研究論文

1. Lee CH, Wu YL, Kuo JF, Chen JF, Chin MC, Hung YJ. Prevalence of diabetic macrovascular complications and related factors from 2005 to 2014 in Taiwan: A nationwide survey. J Formos Med Assoc. 2019 Nov;118 Suppl 2:S96-S102. (SCI) (First author)

2. Lu CH, Chung CH, Lee CH, Su SC, Liu JS, Lin FH, Tsao CH, Hsieh PS, Hung YJ, Hsieh CH, Chien WC. Combination of COX-2 inhibitor and metformin attenuates rate of admission in patients with rheumatoid arthritis and diabetes in Taiwan. Medicine (Baltimore). 2019 Oct;98(41):e17371. (SCI)

3. Lee CH, Kuo FC, Tang WH, Lu CH, Su SC, Liu JS, Hsieh CH, Hung YJ, Lin FH. Serum E-selectin concentration is associated with risk of metabolic syndrome in females. PLoS One. 2019 Sep 24;14(9):e0222815. (SCI) (First author)

4. Su SC, Hung YJ, Huang CL, Shieh YS, Chien CY, Chiang CF, Liu JS, Lu CH, Hsieh CH, Lin CM, Lee CH. Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways. J Biomed Sci. 2019 Sep 6;26(1):68. (SCI) (Correspondent author)

5. Peng CK, Wu CP, Lin JY, Peng SC, Lee CH, Huang KL, Shen CH. Gas6/Axl signaling attenuates alveolar inflammation in ischemia-reperfusion-induced acute lung injury by up-regulating SOCS3-mediated pathway. PLoS One. 2019 Jul 18;14(7):e0219788. (SCI)

6. Lin MH, Lee CH, Lin C, Zou YF, Lu CH, Hsieh CH, Lee CH. Low-Dose Aspirin for the Primary Prevention of Cardiovascular Disease in Diabetic Individuals: A Meta-Analysis of Randomized Control Trials and Trial Sequential Analysis. J Clin Med. 2019 May 5;8(5). (SCI)

7. Li YH, Lu CH, Lin FH, Su SC, Liu JS, Hsieh CH, Hung YJ, Shieh YS, Lee CH. Plasma Growth Arrest-Specific 6 Protein and Genetic Variations in the GAS6 Gene in Patients with Metabolic Syndrome. Metab Syndr Relat Disord. 2019 Feb;17(1):22-28. (SCI) (Correspondent author)

8. Lu CH, Chung CH, Lee CH, Hsieh CH, Hung YJ, Lin FH, Tsao CH, Hsieh PS, Chien WC Combination COX-2 inhibitor and metformin attenuate rate of joint replacement in osteoarthritis with diabetes: A nationwide, retrospective, matched-cohort study in Taiwan. PLoS One. 2018 Jan 31;13(1):e0191242 (SCI)

9. Lee CH, Su SC, Chiang CF, Chien CY, Hsu CC, Yu TY, Huang SM, Shieh YS, Kao HW, Tsai CS, Hung YJ, Lin CY. Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1. Oncotarget. 2017 Nov; 8:22546-22558. (SCI) (First author)

10. Huang TW, Lin KF, Lee CH, Chang H, Lee SC, Shieh YS. The role of Thyroid Transcription Factor-1 and Tumor differentiation in Resected Lung Adenocarcinoma. Sci Rep. 2017 Oct 27;7(1):14222. (SCI)

11. Yang CJ, Liao WI, Wang JC, Tsai CL, Lee JT, Peng GS, Lee CH, Hsu CW, Tsai SH. Usefulness of glycated hemoglobin A1c-based adjusted glycemic variables in diabetic patients presenting with acute ischemic stroke. Am J Emerg Med. 2017 Sep;35(9):1240-1246. (SCI)

12. Lin CM, Hsieh CH, Lee CH, Pei D, Lin JD, Wu CZ, Liang YJ, Hung YJ, Chen YL. Predictive Value of Serum Gamma-glutamyltranspeptidase for Future Cardiometabolic Dysregulation in Adolescents- a 10-year longitudinal study. Sci Rep. 2017 Aug 29;7(1):9636. (SCI)

13. Yang CJ, Liao WI, Tang ZC, Wang JC, Lee CH, Chang WC, Hsu CW, Tang SE, Tsai SH. Glycated hemoglobin A1c-based adjusted glycemic variables in patients with diabetes presenting with acute exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2017 Jul 3;12:1923-1932. (SCI)

14. Chien CY, Hung YJ, Shieh YS, Hsieh CH, Lu CH, Lin FH, Su SC, Lee CH. A novel potential biomarker for metabolic syndrome in Chinese adults: Circulating protein disulfide isomerase family A, member 4. PLoS ONE 2017 Jun;12(6): e0179963. (SCI) (Correspondent author)

15. Huang IH, Lee CH, Huang JL, Hung YJ. Sodium-Glucose Co-transporter 2 Inhibitor-Associated Euglycemic Diabetic Ketoacidosis in a Patient with Type 2 Diabetes Mellitus: A Case Report. Formosan Journal of Endocrinology and Metabolism 2017 8 (1), 24-27 (non-SCI)

