E-MAIL

Pshsieh0465@gmail.com

經歷

國防生理學科助教、講師及助理教授、生物及解剖學科助理教授
生理學科副教授 、生理學科教授兼主任(98-104)、預防醫學研究所所長 (104-109)
中國生理學會常務理事 (105-109)
中國生理學會第22, 23屆理事長(101- 105)
中國生理學會理事(96-101)
國防醫學院醫學科學研究所 所長 (110.7 – )

期刊主編
Journal of Medical Science (Editor in Chief, 2011-2020)
Chinese Journal of Physiology (Editor in Chief, SCI, 2017-2023)

研究方向

經過多年來的努力，我們不僅發展建立了目前獨步國內評估代謝性症候群和糖尿病的黃金標準方法(Gold standard)，包括評估活體胰島素敏感性的euglycemic hyperinsulinemic clamp technique with tracer dilution method和活體胰臟胰島素分泌功能的hyperglycemic clamp technique，相關研究技術均已達國際一流水準，我們亦已建立評估骨骼肌之葡萄糖代謝速率和胰島素分泌細胞功能的離體功能性定量的實驗模式，目前都有具體的成果，我們亦同時發展使用多種發炎相關基因剔除及基因轉殖鼠模式，配合多項分子生物學的實驗技術real-time PCR、Western Blotting、ELISA、flow cytometry、immunocytochemical staining、co-culture、in vitro and in vivo RNAi knockdown和 inducible gene overexpression等，以進一步探討其細胞間和細胞內作用機轉，朝建立肥胖，代謝性症和糖尿病的動物研究中心的理想邁進，迄今我們發表的相關研究成果提供進一步的證據，有助於釐清肥胖及糖尿病之胰島素抗性與其相關症候群的交互關係以及其形成的可能病因，並提供相關疾病治療上的重要參考，除此之外，為擴展生理學在轉譯醫學的應用，我們亦朝與臨床新陳代謝科和產學研的合作上，在生技醫藥國家型計畫及經濟部科專計畫的目標導向研究方向上做進一步的推展，希望能建立國內基礎及臨床有關代謝症候群的藥物和診斷試劑最完整的開發平台。

實驗室成員

實驗室成員：謝博軒教授

碩士班學生：碩二 黃向陽

研究助理：農君怡

博士後研究員: 詹沛祺

編輯助理：蘇詩涵

研究論文

期刊論文

1. Pei-Chi Chan, Po-Shiuan Hsieh (2021, Dec). The chemokine systems at the crossroads of inflammation and energy metabolism in the development of obesity. International Journal of Molecular Science, 2021; 22(24):13528. . (SCI, 67/295, Biochemistry & Molecular Biology). MOST 107-2320-B-016-MY3. 本人為通訊作者. https://doi.org/10.3390/ijms222413528.

2. Pei-Chi Chan, Li-Man Hung, Jiung-Pang Huang, Yuan-Ji Day, Chao-Lan Yu, Feng-Chih Kuo,Chieh-Hua Lu, Yu-Feng Tian,
Po-Shiuan Hsieh (2021, Nov). Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive
thermogenesis and worsens insulin resistance in obesity. Clinical Science, 2021; CS20210959. ahead of print, doi: https://doi.org/10.1042/CS20210959. (SCI, 31/140, Medicine, Research & Experimental). MOST 107-2320-B-016-MY3.
本人為通訊作者.

3. Pei-Chi Chan, Min-Tser Liao, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh (2021, Jan). Targeting inhibition of CCR5 on improving obesity-associated insulin resistance and impairment of pancreatic insulin secretion in high fat-fed rodent models. European Journal of Pharmacology, 891, 2021, 173703. (SCI, 96/271 Pharmacology & Pharmacy). MOST 107-2320-B-016-010-MY3. 本人為通訊作者.

4. Yu-Hsiu Chang, Chih-Heng Huang, Po-Shiuan Hsieh (2020, Dec). Interplay of COVID-19 and Physiological Dysfunctions. Chinese Journal of Physiology, 63:245-9. (SCI, 72/84, Physiology). MOST 109-2003-B-016-002.
本人為通訊作者.

5. Chieh-Hua Lu, Chi-Hsiang Chung, Feng-Chih Kuo, Kuan-Chan Chen, Chia-Hao Chang, Chih-Chun Kuo, Chien-Hsing Lee, Sheng-Chiang Su, Jhih-Syuan Liu, Fu-Huang Lin, Chang-Huei Tsao, Po-Shiuan Hsieh, Yi-Jen Hung, Chang-Hsun Hsieh, Wu-Chien Chien (2020, Sep). Metformin Attenuates Osteoporosis in Diabetic Patients with Carcinoma in Situ: A Nationwide, Retrospective, Matched-Cohort Study in Taiwan. Journal of Clinical Medicine, 9(9), 2839;
https://doi.org/10.3390/jcm9092839. (SCI, 36/165, Medicine: general and internal).

