學位

國立臺北科技大學工程學院工程科技博士
國防醫學院M95醫學士

經歷

國防醫學院 醫學系 一般病理科主任
國防醫學院 醫學系 生殖區段長
三軍總醫院 電鏡診斷室主任
三軍總醫院病理部 主治醫師
三軍總醫院病理部 總醫師
三軍總醫院病理部 住院醫師

專長學科

1. 腦瘤分子生物及病理機轉之研究
2. 胸腔腫瘤分子診斷與致癌基因研究
3. 免疫治療分子基因檢測
4. 血液淋巴疾病診

獲獎情形

◎109學年度醫學系優良導師
◎110學年度醫學系優良教師
◎110學年度醫學系教學之星
◎110學年度醫學系優良區段長

相關著作

1. Lin HH, Tsai WC, Tsai CK, Chen SH, Huang LC, Hueng DY, Hung KC. Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas. J Mol Neurosci. 2021 Aug;71(8):1614-1621.
2. Luo SM, Tsai WC, Tsai CK, Chen Y, Hueng DY. ARID4B Knockdown Suppresses PI3K/AKT Signaling and Induces Apoptosis in Human Glioma Cells. Onco Targets Ther. 2021 Mar 10;14:1843-1855.
3. Liu PY, Chen CC, Chin CY, Liu TJ, Tsai WC, Chou JL, Huang CY, Chen YG, Chen YC. E3 ubiquitin ligase Grail promotes hepatic steatosis through Sirt1 inhibition. Cell Death Dis. 2021 Mar 26;12(4):323. 
4. Tsai CC, Su YC, Bamodu OA, Chen BJ, Tsai WC, Cheng WH, Lee CH, Hsieh SM, Liu ML, Fang CL, Lin HT, Chen CL, Yeh CT, Lee WH, Ho CL, Lai SW, Tzeng HE, Hsieh YY, Chang CL, Zheng YM, Liu HW, Yen Y, Whang-Peng J, Chao TY. High-Grade B-Cell Lymphoma (HGBL) with MYC and BCL2 and/or BCL6 Rearrangements Is Predominantly BCL6-Rearranged and BCL6-Expressing in Taiwan. Cancers (Basel). 2021 Mar 31;13(7):1620
5. Chen SH, Lin HH, Li YF, Tsai WC, Hueng DY. Clinical Significance and Systematic Expression Analysis of the Thyroid Receptor Interacting Protein 13 (TRIP13) as Human Gliomas Biomarker. Cancers (Basel). 2021 May 12;13(10):2338
6. Kao Y, Tsai WC, Chen SH, Hsu SY, Huang LC, Chang CJ, Huang SM, Hueng DY. Shugosin 2 is a biomarker for pathological grading and survival prediction in patients with gliomas. Sci Rep. 2021 Sep 17;11(1):18541
7. Chen WT, Lin YH, Changchien CY, Chen Y, Chang HH, Tsai WC, Tsai HC, Wang CY, Shen MS, Cheng LT, Tsai CL. Concurrent Blockade of Endothelial EGFR and VEGF Signaling on Malignant Associated Pleural Fluid Induced Angiogenesis: From Clinic to Bench. Biomedicines. 2021 Sep 26;9(10):1327
8. Pai FC, Huang HW, Tsai YL, Tsai WC, Cheng YC, Chang HH, Chen Y. Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells. Cells. 2021 Oct 17;10(10):2782.
9. Tsai HF, Chang YC, Li CH, Chan MH, Chen CL, Tsai WC, Hsiao M. Type V collagen alpha 1 chain promotes the malignancy of glioblastoma through PPRC1-ESM1 axis activation and extracellular matrix remodeling. Cell Death Discov. 2021 Oct 26;7(1):313
10. Li YF, Tsai WC, Chou CH, Huang LC, Huang SM, Hueng DY, Tsai CK. CKAP2L Knockdown Exerts Antitumor Effects by Increasing miR-4496 in Glioblastoma Cell Lines. Int J Mol Sci. 2020 Dec 27;22(1):197.
11. Chang HH, Cheng YC, Tsai WC, Chen Y. PSMB8 inhibition decreases tumor angiogenesis in glioblastoma through vascular endothelial growth factor A reduction. Cancer Sci. 2020 Nov;111(11):4142-4153.
12. Dai YL, Hsu RJ, Huang HK, Huang TW, Tsai WC, Chang H, Lan CC, Huang KL. Adaptive support ventilation attenuates postpneumonectomy acute lung injury in a porcine model. Interact Cardiovasc Thorac Surg. 2020 Nov 1;31(5):718-726.
