現職

中央研究院生物醫學研究所專案研究員

E-MAIL

yshuang@ibms.sinica.edu.tw

最高學歷

國防醫學院生命科學研究所

期刊編輯

Biomedical Reports

Life (special issue of non-coding RNAs: genomics, biogenesis, mechanisms, and functions)

研究興趣

小鼠建立人類疾病的模式

致病分子機轉

非編碼核糖核酸

褪黑激素

研究論文

1.     Huang, Y.S*., C.C. Wu, C.C. Chang, S.F. Huang, H.Y. Kuo, H.M. Shih. 2022. Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth. Cellular and Molecular Life Sciences 79:367-381. (Biochemistry & Molecular Biology 34/296) *責任作者

2.     Huang, Y.S., C.H. Lo, P.H. Tsai, Y.C. Hou, Y.T. Chang, C.Y. Guo, H.Y. Hsieh, K.C. Lu, H.M. Shih, C.C. Wu. 2021. Downregulation of AANAT by c-Fos in tubular epithelial cells with membranous nephropathy. Biochemical and Biophysical Research Communications 584: 32-38. (Biophysic 39/72)

3.     Lin, H.*, Y.S. Huang*, J.M. Fustin, M. Doi, H. Chen, H.H. Lai, S.H. Lin, Y.L. Lee, P.C. King, H.S. Hou, H.W. Chen, P.Y. Young, and H.W. Chao. 2021. Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver. Nature Communications 12: 645-663. (Multidisciplinary Sciences 6/73) *共同第一作者 (54 terms cited)

4.     Huang, Y.S., K.C. Lu, H.W. Chao, A. Chen, T.K. Chao, C.Y. Guo, H.Y. Hsieh, H.M. Shih, H.K. Sytwu, and C.C. Wu. 2021. The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells. Journal of Cellular Physiology 236: 2023-2035. (Physiology 10/81)

5.     Chang, C.C., Y.S. Huang, Y.M. Lin, C.J. Lin, J.C. Jeng, S.M. Liu, T.L. Ho, R.T. Chang, C.A. Changou, C.C. Ho, and H.M. Shih. 2018. The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis. Scientific Reports 8: 9786-9797. (Multidisciplinary Sciences 19/73)

6.     Hu, L.Y., C.C. Chang, Y.S. Huang, W.C. Chou, Y.M. Lin, C.C. Ho, W.T. Chen, H.M. Shih, C.N. Hsiung, P.E. Wu, and C.Y. Shen. 2018. SUMOylation of XRCC1 activated by poly(ADP-ribosyl)ation regulates DNA repair. Human Molecular Genetics 27: 2306-2317. (Genetics & Heredity 36/175)

7.     Huang, Y.S., K.C. Lu, T.K. Chao, J.S. Chen, A. Chen, C.Y. Guo, H.Y. Hsieh, H.M. Shih, H.K. Sytwu, and C.C. Wu. 2018. Role of MTNR1A and PITX1 coexpression in protecting tubular epithelial cells in membranous nephropathy. Journal of Pineal Research 65:e12482-e12495. (Endocrinology & Metabolism 8/146)

8.     Huang, Y.S., S.H. Fu, K.C. Lu, J.S. Chen, H.Y. Hsieh, H.K. Sytwu, and C.C. Wu. 2017. Inhibition of tumor necrosis factor signaling attenuates renal immune cell infiltration in experimental membranous nephropathy. Oncotarget 8:111631-111641.

