E-MAIL

ccchou@nchu.edu.tw

經歷

國立中興大學獸醫學院院長 2015.2－ 2018.1
國立中興大學終身特聘教授 2017.8－
國立中興大學特聘教授 2012.8－ 2014.7
國立中興大學獸醫教學醫院檢驗科主任 2012.2－2015.2 2018.2-
國立中興大學教務務處副教務長 2012.2－2014.2
國立中興大學國際事務處副國際長 2010.9－2011.8
外籍學生事務組長 2007.9－2009.2
國立中興大學教授 2010.8－, 國立中興大學副教授 2007.2－2010.8, 助理教授 2002.8-2007.2
美國北卡州立大學化學毒理及藥物動力學中心副研究員 2001.7 – 2002.7國立中興大學 96 學年度特優導師 2008. 9
美國佛羅里達大學、美國北卡州立大學訪問學者 2011, 2007
行政院專門職業及技術人員高等考試獸醫師 (第一名) 1992.3.5

專長學科

1. 獸醫藥物動力學
2. 獸醫臨床病理學
3. 水生動物藥理學及藥物動力學
4. 獸醫毒理學

成果簡述

學術
1. 論文Pharmacokinetic-pharmacodynamic modeling for determination of optimal dosing regimen of florfenicol in Nile tilapia (Oreochromis niloticus) at different water temperatures and antimicrobial susceptibility levels. 2019年獲Journal of Fish Diseases期刊(SCI, 16%, IF=1.988) 獲選為封頁
2. 論文Expression Profiling of Human Epidermal Keratinocyte Response Following One-Minute JP-8 Exposure.獲Cutaneous and Ocular Toxicology 期刊選為2006年年度最佳論文。於2007年世界毒理學年會(Society of Toxicology)頒獎。
3. 論文Fast Differentiation of Meats from Fifteen Animal Species by Liquid Chromatography with Electrochemical Detection using Copper Nanoparticle Plated Electrodes. J Chromatogr B Analyt Technol Biomed Life Sci. (2006)獲化學分析專業網頁SeparationsNow.com (John Wiley & Sons Ltd.)專文報導，題目為”One kebab, but hold the pigeon”
專利
1. 氟甲磺氯黴素作為抗生素之抗菌促進劑的用途。(發明第 I 615140 號) 專利權期：2018/2/21~2035/6/25 (第一發明人)
2. 利用胺基酸消耗圖譜鑑定或區別細菌種別及型別之方法(發明第I532841號) 專利權期：2016/5/13~2034/11/21 (第一發明人)
3. 氯黴素類抗菌劑組合物及其應用(發明第 I 415602 號) 專利權期：2013/11/21~ 2030/2/7 (第一發明人)
4. 用於肉品種別及新鮮度鑑定之高效能液相層析術結合電化學分析(HPLC-EC)測定方法(發明第 I 316134 號) 專利權期：2009/10/21~2026/8/15 (第一發明人)
獲獎
李崇道基金會104年度臺灣獸醫菁英獎-教學研究獎 2016
國立中興大學建教合作計劃績優教師 2006. 9 - 2007. 6
國立中興大學獸醫學院教學及服務獎勵教師 2006. 9 - 2007. 6
期刊編輯
Associate Editor, Frontiers in Veterinary Science (IF=2.029 Q1 13%), Veterinary Pharmacology and Toxicology section Since 2018
Associate Editor, Frontiers in Veterinary Science (IF=2.029 Q1 13%), Animal Nutrition and Metabolism section 2015-2018

