E-MAIL

ccwu@mail.ndmctsgh.edu.tw

經歷

1986/08-1987/07 國防醫學院 助教
1989/02-1990/06 美國密西根大學 客座研究員
1987/08-1995/07 國防醫學院 講師
1995/08-2000/07 國防醫學院 副教授
1999/10-2000/02 美國密西根大學 客座副教授
2002/11-2005/10 英國巴斯大學 客座教授
2005/08-2006/07 美國喬治亞醫學院 客座教授
2005/05-2011/08 國防醫學院 藥理學科主任兼所長
2008/04~2012/03 國防醫學院生命科學研究所系統生物組 組長
2012/07~2014/06 國防醫學院實驗動物照護及使用委員會 召集人

榮譽

1990年國際高血壓會議青年研究獎 　　　　 　　　　　　　　 　
1990年美國密西根大學生理學科研究獎　　　　　　　　　　　　　　
1991年中國生理學會優秀論文獎　　　　　　　　　　　　　　　　　
1996年中華藥理學會優秀論文獎 　　　　　　　　　　　　　　　　
2002年中華民國十大傑出青年　

校外職位

1998/08~迄今 考試院考選部藥理學 命題委員
2004/04~迄今 台灣藥理學會 理事
2020/04~迄今 台灣藥理學會 常務理事
2013/08~迄今 財團法人劉氏基金會 董事
2014/05~迄今 財團法人思源學術促進基金會 董事
2020/09~迄今 財團法人桃園市香雲福利慈善基金會 董事

研究領域

1. 敗血症　　　
2. 自由基　　
3. 血管生理及藥理學

研究論文(近五年代表著作)

1. Shih, C.C., H.P. Hii, C.M. Tsao, S.J. Chen, S.M. Ka, M.H. Liao, C.C. Wu*: Therapeutic effects of a DNA methyltransferase inhibitor procainamide endotoxin-induced rhabdomyolysis in rats. PLoS One 11(2): e0150319, 2016.

2. Shih, C.C., L.P. Hsu, M.H. Liao, S.T. Ho, C.C. Wu*: Role of sterile 20/SPS1-related proline/alanine-rich kinase in mice with endotoxic shock. J Med Sci 36(2): 101-107, 2016.

3. Shih, C.C., H.P. Hii, C.H. Shen, M.H. Liao, S.J. Chen, S.M. Ka, C.C. Wu*: Procainamide inhibits DNA methylation and alleviates multiple organ dysfunction in rats with enodotoxic shock. PLoS One 11(9): e0163690, 2016.

4. Huang, H.C., H.J. Tsai, C.C. Wang, C.M. Tsao, S.M. Ka, W.J. Liaw, C.C. Wu: Levosimendan mitigates coagulopathy and organ dysfunction in rats with early endotoxemia. J. Chin. Med. Assoc., 80(7):432-441, 2017.

5. Shih, C.C., L.P. Hsu, M.H. Liao, S.S. Yang, S.T. Ho, C.C. Wu*: Effects of SPAK on vascular reactivity and nitric oxide production in endotoxemic mice. Eur. J. Pharmacol. 814:248-254, 2017.

6. Tsai, H.J., M.H. Liao, C.C. Shih, S.M. Ka, C.M. Tsao, C.C. Wu. Angiotensin-(1-7) attenuates organ injury and mortality in rats with polymicrobial sepsis. Critical Care 22:269, 2018.

7. Shih, C.C., P.Y Liu, J.H. Chen, M.H. Liao, C.M. Hsieh, S.M. Ka, C.C. Wu, H.T. Lin, T.H. Wu, Y.C. Chen: Macrophage expression of E3 ubiquitin ligase Grail protects mice from lipopolysaccharide-induced hyperinflammation and organ injury. PLoS ONE 13(12):e0208279, 2018.

8. Chou, C.L., C.H. Li, H. Lin, M.H. Liao, C.C. Wu, J.S. Chen, Y.M. Sue, T.C. Fang: Role of activating transcription factor 3 in fructose-induced metabolic syndrome in mice. Hypertens. Res. 41:589-597, 2018.

9. Shih, C.C., J.H. Chen, M.H. Liao, C.M. Tsao, C.C. Huang, C.C. Wu*: The effect of adenosine A2A receptor antagonist istradefylline on multiple organ dysfunction in heatstroke rats. J. Med. Sci. 40(2):76-82, 2020.

10. Huang, H.C., T.S. Hsiao, M.H. Liao, C.M. Tsao, C.C. Shih, C.C. Wu*: Low-dose hydralazine improves endotoxin-induced coagulopathy and multiple organ dysfunction via its anti-inflammatory and anti-oxidative/nitrosative properties. Eur. J. Pharmacol. 882:173279, 2020.

11. Tsai, H.J., C.C. Shih, K.Y. Chang, M.H. Liao, W.J. Liaw, C.C. Wu, C.M. Tsao: Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats. Sci. Report 11:610, 2021.

12.Hsin-Jung Tsai, Chih-Feng Chian, Chih-Chin Shih, Shiu-Jen Chen, Wen-Jinn Liaw, Hsieh-Chou Huang, Cheng-Ming Tsao, Chin-Chen Wu (2022, Nov). Olmesartan Ameliorates Organ Injury and Mortality in Rats With Peritonitis-Induced Sepsis. Journal of Surgical Research, 279:526-532.

13.Hiong-Ping Hii, Whai-Zer Lo, Yung-Hui Fu, Ming-Hua Chen, Chia-Ching Shih, Cheng-Ming Tsao, Shuk-Man Ka, Yi-Lin Chiu, Chin-Chen Wu, Chih-Chin Shih* (2022, Dec). Improvement in heat stress-induced multiple organ dysfunction and intestinal damage through protection of intestinal goblet cells from prostaglandin E1 analogue misoprostol. Life Sciences, 310:121039.

14.Chih-Chin Shih, Shiu-Jen Chen, Wen-Kuei Chang, Hsin-Jung Tsai, Hsieh-Chou Huang, Chin-Chen Wu, Cheng-Ming Tsao (2023, Mar). Stimulation of Angiotensin II Type 2 Receptor Attenuates Organ Injury in Rats With Polymicrobial Sepsis. J Chin Med Assoc.

15.Chih-Chin Shih*, Wei-Chieh Liao, Hung-Yen Ke, Chia-Wen Kuo, Cheng-Ming Tsao, Wen-Chiuan Tsai, Yi-Lin Chiu, Hsieh-Chou Huang, Chin-Chen Wu (2023, May). Antimicrobial peptide cathelicidin LL-37 preserves intestinal barrier and organ function in rats with heat stroke. Biomedicine & Pharmacotherapy, 161:114565.