9.     Huang, Y.S., C.C. Chang, S.S. Lee, Y.S. Jou, and H.M. Shih. 2016 Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression. Oncotarget 7:43256-43266. (86 times cited)

10.   Lin, G.J.*, Y.S. Huang*, C.K. Lin, S.H. Huang, H.M. Shih, H.K. Sytwu, and Y.W. Chen. 2016. Daxx and TCF4 interaction links to oral squamous cell carcinoma growth by promoting cell cycle progression via induction of cyclin D1 expression. Clinical Oral Investigations 20: 533-540. *共同第一作者

11.   Wu, C.C., Y.S. Huang, J.S. Chen, C.F. Huang, S.L. Su, K.C. Lu, Y.F. Lin, P. Chu, S.H. Lin, H.K. and Sytwu. 2015. Resveratrol ameliorates renal damage, increases expression of heme oxygenase-1, and has anti-complement, anti-oxidative, and anti-apoptotic effects in a murine model of membranous nephropathy. PLoS One 10:e0125726-e0125742. (59 times cited)

12.   Kuo, H.Y., Y.S. Huang, C.H. Tseng, Y.C. Chen, Y.W. Chang, H.M. Shih, and C.W. Wu. 2014. PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2. Cell Cycle 13:3132-3142.

13.   Huang, Y.S., H.Y. Hsieh, H.M. Shih, H.K. Sytwu, and C.C. Wu. 2014. Urinary Xist is a potential biomarker for membranous nephropathy. Biochemical and Biophysical Research Communications 452:415-421. (48 times cited)

14.   Huang, Y.S., C.C. Chang, T.C. Huang, Y.L. Hsieh, and H.M. Shih. 2012. Daxx interacts with and modulates the activity of CREB. Cell Cycle 11:99-108.

15.   Chang, C.C.*, M.T. Naik*, Y.S. Huang, J.C. Jeng, P.H. Liao, H.Y. Kuo, C.C. Ho, Y.L. Hsieh, C.H. Lin, N.J. Huang, N.M. Naik, C.C. Kung, S.Y. Lin, R.H. Chen, K.S. Chang, T.H. Huang, and H.M. Shih. 2011. Structural and functional roles of Daxx SIM phosphorylation in SUMO paralogue-selective binding and apoptosis modulation. Molecular Cell 42:62-74. *共同第一作者 (128 times cited)

16.   Huang, Y.S. and Shih H.M. 2009. Daxx positively modulates beta-catenin/TCF4-mediated transcriptional potential. Biochemical and Biophysical Research Communications 386:762-768.

17.   Wang, H.C., Y.S. Huang, C.C. Ho, J.C. Jeng, and H.M. Shih. 2009. SUMO modification modulates the activity of calpain-2. Biochemical and Biophysical Research Communications 384:444-449.

18.   Hsieh, J.L., C.H. Lee, M.L. Teo, Y.J. Lin, Y.S. Huang, C.L. Wu, and A.L. Shiau. 2009. Transthyretin-driven oncolytic adenovirus suppresses tumor growth in orthotopic and ascites models of hepatocellular carcinoma. Cancer Science 100:537-545.

19.   Hsu, K.F., C.L. Wu, S.C. Huang, J.L. Hsieh, Y.S. Huang, Y.F. Chen, M.R. Shen, W.J. Chung, C.Y. Chou, and A.L. Shiau. 2008. Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy. Cancer Gene Therapy 15:526-534.

20.   Lin, D.Y., Y.S. Huang, J.C. Jeng, H.Y. Kuo, C.C. Chang, T.T. Chao, C.C. Ho, Y.C. Chen, T.P. Lin, H.I. Fang, C.C. Hung, C.S. Suen, M.J. Hwang, K.S. Chang, G.G. Maul, and H.M. Shih. 2006. Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Molecular Cell 24:341-354. (334 times cited)

21.   Lin, D.Y., H.I. Fang, A.H. Ma, Y.S. Huang, Y.S. Pu, G. Jenster, H.J. Kung, and H.M. Shih. 2004 Negative modulation of androgen receptor transcriptional activity by Daxx. Molecular and cellular Biology 24:10529-10541. (93 times cited)

22.   Shiau, A.L., Y.L. Chen, C.Y. Liao, Y.S. Huang, and C.L. Wu. 2001. Prothymosin-α enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis. Vaccine 19:3947-3956.