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::: 合聘教師

許育瑞 合聘副教授

許育瑞 合聘副教授      
Yu-Juei Hsu

現職

三軍總醫院腎臟科主任
三軍總醫院內科部副部主任
三軍總醫院總病房暨門診主任
三軍總醫院腎臟科主治醫師
生化學科合聘副教授

研究興趣

Clinical acid-base and electrolytes disorders
Ion channels and mineral metabolism
Uremic toxins and vascular biology
Graft function in kidney transplantation

聯絡分機

+886-2-87927213

E-MAIL

yujuei@ndmctsgh.edu.tw

最高學歷

荷蘭拉德堡德大學
生理學博士

研究論文

Tsai FC, Chang GJ, Hsu YJ, Lin YM, Lee YS, Chen WJ, Kuo CT, Yeh YH. Proinflammatory gene expression in patients undergoing mitral valve surgery and maze ablation for atrial fibrillation. J Thorac Cardiovasc Surg. 2015 Dec 13. pii: S0022-5223(15)02378-8

Liu CY, Hsu YJ, Chien YE, Cha TL, Tsao CW. Dietary resistant maltodextrin ameliorates testicular function and spermatogenesis in streptozotocin-nicotinamide-induced diabetic rats. Andrologia. 2016 May;48(4):363-73

Lin CY, Hsu YJ, Hsu SC, Chen Y, Lee HS, Lin SH, Huang SM, Tsai CS, Shih CC. CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia. J Mol Cell Cardiol. 2015 Jun 18;85:249-261

Sung CC, Cheng CJ, Chiang WF, Chau T, Hsu YJ, Yang SS, Lin SH. Etiologic and therapeutic analysis in patients with hypokalemic nonperiodic paralysis. Am J Med. 2015 Mar;128(3):289-296.

Hsu YJ, Yang SS, Cheng CJ, Liu ST, Huang SM, Chau T, Chu P, Salter DM, Lee HS, Lin SH. Thiazide-sensitive Na+-Cl- cotransporter (NCC) gene inactivation results in increased duodenal Ca2+ absorption, enhanced osteoblast differentiation and elevated bone mineral density. J Bone Miner Res. 2015 Jan;30(1):116-27

Hsu SC, Huang SM, Lin SH, Ka SM, Chen A, Shih MF, Hsu YJ. Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway. Biochem J. 2014 Dec 1;464(2):221-9.

Hsu SC, Huang SM, Chen A, Sun CY, Lin SH, Chen JS, Liu ST, Hsu YJ. Resveratrol increases anti-aging Klotho gene expression via the activating transcription factor 3/c-Jun complex-mediated signaling pathway. Int J Biochem Cell Biol. 2014 Aug;53:361-71.

Yang SM, Chan YL, Hua KF, Chang JM, Chen HL, Tsai YJ, Hsu YJ, Chao LK, Feng-Ling Y, Tsai YL, Wu SH, Wang YF, Tsai CL, Chen A, Ka SM. Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis. Free Radic Biol Med. 2014 Aug;73:260-9.

Hsu YJ, Hsu SC, Huang SM, Lee HS, Lin SH, Tsai CS, Shih CC, Lin CY. Hyperphosphatemia induces protective autophagy in endothelial cells through the inhibition of Akt/mTOR signaling. J Vasc Surg. 2014 May. pii: S0741-5214(14)00269-9.

Wang WM, Chen JF, Liu ST, Hsu YJ, Liu YC, Huang SM. Biochemical properties of the recurrent LMX1b truncated mutant carried in a Taiwanese family with nail-patella syndrome. Br J Dermatol. 2014 Aug;171(2):356-62

Chen CT, Lin SH, Chen JS, Hsu YJ. Muscle wasting in hemodialysis patients: new therapeutic strategies for resolving an old problem. Scientific World Journal. 2013 Dec;2013:643954.

Chu YH, Hsu YJ, Lee HS, Ho ST, Tung CS, Tseng CJ, Li MH, Lin TC, Lu CC. The osmopressor response is linked to upregulation of aquaporin-1 tyrosine phosphorylation on red blood cell membranes. Hypertension. 2013 Jul;62(1):197-202.