研究論文

1. Liu, Y. K., Kuo, h.c., Lai, C.H and Chou, C. C.* (2020) Single amino acid utilization for bacterial categorization. Scientific Report (under revision, 7658df3a-7cfd-410d-9c2f-18659330133c) (SCI, 13%, IF=4.702)
2. Rairat, T., Thongpiam, W., Hsieh, C.Y., Liu, Y.K., Tunkijjanukij, S., and Chou, C.C.* (2020) Salinity-dependent pharmacokinetics of florfenicol in Nile tilapia (Oreochromis niloticus) and its implication in optimal dosing regimen Aquaculture Vol. 519 https://doi.org/10.1016/j.aquaculture.2019.734900 (SCI, 13%, IF=3.002)
3. Rairat, T., Hsieh, C.Y., Thongpiam, W., and Chou, C.C.* (2020) Temperature-dependent non-linear pharmacokinetics of florfenicol in Nile tilapia (Oreochromis niloticus) and its implementation in optimal dosing regimen determination Aquaculture Vol. 517 https://doi.org/10.1016/j.aquaculture.2019.734794 (SCI, 13%, IF=3.022)
4. Lin, TL., Ou, S.C., Maeda, K., Shimoda, K., Chan, J.P.W., Tu, W.C., Hsu, W.L.* and Chou, C.C.* (2020) The First Discovery of Severe Fever with Thrombocytopenia Syndrome Virus in Taiwan. Emerging Microbes & Infections Vol. 9 148-151(SCI, 14%, IF=6.212)
5. Rattanapanadda, P., Kuo, H.C., Vickroy, T.W., Sung, C.H., Rairat, T., Lin, T.L., Yeh, S.Y., and Chou, C.C.* (2019) In Vitro and In Vivo Synergistic Effects of Florfenicol and Thiamphenicol in Combination against Swine Actinobacillus pleuropneumoniae and Pasteurella multocida Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.02430 (SCI, 24%, IF=4.259)
6. Liu, HT., Wang, TN., Hsu, YT., Chou, C.C., Huang, KH., Hsu, CC., Liang, HJ., Chang, HW., Lee, TH and Tsai, PS. (2019) Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis. Antioxidents 8:466 (SCI, 7%, IF=4.520)
7. Lin, T.L., Chung, H.S., Sung, C.H., Yeh, S.Y., Cheng, T.L. and Chou, C.C.* (2019) Establishment of feline in-house reference intervals for hematologic and biochemical parameters and potential age-related differences Polish Journal of Veterinary Sciences 22(3), 599–608 (SCI, 61%, IF=0.802)
8. Rairat, T., Hsieh, C.Y., Thongpiam, W., and Chou, C.C.* (2019) Pharmacokinetic-pharmacodynamic modeling for determination of optimal dosing regimen of florfenicol in Nile tilapia (Oreochromis niloticus) at different water temperatures and antimicrobial susceptibility levels. Journal of Fish Diseases 42:8 1181-1190 (SCI, 16%, IF=1.988) selected as back cover story
9. Rairat, T., Hsieh, C.Y., Thongpiam, W., Sung, C.H., and Chou, C.C.* (2019) Temperature-dependent pharmacokinetics of florfenicol in Nile tilapia (Oreochromis niloticus) following single oral and intravenous administration. Aquaculture 503: 483–488 (SCI, 13%, IF=3.002)
10. Liao, Y.L., Chou, C.C.# and Lee Y.J. (2019) The association of indoxyl sulfate with fibroblast growth factor 23 in cats with chronic kidney disease. Journal of Veterinary Internal Medicine 33(2):686-693. doi: 10.1111/jvim.15457. (SCI, 9%, IF=2.286) #equal contribution to 1st author
11. Hsieh, M.K., Sung, C.H., Hsieh, P.F., Hsiao, P.F., Wu, B.Y. and Chou, C.C.* (2019) Identification and Characterization of Infectious Bursal Disease Virus Subviral Particles by Capillary Zone Electrophoresis: Potential Application for Vaccine Production and Quality Control. Poultry Science 98(4):1658-1663. doi: 10.3382/ps/pey537. (SCI, 13%, IF=2.027)
12. Yeh, S.Y., Sung, C.H., Lin, T.L., Cheng, T.L. and Chou C.C.* (2019) The effects of crossbreed, age, and sex on hematologic and biochemical variables in cross-breed pet rabbits (Oryctolagus cuniculus) Veterinary Clinical Pathology 48(3):469-480DOI: 10.1111/vcp.12775 (SCI, 52%, IF=0.948)