6. Jung-Pang Huang, Mei-Ling Cheng, Chao-Hung Wang, Shiang-Suo Huang, Po- Shiuan Hsieh, Chih-Chun Chang, Chao-Yu Kuo, Kuan-Hsing Chen, Li-Man Hung (2020, Sep). Therapeutic potential of cPLA2 inhibitor to counteract
dilated-cardiomyopathy in cholesterol-treated H9C2 cardiomyocyte and MUNO rat. Pharmacological Research, 15: 105201. (SCI, 19/270, Pharmacy and Pharmacology).

7. Yung-Chieh Tsai, Chyi-Wen Wang, Bo-Yao Wen, Po-Shiuan Hsieh, Yen-Mei Lee, Mao-Hsiung Yen, Pao-Yun Cheng (2020, Jun). Involvement of the p62/Nrf2/HO-1 pathway in the browning effect of irisin in 3T3-L1 adipocytes.
Molecular and Cellular Endocrinology, 514:110915. (SCI, 42/143, Endocrinology & Metabolism).

8. Chieh-Hua Lu, Sen-Wen Teng, Chung-Ze Wu, Chang-Hsun Hsieh, Jin-Biou Chang, Yen-Lin Chen, Yao-Jen Liang, Po-Shiuan Hsieh, Dee Pei, Jiunn-Diann Lin (2020, Mar). The roles of first phase, second phase insulin secretion, insulin
resistance, and glucose effectiveness of having prediabetes in nonobese old Chinese women. Medicine, 99 (12) - p e19562. (SCI, 89/165, Medicine: general and internal).

9. Chieh-Hua Lu, Chi-Hsiang Chung, Chien-Hsing Lee, Sheng-Chiang Su, JhihSyuan Liu, Fu-Huang Lin, Chang-Huei Tsao, Po-Shiuan Hsieh, Yi-Jen Hung, Chang-Hsun Hsieh, Wu-Chien Chien (2019, Oct). Combination of COX-2
inhibitor and metformin attenuates rate of admission in patients with rheumatoid arthritis and diabetes in Taiwan. Medicine, 98(41): e17371. (SCI, 56/154, Medicine: general and internal).

10. Pei-Chi Chan, Min-Tser Liao,Po-Shiuan Hsieh (2019, Jun). The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin Resistance. International Journal of Molecular Sciences, 20 (3115), 1-13. (SCI, 78/298, Biochemistry & molecular biolgoy). 本人為通訊作者.

11. Szu-Chia Lai, Yu-Yine Huang, Pei-Yun Shu, Shu-Fen Chang, Po-Shiuan Hsieh, Jiunn-Jye Wey, Meng-Hung Tsai, Ren-Jy Ben, Yi-Ming Hsu, Yi-Chien Fang, Mei-Ling Hsiao, Chang-Chi Lin (2019, Apr). Development of Dengue-type NS1
ELISA for Rapid Detection and Differentiation of Dengue Serotypes during Early Infection. Journal of Clinical Microbiology, 57 (7), e00221-19. (SCI, 24/133, Microbiology).

12. Yi-Jung Ho, Feng-Cheng Liu, Chia-Tsui Yeh, Chuen Mi Yang, Chang-Chi Lin, Te-Yu Lin, Po-Shiuan Hsieh, Ming-Kuan Hu, Zhiyuan Gong, Jeng-Wei Lu (2018, Nov). Micafungin is a novel anti-viral agent of chikungunya virus through
multiple mechanisms. Antiviral research, 159, 134-142. (SCI, 32/261, Pharmacology and phamacy).

13. Hung-Che Chien, Pei-Chi Chan, Chuan-Chou Tu, Yuan-Ji Day, Li-Man Hung, Chi-Chang Juan, Yu-Feng Tian, Po-Shiuan Hsieh (2018, Oct). Importance of PLC-Dependent PI3K/AKT and AMPK Signaling in RANTES/CCR5 Mediated
Macrophage Chemotaxis. Chinese Journal of Physiology, 61(5): 266-279. (SCI, 74/83, Physiology). NSC 102-2320-B-016-009-MY3. 本人為通訊作者.