13. Tsai YL, Chang HH, Chen YC, Chang YC, Chen Y, Tsai WC. Molecular Mechanisms of KDELC2 on Glioblastoma Tumorigenesis and Temozolomide Resistance. Biomedicines. 2020 Sep 10;8(9):339.
14. Changchien CY, Chen Y, Chang HH, Chang SY, Tsai WC, Tsai HC, Wang CY, Lee HS, Tsai CL. Effect of malignant-associated pleural effusion on endothelial viability, motility and angiogenesis in lung cancer. Cancer Sci. 2020 Oct;111(10):3747-3758.
15. Ko KH, Huang HK, Chen YI, Chang H, Tsai WC, Huang TW. Surgical outcomes of second primary lung cancer after the extrapulmonary malignancy. J Cancer Res Clin Oncol. 2020 Dec;146(12):3323-3332.
16. Li LH, Chen TL, Chiu HW, Hsu CH, Wang CC, Tai TT, Ju TC, Chen FH, Chernikov OV, Tsai WC, Hua KF. Critical Role for the NLRP3 Inflammasome in Mediating IL-1β Production in Shigella sonnei-Infected Macrophages. Front Immunol. 2020 Jun 3;11:1115.
17. Wu YY, Huang TC, Ye RH, Fang WH, Lai SW, Chang PY, Liu WN, Kuo TY, Lee CH, Tsai WC, Lin C. A Hematologist-Level Deep Learning Algorithm (BMSNet) for Assessing the Morphologies of Single Nuclear Balls in Bone Marrow Smears: Algorithm Development. JMIR Med Inform. 2020 Apr 8;8(4):e15963.
18. Changchien CY, Sung MH, Chang HH, Tsai WC, Peng YS, Chen Y. Uremic toxin indoxyl sulfate suppresses myocardial Cx43 assembly and expression via JNK activation. Chem Biol Interact. 2020 Mar 1;319:108979.
19. Changchien CY, Chang HH, Dai MS, Tsai WC, Tsai HC, Wang CY, Shen MS, Cheng LT, Lee HS, Chen Y, Tsai CL. Distinct JNK/VEGFR signaling on angiogenesis of breast cancer-associated pleural fluid based on hormone receptor status. Cancer Sci. 2021 Feb;112(2):781-791.
20. Huang ZY, Hueng DY, Tsai WC. The Application of FOXO1A Expression Predicts Aggressive Behavior and Poor Prognosis in Gliomas. Appl Immunohistochem Mol Morphol. 2020 Jan;28(1):74-82.
21. Lan CC, Huang HK, Wu CP, Tu CC, Huang TW, Tsai WC, Tseng NC, Chang H. Recruitment maneuver leads to increased expression of pro-inflammatory cytokines in acute respiratory distress syndrome. Respir Physiol Neurobiol. 2020 Jan;271:103284.
22. Yu CH, Ting HK, Kao CC, Tsai WC, Wu ST, Yu DS. A rare case of extraluminal gastrointestinal stromal tumor of the ileum presenting with lower urinary tract symptoms: A case report. Medicine (Baltimore). 2019 Dec;98(49):e18103.
23. Chang YC, Tsai HF, Huang SP, Chen CL, Hsiao M, Tsai WC. Enrichment of Aldolase C Correlates with Low Non-Mutated IDH1 Expression and Predicts a Favorable Prognosis in Glioblastomas. Cancers (Basel). 2019 Aug 23;11(9):1238.
24. Chi KC, Tsai WC, Wu CL, Lin TY, Hueng DY. An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. Mol Neurobiol. 2019 Jun;56(6):4589-4599.
25. Wang SH, Chung CH, Huang TW, Tsai WC, Peng CK, Huang KL, Perng WC, Chian CF, Chien WC, Shen CH. Bidirectional association between tuberculosis and sarcoidosis. Respirology. 2019 May;24(5):467-474.
