E-MAIL

tlcha@ndmctsgh.edu.tw

研究興趣

探討攝護腺癌、膀胱癌、乳癌中高表現癌化蛋白EZH2的分子機轉，包括經由AKT磷酸化EZH2促進癌化作用模式與應用降解EZH2作為癌症治療策略相關的基礎研究。
以動物模式建立臨床用藥Sorafenib抗藥性研究平台，應用於發展與癌症微環境(tumor microenvironment)、血管新生作用(angiogenesis)、缺氧誘導因子(hypoxia-induced factor)等相關治療策略互相配合的整合癌症療法。
研究蔥菎類藥物(anthroquinone derivatives)、抗血管新生類藥物(anti-angiogenesis drugs)與組蛋白去乙醯酵素抑制劑(HDAC inhibitor)等抗癌藥物的分子作用機制並發展在癌症治療上的創新應用。
建立活體生物冷光顯像的動物模式系統，協助抗癌藥物篩選、發現及研究發展。
建立動物模式研究K他命使用者膀胱功能受損的可能機轉 。

研究論文

Tai-Lung Cha, Mei-Jen Chuang, Shou-Hung Tang, Sheng-Tang Wu, Kuang-Hui Sun,Tzu-Ting Chen, Guang-Huan Sun, Sun-Yran Chang, Cheng-Ping Yu, Jar-Yi Ho, Shu-Yu Liu, Shih-Ming Huang, and Dah-Shyong Yu (2015) Emodin Modulates Epigenetic Modifications and Suppresses Bladder Carcinoma Cell Growth. Molecular Carcinogenesis, 54(3):167-77 (SCI:4.770)
Chih-Wei Tsao, Chin-Yu Liu, Yu-Ching Chou, Tai-Lung Cha, Shih-Chang Chen, Chien-Yeh Hsu (2015) Exploration of the Association between Obesity and Semen Quality in a 7630 Male Population. PLOS ONE. 10(3): e0119458 (IF=3.534, R/C=8/55)
C.-W. Tsao, C.-Y. Liu, T.-L. Cha, S.-T. Wu, S.-C. Chen & C.-Y. Hsu (2015) Exploration of the association between chronic periodontal disease and erectile dysfunction from a population-based view point. Andrologia 47(5):513-8. (IF=1.172, R/C=5/7)
HSIN CHUNG LIN, HERNG SHENG LEE, TZONG SHI CHIUEH, YU CHIEH LIN, HSIN AN LIN, YU CHUN LIN, TAI LUNG CHA and EN MENG. (2015) Histopathological assessment of inflammation and expression of inflammatory markers in patients with ketamine-induced cystitis. MOLECULAR MEDICINE REPORTS 11: 2421-2428 (IF=1.484, R/C=86/124)
Chih-Wei Tsao , Ching-Yu Liu, Tai-Lung Cha, Sheng-Tang Wu , Guang-Huan Sun, Dah-Shyong Yu, Hong-I Chen, Sun-Yran Chang, Shih-Chang Chen , Chien-Yeh Hsu (2014) Artificial neural network for predicting pathological stage of clinically localized prostate cancer in a Taiwanese population. Journal of medical association 77;513-518
Shou-Hung Tang, Hsu-Shan Huang, Hong-Ui Wu, Yi-Ta Tsai, Mei-Jen Chuang, Cheng-Ping Yu, Shih-Ming Huang, Guang-Huan Sun, Sun-Yran Chang, Pei-Wen Hsiao, Dah-Shyong Yu, and Tai-Lung Cha (2014) Pharmacologic Down-regulation of EZH2 Suppresses Bladder Cancer in vitro and in vivo. Oncotarget, 5(21):10342-10355 (SCI:6.627)
Chang-Shuo Huang, Shye-Jye Tang, Ling-Yen Chung,Cheng-Ping Yu, Jar-Yi Ho, Tai-Lung Cha, Chii-Cheng Hsieh, Hsiao-Hsien Wang, Guang-Huan Sun, and Kuang-Hui Sun (2014) Galectin-1 Upregulates CXCR4 to Promote Tumor Progression and Poor Outcome in Kidney Cancer. J AmSoc Nephrol 25: 1486–1495 (SCI:9.466)
Ming-Hsin Yang, Chih-Wei Tsao, Sheng-Tang Wu, Feng-Ping Chuang, En Meng, Shou-Hung Tang, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Tai-Lung Cha (2014) The effect of circumcision on young adult sexual function. Kaohsiung Journal of Medical Sciences 30:305-309.(SCI:0.502)
C.-L. Chen, S.-T. Wu, C.-C. Kao, T.-L. Cha, C.-Y. Lee, and S.-H. Tang (2014) Short-Term Result of Renal Transplantation Using Extracorporeal Membrane Oxygenation Supported Brain-Dead Donors. Transplantation Proceedings, 46:1061-1063
En Meng, Sheng-Tang Wu, Tai-Lung Cha, Guang-Huan Sun, Dah-Shyong Yu, Sheng-Yran Chang. (2013) A murderer of young bladders: Ketamine-associated cystitis. Urological Science 24:113-116.
