學位

國防醫學院醫學系學士 (1998-2005)
英國倫敦大學學院博士 (2015-2019)

經歷

三軍總醫院 病理部 資深住院醫師
三軍總醫院 病理部 住院醫師
三軍總醫院 病理部 總醫師

研究領域 & 專長 &興趣

1. 中樞神經病理學 (Neuropathology)
2. 一般解剖病理學 (General Pathology)
3. 分子病理學 (Molecular Pathology)
4. 免疫組織化學染色&影像分析/量化
5. TCGA/UCSC數據庫分析
6. 統計、SPSS、R 操作
7. 3D組織透視技術
8. Organotypic brain slice cultures
9. AI數位病理

EDITORIAL ACTIVITIES

Social Media Editor at Neuropathology and Applied Neurobiology (IF=6.878) 2020.01-present
https://onlinelibrary.wiley.com/page/journal/13652990/homepage/editorialboard.html

已完成計劃主題

1. The role of cellular diversity in developmental cortical lesions (2015-2019)

目前實驗計劃

1. 利用3D組織透視技術(CLARITY)解析大鼠腦創傷經幹細胞治療之修復情形
2. 研究IDH1 mutant 對IDH1 wild type膠質瘤之差異基因表現
3. 探討乳癌tumor stroma ratio對預後相關性
4. 脂肪肝病理影像分析 (NASH)

論文發表

1. Pan WG, Chen BC, Li YF, Wu RX, Wang CH. An unusual case of reactivated latent pulmonary cryptococcal infection in a patient after short-term steroid and azathioprine therapy: a case report. BMC Pulm Med. 2021 Mar 4;21(1):76.
2. Yen IC, Tu QW, Chang TC, Lin PH, Li YF, Lee SY. 4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation. Biomed Pharmacother. 2021 Jun;138:111504.
3. Li YF, Scerif F, Picker SR, Stone TJ, Pickles JC, Moulding DA, Avery A, Virasami A, Fairchild AR, Tisdall M, Harkness W, Cross JH, Hargrave D, Guillemot F, Paine SM, Yasin SA, Jacques TS. Identifying cellular signalling molecules in developmental disorders of the brain: Evidence from focal cortical dysplasia and tuberous sclerosis. Neuropathol Appl Neurobiol. 2021 Oct;47(6):781-795.
4. Chang CM, Li YF, Lin HC, Lu KH, Lin TW, Liu LC, Su KM, Chang CC. Dysregulated Immunological Functionome and Dysfunctional Metabolic Pathway Recognized for the Pathogenesis of Borderline Ovarian Tumors by Integrative Polygenic Analytics. Int J Mol Sci. 2021 Apr 15;22(8):4105.
5. Lorio S, Sedlacik J, So PW, Parkes HG, Gunny R, Löbel U, Li YF, Ogunbiyi O, Mistry T, Dixon E, Adler S, Cross JH, Baldeweg T, Jacques TS, Shmueli K, Carmichael DW. Quantitative MRI susceptibility mapping reveals cortical signatures of changes in iron, calcium and zinc in malformations of cortical development in children with drug-resistant epilepsy. Neuroimage. 2021 Sep;238:118102.
6. Chen SH, Lin HH, Li YF, Tsai WC, Hueng DY. Clinical Significance and Systematic Expression Analysis of the Thyroid Receptor Interacting Protein 13 (TRIP13) as Human Gliomas Biomarker. Cancers (Basel). 2021 May 12;13(10):2338. 
7. Liu WT, Li YF, Hsieh TY. Unusual severe gastritis and gastric ulcers caused by pembrolizumab. J Postgrad Med. 2022 Jan-Mar;68(1):38-40. 
8. Su KM, Gao HW, Chang CM, Lu KH, Yu MH, Lin YH, Liu LC, Chang CC, Li YF, Chang CC. Synergistic AHR Binding Pathway with EMT Effects on Serous Ovarian Tumors Recognized by Multidisciplinary Integrated Analysis. Biomedicines. 2021 Jul 22;9(8):866.
9. Chang YL, Li YF, Chou CH, Huang LC, Wu YP, Kao Y, Tsai CK. Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux. Int J Mol Sci. 2021 Sep 28;22(19):10453.
10. Li YF, Tsai WC, Chou CH, Huang LC, Huang SM, Hueng DY, Tsai CK. CKAP2L Knockdown Exerts Antitumor Effects by Increasing miR-4496 in Glioblastoma Cell Lines. Int J Mol Sci. 2020 Dec 27;22(1):197. 
11. Li YF, Thom M, Jacques TS. Novel therapeutic targets in epilepsy: oxidative stress and iron metabolism. Neuropathol Appl Neurobiol. 2020 Oct;46(6):519-521.
12. Wang CY, Lin JC, Li YF, Yang CW. Alpha-fetoprotein producing pancreatic neuroendocrine tumour. QJM. 2020 Aug 1;113(8):565-566.
13. Cheng YW, Chen HC, Lyu SY, Li YF, Lu CC. Progressive white matter disease in Sjögren's syndrome. Rheumatology (Oxford). 2021 Apr 6;60(4):e146-e148.