Liu ST, Lu GY, Hsu YJ, Chang LC, Ho CL, Huang SM. Dual roles for lysine 490 of promyelocytic leukemia protein in the transactivation of glucocorticoid receptor-interacting protein 1. Biochim Biophys Acta. 2013 Aug;1833(8):1799-810

Lin CY, Hsu SC, Lee HS, Lin SH, Tsai CS, Huang SM, Shih CC, Hsu YJ. Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure. J Vasc Surg. 2013 Feb;57(2):475-85

Tseng MH, Yang SS, Hsu YJ, Fang YW, Wu CJ, Tsai JD, Hwang DY, Lin SH. Genotype, phenotype, and follow-up in Taiwanese patients with salt-losing tubulopathy associated with SLC12A3 mutation. J Clin Endocrinol Metab. 2012 Aug;97(8):E1478-82

Chiang WF, Hsu YJ, Chang CC, Lin SH. Hypokalemic paralysis in a young obese female. Clin Chim Acta. 2012 Aug 16;413(15-16):1295-7

Wang CC, Hsu YJ, Wu CC, Yang SS, Chen GS, Lin SH, Chu P. Serum fetuin-A levels increased following parathyroidectomy in uremic hyperparathyroidism. Clin Nephrol. 2012 Feb;77(2):89-96

Su SL, Lu KC, Lin YF, Hsu YJ, Lee PY, Yang HY, Kao SY. Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type 1 receptor among chronic kidney disease patients in a Chinese population. J Renin Angiotensin Aldosterone Syst. 2012 Mar;13(1):148-54

Cheng CJ, Lin SH, Lo YF, Yang SS, Hsu YJ, Cannon SC, Huang CL. Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis. J Biol Chem. 2011 Aug 5;286(31):27425-35

Huang TH, Ka SM, Hsu YJ, Shui HA, Tang BL, Hu KY, Chang JL, Chen A. Rab23 plays a role in the pathophysiology of mesangial cells--a proteomic analysis. Proteomics. 2011 Feb;11(3):380-94

Yang SS, Lo YF, Yu IS, Lin SW, Chang TH, Hsu YJ, Chao TK, Sytwu HK, Uchida S, Sasaki S, Lin SH. Generation and analysis of the thiazide-sensitive Na+ -Cl- cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome. Hum Mutat. 2010 Dec;31(12):1304-15

Tsao YT, Wu CC, Hsu YJ, Chu P. Acute right ventricular failure in lupus-associated protein-losing enteropathy. Am J Emerg Med. 2010 Sep;28(7):845.e1-3

Wang MT, Su CY, Chan AL, Lian PW, Leu HB, Hsu YJ. Risk of digoxin intoxication in heart failure patients exposed to digoxin-diuretic interactions: a population-based study. Br J Clin Pharmacol. 2010 Aug;70(2):258-67

Ka SM, Kuo YC, Ho PJ, Tsai PY, Hsu YJ, Tsai WJ, Lin YL, Shen CC, Chen A. (S)-armepavine from Chinese medicine improves experimental autoimmune crescentic glomerulonephritis. Rheumatology (Oxford). 2010 Oct;49(10):1840-51

Sung-Sen Yang, Yu-Juei Hsu, Motoko Chiga, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida and Shih-Hua Lin. Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice. Endocrinology. 2010 Apr;151(4):1829-36

Yu-Juei Hsu, Henrik Dimke, Joost P.H. Schoeber, Shih-Che Hsu, Shih-Hua Lin, Pauling Chu, Joost G.J. Hoenderop, René J.M. Bindels. Testosterone increases urinary Ca2+ excretion and inhibits the expression of renal Ca2+ transport proteins. Kidney Int. 2010 Apr;77(7):601-8

Yu-Juei Hsu, Henrik Dimke, Joost G.J. Hoenderop, René J.M. Bindels. Calcitonin-stimulated renal Ca2+ reabsorption occurs independently of TRPV5. Nephrol Dial Transplant. 2010 May;25(5):1428-35

Yu-Juei Hsu, Shih-Hua Lin, Yuh-Feng Lin, Fu-Chiu Yu, Lamin E S Jaiteh. Pitfalls of technetium-99m-labeled human serum albumin scintigraphy for protein-losing enteropathy. Kidney Int. 2009 Oct;76(8):911.