26. Ke HH, Hueng DY, Tsai WC. Low expression of pentraxin 3 and nuclear factor-like 2 implying a relatively longer overall survival time in gliomas. Chin J Physiol. 2019 Jan-Feb;62(1):35-43.
27. Shih CP, Tsai WC. Initial presentation of tonsillar carcinoma with candidiasis. Indian J Med Res. 2019 Jan;149(1):80.
28. Chen YH, Hueng DY, Tsai WC. Proteolipid Protein 2 Overexpression Indicates Aggressive Tumor Behavior and Adverse Prognosis in Human Gliomas. Int J Mol Sci. 2018 Oct 26;19(11):3353.
29. Lin MC, Li CZ, Hsieh CC, Hong KT, Lin BJ, Lin C, Tsai WC, Lee CH, Lee MG, Chung TT, Tang CT, Ju DT, Ma HI, Liu MY, Chen YH, Hueng DY. Preoperative grading of intracranial meningioma by magnetic resonance spectroscopy (1H-MRS). PLoS One. 2018 Nov 19;13(11):e0207612.
30. Lai SW, Bamodu OA, Tsai WC, Chang YM, Lee WH, Yeh CT, Chao TY. The therapeutic targeting of the FGFR1/Src/NF-κB signaling axis inhibits pancreatic ductal adenocarcinoma stemness and oncogenicity. Clin Exp Metastasis. 2018 Oct;35(7):663-677.
31. Tsai, Tsai NM, Chang KF, Wang JC. Juniperus Communis Extract Exerts Antitumor Effects in Human Glioblastomas Through Blood-Brain Barrier. Cell Physiol Biochem. 2018;49(6):2443-2462.
32. Chang HH, Cheng YC, Tsai WC, Tsao MJ, Chen Y. Pyr3 Induces Apoptosis and Inhibits Migration in Human Glioblastoma Cells. Cell Physiol Biochem. 2018;48(4):1694-1702.
33. Gao HW, Tsai WC, Perng CL, Wang WM, Chiang CP. Distinct MAPK and PI3K pathway mutations in different melanoma types in Taiwanese individuals. Eur J Dermatol. 2018 Aug 1;28(4):509-518.
34. Cheng YC, Tsai WC, Sung YC, Chang HH, Chen Y. Interference with PSMB4 Expression Exerts an Anti-Tumor Effect by Decreasing the Invasion and Proliferation of Human Glioblastoma Cells. Cell Physiol Biochem. 2018;45(2):819-831.
35. Tsai CK, Huang LC, Tsai WC, Huang SM, Lee JT, Hueng DY. Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomas. Oncotarget. 2018 Feb 28;9(21):15705-15720.
36. Tsai WC, Hueng DY, Lin CR, Yang TCK, Nieh S, Gao HW. Applying DDX3X Biomarker to Discriminate Atypical from Benign Meningiomas in Tissue Microarray. Appl Immunohistochem Mol Morphol. 2018 Apr;26(4):263-267
37. Tsai WC, Hueng DY, Lin CK. Nuclear overexpression of urocortin discriminates primary brain tumors from reactive gliosis. APMIS. 2015 Jun;123(6):465-72.
38. Cheng MF, Tsai WC, Hsia KT, Yang YS, Jin JS. Expression of urocortin in pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasia. APMIS. 2014 Feb;122(2):147-54.
39. Cheng MF, Tsai WC, Yu-Chieh L, Hsia KT, Jin JS. The association of urocortin expression with clinicopathologic parameters of gastric adenocarcinomas. Appl Immunohistochem Mol Morphol. 2014 Apr;22(4):288-94.
40. Tsai WC, Chen Y, Huang LC, Lee HS, Ma HI, Huang SM, Sytwu HK, Hueng DY. EMMPRIN expression positively correlates with WHO grades of astrocytomas and meningiomas. J Neurooncol. 2013 Sep;114(3):281-90