E-MAIL

ccshih@mail.ndmctsgh.edu.tw

經歷

英國帝國大學醫學院國家心肺研究所訪問學者 (2017-2018)
英國倫敦大學巴茲與倫敦醫學暨牙醫學院威廉哈維研究所訪問學者 (2013-2014)
國防醫學院副教授 (2017-present)
國防醫學院助理教授 (2013-2017)
國防醫學院講師 (2010-2013)

研究興趣

1. 尋找敗血症和熱中暑的生物預測指標與治療藥物。
2. 探討血管周圍脂肪組織在血管張力調節中所扮演的角色。
3. 探討敗血症和熱中暑血小板低反應的機制與治療策略。

學術著作

1. Chih-Chin Shih*, Wei-Chieh Liao, Hung-Yen Ke, Chia-Wen Kuo, Cheng-Ming Tsao, Wen-Chiuan Tsai, Yi-Lin Chiu, Hsieh-Chou Huang, Chin-Chen Wu (2023, May). Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke. Biomedicine & Pharmacotherapy, 161:114565. 本人為第一作者、通訊作者.
2. Chih-Chin Shih, Shiu-Jen Chen, Wen-Kuei Chang, Hsin-Jung Tsai, Hsieh-Chou Huang, Chin-Chen Wu, Cheng-Ming Tsao (2023, Mar). Stimulation of Angiotensin II Type 2 Receptor Attenuates Organ Injury in Rats With Polymicrobial Sepsis. J Chin Med Assoc. doi: 10.1097/JCMA.0000000000000911. 本人為第一作者.
3. Hiong-Ping Hii, Whai-Zer Lo, Yung-Hui Fu, Ming-Hua Chen, Chia-Ching Shih, Cheng-Ming Tsao, Shuk-Man Ka, Yi-Lin Chiu, Chin-Chen Wu, Chih-Chin Shih* (2022, Dec). Improvement in heat stress-induced multiple organ dysfunction and intestinal damage through protection of intestinal goblet cells from prostaglandin E1 analogue misoprostol. Life Sciences, 310:121039. 本人為通訊作者.
4. Hsin-Jung Tsai, Chih-Feng Chian, Chih-Chin Shih, Shiu-Jen Chen, Wen-Jinn Liaw, Hsieh-Chou Huang, Cheng-Ming Tsao, Chin-Chen Wu (2022, Nov). Olmesartan Ameliorates Organ Injury and Mortality in Rats With Peritonitis-Induced Sepsis. Journal of Surgical Research, 279:526-532.
5. CC Shih, MV Chan, NS Kirkby, I Vojnovic, JA Mitchell, PC Armstrong, TD Warner (2021, Dec). Platelet inhibition by P2Y12 antagonists is potentiated by adenosine signalling activators. British Journal of Pharmacology, 178:4758-4771. 本人為第一作者.
6. HJ Tsai, CC Shih, KY Chang, MH Liao, WJ Liaw, CC Wu, CM Tsao (2021, Jan). Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats. ScientificReports, 11:610.
7. HC Huang, TS Hsiao, MH Liao, CM Tsao, CC Shih*, CC Wu (2020, Sep). Low dose hydralazine improves endotoxin-induced coagulopathy and multiple organ dysfunction via its anti-inflammatory and anti-oxidative/nitrosative properties. European Journal of Pharmacology, 882:173279. 本人為通訊作者.
8. PC Armstrong, PM Ferreira, MV Chan, MH Lundberg Slingsby, M Crescente, CC Shih, NS Kirkby, AJ Hobbs, TD Warner (2020, Jul). Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti‐platelet therapy. Journal of thrombosis and haemostasis, 18:1705-1713.
9. Fu-Kai Chuang, Ching-Len Liao, Ming-Kuan Hu, Yi-Lin Chiu, An-Rong Lee, Shih-Ming Huang, Yu-Lung Chiu, Pei-Ling Tsai, Bo-Cyuan Su, Tsung-Hsien Chang, Chang-Chi Lin, Chih-Chin Shih and Li-Chen Yen (2020, Jun). Antiviral Activity of Compound L3 against Dengue and Zika Viruses In Vitro and In Vivo. International Journal of Molecular Sciences, 21(11), 4050.
