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黃翊恭 教授兼所長及主任

黃翊恭 教授兼所長及主任      
HUANG, Eagle Yi-Kung

現職

國防醫學院藥理學科 主任
國防醫學院 教授

學位

國立台灣大學畜牧學系學士
英國南安普頓大學(University of Southampton)生理暨藥理學博士

聯絡分機

18670

E-MAIL

eyh58@ndmctsgh.edu.tw

經歷

中央研究院動物研究所內分泌研究室研究助理
國防醫學院藥理學科博士後研究
長庚大學藥理學科博士後研究
長庚紀念醫院醫學研究中心研究員
長庚大學臨床醫學研究所助理教授
英國南安普頓大學(University of Southampton)生化學系訪問學者
國防醫學院藥理學科助理教授
國防醫學院藥理學科副教授

專長學科

主要研究方向:
1. Neuropeptide FF (NPFF)及其類似物之生理功能與藥理學上之應用
2. LVV-hemorphins及angiotensin IV在中樞之調節作用
3. 麻醉及止痛藥物之新藥研發
4. 脊髓電生理學
主要研究設備:
1. 離體脊髓電生理細胞外記錄系統
2. Peptides 合成及分析系統
3. 晶片式細胞箝制電生理記錄系統
4. Panasonic MED64 system
5. 各種疼痛及成癮相關動物行為測試儀器

研究論文

•2021
1.Hung, H. Y., Chow, L. H., Kotlinska, J. H., Drabik, A., Silberring, J., Chen, Y. H., & Huang, E. Y. K. (2021). LVV-hemorphin-7 (LVV-H7) plays a role in antinociception in a rat model of alcohol-induced pain disorders. Peptides, 136, 170455.

2.Mielczarek, P., Hartman, K., Drabik, A., Hung, H. Y., Huang, E. Y. K., Gibula-Tarlowska, E., ... & Silberring, J. (2021). Hemorphins—From discovery to functions and pharmacology. Molecules, 26(13), 3879.

3.Hung, H. Y., Chien, W. C., Chung, C. H., Kao, L. T., Chow, L. H., Chen, Y. H., ... & Huang, E. Y. K. (2021). Patients with alcohol use disorder increase pain and analgesics use: A nationwide population-based cohort study. Drug and Alcohol Dependence, 229, 109102.

•2020
1.Loh SH, Chang CY, Huang SF, Chao SC, Lin WK, Huang EY, Tsai CS, Tsai YT. (2020). Functional effects of urotensin-II on intracellular pH regulators in human radial artery smooth muscle cells. Peptides, 126, 170236.

•2019
1.Chen YH, Hsieh TH, Kuo TT, Kao JH, Ma KH, Huang EY, Chou YC, Olson L, Hoffer BJ.(2019). Release parameters during progressive degeneration of dopamine neurons in a mouse model reveal earlier impairment of spontaneous than forced behaviors. Journal of neurochemistry, 150(1), 56-73.

2.Wu WL, Cheng SJ, Lin SH, Chuang YC, Huang EY, Chen CC1,. (2019). The effect of ASIC3 knockout on corticostriatal circuit and mouse self-grooming behavior. Frontiers in Cellular Neuroscience, 13, 86.

3.Chen YH, Wang V, Huang EY, Chou YC, Kuo TT, Olson L, Hoffer BJ. (2019). Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice. International Journal of Molecular Sciences, 20(24), 6251.

•2018
1.Yuan-Hao Chen , Tung-Tai Kuo, Jen-Hsin Kao, Eagle Yi-Kung Huang, Tsung-Hsun Hsieh, Yu-Ching Chou & Barry J. Hofer.(2018) Exercise Ameliorates Motor Defcits and Improves Dopaminergic Functions in the Rat Hemi-Parkinson’s Model. Scientific Reports, 8:3973.

2.Yuan-Hao Chen, Bon-Jour Lin, Tsung-Hsun Hsieh, Tung-Tai Kuo, Jonathan Miller, Yu-Ching Chou, Eagle Yi-Kung Huang, and Barry J. Hoffer.(2018) Differences in Nicotine Encoding Dopamine Release between the Striatum and Shell Portion of the Nucleus Accumbens. SAGE Journal. Jan 1:963689718775382.

3.Yuan-Hao Chen, Tung-Tai Kuo, Eagle Yi-Kung Huang, Barry J. Hoffer, Jen-Hsin Kao, Yu-Ching Chou, Yung-Hsiao Chiang, Jonathan Miller.(2018) Nicotine-Induced Conditional Place Preference Is Affected by Head Injury: Correlation with Dopamine Release in the Nucleus Accumbens Shell. International Journal of Neuropsychopharmacol. Oct 1;21(10):949-961.

