專長

延緩腎臟病尿毒症惡化與透析治療
高血壓腎病變
糖尿病腎病變
腎毒性物質和急慢性腎臟損傷
水腫蛋白尿與血尿
血液透析治療
腹膜透析治療
酸鹼和電解質異常
腎絲球腎炎
泌尿系統感染症

學會

美國腎臟醫學會會員
中華民國腎臟醫學會會員
中華民國內科醫學會會員

研究著作

Chang, J.-F.; Hsieh, C.-Y.; Liou, J.-C.; Lu, K.-C.; Zheng, C.-M.; Wu, M.-S.; Chang, S.-W.; Wang, T.-M.; Wu, C.-C. Circulating p-Cresyl Sulfate, Non-Hepatic Alkaline Phosphatase and Risk of Bone Fracture Events in Chronic Kidney Disease-Mineral Bone Disease. Toxins 2021, 13, 479. 本人為第一作者
Chen, P.-C.; Chang, S.-W.; Hsieh, C.-Y.; Liou, J.-C.; Chang, J.-F.; Wang, T.-M. Fat-Bone Relationship in Chronic Kidney Disease—Mineral Bone Disorders: Adiponectin Is Associated with Skeletal Events among Hemodialysis Patients. Diagnostics 2021, 11, 1254.本人為通訊作者
Chang JF, Chen PC, Hsieh CY, Liou JC. A Growth Differentiation Factor 15-Based Risk Score Model to Predict Mortality in Hemodialysis Patients. Diagnostics (Basel). 2021 Feb 11;11(2):286. doi: 10.3390/diagnostics11020286. PMID: 33670413; PMCID: PMC7918408. 本人為第一作者
Hsu CM, Lin SC, Wu KW, Wang TM, Chang JF, Lee CC. Preliminary Results of Subtalar Arthroereisis with Vulpius Procedure for Symptomatic Flatfoot in Patients with Type I Osteogenesis Imperfecta. Int J Environ Res Public Health. 2020 Dec 24;18(1):E67.
Hung KC, Chang JF, Hsu YH, Hsieh CY, Wu MS, Wu MY, Chiu IJ, Syu RS, Wang TM, Wu CC, Hung LY, Zheng CM, Lu KC. Therapeutic Effect of Calcimimetics on Osteoclast-Osteoblast Crosslink in Chronic Kidney Disease and Mineral Bone Disease. Int J Mol Sci. 2020 Nov 18;21(22):8712. doi: 10.3390/ijms21228712. 本人為共同第一作者. 2019 Impact factor‎: ‎4.6
Song JY, Shen TC, Hou YC, Chang JF, et al. Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease. Int J Mol Sci. 2020 Aug 31;21(17):6294.
Wu CY, Hua KF, Yang SR, Tsai YS, Yang SM, Hsieh CY, Wu CC, Chang JF, Arbiser JL, Chang CT, Chen A, Ka SM. Tris DBA ameliorates IgA nephropathy by blunting the activating signal of NLRP3 inflammasome through SIRT1- and SIRT3-mediated autophagy induction. J Cell Mol Med. 2020 Nov 1;24(23):13609–22. doi: 10.1111/jcmm.15663. 2018 Impact factor‎: ‎4.6
Hsieh CH, Lee CC, Tseng TH, Wu KW, Chang JF, Wang TM. Endosinotarsal device exerts a better postoperative correction in Meary's angle than exosinotarsal screw from a meta-analysis in pediatric flatfoot. Sci Rep. 2020 Aug 11;10(1):13532. doi: 10.1038/s41598-020-70545-6. PMID: 32782334; PMCID: PMC7419313.
Chang JF, Hsieh CY, Liou JC, et al. Scavenging Intracellular ROS Attenuates p-Cresyl Sulfate-Triggered Osteogenesis through MAPK Signaling Pathway and NF-κB Activation in Human Arterial Smooth Muscle Cells. Toxins (Basel). 2020;12(8):E472. Published 2020 Jul 24. 本人為第一作者.2018 Impact factor‎: ‎3.895
Chang JF, Hsieh CY, Lu KC, et al. Therapeutic Targeting of Aristolochic Acid Induced Uremic Toxin Retention, SMAD 2/3 and JNK/ERK Pathways in Tubulointerstitial Fibrosis: Nephroprotective Role of Propolis in Chronic Kidney Disease. Toxins (Basel). 2020;12(6):364. Published 2020 Jun 2. 本人為第一作者. 2018 Impact factor‎: ‎3.895
Chang JF, et al. A Joint Evaluation of Neurohormone Vasopressin-Neurophysin II-Copeptin and Aortic Arch Calcification on Mortality Risks in Hemodialysis Patients. Front Med (Lausanne). 2020 Mar 31;7:102. Published 2020 Mar 31.本人為第一作者.2019 Impact factor‎: ‎3.9
Chang JF, Wu CC, Hsieh CY, Li YY, Wang TM, Liou JC. A Joint Evaluation of Impaired Cardiac Sympathetic Responses and Malnutrition-Inflammation Cachexia for Mortality Risks in Hemodialysis Patients. Front Med (Lausanne). 2020;7:99. Published 2020 Mar 27.本人為第一作者.2019 Impact factor‎: ‎3.9
Chang JF, Liu SH, Lu KC, et al. Uremic Vascular Calcification Is Correlated With Oxidative Elastic Lamina Injury, Contractile Smooth Muscle Cell Loss, Osteogenesis, and Apoptosis: The Human Pathobiological Evidence. Front Med (Lausanne). 2020;7:78. Published 2020 Mar 24. 本人為第一作者.2019 Impact factor‎: ‎3.9
Hsu CM, Wu KW, Lin MW, Kuo KN, Chang JF, Wang TM. Pioneering Experience of Uniportal Video-Assisted Thoracoscopic Surgery for Anterior Release of Severe Thoracic Scoliosis. Sci Rep. 2020;10(1):841. Published 2020 Jan 21. 本人為共同作者.
Chang JF, et al. Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia. Int J Mol Sci. 2019 Sep 6;20(18). pii:E4393. 本人為第一作者. 2019 Impact factor‎: ‎4.556