16. Kuo FC, Huang YH, Lin FH, Hung YJ, Hsieh CH, Lu CH, Su SC, Huang CL, Lee CH, Chu NF. Circulating Soluble IL-6 Receptor Concentration and Visceral Adipocyte Size Are Related to Insulin Resistance in Taiwanese Adults with Morbid Obesity. Metab Syndr Relat Disord. 2017 May;15(4):187-193. (SCI) (Co-Correspondent author)

17. Chang JB, Chen YL, Hung YJ, Hsieh CH, Lee CH, Pei D, Lin JD, Wu CZ, Liang YJ, Lin CM. The Role of Uric Acid for Predicting Future Metabolic Syndrome and Type 2 Diabetes in Older People. J Nutr Health Aging. 2017;21(3):329-335. (SCI)

18. Wang HI, Yiang GT, Hsu CW, Wang JC, Lee CH, Chen YL. Thyroid Storm in a Patient with Trauma - A Challenging Diagnosis for the Emergency Physician: Case Report and Literature Review. J Emerg Med. 2017 Mar;52(3):292-298. (SCI)

19. Lee CH, Hung YJ, Shieh YS, Chien CY, Hsu YJ, Lin CY, Chiang CF, Huang CL, Hsieh CH. Cilostazol inhibits uremic toxin-induced vascular smooth muscle cell dysfunction : role of Axl signaling. Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F398-F406. (SCI) (First and Correspondent author)

20. Hu HF, Hsiu H, Sung CJ, Lee CH. Combining laser-Doppler flowmetry measurements with spectral analysis to study different microcirculatory effects in human prediabetic and diabetic subjects. Lasers Med Sci. 2017 Feb;32(2):327-334. (SCI)

21. Chen YL, Lee SF, Pei C, Pei D, Lee CH, He CT, Liang YJ, Lin JD. Predicting Glucose Effectiveness in Chinese Participants Using Routine Measurements. Metab Syndr Relat Disord. 2016 Oct;14(8):386-390. (SCI)

22. Chang HW, Chang JB, Li PF, Chen JH, Huang CL, Liang YJ, Lee CH, Lin CH, Liao MT, Hsieh CH. The association of hematological parameters and metabolic syndrome in an older population: A cross-sectional and longitudinal study. Journal of Medical Sciences. 2016 Aug; 36 (5), 180 (non SCI)

23. Huang CL, Chang HW, Chang JB, Chen JH, Lin JD, Wu CZ, Pei D, Hung YJ, Lee CH, Chen YL, Hsieh CH. Normal fasting plasma glucose predicts type 2 diabetes and cardiovascular disease in elderly population in Taiwan. QJM. 2016 Aug;109(8):515-22. (SCI)

24. Chuang TJ, Huang CL, Lee CH, Hsieh CH, Hung YJ, Hung CF, Liang YJ, Chen YL, Hsia TL, Pei D. The differences of metabolic syndrome in elderly subgroups: A special focus on young-old, old-old and oldest old. Arch Gerontol Geriatr. 2016 Jul-Aug;65:92-7. (SCI)

25. Tsai SH, Huang PH, Hsu YJ, Peng YJ, Lee CH, Wang JC, Chen JW, Lin SJ. Inhibition of hypoxia inducible factor-1α attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases. Sci Rep. 2016 Jul 1;6:28612. (SCI)

26. Liao WI, Lin CS, Lee CH, Wu YC, Chang WC, Hsu CW, Wang JC, Tsai SH.An Elevated Glycemic Gap is Associated with Adverse Outcomes in Diabetic Patients with Acute Myocardial Infarction. Sci Rep. 2016 Jun 13;6:27770.(SCI)

27. Cheng JC, Chiang MT, Lee CH, Liu SY, Chiu KC, Chou YT, Huang RY, Huang SM, Shieh YS. γ-Synuclein Expression Is a Malignant Index in Oral Squamous Cell Carcinoma. J Dent Res. 2016 Apr;95(4):439-45. (SCI)

28. Chung TJ, Hsu KY, Chen JH, Liu JS, Chang HW, Li PF, Huang CL, Shieh YS , Lee CH. Association of Salivary Alpha 2-Macroglobulin Levels and Clinical Characteristics in Type 2 Diabetes. J Diabetes Investig. 2016 Mar;7(2):190-6. (SCI) (Correspondent author)

29. Chang HW, Lin FH, Li PF, Huang CL, Chu NF, Su SC, Lu CH, Lee CH, Hung YJ, Hsieh CH. Association Between a Glucokinase Regulator Genetic Variant and Metabolic Syndrome in Taiwanese Adolescents. Genet Test Mol Biomarkers. 2016 Mar;20(3):137-42. (SCI)

30. Chen CH, Chen HC, Chang CC, Peng YJ, Lee CH, Shieh YS, Hung YJ, Lin YF Growth Arrest-Specific 6 Protein in Patients with Sjögren Syndrome: Determination of the Plasma Level and Expression in the Labial Salivary Gland PLoS One. 2015 Oct 7;10(10):e0139955. (SCI)

