聯絡方式

02-23123456#62221

Mail:wwllaura1119@ntu.edu.tw

專長

先天免疫受體及宿主的防禦功能; 角質細胞的分化調節機制及對發炎與乾癬(牛皮癬)的影響; 發炎與免疫調節分子 Decoy receptor 3 與疾病的關係; 不同種細胞死亡模式的調節機制

發表論文

Chiu LY, Ho FM, Shiah SG, Chang Y, and Lin WW. (2011) Oxidative stress initiates DNA damager MNNG-induced poly(ADP-ribose)polymerase-1-dependent parthanatos cell death. Biochem. Pharmacol. 81:459-470.

Chen SY, Maa MC, Chiu LY, Wang JS, Chien CL, and Lin WW. (2011) zVAD induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation. Autophagy 7:2, 217-228.

Tsai WH, Huang DY, Yu YH, Chen CY, and Lin WW. (2011) Dual roles of NOD2 in TLR4-mediated signal transduction and -induced inflammatory gene expression in macrophages. Cell. Microbiol. 13:717-730.

Wu NL, LeeaTA, Tsai TL, and Lin WW. (2011) TRAIL-induced keratinocyte differentiation requires caspase activation and p63 expression. J. Invest. Dermatol. 131:874-883.

Wang JS, Ho FM, Kang HC, Lin WW, and Huang KC. (2011) ROS-dependent signaling for celecoxib-induced heme oxygenase-1 expression. Naunyn-Schmiedeberg Arch Pharmacol. 383:159-168.

Lin WW and Hsieh SL. (2011) Decoy receptor 3: A pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer. Biochem. Pharmacol. 81:838-847.

Lai YC, Chen CK, Lin WW, and Lee SS. (2012) A comprehensive investigation of anti-inflammatory diarylheptanoids from the leaves of Alnus formosana. Phytochemistry 73:84–94.

Huang DY, Chao Y, Tai MH, Yu YH, and Lin WW. (2012) STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by death receptor leads to stress kinase-dependent cell death. J. Biomed. Sci. 19:35

Ho FM, Liao YH, Yang AJ, Chao Lee PD, Hou YC, Huang CT, Lin SR, Lee KR, Huang KC, and Lin WW. (2012) Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes. J. Ethanopharmacol. 142:175-187.

Chang MY, Huang DY, Ho FM, Huang KC, and Lin WW. (2012) PKC-dependent human monocyte adhesion requires AMPK and Syk activation. Plos One 7:e40999
Wang JS, Chang YL, Yu YH, Chen CY, Kao MC, Li TK, and Lin WW. (2012) Cell type-specific effects of adenosine 5’-triphosphate and pyrophosphate on the antitumor activity of doxorubicin. Cancer Sci. 103:1811–1819.

Ho HJ*, Huang DY*, Ho FM, Lee LT,# and Lin WW.# (2012) Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase expression by endoplasmic reticulum stress. Cell. Signal. 24:2166-2178. (*equal contribution; #equal correspondence)

Lin YC, Kuo HC, Wang JS, and Lin WW. (2012) Regulation of inflammatory response by 3-methyladenine involves the coordinative actions on Akt and GSK3 rather than autophagy. J. Immunol. 189:4154-4164.

Cheng YB, Fazary AE, Lin YC, Lo IW, Ong SC, Chen SY, Chien CT, Lin YJ, Lin WW. and Shen YC. (2013) Hyperinakin, a new anti-inflammatory phloroglucinol derivatives from Hypericum nakamurai. Natural Product Research 27:727-734.

Wu MF, Chen ST, Yang AH, Lin WW, Lin YL, Chen NJ, Tsai IS, Li L, Hsieh SL. (2013) CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood 121:95-106.

Liao YH, Lin YC, Tsao ST, Lin YC. Yang AJ, Huang CT, Huang KC,# and Lin WW.# (2013) HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation. J. Leuko. Biol. 93:289-299. (#equal correspondence)

Wu CA, Chao Y, Shiah SG, and Lin WW. # (2013) Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase. BBA—Mol. Cell Res. 1833:1147-1156. (high download and viewed)

Wu NL, Huang DY, Hsieh SL, Hsiao CH, Lee TA, and Lin WW. (2013) EGFR-driven up-regulation of decoy receptor 3 in keratinocytes contributes to the pathogenesis of psoriasis. BBA- Molecular Basis of Disease 1832:1538-1548.

Lin YC, Huang DY, Chu CL, Lin YL, and Lin WW. (2013) The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3. Science Signaling 6:ra71.