Jeng-Chuan Shiang, Chih-Jen Cheng, Ming-Kai Tsai, Yi-Jen Hung, Yu-Juei Hsu, Sung-Sen Yang, Shi-Jye Chu, Shih-Hua Lin. Therapeutic analysis in Chinese patients with thyrotoxic periodic paralysis over 6 years. Eur J Endocrinol. 2009 Dec;161(6):911-6.

Huang WT, Hsu YJ, Chu PL, Lin SH. Neurotoxicity associated with standard doses of piperacillin in an elderly patient with renal failure. Infection. 2009 Aug;37(4):374-6.

Yu-Juei Hsu, Sung-Sen Yang, Nain-Feng Chu, Huey-Kang Sytwu, Chih-Jen Cheng, Shih-Hua Lin. Heterozygous mutations of the sodium chloride cotransporter in Chinese children: prevalence and association with blood pressure. Nephrol Dial Transplant. 2009 Apr;24(4):1170-5.

Yu-Tzu Tsao, Yu-Juei Hsu, Nien-Feng Chu, Ching-Huang Lai, Jiann-Shiun Chiu, , Shih-Hua Lin. Association of Plasma Adiponectin and Cardiovascular Risk Profiles in Non-diabetic Uremic Patients on Peritoneal Dialysis. J Nephrol. 2008 Sep-Oct;21(5):744-52

Wei-Liang Chen, Yu-Juei Hsu, Wei-Chi Tsai, Yu-Tzu Tsao. An Unusual Case of Febrile Neutropenia: Acute Myeloid Leukemia Presenting as Myeloid Sarcoma of the Spleen. J Natl Med Assoc 2008 Aug;100(8):957-9

Cheng CJ, Shiang JC, Hsu YJ, Yang SS, Lin SH. Hypocalciuria in patients with Gitelman syndrome: role of blood volume. Am J Kidney Dis 2007 May;49(5):693-700.

Yu-Juei Hsu, Joost G. Hoenderop, René J. Bindels. TRP Channels in Kidney Disease. Biochim Biophys Acta 2007 Aug;1772(8):928-36.

Yu-Juei Hsu, Dimitra Gkika, Annemiete W. van der Kemp, Sylvia Christakos, René J. Bindels and Joost G. Hoenderop. Critical Role of the Epithelial Ca2+ Channel TRPV5 in Active Ca2+ Reabsorption as Revealed by TRPV5/Calbindin-D28K Knockout Mice. J Am Soc Nephrol 2006 Nov;17(11):3020-7.

Chiou-An Chen, Shih-Hua Lin, Yu-Juei Hsu, Yu-Chuan Li, Yuh-Feng Wang, Jainn-Shiun Chiu. Neural network modeling to stratify peritoneal membrane transporter in predialytic patients. Intern Med 2006 Sep;45(9):663-4.

Chih-Yuan Lin, Yu-Juei Hsu, Gou-Jieng Hong, Chien-Sung Tsai, Shih-Hua Lin. Broken guidewire during subclavian venous catheterization. Dialysis & Transplantation 2006 Aug; 35(8):536-7.

Yu-Juei Hsu, Jainn-Shiun Chiu, Kuo-Cheng Lu, Tom Chau,,Shih-Hua Lin. Biochemical and etiological characteristics of acute hyponatremia in the emergency department. J Emerg Med 2005 Nov;29(4):369-74.

Shih-Hua Lin, Jen-Chuan Shiang, Che-Chung Huang, Sung-Sen Yang, Yu-Juei Hsu and Chih-Jen Cheng. Phenotype and genotype analysis in Chinese patients with Gitelman's syndrome. J Clin Endocrinol Metab 2005 May;90(5):2500-7.

