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addy0918@gmail.com

經歷

2007-2009 國防醫學院預防醫學研究所研究助理
2013-2014 國防醫學院預防醫學研究所助理研究員
2014/11-2019/1 國防醫學院生理學科專任助理教授
2019/2- 國防醫學院生理學科專任副教授

實驗室簡介

脂肪肝,發炎疾病及癌症研究實驗室

The prevalence of obesity caused by excessive energy intake and sedentary lifestyle has significantly increased in recent decades. Non-alcoholic fatty liver disease (NAFLD) is the major symptom found in obese adult and accompanied with multiple metabolic dysfunctions. It is reported that upregulated hepatic gluconeogenesis and fatty acid synthesis are crucial mediators with the development of NAFLD. The excessive energy will be stored in hepatocyte and adipocyte in the form of triglyceride droplets. Increasing hepatic lipid accumulation causes liver injury and inflammatory response. This inflammation process is strongly associated with the secretion of interleukin-6 (IL-6). IL-6, as a pro-inflammatory cytokine, can induce monocyte chemoattractant protein (MCP)-1 expression, thereby resulting in monocytes accumulation.

Gene related to anergy in lymphocytes (Grail) was first discovered in anergic CD4+ T cell clones. The major function of Grail is to regulate T-lymphocyte unresponsiveness, and it also exerts multiple biological capacities in metabolism.
A recent study from our lab demonstrated that Grail is involved in high-fat diet (HFD)-induced obesity and NAFLD. However, the role of Grail in hepatic inflammation, lipid metabolism and insulin pathway remains to be elucidated.
We are interested in the role of Grail in NAFLD, inflammatory diseases and cancer. Several diseases serve as models to study such processes. In particular, we investigate pathogenic mechanisms of the following diseases: NAFLD, inflammatory diseases and cancer. We have developed several in vitro and in vivo systems to determine potential effects of Grail on NAFLD, inflammatory diseases and cancer.


我們歡迎邏輯性強且對研究充滿熱誠之新血的加入，期能在原有的實驗基礎上，再創佳績!

實驗室成員：陳英傳 副教授
博士後研究員: 呂姵瑤 博士

實驗室成員

實驗室成員：
碩士班學生：王詩芸
博士班學生：金佳營(生科所), 劉得榮(醫科所)

研究論文

近年著作 ：
1.Pei-Yao Liu, Cheng-Cheung Chen, Chia-Ying Chin, Te-Jung Liu, Wen-Chiuan Tsai, Jian-Liang Chou, Chuan-Yu Huang, Yu-Guang Chen, Ying-Chuan Chen*. E3 ubiquitin ligase Grail promotes hepatic steatosis through Sirt1 inhibition. Cell Death & Disease. 2021 Mar 26;12(4):323. IF: 8.4.

2.Chia-ying Chin, Cheng-cheung Chen, Xin-an Chen, Hui-ju Yen, Hsin-lun Hsien, Jenn-jong Young* , Ying-chuan Chen** .High sensitivity enhancement of multi-shaped silver-nanoparticle-decorated hydrophilic PVDF-based SERS substrates using solvating pretreatment. Sensors and Actuators: B. Chemical, 2021, Nov.374;130614. IF:7.4.

3.Yu-Ling Tsai, Hsin-Han Chang, Ying-Chuan Chen, Yu-Chan Chang , Ying Chen and Wen-Chiuan Tsai. Molecular Mechanisms of KDELC2 on Glioblastoma Tumorigenesis and Temozolomide Resistance. Biomedicines 2020, 8, 339; doi:10.3390/biomedicines. IF: 6.8.

