E-MAIL
chencheliu2002@gmail.com
經歷
曾任：預防醫學研究所助理研究員、國防醫學院解剖學研究所兼任
助理教授、疾病管制署生恐應變師資、臺北科技大學化學工程學系
兼任助理教授
實驗室介紹
１．金奈米粒子之致病原檢測應用: 金奈米粒子(gold nanoparticle) 具有特殊光學特性，其可藉化學修飾或物理吸附方式，於粒子表面接上抗體、核酸或適體 (aptamer)，形成功能化之金奈米探針(gold nanoparticle probes)，可應用於偵測疾病致病原或其他生醫標的分子，發展簡易、靈敏、專一之感測平台。近年實驗室便陸續結合此類金奈米探針架構於側流層析紙膜或比色分析法，發展病原偵檢技術，分別應用於慢性牙周病致病原牙齦紫質單孢菌檢測與人類多瘤BK病毒之監測。
２．應用新一代定序技術分析空氣中微生物菌相: 相對於傳統定序法(Sanger sequencing)， NGS (next-generation sequencing)、nanopore 或PacBio等新一代定序之結果更具效率與全面性，先前實驗室規劃應用上述技術，分別結合高通量空氣採樣與16S全基因組(metagenomics)分析，嘗試窺探與建構空氣中微生物菌相組成。
非常歡迎對上述研究或生醫檢測技術開發有興趣的同學來討論或加入我們實驗室!
實驗室成員
碩士班學生：黃慈崴(二年級/程雲詳老師共同指導)、陳冠妤(二年級/劉亞平教授共同指導)
博士班學生：余冠毅(生命科學研究所)、鄭語嫣(生命科學研究所/劉亞平教授共同指導)、周汶熹(醫學科學研究所)、許書禎(醫學科學研究所/張天耀助理教授共同指導)
研究論文
Original papers
I. SCI articles:
1. Chia-Yu Wang, Po-Da Hong, Ding-Han Wang, Juin-Hong Cherng, Shu-Jen Chang, Cheng-Che Liu*, Tong-Jing Fang, and Yi-Wen Wang (2020, Nov). Polymeric Gelatin Scaolds Aect Mesenchymal Stem Cell Differentiation and Its
Diverse Applications in Tissue Engineering. International Journal of Molecular Sciences, 21, 8632.
2.Yi-Huei Huang, Kuan-Yi Yu, Shou-Ping Huang, Hui-Wen Chuang, Wen-Zhi Lin, Juin-Hong Cherng, Yao-Wen Hung, Ming-Kung Yeh, Po-Da Hong, Cheng-Che Liu* (2020, Jun). Development of a Nucleic Acid Lateral Flow Immunoassay
for the Detection of Human Polyomavirus BK. Diagnostics, 10(6), 403.
3.Zhao-Chi Chen, Tien-Li Chang, Cheng-Che Liu*, Wen-Tse Hsiao, Chih-Heng Huang (2020, Apr). Picosecond laser surface modification of aluminum oxide with fish-scale structures for cell culture. Ceramics International, 46 (2020),
17651-17658.
4.Yi-Wen Wang, Chuan-Chieh Liu, Juin-Hong Cherng, Chien-Seng Lin, Shu-Jen Chang, Zhi-Jie Hong, Cheng-Che Liu*, Yaw-Kwan Chiu, Sheng-Der Hsu, Hung Chang (2019, Nov). Biological Effects of Chitosan-Based Dressing on
Hemostasis Mechanism. Polymers, 11(11), 1906.
5.Zhao-Chi Chen, Tien-Li Chang, Ching-Hao Li, Kai-Wen Su, Cheng-Che Liu* (2019, Aug). Thermally stable and uniform DNA amplification with picosecond laser ablated graphene rapid thermal cycling device. Biosensors &
Bioelectronics, 146, 111581.
6.En Meng, Chin-Li Chen, Chuan-Chieh Liu, Cheng-Che Liu*, Shu-Jen Chang, Juin-Hong Cherng, Hsiao-Hsien Wang, Sheng-Tang Wu (2019, Jun). Bioapplications of Bacterial Cellulose Polymers Conjugated with Resveratrol for
Epithelial Defect Regeneration. Polymers, 11(6), pii: E1048.
7.Chia-Yu Wang, Dewi Sartika, Ding-Han Wang, Po-Da Hong, Juin-Hong Cherng, Shu-Jen Chang, Cheng-Che Liu*, Yi-Wen Wang, Sheng-Tang Wu (2019, Mar). Wet-spinning-based Molding Process of Gelatin for Tissue Regeneration.
Journal of Visualized Experiments, 145, e58932.
8.Wen-Zhi Lin, Yi-Hsiang Chen, Chih-Kai Liang, Cheng-Che Liu*, Shao-Yi Hou (2019, Jan). A competitive immunoassay for biotin detection using magnetic beads and gold nanoparticle probes. Food Chemistry, 271, p.440-444.
9.Gang-Yi Fan, Juin-Hong Cherng, Shu-Jen Chang, Raju Poongodi, Chih-Hsin Wang, Yi-Wen Wang, Yao-Horng Wang, Cheng-Che Liu*, En Meng (2018, Nov). Severe burn injury in a swine model for clinical dressing assessment.
Journal of Visualized Experiments, 141, e57942.