Mei-Jen Chuang, Sheng-Tang Wu, Thou-Hung Tang, Xiang-Me Lai, Hsiao-Chu Lai, Kai-Hsiang Hsu, Kuang-Hui Sun, Guang-Huan Sun, Sun-Yran Chang, Dah-Shyong Yu, Pei-Wen Hsiao, Shih-Ming Huang, Tai-Lung Cha (2013) The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation. PLOS ONE 8(9): e73401 (SCI:3.534)
En Meng, Sheng-Tang Wu, Tai-Lung Cha, Guang-Huan Sun, Dah-Shyong Yu, Sheng-Yran Chang (2013) A murderer of young bladders: Ketamine-associated cystitis. Urological Science 24(4):113-116
Cheng-Hsi Liao, Sheng-Tang Wu, Chien-Chang Kao, Tai-Lung Cha, Dah-Shyoung Yu, Guang-Huan Sun, and Shou-Hung Tang (2013) Symptomatic Lymphoceles Following Cadaveric Transplantation: Single Center Experience. Journal of Medical Science 33(3):155-158
Jin-Li Chen, Tai-Lung Cha, Sheng-Tang Wu, Shou-Hung Tang, Chih-Wei Tsao, En Meng MD (2013) Renal infarction secondary to ketamine abuse. American Journal of Emergency Medicine 31;1153.e3–1153.e5
Po-Wei Huang, Tai-Lung Cha, Huang-Ching Chang, Guang-Huan Sun, Dah-Shyong Yu and En Meng (2013) Hidden problem in an elderly woman with repeated urinary tract infection: Giant megaureters resulting from a ‘yo-yo’ phenomenon. Surgical Practice 17:110–114
Chih-Wei Tsao, Ming-Hung Lin, Sheng-Tang Wu, En Meng, Shou-Hung Tang, Hong-I Chen, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Tai-Lung Cha (2013) Combining prostrate-specific antigen and Gleason score increases the diagnostic power of endorectal coil magnetic resonance imaging in prostate cancer pathological stage. Journal of the Chinese Medical Association 76:20-24
Chih-Wei Tsao, Ming-Hung Lin, Sheng-Tang Wu, En Meng, Shou-Hung Tang, Hong-I Chen, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Tai-Lung Cha (2013) Combining prostrate-specific antigen and Gleason score increases the diagnostic power of endorectal coil magnetic resonance imaging in prostate cancer pathological stage. Journal of the Chinese Medical Association 76 20-24
Ren-Jun Hsu, Jar-Yi Ho, Tai-Lung Cha, Dah-Shyong Yu, Chieh-Lin Wu, Wei-Ping Huang, Pauling Chu, Ying-Hsin Chen, Jiann-Torng Chen, Cheng-Ping Yu. (2012) WNT10A Plays an Oncogenic Role in Renal Cell Carcinoma by Activating WNT/-catenin Pathway. PLOS ONE 7(10):e47649 (SCI:3.534)
Chien-Chang Kao, Tai-Lung Cha, Guang-Huan Sun, Dah-Shyong Yu, Hong-I Chen, Sun-Yran Chang, Cheng-Ping Ma, Sheng-Tang Wu (2012) Cost-effective homemade specimen retrieval bag for use in laparoscopic surgery: Experience at a single center. Asian Journal of Surgery 35:140-143
Ming-Yi Ho, Shye-Jye Tang, Mei-Jen Chuang, Tai-Lung Cha, Jing-Yao Li, Guang-Huan Sun, and Kuang-Hui Sun (2012) TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism. Mol Cancer Res. 10(8):1109-19.
