經歷

國防醫學院藥理學科助教 (1993/9~1998/7)
講師 (1998/8~2001/7)
助理教授 (2001/8~2006/7)
副教授 (2006/8~2015/7)

E-MAIL

ymlee@mail.ndmctsgh.edu.tw

學科專長

1.停經後期生理、病理及藥理學之研究

2.敗血症及熱休克治療評估及致病機轉之探討

3.心肌缺血/再循環損傷

研究論文(2016-)

1. Yi-Li Wang, Hsin-Hsueh Shen, Pao-Yun Cheng, Yen-Ju Chu, Hwong-Ru Hwang, Kwok-Keung Lam*, Yen-Mei Lee*. 17-DMAG, An HSP90 inhibitor, Ameliorates Multiple Organ Dysfunction Syndrome via Induction of HSP70 in Endotoxemic Rats. PLoS One 2016 May 25;11(5):e0155583; SCI, IF: 3.240, Ranking: 35.62 % (Multidisciplinary sciences 26/73).

2.Yung-Chieh Tsai, Kwok-Keung Lam, Yi-Jen Peng, Yen-Mei Lee, Chung-Yu Yang, Yi-Ju Tsai, Mao-Hsiung Yen, Pao-Yun Cheng*. Heat shock protein 70 and AMP-activated protein kinase contribute to 17-DMAG-dependent protection against heat stroke. Journal of Cellular and Molecular Medicine 2016 Oct;20(10):1889-97. SCI, IF: 5.310, Ranking: 31.43 % (Medicine, Research and Experimental 44/140).
3.Yung-Chieh Tsai, Sy Ying Leu, Yi-Jen Peng, Yen-Mei Lee, Chih-Hsiung Hsu, Shen-Chieh Chou, Mao-Hsiung Yen, Pao-Yun Cheng*. Genistein suppresses leptin-induced proliferation and migration of vascular smooth muscle cells and neointima formation. Journal of Cellular and Molecular Medicine 2017 Mar;21(3):422-431. SCI, IF: 5.310, Ranking: 31.43 % (Medicine, Research and Experimental 44/140).

4.Hsin-Hsueh Shen, Shieh-Yang Huang, Pao-Yun Cheng, Yen-Ju Chu, Shu-Ying Chen, Kwok-Keung Lam*, Yen-Mei Lee*. Involvement of HSP70 and HO-1 in the protective effects of raloxifene on multiple organ dysfunction syndrome by endotoxemia in ovariectomized rats. Menopause 2017 Aug;24(8):959-969, SCI, IF: 3.305, Ranking: 40.96 % (Obstetrics & Gynecology 34/83).

5.Ming-Tzeung Chung#, Yen-Mei Lee#, Hsin-Hsueh Shen, Pao-Yun Cheng, Yu-Chen Huang, Yu-Ju Lin, Yu-Yang Huang, Kwok-Keung Lam*. Activation of autophagy is involved in the protective effect of 17-oestradiol on endotoxaemia-induced multiple organ dysfunction in ovariectomized rats. Journal of Cellular and Molecular Medicine 2017 Dec; 21(12):3705-3717. SCI, IF: 5.310, Ranking: 31.43 % (Medicine, Research and Experimental 44/140).

6.Sy-Ying Leu, Yi-Chen Chen, Yung-Chieh Tsai, Yao-Wen Hung, Chih-Hsiung Hsu, Yen-Mei Lee, and Pao-Yun Cheng* Raspberry ketone reduced lipid accumulation in 3T3-L1 cells and ovariectomy-induced obesity in Wistar rats by regulating autophagy mechanisms. Journal of Agricultural and Food Chemistry 2017 Dec 20;65(50):10907-10914. SCI, IF: 5.279, Ranking: 8.62 % (Argriculture, Multidisciplinary 5/58).

7. Sy-Ying Leu, Yung-ChiehTsai, Wen-ChiChen, Chih-HsiungHsu, Yen-MeiLee, Pao-Yun Cheng*. Raspberry ketone induces brown-like adipocyte formation through suppression of autophagy in adipocytes and adipose tissue. Journal of Nutritional Biochemistry 2018 Jun;56:116-125. SCI, IF: 6.048, Ranking: 18.18 % (Nutrition & Dietetics 16/88).