10.Cheng-Che Liu*, Wen-Zhi Lin, Shang-Ting Tsai, Jia-Hao Chang, Yao-Wen Hung, Shao-Yi Hou* (2018, Oct). Dichroic behavior of gold nanoparticles synthesized in aqueous solution with insufficient reducing agent. Journal of
Nanoscience and Nanotechnology, 18, p.7197–7202.
11.Chin-Sheng Lin, Po-Shiuan Hsieh, Ling-Ling Hwang, Yen-Hsien Lee, Shih-Hung Tsai, Yun-Chin Tu, Yao-Wen Hung, Cheng-Che Liu*, Yi-Ping Chuang, Min-Tser Liao, Shu Chien, Min-Chien Tsai (2018, May). The CCL5/CCR5 axis
promotes vascular smooth muscle cell proliferation and atherogenic phenotype switching. Cellular Physiology and Biochemistry, 47, p.707-720.
12. Wen-Zhi Lin, Chun-YanYeung, Chih-Kai Liang, Yi-Huei Huang, Cheng-Che Liu*, Shao-Yi Hou (2018, May). A colorimetric sensor for the detection of hydrogen peroxide using DNA-modified gold nanoparticles. Journal of the Taiwan
Institute of Chemical Engineers, 89, p.49–55.
13.Chih-Chien Wang, Chih-Hsin Wang, Hsiang-Cheng Chen, Juin-Hong Cherng, Shu-Jen Chang, Yi-Wen Wang, Adrienne Chang, Jue-Zong Yeh, Yi-Huei Huang, Cheng-Che Liu* (2018, Mar). Combination of resveratrol-containing
collagen with adipose stem cells for craniofacial tissue-engineering applications. International Wound Journal, 15(4), p.660-672.
14.Wai-Tao Chan, Cheng-Che Liu*, Jen-Shiu Chiang Chiau, Shang-Ting Tsai, Chih-Kai Liang, Mei-Lien Cheng, Hung-Chang Lee, Chun-Yun Yeung, and Shao-Yi Hou (2017, Apr). In vivo toxicologic study of larger silica nanoparticles in
mice. International Journal of Nanomedicine, 2017(12), 3421–3432.
15.Pei-Yi Tsui, Hui-Ping Tsai, Der-Jiang Chiao, Cheng-Che Liu*, Rong-Hwa Shyu (2015, Sep). Rapid detection of Yersinia pestis recombinant fraction 1 capsular antigen. Applied Microbiology and Biotechnology, 99(18), 7781-7789.
16.Kuang-Ming Cheng, Yao-Wen Hung, Cheng-Cheung Chen, Cheng-Che Liu*, Jenn-Jong Young (2014, Sep). Green synthesis of chondroitin sulfate-capped silver nanoparticles: characterization and surface. Carbohydrate Polymers,
110, p.195-202.
17.Chun-Yan Yeung, Cheng-Che Liu*, Yu-Ting Tseng, Kun-Chou Tsai,Ming-An Hsieh, Wai-Tao Chan, Hsuan-Liang Liu, Hung-Chang Lee, Shao-Yi Hou (2014, Apr). Rapid identification of Salmonella using Hektoen enteric agar and 16S
ribosomal DNA probe-gold nanoparticle immunochromatography assay in clinical faecal specimens. Letters in Applied Microbiology, 58(4), 311-317.
18.Cheng-Che Liu*, Chun-Yan Yeung, Po-Hao Chen, Ming-Kung Yeh, Shao-Yi Hou (2013, Dec). Salmonella detection using 16S ribosomal DNA/RNA probe-gold nanoparticles and lateral flow immunoassay. Food Chemistry, 141(3),
2526–2532.
19.Juin-Hong Cherng, Shu-Jen Chang, Jue-Zong Yeh, Yao-Wen Hung, Hsin-Chih Lai, Nien-Hsien Liou, Chung-Hsing Li, Chung-Ang Tsao, Cheng-Che Liu* (2013, Nov). Development of fabrication technique in nano-scale resveratrol by
collagen. International Journal of Nanotechnology, 10(10/11), 984-995.
20.Shu-Jen Chang, Nien-Hsien Liou, Juin-Hong Cherng, Cheng-Che Liu*, Yi-Cheng Chiu, Tong-Jing Fang, Ming-Lun Hsu (2013, Nov). Application of refractable nanocomposite on cell based therapy in central nervous system.
International Journal of Nanotechnology, 10(10/11), 891-904.
II. non-SCI articles：
1.Der-Jiang Chiao, Jiunn-Jye Wey, Wen-Zhi Lin, Shiao-Shek Tang, Pei-Yi Tsui, Rong-Hwa Shyu, Jyh-Hwa Kau, Chih-Heng Huang, Chuan-Wang Li, Cheng-Cheung Chen, Cheng-Che Liu* (2019, Feb). A monoclonal enzyme-linked
immunoassay for the detection of botulinum neurotoxin type E. Journal of Medical Sciences, 39(5), 217-222.
2.劉正哲*、侯劭毅〈運用金奈米粒子的層流法生物感測器〉，《化學》，2011年， 249-254頁。
Book chapter
1. 周汶熹,陳詩芸,張慧娟,程君弘,黃苑菱,劉正哲*（2017年12月）。Netter"s人體解剖著色書（ISBN：9789869475860）（2）。台灣：Elsevier Taiwan LLC (台灣愛思唯爾)。
2. 陳詩芸、黃菀菱、張慧娟、程君弘、劉正哲*（2015年01月）。解剖學一點通（ISBN：9789863680161）（1）。Taipei, Taiwan：Ho-Chi Book Publishing
CO. 合記出版社。