4.Chow LH, Chen YH, Lai CF, MD, Lin TY, Chen YJ, Kao JH, Huang EY. (2018) Sex difference of angiotensin IV-, LVV-hemorphin 7-, and oxytocin-induced antiallodynia at the spinal level in mice with neuropathic pain. Anesthesia & Analgesia (in press)
Lok-Hi Chow, Chen YH, Huang EY, Kuo TT, Hoffer BJ, Miller J, Chou YC, Chiang YH. (2017) Dopamine release in the nucleus accumbens is altered following traumatic brain injury. Neuroscience 348: 180-190

•2017
1.Chen YH, Huang EY, Kuo TT, Hoffer BJ, Miller J, Chou YC, Chiang YH. (2017) Dopamine release in the nucleus accumbens is altered following traumatic brain injury. Neuroscience 348: 180-190
Chen YH, Huang EY, Kuo TT, Miller J, Chiang YH, Hoffer BJ. (2017) Impact of traumatic brain injury on dopaminergic transmission. Cell Transplantation 26(7): 1156-1168

•2016
1.Lok-Hi Chow, Yuan-Hao Chen, Wan-Chuan Wu, En-Pei Chang, and Eagle Yi-Kung Huang (2016) Sex difference in oxytocin-induced anti-hyperalgesia at the spinal level in rats with intraplantar carrageenan-induced inflammation. PLoS ONE 11(9): e0162218

2.Yuan-Hao Chen, Wan-Chuan Wu, En-Pei Chang, and Eagle Yi-Kung Huang (2016) Sex difference in oxytocin-induced anti-hyperalgesia at the spinal level in rats with intraplantar carrageenan-induced inflammation. PLoS ONE 11(9): e0162218
Eagle Yi-Kung Huang, Yuan-Hao Chen, Tzu-Ying Huang, Ying-Jie Chen, and Lok-Hi Chow (2016) Chronic administration of nandrolone increases susceptibility to morphine dependence without correlation with LVV-hemorphin 7 in rats. Neuropeptides 59: 63-69

3.Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Barry J. Hoffer, Pei-Jie Wu, Hsin-I Ma, Jing-Jr Tsai, Yu-Ching Chou, and Yung-Hsiao Chiang (2016) Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury. Brain Res. 1642: 581-589

4.Eagle Yi-Kung Huang, Yuh-Chiang Shen, and Chieh-Fu Chen (2016) Mitochondria: Target for the develop of anti-inflammatory drugs. Journal of Chinese Medicine (in press)

•2015
1.Lok-Hi Chow, Pao-Luh Tao, Yuan-Hao Chen, Yu-Hui Lin and Eagle Yi-Kung Huang (2015) Angiotensin IV possibly acts through PKMzeta in hippocampus to regulate cognitive memory in rats. Neuropeptides 53: 1-10

2.Pao-Pao Yang, Geng-Chang Yeh, Eagle Yi-Kung Huang, Ping-Yee Law, Horace H. Loh and Pao-Luh Tao (2015) Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice. J. Biomed. Sci. 22(1): 81

3.Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Hsin-I Ma, Barry J. Hoffer, Pi-Fen Tsui, Jing-Jr Tsai, Yu-Ching Chou and Yung-Hsiao Chiang (2015) Dopamine release impairment in striatum after different levels of cerebral cortical fluid percussion injury. Cell Transplantation 24(10): 2113-2128

•2014
1.Yi-Ting Tsai, Chung-Yi Lee, Chih-Chin Hsu, Chung-Yi Chang, Ming-Kai Hsueh, Eagle Yi-Kung Huang, Chien-Sung Tsai, Shih-Hurng Loh (2014) Effects of Urotensin II on intracellular pH regulation in cultured human internal mammary artery smooth muscle cells. Peptides 56: 173-182

2.Eagle Yi-Kung Huang, Tung-Tai Kuo, Jing-Jr Tsai, Pi-Fen Tsui, Yu-Ching Chou, Tsai Tung-Han, Hsin-I. Ma, Yung-Hsiao Chiang and Yuan-Hao Chen (2014) Remote effects on the striatal dopamine system after fluid percussion injury. Behavioural Brain Research 267: 156-172

3.Eagle Yi-Kung Huang, Pi-Fen Tsui, Tung-Tai Kuo, Jing-Jr Tsai, Yu-Ching Chou, Hsin-I Ma, Yung-Hsiao Chiang and Yuan-Hao Chen (2014) Amantadine ameliorates dopamine-releasing deficits and behavioral deficits in rats after fluid percussion injury. PLoS ONE 9(1): e86354

