最高學歷

國防醫學院
生命科學所博士

研究興趣

Tumor biology: tumor microenvironment and cancer progression
Epigenetics: signal transduction and gene regulation
Inflammation and oral health: DM and oral diseases

研究論文

1.Huang TW, Lin KF, Lee CH, Chang H, Lee SC, Shieh YS*. The role of Thyroid Transcription Factor-1 and Tumor differentiation in Resected Lung Adenocarcinoma. Sci Rep. 2017; 27;7(1):14222.

2.Sua CC, Wu YC, Chung MP, Huang RY, Cheng WC, Cathy Tsai YW, Hsieh CY, Chiang HS, Chen CY, Shieh YS*. Geometric features of second mesiobuccal canal in permanent maxillary first molars: a cone-beam computed tomography study. 2017; 12(3):241-248.

3.Chien CY, Hung YJ, Shieh YS, Hsieh CH, Lu CH, Lin FH, Su SC, Lee CH. A novel potential biomarker for metabolic syndrome in Chinese adults: Circulating protein disulfide isomerase family A, member 4. PLoS One. 2017;12(6):e017996

4.Mau LP, Kuan YC, Tsai YC, Lin JJ, Huynh-Ba G, Weng PW, Shieh YS, Cheng WC, Huang RY. Patients with chronic periodontitis present increased risk for osteoporosis: A population-based cohort study in Taiwan. J Periodontal Res. 2017 May 2. doi: 10.1111/jre.1246

5.Lee CH, Shieh YS, Tsai CS, Hung YJ, Tsai YT, Lin CY. Plasma Concentrations Predict Aortic Expression of Growth-Arrest-Specific Protein 6 in Patients Undergoing Coronary Artery Bypass Grafting. PLoS One. 2017 Apr 24;12(4):e0175754.

6.Yang CY, Lin CK, Tsao CH, Hsieh CC, Lin GJ, Ma KH, Shieh YS, Sytwu HK, Chen YW. Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models. Oncotarget. 2017;8(20):33756-33769.

7.Wu YC, Su CC, Tsai YC, Cheng WC, Chung MP, Chiang HS, Hsieh CY, Chung CH, Shieh YS, Huang RY. Complicated Root Canal Configuration of Mandibular First Premolars Is Correlated with the Presence of the Distolingual Root in Mandibular First Molars: A Cone-beam Computed Tomographic Study in Taiwanese Individuals. J Endod. 2017 Jul;43(7):1064-1071.

8.Tsung-I Li, Meng-Ta Chiang, Kuo-Chou Chiu, Ching-Huang Lai, Yi-Shing Shieh*. The association of betel quid, alcohol, and cigarette with salivary gland tumor – a case-control study. J Dent Sci 2017; 12 (2): 151–155.

9.Chang WM, Lin YF, Su CY, Peng HY, Chang YC, Hsiao JR, Chen CL, Chang JY, Shieh YS, Hsiao M, Shiah SG. Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation. Sci Rep. 2017;7:41131.

10.Lee CH, Hung YJ, Shieh YS, Chien CY, Hsu YJ, Lin CY, Chiang CF, Huang CL,Hsieh CH. Cilostazol inhibits uremic toxin-induced vascular smooth muscle cell dysfunction : role of Axl signaling. Am J Physiol Renal Physiol. 2016; 312(3):F398-F406.

11.Chang WM, Lin YF, Su CY, Peng HY, Chang YC, Lai TC, Wu GH, Hsu YM, Chi LH, Hsiao JR, Chen CL, Chang JY, Shieh YS*, Hsiao M, Shiah SG. Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2016;76(24):7140-7150.

12.Tsai PT, Shieh YS, Wu CT, Lee SP, Chen YW. Buccal Mucosa Elasticity Influences Surgical Margin Determination in Buccal Carcinoma Resection. J Oral Maxillofac Surg. 2016;74(9):1900.e1-7.

13.Yang CY, Lin CK, Lin GJ, Hsieh CC, Huang SH, Ma KH, Shieh YS, Sytwu HK, Chen YW. Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells. Clin Oral Investig; 2017 ;21(1):419-427.

