, C.-L., Hsieh, H.-S., Chi, C.-W. and Yin, S.-J. (2010) Establishment of steady-state metabolism of ethanol in perfused rat liver: the quantitative analysis using kinetic mechanism-based rate equations of alcohol dehydrogenase. Alcohol 44:541–551. ( IF = 2.407; Toxicology, 35/77 = 45% )
Lee, S.-L., Shih, H.-T., Chi, Y.-C., Li. Y.-P. and Yin, S.-J. (2011) Oxidation of methanol, ethylene glycol, and isopropanol with human alcohol dehydrogenases and the inhibition by ethanol and 4-methylpyrazole. Chem. Biol. Interact., in press. ( IF = 2.457; Toxicology, 33/77 = 43% )
Chiang, C.-P., Jao, S.-W., Lee, S.-P., Chen, P.-C., Chung C.-C., Lee, S.-L., Nieh, S. and Yin, S.-J. (2011) Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: Association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer. Alcohol, in press. ( IF = 2.407; Toxicology, 35/77 = 45% )