13. Rairat, T., Hsieh, M.K., Vickroy, T.W. and Chou, C.C.* (2018) Reduced Resident Time and Tissue Residues of Synergistic Florfenicol-Thiamphenicol Combination in Leghorn Chickens. Pakistan Veterinary Journal 39(2):310-312 (SCI, 31%, IF=1.360)
14. Lin, H.C., Chong, W.H., Huang, H.H., Chou, C.C., Tsai, Y.L., Chu, C.S., Shih, W.L., Lai, J.M. and Su, Y.C. (2018) Seroprevalence and molecular identification of Mycobacterium avium subspecies paratuberculosis in farmed goats in central-southern Taiwan. Taiwan Veterinary Journal 44(4):179-188
15. Wang, T.S,., Liu, H.T., Lai, Y.H., Jan, T.R., Nomura, N., Chang, H.W., Chou, C.C., Lee, Y.J., Tsai P.S. (2018) Honokiol, a Polyphenol Natural Compound, Attenuates Cisplatin-Induced Acute Cytotoxicity In Renal Epithelial Cells Through Cellular Oxidative Stress And Cytoskeleton Modulations. Frontiers in Pharmacology 9:357-370 (SCI, 22%, IF=3.845)
16. Chen, C.N., Chou, C.C.# , Tsai PSJ and Lee Y.J.* (2018) Plasma indoxyl sulfate concentration predicts progression of chronic kidney disease in dogs and cats. The Veterinary Journal 232:33-39 (SCI, 18%, IF=1.919) #equal contribution to 1st author
17. Liao, Z.H., Chen, Y.J., Tzen, Jason T.C., Kuo, P.C., Lee, M.R., Mai, F.D., Rairat, T. and Chou, C.C.* (2018) Effect of Teapot Materials on the Chemical Compositions of Oolong Tea Infusion. Journal of the Science of Food and Agriculture 98(2):751-757. (SCI, 16%, IF=2.422)
18. Chen, H.R., Rairat, T., Loh, S.H., Wu, Y.C., Vickroy, T.W., and Chou, C.C.* (2017) Assessment of Veterinary Drug Risks in Plants Using Pharmacokinetic Approaches: the Absorption, Distribution and Elimination of Tetracycline and Sulfamethoxazole in Ephemeral Vegetables. PLOS ONE 12(8): https://doi.org/10.1371/journal.pone.0183087) (SCI, 23%, IF=2.766)
19. Yeh, Z.J., Lo, D.Y., Chang, S.K., Chou, C.C. and Kuo, H.C. (2017) Antimicrobial susceptibility, serotypes and genotypes of Pasteurella multocida isolates associated with swine pneumonia in Taiwan. Veterinary Record 181(12):323. (10.1136/vr.104023) (SCI, 11%, IF=2.101)
20. Yuasa Yumi, Tsai, Y.L., Chang, C.C., Hsu, T.H., Huang, C.C., Huang, W.C., and Chou, C.C.* (2017) The prevalence of Anaplasma platys and a potential novel Anaplasma sp. exceeds that of Ehrlichia canis in asymptomatic dogs and Rhipicephalus sanguineus in Taiwan. The Journal of Veterinary Medical Science; 79(9):1494-1502. doi: 10.1292/jvms (SCI, 56%, IF=0.910)
21. Lin, C.S., Chang, L.W., Chiang, G.H.,, Liu, C.H., Tsai, H.C., Chen, K., Huang, S.K., Cheng, T.L. and Chou, C.C.* (2017) Comparison of a full spectrum multianalyte clinical analyzer to six reference instruments using canine and feline blood samples. Veterinarni Medicina 62 (06): 342–350 (SCI, 76%, IF=0.34)
22. Yeh, Z.C., Lo, D.Y., Chang, S.K., Chou, C.C. and Kuo, H.C. (2017) Prevalence of plasmid-mediated quinolone resistance in Escherichia coli isolated from diseased animals in Taiwan. Journal of Veterinary Medical Science 79(4):730-735. (SCI, 56%, IF=0.910)
23. Chu, C.H., Huang, H.H., Chiang, S.H., Chou, C.C., Lai, J.M., Shih, W.L., Lin, H.C., Chuang, S.T. and Su, Y.C. (2017) Investigation into antimicrobial resistance, enterotoxin and cassette chromosome gene of Staphylococcus aureus isolates from humans, cows and goats in Taiwan. Thai Journal of Veterinary Medicine 47(4):481-492 (SCI 82%, IF=0.318)
24. Huang, S.M., Chang S.K., Tu, C., Kuo, S.T., Kuo, H.C. and Chou, C.C. (2016) Establishment and characterization of a novel kidney-cell line from orange-spotted grouper, Epinephelus coioides, and its susceptibility to grouper iridovirus. Journal of Marine Science: Research and Development 6:192. (open access, doi:10.4172/2155-9910.1000192)