14.Chung TJ, Hsu KY, Chen JH, Liu JS, Chang HW, Li PF, Huang CL, Shieh YS*, Lee CH. Association of salivary alpha 2-macroglobulin levels and clinical characteristics in type 2 diabetes. J Diabetes Investig. 2016;7(2):190-6.

15.Cheng JC, Chiang MT, Lee CH, Liu SY, Chiu KC, Chou YT, Huang RY, Huang SM, Shieh YS*. γ-Synuclein Expression Is a Malignant Index in Oral Squamous Cell Carcinoma. J Dent Res. 2016 Apr;95(4):439-45.

16.Shiah SG, Shieh YS, Chang JY. The Role of Wnt Signaling in Squamous Cell Carcinoma. J Dent Res. 2016;95(2):129-34.

17.Sung CE, Cochran DL, Cheng WC, Mau LP, Huang PH, Fan WH, Shieh YS, Huang RY. Preoperative assessment of labial bone perforation for virtual immediate implant surgery in the maxillary esthetic zone: A computer simulation study. J Am Dent Assoc. 2015;146(11):808-19.

18.Chen CH, Chen HC, Chang CC, Peng YJ, Lee CH, Shieh YS, Hung YJ, Lin YF. Growth Arrest-Specific 6 Protein in Patients with Sjogren Syndrome: Determination of the Plasma Level and Expression in the Labial Salivary Gland. PLoS One 2015;10(10):e0139955.

19.Huang RY, Cochran DL, Cheng WC, Lin MH, Fan WH, Sung CE, Mau LP, Huang PH, Shieh YS. Risk of lingual plate perforation for virtual immediate implant placement in the posterior mandible: A computer simulation study. J Am Dent Assoc 2015; 146(10):735-42.

20.Chiu KC, Lee CH, Liu SY, Chou YT, Huang RY, Huang SM, Shieh YS*.Polarization of tumor-associated macrophages and Gas6/Axl signaling in oral squamous cell carcinoma. Oral Oncol 2015, 51(7):683-9.

21.Chiang MT, Li TI, Yeh HW, Su CC, Chiu KC, Chung MP, Huang RY, Shieh YS *. Evaluation of missing-tooth effect on articular eminence inclination of temporomandibular joint. J Dent Sci 2015: 10(4), 383-387.

22.Yeh HW, Chen CY, Chen PH, Chiang MT, Chiu KC, Chung MP, Li TI, Su CC, Shieh YS*. Frequency and distribution of mandibular condensing osteitis lesions in a Taiwanese population. J Dent Sci 2015, 10(3), 291-295.

23.Hung YJ, Lee CH, Shieh YS, Hsiao FC, Lin FH, Hsieh CH. Gender differences in plasma growth arrest-specific protein 6 levels in adult subjects. .Clin Chim Acta 2015; 441:1-5.

24.Chang TH, Yuh DY, Wu YT, Cheng WC, Lin FG, Shieh YS, Fu E, Huang RY. The association between temporomandibular disorders and joint hypermobility syndrome: a nationwide population-based study. Clin Oral Investig 2015; 19(8):2123-32.

25.Hung YJ, Lee CH, Shieh YS, Hsiao FC, Lin FH, Hsieh CH. Plasma growth arrest-specific protein 6 levels in premenopausal and postmenopausal women: the role of endogenous estrogen. Endocrine 2014; 47(3):923-9.

26.Shiah SG, Hsiao JR, Chang WM, Chen YW, Jin YT, Wong TY, Huang JS, Tsai ST, Hsu YM, Chou ST, Yen YC, Jiang SS, Shieh YS, Chang IS, Hsiao M, Chang JY. Downregulated miR329 and miR410 promote the proliferation and invasion of oral squamous cell carcinoma by targeting Wnt-7b. Cancer Res 2014; 74(24):7560-72.

27.Hsiao FC, Lin YF, Hsieh PS, Chu NF, Chen YD, Shieh YS, Hsieh CH, Lee CH, Lee TI, Hung YJ. Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents. . Int J Endocrinol. , 2014:674069.