31. Lin CJ, Chu NF, Hung YJ, Pei D, Lee CH, Hsiao FC, Lu CH, Hsieh CH Genetic variants of retinol-binding protein 4 in adolescents are associated with liver function and inflammatory markers but not with obesity and insulin resistance. J Genet. 2015 Sep;94(3):503-7. (SCI)

32. Lee CH, Changchien CY, Hung YJ. Targeting inflammation in type 2 diabetes by antibody-mediated Tyro-3, Axl, Mer receptor activation. J Diabetes Investig. 2015 Sep;6(5):491-4. (SCI) (First author)

33. Liu JS, Chuang TJ, Chen JH, Lee CH, Hsieh CH, Lin TK, Hsiao FC, Hung YJ. Cilostazol attenuates the severity of peripheral arterial occlusive disease in patients with type 2 diabetes: the role of plasma soluble receptor for advanced glycation end-products. Endocrine. 2015 Aug;49(3):703-10. (SCI)

34. Chiu KC, Lee CH, Liu SY, Chou YT, Huang RY, Huang SM, Shieh YS. Polarization of tumor-associated macrophages and Gas6/Axl signaling in oral squamous cell carcinoma. Oral Oncol. 2015 Jul;51(7):683-9. (SCI)

35. Lee CH, Hung YJ. Possible new therapeutic approach for obesity-related diseases: Role of adiponectin receptor agonists. J Diabetes Investig. 2015 May;6(3):264-6. (SCI) (First author)

36. Wu KS, Hung YJ, Lee CH, Hsiao FC, Hsieh PS. The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation. Int J Endocrinol. 2015: 202513. (SCI)

37. Chen YG, Kan LP, Lee CH, Lin SH, Chu DM, Chang FY, Yang YS. Symptomatic hypercalcemia in a rabies survivor underwent hemodialysis. Hemodial Int. 2015 Apr;19(2):347-51. (SCI)

38. Chen YL, Hung YJ, He CT, Lee CH, Hsiao FC, Pei D, Hsieh CH. Platelet count can predict metabolic syndrome in older women. Platelets. 2015;26(1):31-7. (SCI)

39. Hung YJ, Lee CH, Shieh YS, Hsiao FC, Lin FH, Hsieh CH. Gender differences in plasma growth arrest-specific protein 6 levels in adult subjects. Clin Chim Acta. 2014 Dec 6;441C:1-5. (SCI)

40. Hung YJ, Lee CH, Shieh YS, Hsiao FC, Lin FH, Hsieh CH. Plasma growth arrest-specific protein 6 levels in premenopausal and postmenopausal women: the role of endogenous estrogen. Endocrine. 2014 Dec; 47(3):923-9. (SCI)

41. Chen JH, Tang WH, Lee CH. Effective weight loss after treatment with a glucagon-like peptide-1 receptor agonist in a morbidly obese and diabetic patient before bariatric surgery: a case report. J Med Case Rep. 2014 Sep 11;8:304. (non SCI) (Correspondent author)

42. Chiu KC, Lee CH, Liu SY, Yeh CT, Huang RY, Yuh DY, Cheng JC, Chou YT, Shieh YS. Protumoral effect of macrophage through Axl activation on mucoepidermoid carcinoma. J Oral Pathol Med. 2014 Aug 43: 538–544 (SCI)

43. Hsiao FC, Lin YF, Hsieh PS, Chu NF, Chen YD, Shieh YS, Hsieh CH, Lee CH, Lee TI, Hung YJ. Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents. Int J Endocrinol. 2014; 674069. (SCI)

44. He CT, Lee CH, Hsieh CH, Hsiao FC, Kuo P, Chu NF, Hung YJ. Soluble form of receptor for advanced glycation end products is associated with obesity and metabolic syndrome in adolescents. Int J Endocrinol. 2014; 2014:657607. (SCI)

45. Tang WH, Lin FH, Lee CH, Kuo FC, Hsieh CH, Hsiao FC, Hung YJ. Cilostazol effectively attenuates deterioration of albuminuria in patients with type 2 diabetes: a randomized, placebo-controlled trial. Endocrine. 2014 Mar;45(2):293-301. (SCI)

46. Lee CH, Liu SY, Chou KC, Hung PH, Yeh CT, Shiah SG, Huang RY, Cheng JC, Yen CY, Shieh YS. Tumor-Associated Macrophages Promote Oral Cancer Progression Through Activation of the Axl Signaling Pathway. Ann Surg Oncol. 2014 Mar;21(3):1031-7. (SCI) (First author)

47. Lee CH, Shieh YS, Hsiao FC, Kuo FC, Lin CY, Hsieh CH, Hung YJ. High glucose induces human endothelial dysfunction through an Axl-dependent mechanism. Cardiovasc Diabetol. 2014 Feb 26;13(1):53. (SCI) (First author)

48. Kuo FC, Hung YJ, Shieh YS, Hsieh CH, Hsiao FC, Lee CH. The levels of plasma growth arrest-specific protein 6 is associated with insulin sensitivity and inflammation in women. Diabetes Res Clin Pract. 2014 Feb;103(2):304-9. (SCI) (Correspondent author)