10. CC Shih, JH Chen, MH Liao, CM Tsao, HC Huang, CC Wu (2020, Mar). The effect of adenosine A2A receptor antagonist istradefylline on multiple organ dysfunction in heatstroke rats. Journal of Medical Sciences, 40(2):76-82. 本人為第一作者.
11. B Ahmetaj Shala, R Kawai, I M ‐ arei, Z Nikolakopoulou, CC Shih, B Konain, DM Reed, R Mongey, NS Kirkby, JA Mitchell (2020, Jan). A bioassay system of autologous human endothelial, smooth muscle cells, and leukocytes for use in drug discovery, phenotyping, and tissue engineering. The FASEB Journal, 34:1745-1754.
12. FK Chuang, SM Huang, CL Liao, AR Lee, SP Lien, YL Chiu, TH Chang, PL Tsai, RJ Lin, CC Shih, YJ Tsai, GJ Lin, LC Yen (2019, Dec). Anti-inflammatory compound shows therapeutic safety and efficacy against flavivirus infection. Antimicrobial Agents and Chemotherapy, 64(1), e00941-19.
13. CC Shih, PY Liu, JH Chen, MH Liao, CM Hsieh, SM Ka, CC Wu, HT Lin, TH Wu, YC Chen (2018, Dec). Macrophage expression of E3 ubiquitin ligase Grail protects mice from lipopolysaccharide-induced hyperinflammation and organ injury. PLOS ONE, 13 (12): e0208279. 本人為第一作者.
14. HJ Tsai, MH Liao, CC Shih, SM Ka, CM Tsao, CC Wu (2018, Oct). Angiotensin-(1–7) attenuates organ injury and mortality in rats with polymicrobial sepsis. Critical Care, 22:269.
15. B Ahmetaj-Shala, M Olanipekun, A Tesfai, N MacCallum, NS Kirkby, GJ Quinlan, CC Shih, R Kawai, S Mumby, M Paul-Clark, EJ Want, JA Mitchell (2018, Sep). Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping. Scientific Reports, 8:13987.
16. CC Shih, LP Hsu, MH Liao, SS Yang, ST Ho, CC Wu (2017, Nov). Effects of SPAK on vascular reactivity and nitric oxide production in endotoxemic mice. European Journal of Pharmacology, 814, 248-254. 本人為第一作者.
17. CC Shih*, MH Liao, TS Hsiao, HP Hii, CH Shen, SJ Chen, SM Ka, YL Chang, CC Wu (2016, Sep). Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock. PLoS One, 11(9): e0163690. 本人為第一作者、通訊作者. 
18. CC Shih, LP Hsu, MH Liao, SS Yang, CY Wang, ST Ho, CC Wu (2016, Jul). Role of Sterile 20/SPS1-related Proline/Alanine-rich Kinase in Mice with Endotoxic Shock. Journal of Medical Sciences, 36: 101-107. 本人為第一作者. 
19. CC Shih, HP Hii, CM Tsao, SJ Chen, SM Ka, MH Liao, CC Wu (2016, Feb). Therapeutic Effects of Procainamide on Endotoxin-Induced Rhabdomyolysis in Rats. PLoS One, 11(2): e0150319. 本人為第一作者. 
20. HP Hii, MH Liao, SJ Chen, CC Wu, CC Shih* (2015, Jul). Distinct Patterns of Wnt3a and Wnt5a Signaling Pathway in the Lung from Rats with Endotoxic Shock. PLoS One, 10(7): e0134492. 本人為通訊作者.
21. MH Liao, SJ Chen, CM Tsao, CC Shih*, CC Wu (2013, Jul). Possible biomarkers of early mortality in peritonitis-induced sepsis rats. Journal of Surgical Research, 183(1), 362-370. 本人為通訊作者.

其他資訊

◎Research Interests

☆Biomarkers and treatments of septic shock                  

☆The mechanisms of platelet hyporeactivity in heat stroke and sepsis

◎Lab Alumni