14. Chin-Sheng Lin, Po-Shiuan Hsieh, Ling-Ling Hwang,e Yen-Hsien Lee, ShihHung Tsai, Yun-Chin Tub, Yao-Wen Hung, Cheng-Che Liu, Yi-Ping Chuang, Min-Tser Liao,i Shu Chien,k Min-Chien Tsai (2018, May). The CCL5/CCR5
Axis Promotes Vascular Smooth Muscle Cell Proliferation and Atherogenic Phenotype Switching. Cellular Physiology and Biochemistry, 2018, 47:707-720. (SCI). MOST 105-2325-B-016-001.

15. Pei-Chi Chan, Ting-Ni Wu, Ying-Chuan Chen, Chieh-Hua Lu, Martin Wabitsch, Yu-Feng Tian, Po-Shiuan Hsieh (2018, May). Targeted inhibition of CD74 attenuates adipose COX-2-MIF mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance. Clinical Science, 132 (14), 1581-1596. (SCI, 31/140, Medicine: research and experimental). MOST 104-2320-B-016-011-MY3. 本人為通訊作者.

16. Pei-yao Lu, Po-Shiuan Hsieh, Huitsu Lin,Tejung Liu, Hsuehling Wu, Chengcheung Chen and Yingchuan Chen (2018, May). Grail is involved in adipocyte differentiation and diet-induced obesity. Cell Death & Disease, 9:525. (SCI, 39/190, Cell Biology). MOST 106-2320-B-016-008.

17. Chieh-Hua Lu, Chi-Hsiang Chung, Chien-Hsing Lee, Chang-Hsun Hsieh, Yi-Jen Hung, Fu-Huang Lin, Chang-Huei Tsao, Po-Shiuan Hsieh, Wu-Chien Chien. (2018, Jan). Combination COX-2 inhibitor and metformin attenuate rate of joint replacement in osteoarthritis with diabetes: A nationwide, retrospective, matched-cohort study in Taiwan . PLoS one, https://doi.org/10.1371/journal.pone.0191242. (SCI, 15/64, multidisciplinary sciences). 本人為通訊作者.

18. Jeng-Wei Lu, Po-Shiuan Hsieh, Chang-Chi Lin, Ming-Kuan Hu, Shih-Ming Huang, Yu-Ming Wang, Chun-Yu Liang, Zhiyuan Gong, Yi-Jung Ho (2017, Sep).Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus. Biochemical and Biophysical Research Communications (BBRC) , 491 (3): 595–602. (SCI, 163/286/Biochemistry and Molecular Biology).

19. Pei-Chi Chan, Ya-Chin Wang, Yi-Ling Chen, Wan-Ning Hsu, Yu-Feng Tian, PoShiuan Hsieh (2017, Aug). Importance of NADPH oxidase-mediated redox signaling in the detrimental effect of CRP on pancreatic insulin secretion. . Free Radical Biology and Medicine, 112: 200-211. . (SCI, 17/138/Endocrinology and Metabolism). NSC 104-2320-B-106-011-MY3.
本人為通訊作者.

專書

1. Jesmine Khan, Po-Shiuan Hsieh. Cellular Metabolism and Related Disorders (1) (ISBN: 978-1-83880-181-6). London, United Kingdom: IntechOpen. Jul, 2020.

2. Po-Shiuan Hsieh, Chieh-Hua Lu . The therapeutic strategy for obesityassociated Mets and type 2 DM - focusing on adipose tissue inflammation and lipid disorders (1) (ISBN: 978-620-2-19832-5). Düsseldorf, Germany: LAP
LAMBERT Academic Publishing. Jan, 2018.

專書論文
1. Pei-Chi Chan, Po-Shiuan Hsieh. The Role of Adipocyte Hypertrophy and
Hypoxia in the Development of Obesity-Associated Adipose Tissue
Inflammation and Insulin Resistance. Adiposity - Omics and Molecular
Understanding (ISBN: 978-953-51-2998-1). London, United Kington: In Tech.
Mar, 2017: E-publishing.

研討會論文
1. Pei-Chi Chan, Po-Shiuan Hsieh (2020, Sep). Importance of tissue CCL5/CCR5 signaling on monocytic-MDSCs-derived macrophage polarization and inflammation in epididymal fat of high fat diet-induced obese mice. 56th EASD
annual Meeting of the European Association for the study of Diabetes, Virtual meeting . MOST 109-2320-B-016-016.
本人為通訊作者. Diabetologia 2020, 63 (Suppl 1):S83-S84.

2. Pei-Chi Chan, Po-Shiuan Hsieh (2019, Mar). Importance of RANTES/CCR5 signaling in lipid oxidation and adaptive thermogenesis in mice. The 9th FAOPS (Federation of the Asian and Oceanian Physiological Societies) 2019 Congress.
本人為通訊作者