8. Hsin-Hsueh Shen, Shieh-Yang Huang, Ching-Wen Kung, Shu-Ying Chen, Ya-Fen Chen, Pao-Yun Cheng, Kwok-Keung Lam, Yen-Mei Lee*. Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high fat diet. Journal of Nutritional Biochemistry 2019 Feb; 67:111-122; SCI, IF: 6.048, Ranking: 18.18 % (Nutrition & Dietetics 16/88).

9.Hsin-Hsueh Shen, Chien-Yi Yang, Ching-Wen Kung, Shu-Ying Chen, Hong-Min Wu, Pao-Yun Cheng, Kwok-Keung Lam, Yen-Mei Lee*. Raloxifene inhibits adipose tissue inflammation and adipogenesis through Wnt regulation in ovariectomized rats and 3T3-L1 cells. Journal of Biomedical Science 2019; 26(1):62; SCI, IF: 8.410, Ranking: 10.71 % (Medicine, Research & Experimental 15/140).

10.Hsin-Hsueh Shen, Yu-Shiuan Tseng, Ni-Chun Kuo, Ching-Wen Kung, Sherif Amin, Kwok-Keung Lam, Yen-Mei Lee*. Alpha-lipoic acid protects cardiomyocytes against heat stroke induced apoptosis and inflammatory responses associated with the induction of Hsp70 and activation of autophagy. Mediators of Inflammation 2019, Article ID 8187529, SCI, IF: 4.711, Ranking: 41.36 % (Immunology 67/162).

11.Yung-Chieh Tsai, Chyi-Wen Wang, Bo-Yao Wend, Po-Shiuan Hsieh, Yen-Mei Lee, Mao-Hsiung Yen, Pao-Yun Cheng*. Involvement of the p62/Nrf2/HO-1 pathway in the browning effect of irisin in 3T3-L1 adipocytes. Molecular and Cellular Endocrinology 2020, 514: 110915; SCI, IF: 4.102, Ranking: 48.28 % (Endocrinology & Metabolism 70/145).

12. Ni-Chun Kuo, Shieh-Yang Huang, Chien-Yi Yang, Hsin-Hsueh Shen*, and Yen-Mei Lee*. Involvement of HO-1 and autophagy in the protective effect of magnolol in hepatic steatosis-induced NLRP3 inflammasome activation in vivo and in vitro. Antioxidants 2020, 9: 924; SCI, IF: 6.312, Ranking: 7.6 % (Food Science/Technology 11/144)

13. Je-Ming Hu, Chih-Hsueng Hsu, Yu-Chun Lin, Ching-Wen Kung, Shu-Ying Chen, Wen-Ting Lin, Pao-Yun Cheng, Hsin-Hsueh Shen*, and Yen-Mei Lee*. Ethyl pyruvate ameliorates heat stroke-induced multiple organ dysfunction and inflammatory responses by induction of stress proteins and activation of autophagy in rats. International Journal of Hyperthermia 2021, 38(1): 862-874; SCI, IF: 3.914, Ranking: 17.20 % (Radiology, Nuclear Medicine & Medical Imaging 32/186).

14. Pang-Yen Liu, Hsin-Hsueh Shen, Ching-Wen Kung, Shu-Ying Chen, Chia-Hsien Lu, Yen-Mei Lee*. The role of HSP70 in the protective effects of NVP-AUY922 on multiple organ dysfunction syndrome in endotoxemic rats. Frontiers in Pharmacology 2021, 12: 724515; SCI, IF: 5.810, Ranking: 14.55 % (Pharmacology & Pharmacy 40/275)

15.Lai, Z. Z., Shen, H. H., & Lee, Y. M. (2023). Inhibitory effect of β-escin on Zika virus infection through the interruption of viral binding, replication, and stability. Scientific Reports, 13(1), 10014.

研討會論文

1.Yen-Mei Lee. 17-DMAG induces HSP70 to ameliorate multiple organ dysfunction syndrome caused by endotoxemia in rats. Invited speaker, Symposium section title: Heat Shock Protein: The Next Target in The Disease Frontier, Abstract control ID: 2289544, Pacifichem 2015: The International Chemical Congress of Pacific Basin Societies, 15-20 December, 2015, Honululu, Hawaii, USA.

2. Yen-Mei Lee, Hsin-Hsueh Shen, Ya-Fen Chen. The effect of long-term treatment with genistein on white adipose tissues browning and inflammation in ovariectomized rats fed with high fat diet. ID. 7777, 16th World Congress on the Menopause, 6-9 June, 2018, Vancouver, Canada.