25. Rairat, T., Ou, S.C., Chang, S.K., Li, K.P., Vickroy, T.W. and Chou, C.C*. (2016) Plasma pharmacokinetics and tissue depletion of cyromazine and its metabolite melamine following oral administration in laying chickens. Journal of Veterinary Pharmacology and Therapeutics 40 (5): 459-467. (SCI, 40%, IF=1.175)
26. Hsiao, P.F., Chang, S.K., Hsu, T.H., Li, K.P. and Chou, C.C.* (2016) Pharmacokinetics and tissue depletion of doxycycline applied at high dosage to broiler chickens via drinking water. Acta Veterinaria Hungarica 64 (4): 472-481 (SCI 47%, IF=1.059)
27. Wei, C.F., Shien, J.H., Chang, S.K. and Chou, C.C* (2016) Florfenicol as a modulator enhancing antimicrobial activity: example using combination with thiamphenicol against Pasteurella multocida. Frontiers in Microbiology 7: 389-400 (SCI, 24%, IF=4.259)
28. Wei, C.F., Chang, S.K., Shien, J.H., Kuo, H.J. Chen W.Y and Chou, C.C.* (2016) Synergism between the same class of antibiotics florfenicol and thiamphenicol against Staphylococcus aureus. Veterinary Record 178 (13): 319. (doi:10.1136/vr.103554) (SCI, 11%, IF=2.101)
29. Hsieh M.K., Shih, P.Y., Wei, C.F., Vickroy, T.W. and Chou, C.C.* (2016) Detection of undeclared animal by-products in commercial canine canned foods: Comparative analyses by ELISA and PCR-RFLP coupled with slab gel electrophoresis or capillary gel electrophoresis. Journal of the Science of Food and Agriculture 96 (5): 1659-1665. (SCI,16%, IF=2.422)
30. Chung, S.H., Chang, L.W., Cheng, T.L., Lin, C.J., Chen, W.Y and Chou, CC* (2015) Establishing in-house reference intervals for dogs in veterinary clinics. Taiwan Veterinary Journal 42 (2): 53-67.
31. Loh, S.H., Lee, C.Y., Chen, G.S., Wu, C.H., Tsao, C.J., Shih, S.J., Chou, C.C., Tsai, C.S. and Tsai, Y.T. (2015) The effect and underlying mechanism of ethanol on intracellular H+-equivalent membrane transporters in human aorta smooth muscle cells. Alcoholism: Clinical and Experimental Research 39 (12): 2302-2312. (SCI 26%, IF=3.235)
32. Chen, G.S., Wu, C.H., Liau, C.C., Hsu, C.C., Liu, J.Y., Wu, G.J., Chou, C.C. and Loh, S.H. (2015) Physiological and pharmacological characterization of transmembrane acid extruders in cultured human umbilical artery smooth muscle cells. Journal of Medical Sciences 35 (5): 208-217. (DOI: 10.4103/1011-4564.167775)
33. Feng, T.H., Chou, C.C., Yeh, T.M., Su, Y.C., Lu, Y.P., Shih, W.L., Chiang, C.H., Chang, C.D., Liu, S.S., Wu, H.Y, Huang, H.H.* and Liao, M.H* (2015) Molecular prevalence of zoonotic pathogens in pet and stray dogs in southern Taiwan. The Thai Journal of Veterinary Medicine 45 (4): 509-522. (SCI 82%, IF=0.318)
34. Cheng, F.P., Hsieh, M.J., Chou, C.C., Hsu, W.L. and Lee, Y.J* (2015) Detection of indoxyl sulfate levels in dogs and cats suffering from naturally occurring kidney diseases. The Veterinary Journal 205 (3): 399-403. (SCI, 18%, IF=1.919)
35. Lo, Y.H., Chen, Y.J., Chung, T.Y., Lin, N.H., Chen, W.Y., Chen, C.Y.,Lee, M.R. Chou, C.C. and Tzen Jason T.C.* (2015) Emoghrelin, a unique emodin derivative in Heshouwu, stimulates growth hormone secretion via activation of the ghrelin receptor. Journal of Ethnopharmacology 159: 1-8. (SCI, 15%, IF=3.414)
36. Lee, M.Y., Ding, S.Y., Wu, C.C.*, Peng, J., Jiang, C.T. and Chou, C.C. (2015) Fabrication of nanostructured copper phosphate electrodes for the detection of α-amino acids. Sensors & Actuators: B. Chemical 206: 584-591. (SCI, 3%, IF=6.393)