Chien-Chang Kao, Yen-Hwa Chang, Tony Wu, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Tai-Lung Cha (2012) Open, multi-center, phase IV study to assess the efficacy and tolerability of triptorelin in Taiwanese patients with advanced prostate cancer. Journal of the Chinese Medical Association 1-7
Ming-Hsin Yang, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Cheng-Ping Ma, Tai-Lung Cha (2012) CEA-producing urothelial cell carcinoma with metastasis presenting as a rectal adenocarcinoma. Kaohsiung Journal of Medical Sciences 28:624-627
E. Meng, J.S. Young, T.L. Cha, G.H. Sun, D.S. Yu, and A.F. Brading (2012) Neuronal-Derived Nitric Oxide Modulates the Activity of Mouse Detrusor Smooth Muscle, Neurourology and Urodynamics 31:572–578
Shou-Hung Tang, Chien-Chang Kao, Seng-Tang Wu, En Meng, Tai-Lung Cha (2012) Inlay buccal mucosal graft for reoperative posterior Urethroplasty, Kaohsiung Journal of Medical Sciences 28:220-224
En Meng, Han-Yu Chang, Sun-Yran Chang, Guang-Huan Sun, Dah-Shyong Yu, and Tai-Lung Cha (2011) Involvement of purinergic neurotransmission in ketamine induced bladder dysfunction. THE JOURNAL OF UROLOGY 186:1134-1141
F-P Chuang, M Lakin, S-T Wu, T-L Cha, G-H Sun and DK Montague (2011) Experience with intracavernous injection in the treatment of erectile dysfunction after radical prostatectomy: dose considerations, International Journal of Impotence Research 23:146-150
C. T. Lin, T. L. Cha, S. T. Wu and F. P. Chuang (2010) Acute fulminant colon cancer metastasis after renal transplantation. DIG (Madrid) 102(7):447-448
Chien-Chang Kao, Ching-Jiunn Wu, Guang-Huan Sun, Dah-Shyong Yu, Hong-I Chen, ,Sun-Yran Chang, Cheng-Ping Ma, and Tai-Lung Cha (2010) CONGENITAL SEMINAL VESICLE CYST ASSOCIATED WITH IPSILATERAL RENAL AGENESIS MIMICKING BLADDER OUTLET OBSTRUCTION: A CASE REPORT AND REVIEW OF THE LITERATURE. Kaohsiung J Med Sci 26:30-33
Shou-Hung Tang, Chien-Chang Kao, Seng-Tang Wu, Feng-Ping Chuang, Tai-Lung Cha (2010) Combining Free Buccal Mucosal Graft and Local Tissue From Urethral Diverticulectomy to Repair Complex Urethral Sticure: Report of a Case, Formos J Surg 43(5):243-247
Po-Wei Huang1, Tai-Lung Cha, Huang-Ching Chang and Shou-Hung Tang, Target lesions in the bladder from emphysematous Cystitis. Kidney International (2010) 78, 325 (SCI:6.193)
Huang-Ching Chang, Ta-Chin Lin, Chang-Min Lin, Feng-Ping Chuang, Guang-Haun Sun, Tai-Lung Cha, Seng-Tang Wu (2010) Malignant Pelvic Paraganglioma with Bladder Invasion. J Med Sci 30(3): 093-095
C.-M. Lin, T.-H. Tsai, T.-C. Lin, S.-H. Tang, S.-T. Wu, G.-H. Sun, T.-L. Cha (2009) Holmium: Yttrium-Aluminum-Garnet Laser Endoureterotomy for Benign Ureteral Strictures : a Single-Centre Experience, Acta Chir Belg, 109:746-750.
C.-M. Lin, E. Meng, G.-H. Sun, T.-L. Cha (2009) Danish Prostatic Symptom Score is not associated with Loer Urinary Tract Symptom Severity. Acta Chir Belg, 109:751-755
Tsung-Hsun Tsai, Tai-Lung Cha, Chang-Min Lin, Chih-Wei Tsao, Shou-Hung Tang, Feng-Pin Chuang, Sheng-Tang Wu, Guang-Huan Sun, Dah-Shyong Yu and Sun-Yran Chang (2009) Ketamine-associated bladder dysfunction. International Journal of Urology 16:826–829
Ting-Yi Juan, steve R Roffler, Hisien San Hou, Shih-Ming Huang, Kai-Chuan Chen, Yu-Lin Leu, Zelijko M. Prijovich, Cheng-Ping Yu, Chang-Chieh Wu, Guang-Huan Sun and Tai-Lung Cha (2009) Antiangiogenesis Targeting Tumor Microenvironment Synergizes Glucuronide Prodrug Antitumor Activity, Clinical Cancer Research, 15(14):4600-4611.
