最高學歷

台灣大學 生化科學研究所 博士

經歷

2020.12-present 國防醫學院 生命科學所 助理教授
2019.1-2020.10 洛桑大學 癌症研究所/ Ludwig 癌症研究所 博士後研究員
2014.2-2018.12 中央研究院 農業生物科技研究中心 博士後研究員

研究興趣

腫瘤免疫學

腫瘤代謝

醣質生物學

中草藥研究

研究論文

1. Giusy Di Conza, Chin-Hsien Tsai, Hector Gallart Ayala, Yi-Ru Yu, Fabien Franco, Lea Zaffalon, Xin Xie, Xiaoyun Li, Zhengtao Xiao, Lydia N. Raines, Maryline Falquet, Antoine Jalil, Jason Locasale, Piergiorgio Percipalle, David Masson, Stanley Ching-Cheng Huang, Fabio Martinon, Julijana Ivanisevic, Ping-Chih Ho*. Tumor-induced reshuffling of lipid composition on ER membrane sustains macrophage survival and pro-tumorigenic activity. Nat Immunol, 22:1403 22 October 2021(IF 25.606)

2. Valentina Pucino#, Chin-Hsien Tsai#, Michelangelo Certo, Ping-Chih Ho, and Claudio Mauro. Lactate modulation of the immune response in inflammatory disease and cancer. Nat Rev Immunol 21:151 24 August 2020 (#equal contribution, IF 53.106)

3. Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel Trefny, Roberta Zappasodi, Syed Raza Mahmood, Juan Fernandez-Garcia, Florence Picard, Etienne Meylan , Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D. Wolchok, Taha Merghoub, Camilla Jandus, Alfred Zippelius, Chin-Hsien Tsai, Isabell Schulze, and Ping-Chih Ho*. CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors. Nat Immunol, 21:298, 17 Feb 2020. (IF 25.606)

4. Giusy Di Conza#, Chin-Hsien Tsai#, and Ping-Chih Ho*. Fifty Shades of α-Ketoglutarate on Cellular Programming. Molecular Cell 76:1, 3 October 2019. (# equal contribution, IF 17.97)

5. Sheue-Fen Tzeng, Chin-Hsien Tsai, Tai-Kuang Chao, Yu-Ching Chou, Yu-Chih Yang, Mong-Hsun Tsai, Tai-Lung Cha, and Pei-Wen Hsiao*. O-Glycosylation–mediated signaling circuit drives metastatic castration-resistant prostate cancer. FASEB Journal 32:6869, June 15 2018.

6. Chin-Hsien Tsai, Sheue-Fen Tzeng, Shih-Chuan Hsieh, Yu-Chih Yang, Mong-Hsun Tsai, and Pei-Wen Hsiao*. A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer. Scientific Reports, 7:15624, November 15 2017.

7. Chin-Hsien Tsai, Sheue-Fen Tzeng, Shih-Chuan Hsieh, Chia-Jui Tsai, Yu-Chih Yang, Mong-Hsun Tsai and Pei-Wen Hsiao*. A standardized Wedelia chinesis extract overcomes the feedback activation of HER2/3 signaling upon androgen-ablation in prostate cancer. Front. Pharmacol. 8:721, October 10 2017.

8. C-J Ko, S-W Lan, Y-C Lu, T-S Cheng, P-F Lai, Chin-Hsien Tsai, T-W Hsu, H-Y Lin, H-Y Shyu, S-R Wu, H-H Lin, P-W Hsiao, C-H Chen ,H-P Huang and M-S Lee. Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis. ONCOGENE 36:4597, August 10 2017.


Book Chapters
Yi-Ren Chen, Pei-wen Hsiao, Feng-Ming Lin, Guan-James Wu, and Chin-Hsien Tsai. Chapter 6: Evidence-based Anticancer Materia Medica for Prostate Cancer, Vol. 2, p103-127, Evidence-based Anticancer Complementary and Alternative Medicine

Patents
Pei-Wen Hsiao, Chin-Hsien Tsai, Shih-Chuan Hsieh. Development of a standardized and effect-optimized herbal extract of wedelia chinensis and its use for treating disease. 01.09.2020~03.03.2036.