28.Chiu KC, Lee CH, Liu SY, Yeh CT, Huang RY, Yuh DY, Cheng JC, Chou YT, Shieh YS*. Protumoral effect of macrophage through Axl activation on mucoepidermoid carcinoma. J Oral Pathol Med 2014; 43(7):538-44.

29.Chen YW, Huang HS, Shieh YS, Ma KH, Huang SH, Hueng DY, Sytwu HK, Lin GJ. A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo. PLoS One 2014; 9(11):e113703.

30.Lee CH, Shieh YS, Tsai CS, Hung YJ, Tsai YT, Lin CY. Expression of growth arrest-specific protein 6 and Axl molecules in the left internal mammary artery of patients undergoing coronary artery bypass grafting. J Clin Pathol 2014; 67(6):506-11.(co-first author).

31.Chen YW, Lin GJ, Hueng DY, Huang SH, Chia WT, Shieh YS, Ma KH, Sytwu HK. Enhanced anti-tumor activity of triptolide in combination with irradiation for the treatment of oral cancer. Planta Med 2014; 80(4):255-61.

32.Lee CH, Liu SY, Chou KC, Yeh CT, Shiah SG, Huang RY, Cheng JC, Yen CY, Shieh YS*. Tumor associated macrophages promote oral cancer progression through activation of the Axl signaling pathway. Ann Surg Oncol 2014, 21(3):1031-7.

33.Lin MH, Mau LP, Cochran DL, Shieh YS, Huang PH, Huang RY. Risk assessment of inferior alveolar nerve injury for immediate implant placement in the posterior mandible: a virtual implant placement study. J Dent 2014; 42(3):263-70.

34.Huang RY, Lin YF, Kao SY, Shieh YS, Chen JS. A retrospective case-control analysis of the outpatient expenditures for western medicine and dental treatment modalities in CKD patients in Taiwan. PLoS One 2014, 9(2):e88418.

35.Kuo FC, Hung YJ, Shieh YS, Hsieh CH, Hsiao FC, Lee CH. The levels of plasma growth arrest-specific protein 6 is associated with insulin sensitivity and inflammation in women. Diabetes Res Clin Pract 2014, 103(2):304-9.

36.Lee CH, Shieh YS, Hsiao FC, Kuo FC, Lin CY, Hsieh CH, Hung YJ. High glucose induces human endothelial dysfunction through an Axl dependent mechanism. Cardiovasc 2014; 13:53.

37.Yang SM, Ka SM, Wu HL, Yeh YC, Kuo CH, Hua KF, Shi GY, Hung YJ, Hsiao FC, Yang SS, Shieh YS, Lin SH, Wei CW, Lee JS, Yang CY, Chen A. Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis.. Diabetologia 2014, 57(2):424-34.

38.Huang RY, Chen YJ, Fang WH, Mau LP, Shieh YS. Concomitant horner and harlequin syndromes after inferior alveolar nerve block anesthesia. J Endod 2013, 39(12):1654-7.

39.Yeh CT, Huang WC, Rao YK, Ye M, Lee WH, Wang LS, Tzeng DT, Wu CH, Shieh YS, Huang CY, Chen YJ, Hsiao M, Wu AT, Yang Z, Tzeng YM (2013, Dec). A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells.Carcinogenesis, 34(12):2918-28.

40.Yeh CT, Su CL, Huang CY, Lin JK, Lee WH, Chang PM, Kuo YL, Liu YW, Wang LS, Wu CH, Shieh YS, Jan YH, Chuang YJ, Hsiao M, Wu AT.A preclinical evaluation of antimycin a as a potential antilung cancer stem cell agent. Evid Based Complement Alternat Med 2013:910451.

41.Mak KK, Wu AT, Lee WH, Chang TC, Chiou JF, Wang LS, Wu CH, Huang CY, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit. Mol Nutr Food Res 2013; 57(7):1123-34.

42.Hsiao FC, Lin YF, Hsieh PS, Chu NF, Shieh YS, Hsieh CH, Lee CH, Hung YJ. Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. J Clin Endocrinol Metab 2013; 98(2):E267-74.