Tu YC, Huang DY. Shiah SG, Wang JS, and Lin WW. (2013) Regulation of c-Fos gene expression by NF-κB: A p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells. PLos One 8: e84062

Huang CT, Huang DY, Hu CJ, Wu D, and Lin WW. (2014) Energy adaptive response during parthanatos is enhanced by PD98059 and involves mitochondrial function but not autophagy induction. BBA—Mol. Cell Res. 1843:531-543. (high download and viewed)

Wu CA, Huang DY, and Lin WW. (2014) Beclin-1-independent autophagy positively regulates internal ribosomal entry site-dependent translation of hypoxia-inducible factor 1 under nutrient deprivation. Oncotarget 5:7525-7539.

Wu NL*, Huang DY*, Tsou HN, Lin YC, Lin, WW. (2015) Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6. J. Invest. Dermatol 135:490-498. (*equal contribution)

Lin YC, Huang DY, Wang JS, Lin YL, Hsieh SL, Huang KC, and Lin WW. (2015) Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization. J. Leuko. Biol. 97:825-835 (cover page) (Spotlight on Leading Edge Research)

Chen PT, Lin CK, Tsai CJ, Huang DY, Nien FY, Lin WW, Cheng WC. (2015) Expeditious synthesis of enantiopure, orthogonally protected bis-α-amino acids (OPBAAs) and their use in a study of Nod1 stimulation. Chem Asian J. 10:474-82.

Chen KT, Huang DY, Chiu CH, Lin WW*, Liang PH*, Cheng WC.* (2015) Synthesis of diverse N-substituted muramyl dipeptide derivatives and their use in a study of human NOD2 stimulation activity. Chemistry 21:11984-11988. (equal contribution)

Wang JS*, Wu D*, Huang DY, Lin WW. (2015) TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production. J Biomed Sci 2015;22:76 (*equal contribution)

Lin KC*, Huang DY*, Huang DW, Tzeng SJ, Lin WW. (2016) Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response. J Mol. Med (Berl) 94:183-94. (*equal contribution)

Wu NL, Huang DY, Wang LF, Kannagi R, Fan YC, Lin WW. (2016) Spleen tyrosine kinase mediates EGFR signaling to regulate keratinocyte terminal differentiation. J. Invest. Dermatol. 136:192-201.

Chan CM, Huang DY, Huang YP, Hsu SH, Kang LY, Shen CM, Lin WW. (2016) Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction. J Cell Mol Med 20:1749-60.

Chang HC, Huang DY, Wu MS, Chu CL, Tzeng SJ, Lin WW. (2017) Spleen tyrosine kinase mediates the actions of EPO and GM-CSF and coordinates with TGF-β in erythrocyte differentiation. BBA-MCR 1864:687-96.

Jhou JP, Chen SJ, Huang HY, Lin WW, Huang DY, Tzeng SJ. (2017) Up-regulation of FcγRIIB by resveratrol via NF-B activation reduces B cells and ameliorates lupus. Exp Mol Med 49:e381.

Hsieh SL, Lin WW. (2017) Decoy receptor 3: An endogenous immunomodulator in cancer growth and inflammatory reactions. J Biomed Sci 24:39

Sekar P, Huang DY, Chang SF, Lin WW. (2018) Coordinate effects of P2X7 activation and extracellular acidification in microglial cells. Oncotarget 9:12718-31.

Cheng CY*, Yang AJ*, Ekambaranellore P*, Huang KC, Lin WW. (2018) Anti-adipogenesis and anti-obesity actions of INDUS810, a natural compound from Trigonella foenum-graecum. Obes Res Clin Pract. 12:562-569. (*equal contribution)

Chang HC*, Huang DY*, Wu NL, Kannagi R, Wang LF, Lin WW. (2018) BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation. J Dermatol Sci. 92:151-161. (*equal contribution) (cover page)

Sekar P, Huang DY, Chang SF, Hsieh SL, Lin WW. (2018) AMPK-dependent and -independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia. Cell Communication and Signaling 16:83. (MOST 103–2320-B-002-069-MY3, MOST 106–2321-B-002-021, National Taiwan University Hospital 105F025–07 and Academia Sinica IBMS-CRC106-P03 and AS-TP-106-L11–1)

Mohanraj M, Sekar P, Liou HH, Chang SF, Lin WW. (2019) The mycobacterial adjuvant analogue TDB attenuates neuroinflammation via Mincle-independent PLC-γ/PKC/ERK signaling and microglial polarization. Mol Neurobiol. 56:1167-1187.( (MOST 103-2320-B-002-069-MY3; 106-2321-B-002-021; UN107-032)

Chan CM, Huang DY, Sekar P, Hsu SH, Huang YP, Lin WW. (2019) Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death. J Biomed Sci 26:40. (MOST (103–2320-B-002-069-MY3; 106–2321-B-002-021; UN105F025–07; IBMS-CRC106-P03, AS-TP-106-L11–1).

Chiang CH, Kuo CS, Lin WW, Su JH, Chen JD, Huang KC. (2019) Chronic viral hepatitis signifies the association of premixed insulin analogues with liver cancer risks: a nationwide population-based study. Int J Environ Res Public Health 13;16(12). pii: E2097.