Chin-Hsien Tsai, Feng-Min Lin, Yu-Chih Yang, Ming-Ting Lee, Tai-lug Cha, Guan-James Wu, Shih-Chuan Hsieh, Pei-wen Hsiao (2009) Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice. Clinical Cancer Research 15(17):5435-44
Tai-Lung Cha, Mei-Jen Chuang, Sheng-Tang Wu, Guang-Huan Sun, Sun-Yran Chang, Dah-Shyong Yu, Shih-Ming Huang, Steven Kuan-Hua Huan, Tse-Chou Cheng,Tzu-Ting Chen, Pao-Luo Fan, and Pei-Wen Hsiao (2009) Dual Degradation of Aurora A and B Kinases by the Histone Deacetylase Inhibitor LBH589 Infuvrd G2-M Arrest and Apoptosis of Renal Cancer Cells. Clin Cancer Res 15(3):840-850
Tsung-Hsun Tsai, Shou-Hung Tang, Feng-Pin Chuang, Sheng-Tang Wu, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Tai-Lung Cha (2009) Ipsilateral Synchronous Neoplasms of kidndy Presenting as Acute Pyelonephritis and Bladder Metastasis, Urology. 73(5):1163.e9-11
Chien-Chang Kaot, Shou-Hung Tang, Seng-Tang Wu, Tai-Long Cha, Guang-Huan Sun, and Sun-Yran Chang (2008) Abdominal Subcutaneous Metastasis from Sarcomatoid Renal Cell Carcinoma, J Med Sci 28(5):205-208
Shou-Hung Tang, Seng-Tang Wu, Feng-Pin Chunag, Guang-Huan Sun, Shang-Sen Lee, Tai-Lung Cha (2008) Anastomotic Urethroplasty versus Endoscopic Urethral Realignment for Obliterative Urethral Stricture Disease: Experience at a Single Center. JTUA 3(19):165-168
Ming-Hung Lin, Shou-Hung Tang, Feng-Ping Chuang, Shang-Sen Lee, Tai-Lung Cha, Guang-Huan Sun, Seng-Tang Wu. (2008) Transection of the Vas Deferens and Testicular Rupture Following Scrotal Trauma: Report of a Case. JTUA 3(19):189-190.
Chih-Wei Tsao, Chien-Yeh Hsu, Yu-Ching Chou, Sheng-Tang Wu, Guang-Huan Sun, Dah-Shyong Yu, Pao-Luo Fan, Hong-I Chen, Sun-Yran Chang and Tai-Lung Cha (2009) Is obesity correlated with sexual function in young males? Journal of Andrology 30(3):275-279
Chih-Wei, Tsao, T.-L. Cha, S.-T. Wu, K.-H. Tsui & G.-H. Sun. (2008) Association between lower urinary tract symptoms and sexual dysfunction in Taiwanese men. Andrologia 40:387-391
Chih-Wei, Tsao, Chien-Yeh Hsu, Yu-Ching Chou, Sheng-Tang Wu, Guang-Huan Sun, Dah-Shyong Yu, Pao-Luo Fan, Hong-I Chen, Sun-Yran Chang and Tai-Lung Cha (2008) The relationship between varicoceles and obesity in a young adult population. International Journal of Andrology 32:385–390
Feng-Ming Lin, Chin-Hsien Tsai, Yu-Chih Yang, Wei-Chun Tu, Li-Ru Chen, Yun-Sa Liang, Sheng-Yran Wang, Lie-Fen Shyur, Shih-Chan Chien, Tai-Lung Cha, and Pei Wen Hsiao. (2008) A Novel Diterpene Suppresses CWR22Rv1 Tumor Growth In vivo through Antiproliferation and Proapoptosis. Cancer Res 68(16): 6634-6642
Sheng-Tang Wu, Ke-Hung Tsui, Shou-Hung Tang, Dai-Lung Cha, Dah-Shyong Yu, Chung-Yran Yen, Sun-Yran Chang, Hong-I Chen, Guang-Huan Sun (2008) Laparoscopic Radical Prostatectomy: Initial Experience of Robotic Surgery in Taiwan. Anticancer Res, 28:1989-1992
Mei-Jen Chuang, Kuang-Hui Sun, Shye-Jye Tang, Ming-Wei Deng, Yu-Hsin Wu, Jung-Sung Sung, Tai-Lung Cha and Guang-Huan Sun (2008) Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal celll carcinoma cells.Japanese Cancer Association. 99(5):905-913