學位

長庚大學 生物醫學研究所博士

經歷

長庚大學 寄生蟲學科博士後研究員
長庚大學 分子醫學研究中心博士後研究員

研究領域與專長

1. 原蟲抗藥性機制
2. 原蟲發炎之訊號傳遞路徑
3. 原蟲感染菌相研究
4. 原蟲細胞外囊泡對宿主發炎機轉之調控
5. 多體學應用於原蟲致病機轉研究

獲獎情形

◎109年度醫學系優良區段長
◎109年度醫學系區段優良教師
◎109年度優良論文獎
◎110年度醫學系優良區段長
◎110年度優良導師
◎110年度優良論文獎

相關著作

1. Chiu SF, Huang PJ, Cheng WH, Huang CY, Chu LJ, Lee CC, Lin HC, Chen LC, Lin WN, Tsao CH, Tang P, Yeh YM, Huang KY. Vaginal Microbiota of the Sexually Transmitted Infections Caused by Chlamydia trachomatis and Trichomonas vaginalis in Women with Vaginitis in Taiwan. Microorganisms. 2021 Sep 2;9(9):1864.
2. Lin HC, Chen YJ, Wei YH, Lin HA, Chen CC, Liu TF, Hsieh YL, Huang KY, Lin KH, Wang HH, Chen LC. Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation. Front Immunol. 2021 Mar 29;12:630380.
3. Wang JY, Lin HC, Lin HA, Chung CH, Chen LC, Huang KY, Sun CA, Chien WC, Guo JL. Associations between Diabetes Mellitus and Nontuberculous Mycobacterium-Caused Diseases in Taiwan: A Nationwide Cohort Study. Am J Trop Med Hyg. 2021 Oct 18;105(6):1672-1679. 
4. Huang PJ, Huang CY, Li YX, Liu YC, Chu LJ, Yeh YM, Cheng WH, Chen RM, Lee CC, Chen LC, Lin HC, Chiu SF, Lin WN, Lyu PC, Tang P, Huang KY. Dissecting the Transcriptomes of Multiple Metronidazole-Resistant and Sensitive Trichomonas vaginalis Strains Identified Distinct Genes and Pathways Associated with Drug Resistance and Cell Death. Biomedicines. 2021 Dec 2;9(12):1817.
5. Cheng WH, Huang KY, Ong SC, Ku FM, Huang PJ, Lee CC, Yeh YM, Lin R, Chiu CH, Tang P. Protein cysteine S-nitrosylation provides reducing power by enhancing lactate dehydrogenase activity in Trichomonas vaginalis under iron deficiency. Parasit Vectors. 2020 Sep 18;13(1):477.
6. Lin HA, Chien WC, Huang KY, Chung CH, Chen LC, Lin HC, Guo JL. Infection with Toxoplasma gondii increases the risk of psychiatric disorders in Taiwan: a nationwide population-based cohort study. Parasitology. 2020 Nov;147(13):1577-1586. 
7. Lin HC, Chen YJ, Wei YH, Chuang YT, Hsieh SH, Hsieh JY, Hsieh YL, Ojcius DM, Huang KY, Chung IC, Yuan SN, Chang YS, Chen LC. Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition. Int J Mol Sci. 2020 Jul 19;21(14):5104.
8. Lin HC, Chu LJ, Huang PJ, Cheng WH, Zheng YH, Huang CY, Hong SW, Chen LC, Lin HA, Wang JY, Chen RM, Lin WN, Tang P, Huang KY. Proteomic signatures of metronidazole-resistant Trichomonas vaginalis reveal novel proteins associated with drug resistance. Parasit Vectors. 2020 Jun 1;13(1):274.
9. Hu SI, Ko MC, Dai YH, Lin HA, Chen LC, Huang KY, Pang TL, Kuo CY, Lin HC. Pre-clinical assessment of chimeric antigen receptor t cell therapy targeting CD19+ B cell malignancy. Ann Transl Med. 2020 May;8(9):584.
10. Chung IC, Yuan SN, OuYang CN, Hu SI, Lin HC, Huang KY, Lin WN, Chuang YT, Chen YJ, Ojcius DM, Chang YS, Chen LC. EFLA 945 restricts AIM2 inflammasome activation by preventing DNA entry for psoriasis treatment. Cytokine. 2020 Mar;127:154951.
11. Lin WC, Tsai CY, Huang JM, Wu SR, Chu LJ, Huang KY. Quantitative proteomic analysis and functional characterization of Acanthamoeba castellanii exosome-like vesicles. Parasit Vectors. 2019 Oct 9;12(1):467. 
12. Huang KY, Ong SC, Wu CC, Hsu CW, Lin HC, Fang YK, Cheng WH, Huang PJ, Chiu CH, Tang P. Metabolic reprogramming of hydrogenosomal amino acids in Trichomonas vaginalis under glucose restriction. J Microbiol Immunol Infect. 2019 Aug;52(4):630-637.
13. Huang KY, Chen RM, Lin HC, Cheng WH, Lin HA, Lin WN, Huang PJ, Chiu CH, Tang P. Potential role of autophagy in proteolysis in Trichomonas vaginalis. J Microbiol Immunol Infect. 2019 Apr;52(2):336-344.
14. Lin HC, Huang KY, Chung CH, Lin HA, Chen RM, Tsao CH, Chien WC, Chiueh TS. Infection with Trichomonas vaginalis increases the risk of psychiatric disorders in women: a nationwide population-based cohort study. Parasit Vectors. 2019 Mar 12;12(1):88.
15. Hsu PS, Lin CM, Chang JF, Wu CS, Sia KC, Lee IT, Huang KY, Lin WN. Participation of NADPH Oxidase-Related Reactive Oxygen Species in Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2α and COX-2 Expression. Int J Mol Sci. 2019 Mar 2;20(5):1078
16. Chung IC, OuYang CN, Yuan SN, Lin HC, Huang KY, Wu PS, Liu CY, Tsai KJ, Loi LK, Chen YJ, Chung AK, Ojcius DM, Chang YS, Chen LC. Pretreatment with a Heat-Killed Probiotic Modulates the NLRP3 Inflammasome and Attenuates Colitis-Associated Colorectal Cancer in Mice. Nutrients. 2019 Feb 28;11(3):516.
17. Chang CC, Sia KC, Chang JF, Lin CM, Yang CM, Huang KY, Lin WN. Lipopolysaccharide promoted proliferation and adipogenesis of preadipocytes through JAK/STAT and AMPK-regulated cPLA2 expression. Int J Med Sci. 2019 Jan 1;16(1):167-179.
18. Chung IC, Yuan SN, OuYang CN, Lin HC, Huang KY, Chen YJ, Chung AK, Chu CL, Ojcius DM, Chang YS, Chen LC. Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation. Cell Death Dis. 2018 Oct 31;9(11):1109.
19. Huang PJ, Lee CC, Chiu LY, Huang KY, Yeh YM, Yang CY, Chiu CH, Tang P. VAReporter: variant reporter for cancer research of massive parallel sequencing. BMC Genomics. 2018 May 9;19(Suppl 2):86.
20. Huang PJ, Chiu LY, Lee CC, Yeh YM, Huang KY, Chiu CH, Tang P. mSignatureDB: a database for deciphering mutational signatures in human cancers. Nucleic Acids Res. 2018 Jan 4;46(D1):D964-D970. 
21. Chung IC, Yuan SN, OuYang CN, Lin HC, Huang KY, Chen YJ, Chung AK, Chu CL, Ojcius DM, Chang YS, Chen LC. Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation. Cell Death Dis. 2018 Oct 31;9(11):1109.