•2013
1.Ling-Yi Wu, Chieh-Fu Chen and Eagle Yi-Kung Huang (2013) Obesity related metabolic complications and anti-obesity drugs. Journal of Chinese Medicine 24(2): 261-277

2.Yuan-Hao Chen, Tong-Tai Kuo, Ming-Ting Chu, Hsin-I Ma, Yung-Hsiao Chiang and Eagle Yi-Kung Huang (2013) Postnatal systemic inflammation exacerbates impairment of hippocampal synaptic plasticity in animal seizure model. Neuroimmunomodulation 20(4): 223-232

3.Weihong Pan, Xiaojun Wu, Yi He, Hung Hsuchou, Eagle Yi-Kung Huang, Pramod K. Mishra and Abba J. Kastin (2013) Brain interleukin-15 in neuroinflammation and behavior. Neurosci. Biobehav. Rev. 37(2): 184-192

4.Lok-Hi Chow, Pao-Luh Tao, Jin-Chung Chen, Ruey-Ming Liao, En-Pei Chang and Eagle Yi-Kung Huang (2013) A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats. Peptides 39(1): 21-28

•2011
1.Kuo-Hsing Ma, Eagle Yi-Kung Huang, Hsien-Wen Chang, Cheng-Yi Cheng, San-Yuan Huang, Wen-Sheng Huang, I-Hsun Li, San-Chong Chyueh, Chyng-Yann Shiue and Pao-Luh Tao (2011) Effects of dextromethorphan on 3,4-methylenedioxy-methamphetamine-induced rewarding, behavioral sensitization, and neurotoxicity in rats. Addict. Biol. (submitted)

2.Pao-Pao Yang, Eagle Yi-Kung Huang, Yu-Ying Fu, Tsai-Shan Ho and Pao-Luh Tao (2011) Post-treatment of dextromethorphan on methamphetamine-induced drug-seeking and behavioral sensitization. Drug Alcohol Depend.

3.Jen-Hsin Kao, Eagle Yi-Kung Huang and Pao-Luh Tao (2011) NR2B subunit of NMDA receptor at nucleus accumbens is involved in morphine rewarding effect by siRNA study. Drug Alcohol Depend.

4.Shih-Lin Chang, Yao-Chang Chen, Yung-Hsin Yeh, Yu-Jun Lai, Hung-I Yeh, Cheng-I Lin, Yung-Kuo Lin, Yenn-Jiang Lin, Tsu-Juey Wu, Yi-Kung Huang, Shih-Ann Chen, Yi-Jen Chen (2011) Heart failure enhances arrhythmogenesis in pulmonary veins. Clin. Exp. Pharmacol. Physiol.

5.Shiou-Lan Chen, Kuei-Ying Hsu, Eagle Yi-Kung Huang, Ru-Band Lu and Pao-Luh Tao (2011) Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in rats. Drug Alcohol Depend. 117(2-3): 164-169

6.Jain-Fang Chen, Pao-Luh Tao and Eagle Yi-Kung Huang* (2011) Dextromethorphan attenuated the higher vulnerability to inflammatory hyperalgesia caused by prenatal morphine exposure in rat offspring. J. Biomed. Sci. 18(1): 64

•2010
1.Ling-Yi Wu, Eagle Yi-Kung Huang and Pao-Luh Tao (2010) Co-administration of dextromethorphan during pregnancy and throughout lactation prevents morphine-induced hyperprolactinemia in female rats. Fertility and Sterility 93(5): 1686-1694

2.Chun-Hung Wu, Pao-Luh Tao and Eagle Yi-Kung Huang* (2010) Distribution of neuropeptide FF (NPFF) receptors in correlation with morphine-induced reward in the rat brain. Peptides 31(7): 1374-1382

•2009
1.Wei-Li Wu, Chih-Hung Wang, Eagle Yi-Kung Huang and Chih-Cheng Chen (2009) ASIC3-/- Female Mice with Hearing Deficit Affects Social Development of Pups. PLoS ONE 4(8): e6508

2.Ling-Yi Wu, Jain-Fang Chen, Pao-Luh Tao and Eagle Yi-Kung Huang* (2009) Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring. J. Biomed. Sci. 16: 106

•2008
1.Yu-Jun Lai, Eagle Yi-Kung Huang, Hung-I Yeh, Yen-Lin Chen, Jim Jung-Ching Lin and Cheng-I Lin (2008) On the mechanisms of arrhythmias in the myocardium of mXina-deficient murine left atrial-pulmonary veins. Life Sci. 83: 272-283

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  • 更新日期:2021-05-28