專書

1. 周濟眾(總審閱)。獸醫血液學-診斷指引與圖譜 (2016) (譯自John Harvey: Veterinary Hematology: A Diagnostic Guide and Color Atlas, ISBN 9-781437-701739)。由美商Elsevier Ltd.授權。
2. 周濟眾 總校閱。輕鬆掌握獸醫臨床血液學 (獸醫簡明筆記系列) (2016) (譯自Susan M. Cotter, Quick Look Series in Veterinary Medicin: Hematology. ISBN 1-893441-36-9)。Teton Newsmedia授權。藝軒出版社。
3. 周濟眾(等九人編)。動物醫院分科與臨床技術手冊 (2016) Elsevier Ltd.出版
4. 周濟眾譯。藥物動力學變簡單了 (2012) (譯自Donald J Birkett and Australian Prescriber, Pharmacokinetics Made Easy, 2nd Ed.。Mc Graw Hill授權 (ISBN 978-007-0285-27-9) 合記出版社
5. 周濟眾(等十人編譯)。伴侶動物的病史與理學檢查(2010) (譯自A. Rijnberk and F.J. Sluijs: Medical History and Physical Examination in Companion Animals)。負責第24, 25, 26及27章。美商Elsevier Ltd.授權。 (ISBN 978-986-6538-80-3)
6. 周濟眾(等十五人)。最新食品安全衛生學 (2010)負責第八章:食品中之農業化學物質。顏國欽教授 總校閱 (ISBN 978-957-6169-62-5)
7. 周濟眾(譯)。獸醫實驗診斷學-診斷與評估 (2007) (譯自Denny Meyer and John Harvey: Veterinary Laboratory Medicine- Interpretation and Diagnosis 04 ISBN)。由美商Saunders及Elsevier Ltd.授權。 (ISBN 0-7216-8926-4)
8. Chi-Chung Chou, Jen-Lin Chang and Jyh-Myng Zen. Spherical and Anisotropic Copper Nanomaterials in Medical Diagnosis. Chapter 2 of Metallic Nanomaterials for the Life Sciences, Vol. 1, Kumar, Challa S. S. R. (ed.), (Dec. 2008) (ISBN 3-5273-2151-9)