4.Pei-Yao Liu, Po-Shiuan Hsieh, Hui-Tsu Lin, Te-Jung Liu, Hsueh-Ling Wu, Cheng-Cheung Chen, Ying-Chuan Chen* . Grail is involved in adipocyte differentiation and diet-induced obesity. Cell Death & Disease. 2018 May 1;9(5):525. IF: 8.4.
Hui-Tsu Lin, Cheng-Cheung Chen, Pei-Yao Liu, Hsueh-Ling Wu, Ti-Hui Wu, Chih-Heng Huang*, Ying-Chuan Chen* Grail attenuates influenza A virus infection and pathogenesis by inhibiting viral nucleoprotein. Scientific Reports. 2018 Nov 22;8(1):17242. IF: 4.38.

5.Chih-Chin Shih, Pei-Yao Liu, Jye-Hann Chen, Mei-Hui Liao, Chih-Ming Hsieh, Shuk-Man Ka, Chin-Chen Wu, Hui-Tsu Lin, Ti-Hui Wu, Ying-Chuan Chen* . Macrophage expression of E3 ubiquitin ligase Grail protects mice from lipopolysaccharide-induced hyperinflammation and organ injury. PLOS ONE. 2018 Nov. IF: 2.766.

6.Pei-Chi Chan, Ting-Ni Wu, Ying-Chuan Chen, Chieh-Hua Lu, Martin Wabitsch, Yu-Feng Tian, Po-Shiuan Hsieh.Targetted inhibition of CD74 attenuates adipose COX-2-MIF-mediated M1 macrophagepolarization and retards obesity-related adipose tissue inflammation and insulin resistance. Clin Sci (Lond). 2018 Jul 31;132(14):1581-1596. IF: 5.22.

7.Hui-ju Yen, Yen-an Young, Tsung-neng Tsai, Kuang-ming Cheng, Xin-an Chen, Ying-chuan Chen, Cheng-cheung, Chen , Jenn-jong Young, Po-da Honga. Positively charged gold nanoparticles capped with folate quaternary chitosan: Synthesis, cytotoxicity, and uptake by cancer cells. Carbohydrate Polymers. 2018 Mar1 ;183:140-150. IF: 9.3.

8.Yung-Lung Chang, Li-Chun Huang, Ying-Chuan Chen, Yi-Wen Wang, DuengYuan Hueng, Shih-Ming Huang. The synergistic effects of valproic acid and fluvastatin on apoptosis induction in glioblastoma multiforme cell lines. Int J Biochem Cell Biol.  2017 Nov;92:155-163. IF: 3.247.

9.Jenn-jong Young,Cheng-cheung, Chen, Ying-chuan ,Chen, Kuang-ming Cheng, Hui-Ju Yen, Yu-chuan Huang, Tsung-Neng Tsaid. Positively and negatively surface-charged chondroitin sulfate-trimethylchitosan nanoparticles as protein carriers. Carbohydrate Polymers. 2016 Feb 10; 137: 532-540. IF: 9.3.

10.Tsung-Neng Tsai,Hui-Ju Yen,Cheng-cheung Chen, Ying-chuan Chen,Yen-an Young,Kuang-ming Cheng,Jenn-jong Young,Po-da Hong. Novel protein-loaded chondroitin sulfate-N-[(2-hydroxy-3- trimethylammonium)propyl]chitosan nanoparticles with reverse zeta potential: preparation, characterization, and ex vivo assessment. Journal of Materials Chemistry B, 2015,3, 8729-8737. IF: 4.872.

11.James Yi-Hsin Chan12,Ying-Chuan Chen3,Shu-Ting Liu3,Wei-Yuan Chou3*,Ching-Liang Ho4*and Shih-Ming Huang3*. Characterization of a new mouse p53 variant: loss-of-function and gain-of-function. Journal of Biomedical Science 2014, 21:40. (SCI, IF=2.736).

12.Y-C Chen, J Y-H Chan, Y-L Chiu, S-T Liu, G Lozano, S-L Wang, C-L Ho and SM Huang. Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis.
Cell Death and Differentiation . (2013) 20, 732–743. (SCI, IF=15.8).