專長學科
航太醫學/生理學
心血管疾病臨床與病理學之致病機制
發炎相關疾病
分子醫學
學位
國立台北護理學院護理學士
國防醫學院航太醫學研究所碩士
國防醫學院生命科學研究所博士
經歷
三軍總醫院病理部博士後研究員 (經濟部計畫)
三軍總醫院醫學研究部研究員兼執行秘書
香港中文大學炎症疾病/分子治療中心博士後研究員
哈佛大學醫學院基因治療中心博士後研究員
哈佛大學醫學Joslin糖尿病中心訪問學者
澳洲墨爾本Monash大學醫學院訪問學者
國防醫學院醫學系航太及海底醫學研究所所長
實驗室簡介
我們以細胞模式及動物模式，探討缺氧與氧化壓力對心血管疾病機制。心肌梗塞為心血管疾病之重大主因，對軍人、公務人員，乃至一般大民眾，皆屬為人所熟知之無情殺手。由於心肌梗塞為動脈硬化之重大合併症，以動脈硬化為切入點進行研發，將更能達成早期心肌梗塞防治策略之建立。我們使用ApoE缺陷小鼠進行動脈硬化致病機轉與中草藥成分之療效分析，針對發炎媒介物產生與單核球之湧入為缺血性心肌損傷之重要原因，阻斷此一生理病理路徑，將可減少心肌損傷之發生，並促進心臟之修復。
研究論文
代表性著作論文 (SCI)，9篇責任作者 (2020-2022) ：
1) Shin-Ruen Yang, Szu-Chun Hung, Lichieh Julie Chu, Kuo-Feng Hua, Chyou-Wei Wei, I-Lin Tsai, Chih-Chin Kao, Chih-Chien Sung, Chung-Yao Wu1, Ann Chen1, Alexander TH Wu, Feng-Cheng Liu, Hsu-Shan Huang, Shuk-Man Ka*. NSC828779 alleviates renal tubulointerstitial lesions involving interleukin-36 signaling in mice. Cells. 2021, 10 (11), 3060; 10.3390/cells10113060. 2021 (IF:6.6) (責任作者)
2) Shin-Ruen Yang, Kuo-Feng Hua, Chung-Yao Wu, Ann Chen, Yu-Ling Tsai, Chih-Jun Wan, Chia-Chung Lee, Jia-Feng Chan, Chih-Yu Hsieh, Yu-Juei Hsu, Chia-Chao Wu9, Debabrata Mukhopadhyay, Hsu-Shan Huang, Feng-Cheng Liu, Shuk- Man Ka*. Cf-02, a novel benzamide-linked small molecule, blunts NF-κB activation and NLRP3 inflammasome assembly and improves acute onset of accelerated and severe lupus nephritis in mice. FASEB Journal. 2021 Aug;35(8):e21785. (IF: 5.191) (責任作者)
3) Shin-Ruen Yang, Kuo-Feng Hua, Akiko Takahata, Chung-Yao Wu, Chih-Yu Hsieh, Hsiao-Wen Chiu, Cheng-Hsu Chen, Debabrata Mukhopadhyay, Yusuke Suzuki, Shuk-Man Ka*, Hsu-Shan Huang, Ann Chen. LCC18, a benzamide-linked small molecule, ameliorates IgA nephropathy in mice. The Journal of Pathology. 2021 (IF:7.996) (責任作者)
4) Wu C.Y., Hua K.F., Yang S.R., Tsai Y.S., Hsieh C.Y., Wu C.C., Chang J.F., Arbiser J.L., Chang C.T., Chen A., Ka S.M*. Tris DBA ameliorates IgA nephropathy by blunting the activating signal of NLRP3 inflammasome through SIRT1- and SIRT3-mediated autophagy induction. J Cell Mol Med. 2020 Nov 1. doi: 10.1111/jcmm.15663. (IF: 5.310) (責任作者)
5) Yang S.R., Hsu W.H., Wu C.Y., Shang H.S., Liu F.C., Chen A., Hua K.F., Ka S.M.* Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-κB/NLRP3 inflammasome and sirtuin 1/autophagy axis. FASEB Journal. 2020 August https://doi.org/10.1096/fj.202001326R. (IF: 5.191) (責任作者)
6) Yang S.R., Hua K.F., Chu L.J., Hwu Y.K., Yang S.M., Wu C.Y., Lin T.J., Weng J.C., Zhao H., Hsu W.H., Liu F.C, Liaw W.J., Ma D, Ka S.M*, Chen A. Xenon blunts NF-κB/NLRP3 inflammasome activation and improves acute onset of accelerated and severe lupus nephritis in mice. Kidney Int. 2020 Apr 6:S0085-2538(20)30357-4. doi: 10.1016/j.kint.2020.02.033. (IF: 10.612) (責任作者)
7) Wu C.Y., Hua K.F., Hsu W.H., Suzuki Y., Chu L.J., Lee Y.C., Takahata A., Lee S.L., Wu C.C., Nikolic-Paterson D.J., Ka S.M.*, Chen A. IgA nephropathy benefits from compound K treatment by inhibiting NF-κB/ NLRP3 inflammasome and enhancing autophagy and SIRT1. J Immunol 2020 Jul 1;205(1):202-212. (IF: 4.886) (責任作者)
8) Wu C.Y., Hua K.F., Chu C.L., Yang S.R., Arbiser J.L., Yang S.S., Lin Y.C., Liu F..C, Yang S.M., Ka S.M., Chen A.*. Tris DBA Ameliorates Accelerated and Severe Lupus Nephritis in Mice by Activating Regulatory T Cells and Autophagy and Inhibiting the NLRP3 Inflammasome. J Immunol. 2020 Mar 15;204(6):1448-1461. (IF: 4.886) (責任作者)
9) Hsu W.H., Hua K.F., Tuan L.H., Tsai Y.L., Chu L.J., Lee Y.C., Wong W.T., Lee S.L., Lai J.H., Chu C.L., Ho L.J., Chiu H.W., Hsu Y.J., Ka S.M.*, Chen A. Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions. Nephrol Dial Transplant 2020 Jan 1;35(1):74-85. (IF: 5.992) (責任作者)
More information,
https://www.researchgate.net/profile/Shuk-Man-Ka