Hsieh CH, Lee CC, Tseng TH, Wu KW, Chang JF, Wang TM. Body Weight Effects on Extra-Osseous Subtalar Arthroereisis. J Clin Med. 2019;8(9):1273. Published 2019 Aug 22. 本人為共同作者. 2018 Impact Factor: 5.688
Hsu PJ, et al. Less Is More: Ulnar Lengthening Alone without Radial Corrective Osteotomy in Forearm Deformity Secondary to Hereditary Multiple Exostoses. J Clin Med. 2019 Oct 23;8(11). pii: E1765. 本人為共同作者. 2018 Impact Factor: 5.688
Hsu PS, et al. Participation of NADPH Oxidase-Related Reactive Oxygen Species in Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2α and COX-2 Expression. Int J Mol Sci. 2019 Mar 2;20(5). pii: E1078. 本人為共同作者. 2018 Impact factor‎: ‎4.183
Yeh JC, et al. Non-Hepatic Alkaline Phosphatase, hs-CRP and Progression of Vertebral Fracture in Patients with Rheumatoid Arthritis: A Population-Based Longitudinal Study. J Clin Med. 2018 Nov 13;7(11). pii: E439. 本人為通訊作者. 2018 Impact Factor: 5.688
Chang JF, et al. Translational Medicine in Pulmonary-Renal Crosstalk: Therapeutic Targeting of p-Cresyl Sulfate Triggered Nonspecific ROS and Chemoattractants in Dyspneic Patients with Uremic Lung Injury. J Clin Med. 2018 Sep 9;7(9). pii: E266. 本人為第一作者. 2018 Impact Factor: 5.688
Ko WC, et al. Galectin-3 Interacts with Vascular Cell Adhesion Molecule-1 to Increase Cardiovascular Mortality in Hemodialysis Patients. J Clin Med. 2018 Sep 24;7(10). pii: E300. 本人為通訊作者. 2018 Impact Factor: 5.688
Chang CC, et al. Lipopolysaccharide promoted proliferation and adipogenesis of preadipocytes through JAK/STAT and AMPK-regulated cPLA2 expression. Int J Med Sci. 2019 Jan 1;16(1):167-179. 本人為共同作者. 2018 Impact factor‎: ‎4.183
Chen PC, et al. Snake venom proteome and immune -profiling of the hundred-pace viper, Deinagkistrodon acutus, in Taiwan. Acta Trop. 2019 Jan;189: 137-144. 本人為共同作者.
Chang JF*, et al (2017, Jan). Periodontal Pocket Depth, Hyperglycemia, and Progression of Chronic Kidney Disease: A Population-Based Longitudinal Study. Am J Med. Jan;130(1):61-69.e1. 本人為第一作者、通訊作者. 5-year Impact Factor 5.561
Chen HM, et al. (2016, Aug). AdipoRincreased intracellular ROS promotes cPLA2 and COX-2 expressions via activation of PKC and p300 in adiponectin-stimulated human alveolar type II cells. Am J Physiol Lung Cell Mol Physiol. 311(2):L255-69. 本人為共同作者.Impact Factor: 4.092 (2017)
Chang JF*, et al. (2016). Dyspnoea in a patient with hepatitis C. Heart, 1;102(23):1889. 本人為第一作者、通訊作者. Impact Factor: 5.420 (2017)
Hsu PS, Wu CS, Chang JF, Lin WN. (2015, Nov). Leptin Promotes cPLA₂ Gene Expression through Activation of the MAPK/NF-κB/p300 Cascade. Int J Mol Sci. (11):27640-58.Impact Factor: 3.687 (2017)
Chang JF, et al. (2015). Intraventricular hemorrhage as a complication of microscopic polyangiitis. Kidney Int.88(3):642-3. 本人為第一作者. Impact Factor: 8.395 (2016)
Chang JF, et al. (2015). Resolution of Late Steroid-Responsive Nephrotic Syndrome in a Patient with Alport Syndrome Treated with Atorvastatin. . Open Journal of Pediatrics, 5: 12-16. 本人為第一作者.
Chang JF, et al. (2014). Combined alkaline phosphatase and phosphorus levels as a predictor of mortality in maintenance hemodialysis patients. Medicine (Baltimore), 93(18):e106.本人為第一作者. Impact Factor: 5.723 (2014)
Chang JF, et al. (2013). High soluble vascular cell adhesion molecule-1 concentrations predict long-term mortality in hemodialysis patients. Int Urol Nephrol. 45(6):1693-701. 本人為第一作者. 2018 Impact Factor: 1.596
Tsai WC, Peng YS, Yang JY, et al. Short- and long-term impact of subtotal parathyroidectomy on the achievement of bone and mineral parameters recommended by clinical practice guidelines in dialysis patients: a 12-year single-center experience. Blood Purif. 2013;36(2):116-121.
Tsai WC, Chang JF, Wu HY, Yang JY, Chen HY, Pai MF, Hsu SP, Peng YS. Ten-Year Descriptive Analysis of Infective Endocarditis in Hemodialysis Patients. Acta Nephrologica 2012; 26(4): 213-217
Chang JF, et al. (2011). A possible rare cause of renal failure in streptococcal infection. Nephrol Dial Transplant, 26 (1): 368-371. 本人為第一作者. Impact Factor of 4.198.
Chang JF ; Lin, Chih-ming ; Huang, Chi-hung ; Lin, Ching-ling ; Huang, Shih-hung ; Chin, Chih-hui Preoperative Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy before Surgical Resection of Pheochromocytoma. Acta Cardiologica Sinica 26:3 2010.189-192. 本人為第一作者.
研討會壁報論文:

Chang JF, et al. Pathomechanistic insights into Uremic Vascular Calcification: Oxidative Elastic Lamina Injury as A Key Player in Arterial Stiffness, Osteogenesis and Apoptosis. Taiwan Society of Nephrology Annual Meeting 2019.
Chang JF. Translational Medicine in Chronic Kidney Disease: Therapeutic Targeting of p-Cresyl Sulfate Triggered Nonspecific ROS in Uremic Lung Injury. American Society of Nephrology Annual Program Committee 2018. Session Title: Molecular Mechanisms of CKD - I [PO1903-1] Session Date, Time: October 25, 2018 from 10:00 AM to 12:00 PM
Chang JF, et al. Therapeutic Targeting of ROS Triggered Signalling Pathways in Obese Kidney Fibrosis with Metabolic Endotoxemia. Taiwan Society of Nephrology Annual Meeting 2018.
Chang JF, et al. Therapeutic Effects of Taiwanese Green Propolis on Tubulointerstitial Fibrosis in A Murine Model of Chronic Kidney Disease. Taiwan Society of Nephrology Annual Meeting 2019.
Chang JF, et al. Autonomic Response and Heart Rate Variability by Real-Time Photoelectric Detection of Light Emitter Diode Predict Hypotensive Events in Hemodialysis Patients. Taiwan Society of Nephrology Annual Meeting 2016.
Chang JF, et al. P-Cresyl Sulfate and Non-Hepatic Alkaline Phosphatase Interact to Increase the Mortality Risk in Hemodialysis Patients with Aortic Calcification. Taiwan Society of Nephrology Annual Meeting 2016.
Chang JF, et al. Participation of Reactive Oxygen Species on p-Cresyl Sulfate Reduced Human Type II Epithelial Cells Viability. 第三十一屆生物醫學聯合學術年會. 本人為第一作者.
Chang JF, et al. Effect of P-Cresyl Sulfate on Alveolar Cell Apoptosis via Reactive Oxygen Species Production. Taiwan Society of Nephrology Annual Meeting 2016.
Chang JF, et al. Combined Heart Rate Variability and Muscle Strength as A Predictor of Clinical Events in Maintenance Hemodialysis Patients.Taiwan Society of Nephrology Annual Meeting 2015.
Chang JF, et al. Combined Low-Protein Diet and Early Initiation of Ketoanalogs as A Cost-Saving Therapeutic Strategy in Advanced Chronic Kidney Disease.. Taiwan Society of Nephrology Annual Meeting 2015.
Chang JF, et al. The Association Between Serum Phosphorus and Mortality Among Hemodialysis Patients Was Not Modified by Alkaline Phosphatase. . Taiwan Society of Nephrology Annual Meeting 2013.
Chang JF, et al. P-Cresol Sulfate Inhibits Aquaporin 5 Expression in A549 Human Lung Epithelial Cells. . Taiwan Society of Nephrology Annual Meeting2013.