主要研究方向

1. 癌症研究平台
研究具潛力藥物或天然物之抗腫瘤血管新生，腫瘤生長，代謝及轉移的功效及機轉。
研究中草藥或天然物對改善癌症及化療藥物所誘發之惡病質病徵之療效及機轉探討。
專利: 厚朴酚改善癌症惡病質的作用 (台灣及大陸地區)。
2. 血管及發炎性急慢性疾病致病的機轉探討及改善藥物研發
研究各類發炎性及慢性疾病包括:急性肺損傷，肺高壓、糖尿病、糖尿病腎病變、敗血症、感
染性傷口、牙周病，骨質流失等的致病機轉及具治療潛力藥物及天然物研發。
3. 血小板凝集功能相關研究
研究各類臨床藥物和中草藥抽取物等對血小板凝集功能和血管性疾病的作用及機轉探討。
4. 各類中草藥抽取物，天然物和食品之生物活性及疾病療效研究。
*執行科技部三年計畫 (2019/08/01~2022/07/31)
獲獎: 慈濟大學 2016 研究優良獎第一名。慈濟大學 2017 研究論文獎。

Selected papers

1. Shih CY, Chou TC*. The antiplatelet activity of magnolol is mediated by PPAR.Biochem Pharmacol 84:793-803, 2012.
2. Lu SH, Huang RY, Chou TC*. Magnolol ameliorates ligature-induced periodontitis in rats and
osteoclastogenesis: in vivo and in vitro study. Evid Based Complement Altern Med 2013: Article ID
634095, 2013.
3. Chen MC, Lee CF, Huang WH, Chou TC*. Magnolol suppresses hypoxia-induced angiogenesis via
inhibition of HIF-1/VEGF signaling pathway in human bladder cancer cells. Biochem Pharmacol
85:1278-1287, 2013.
4. ShihCY, Lin MH, Fan HC, Chen FC, Chou TC*. Mechanisms of antiplatelet activity of nifedipine: role
of peroxisome proliferator-activated receptor-β-γ-dependent processes. J Hypertens 32:181-192, 2014.
5. Shih CY, Lin IH, Ding JC, Chen FC, Chou TC*. Antiplatelet activity of nifedipine is mediated by
inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity. Br J Pharmacol
171:1490-1500, 2014.
6. Tsai CL, Lin YC, Wang HM, Chou TC*. Baicalein, an active component of Scutellaria baicalensis,
protects against lipopolysaccharide-induced acute lung injury in rats. J Ethnopharmacol 153:197-206,2014.
7. Lu SH, Chen TH, Chou TC*. Magnolol inhibits RANKL-induced osteoclast differentiation of RAW
264.7 macrophages through heme oxygenase-1-dependent inhibition of NFATc1 expression. J Nat Prod
78:61-68, 2015.
8. Chen TH, Shih CY, Hsu WL, Chou TC*. Mechanisms of nifedipine-downregulated CD40L/sCD40L
signaling in collagen stimulated human platelets. Plos One 10:e0127054, 2015
9. Chen MC, Chen YL, Lee CF, Huang CH, Chou TC*. Supplementation of magnolol attenuates skeletal
muscle atrophy in bladder cancer-bearing mice undergoing chemotherapy via suppression of FoxO3
activation and induction of IGF-1. Plos One 10:e0143594, 2015.
10. Chen MC, Hsu WL, Chang WL, Chou TC*. Antiangiogenic activity of phthalides-enriched Angelica
Sinensis extract by suppressing WSB-1/pVHL/HIF-1VEGF signaling in bladder cancer. Sci Rep
7:5376, 2017.
11. Yu WC, Chen YL, Hwang PA, Chen TH, Chou TC*. Fucoidan ameliorates pancreatic β-cell death and
impaired insulin synthesis in streptozotocin-treated  cells and mice via a Sirt-1-dependent manner.
Mol Nutr Food Res 61:1700136, 2017.
12. Hsu WL, Lin YC, Jeng JR, Chang HY, Chou TC*. Baicalein ameliorates pulmonary arterial
hypertension caused by monocrotaline through downregulation of ET-1 and ETAR in
pneumonectomized rats. Am J Chin Med 46:769-783, 2018.
13. Chang H, Chang CY, Lee HJ, Chou CY, ChouTC*. Magnolol ameliorates pneumonectomy and
monocrotaline-induced pulmonary arterial hypertension in rats through inhibition of angiotensin II and
endothelin-1 expression. Phytomedicine 51:205-213, 2018.
14. Lu SH, Hsia YJ, Shih KC, Chou TC*. Fucoidan prevents RANKL-stimulated osteoclastogenesis and
LPS-induced inflammatory bone loss via regulation of Akt/GSK3β/PTEN/NFATc1 signaling pathway
and calcineurin activity. Marine Drugs 17:345, 2019.