E-MAIL

mhyen@ndmctsgh.edu.tw

經歷

1967/6~1968/6 國防醫學院生物物理學科 助教

1970/8~1975/2 國防醫學院生物物理學科 講師

1979/9~1985/12 國防醫學院藥理學科 副教授

1986/1~ 國防醫學院藥理學科 教授

專長學科

1.敗血性休克治療評估及致病機轉之探討
2.先天性高血壓成因之探討
3.血管藥理學

研究論文

1.Lee CY, Yen MH*. Nitric oxide and carbon monoxide, collaborative and competitive regulators of hypertension. Chang Gung Med J. 2009 ;32:12-21. Review.

2.Lam KK, Cheng PY, Hsiao G, Chen SY, Shen HH, Yen MH, Lee YM*. Estrogen deficiency-induced alterations of vascular MMP-2, MT1-MMP, and TIMP-2 in ovariectomized rats. Am J Hypertens. 2009 ;22:27-34.

3.Chung MT, Cheng PY, Lam KK, Chen SY, Ting YF, Yen MH, Lee YM*. Cardioprotective effects of long-term treatment with raloxifene, a selective estrogen receptor modulator, on myocardial ischemia/reperfusion injury in ovariectomized rats. Menopause 2010; 17(1):127-134

4.Tsai YC, Lee YM, Lam KK, Wu YC, Yen MH, Cheng PY*. The role of hypothalamic AMP-activated protein kinase in the ovariectomy-induced obesity in rats. Menopause 2010; Nov-Dec;17(6):1194-200.

5.Tsai YC, Cheng PY, Kung CW, Peng YJ, Ke TH, Wang JJ, Yen MH*. Beneficial effects of magnolol in a rodent model of endotoxin shock. Eur J Pharmacol. 2010 Sep 1;641(1):67-73.

6.Liu WH, Lee YM, Lam KK, Chen YF, Wang JJ, Yen MH, Cheng PY*. The role of receptor-interacting protein 140 in the accumulation of fat in ovariectomised rats. Obes Surg. 2011 Jul;21(7):935-40.

7.Day SA, Lakner AM, Moore CC, Yen MH, Clemens MG, Wu ES, Schrum LW. Opioid-like compound exerts anti-fibrotic activity via decreased hepatic stellate cell activation and inflammation. Biochem Pharmacol. 2011 Apr 5;81(8):996-1003.

8.Kung CW, Lee YM, Cheng PY, Peng YJ, Yen MH*. Ethyl pyruvate reduces acute lung injury via regulation of iNOS and HO-1 expression in endotoxemic rats. J Surg Res. 2011 May 15;167(2):e323-31.

9.Kung CW, Lee YM, Yen MH*. In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats. Thromb Res. 2011 Jun;127(6):582-8.

10.Cheng PY, Lee YM, Yen MH, Peng JC, Lam KK*. Reciprocal effects of α-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats. Menopause. 2011 Sep;18(9):1010-7.

11.Cheng PY, Lee YM, Chung MT, Shih YC, Yen MH*. Role of AMP-activated protein kinase in α-lipoic acid-induced vasodilatation in spontaneously hypertensive rats. Am J Hypertens. 2012 Feb;25(2):152-8.

12.Lam KK, Cheng PY, Lee YM, Liu YP, Ding C, Liu WH*, Yen MH*. The role of heat shock protein 70 in the protective effect of YC-1 on heat stroke rats. Eur J Pharmacol. 2013 Jan 15;699(1-3):67-73.

13.Wang KC, Tsai CP, Lee CL, Chen SY, Lin GJ, Yen MH, Sytwu HK, Chen SJ*. α-Lipoic acid enhances endogenous peroxisome-proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis in mice. Clin Sci (Lond). 2013 Oct;125(7):329-40.

14.Yen MH*. High-mobility group box 1 protein may be a therapeutic target in inflammation. Acta Anaesthesiol Taiwan. 2013 Mar;51(1):1-2.

15.Tsai YC, Lee YM, Lam KK, Lin JF, Wang JJ, Yen MH*, Cheng PY*. The Role of Heat Shock Protein 70 in the Protective Effect of YC-1 on β-Amyloid-Induced Toxicity in Differentiated PC12 Cells. PLoS One. 2013 Jul 26;8(7):e69320.

16.Liu CW, Li CH, Peng YJ, Cheng YW, Chen HW, Liao PL, Kang JJ*, Yen MH*. Snail regulates Nanog status during the epithelial–mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer.Oncotarget 2014 Jun 15;5(11):3880-94.