Kuo-Cheng Lu, Yu-Juei Hsu, Jainn-Shiun Chiu, Yaw-Don Hsu, Shih-Hua Lin. Effects of potassium supplementation on the recovery of thyrotoxic periodic paralysis. Am J Emerg Med 2004 Nov;22(7):544-7.

Weng-Sheng Tsai, Chien-Ping Wu, Yu-Juei Hsu, Shih-Hua Lin. Life-threatening hypokalemia in an asthmatic patient treated with high-dose hydrocortisone. Am J Med Sci. 2004 Mar;327(3):152-5.

Shih-Hua Lin, Nai-Lin Cheng, Yu-Juei Hsu, Halperin ML. Intrafamilial phenotype variability in patients with Gitelman’s syndrome having the same mutations in their Thiazide-Sensitive sodium/chloride cotransporter. Am J Kidney Dis 2004 Feb;43(2):304-312.

Shih-Hua Lin, Yu-Juei Hsu, Jainn-Shiun Chiu, Tom Chau, Chin-Wang Hsu, Halperin ML. Osmotic demyelination syndrome: a potentially avoidable disaster. QJM. 2003 Dec; 96(12): 935-47.

Shih-Hua Lin, Yuh-Feng Lin, Shi-Wen Kuo, Yu-Juei Hsu, Yi-Jen Hung. Rosiglitazone improves glucose metabolism in nondiabetic uremic patients on CAPD. Am J Kidney Dis. 2003 Oct; 42(4): 774-80.

Yu-Juei Hsu, Ching-Liang Ho, Yeu-Chin Chen, Woei-Yau Kao, Tsu-Yi Chao. Adult Intracranial Germ Cell Tumors in Taiwan. J Med Sci. 2003 Oct; 23(5): 265-269.

Yu-Juei Hsu, Tom Chau, Jun-Ting Liou, Shi-Wen Kuo, Shih-Hua Lin. Electrocardiographic manifestations in patients with thyrotoxic periodic paralysis. Am J Med Sci. 2003 Sep; 326(3): 128-32.

Shyu RY, Jiang SY, Chou JM, Shih YL, Lee MS, Yu JC, Chao PC, Hsu YJ, Jao SW. RARRES3 expression positively correlated to tumor differentiation in tissues of colorectal adenocarcinoma. Br J Cancer. 2003 Jul 7; 89(1): 146-51.

Yu-Huei Hsu, Tom Chau, Sung-Sen Yang, Weng-Sheng Tsai, Shih-Hua Lin. Rathke's cleft cyst presenting with hyponatremia and transient central diabetes insipidus. Acta Neurol Scand. 2003 May; 107(5): 382-5.

Yu-Juei Hsu, Yeu-Chin Chen, Ching-Liang Ho, Woei-Yau Kao, Tsu-Yi Chao. Diabetic ketoacidosis and persistent hyperglycemia as long-term complications of L-asparaginase-induced pancreatitis. Chin Med J. 2002 Sep; 65(9): 441-5.

Yu-Juei Hsu, Lu Pai, Yeu-Chin Chen, Ching-Liang Ho, Woei-Yau Kao, Tsu-Yi Chao. Extragonadal germ cell tumors in Taiwan: an analysis of treatment results of 59 patients. Cancer. 2002 Aug 15; 95(4): 766-74

Yu-Juei Hsu, Jing-Ren Jeng. Uterine Myoma Associated with Deep Vein Thrombosis and Pulmonary Embolism - Report of Two Cases. Acta Cardiol Sin. 2002 Feb; 22(1): 49-55.

Weng-Sheng Tasi, Chun-Jen Hsueh, Yu-Juei Hsu, Shih-Hau Lin. Osmotic Demyelination Syndrome in a Patient with Chronic Hyponatremia and Hypokalemia. J Med Sci 2002 Feb; 22(1): 35-38.

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  • 更新日期:2019-10-03