專長學科

1. 以角質細胞與黑色素細胞共同培養模式探討黑色素體的傳導機制
2. 探討表皮分化過程中53及63對角質素14基因表現的調控

經歷

國防醫學院生解學科助理教授 (2001~至今)

威今基因科技研發部主任 (2000~2001)

慈濟醫學院兼任助理教授 (1999-2000)

慈濟技術學院兼任助理教授 (1998-1999)

慈濟醫學院博士後研究員 (1997~2000)

國防醫學院生解學科講師 (1983~1993)

研究著作

1. Bi-He Cai, Chung-Faye Chao, Hwang-Chi Lin, Hua-Ying Huang, Reiji Kannagi and Jang-Yi Chen* (2016)A/T gap tolerance in the core sequence and flanking sequence requirements of non-canonical p53 response elements. J. Biochem. 1-10 doi:10.1093/jb/mvw005. ( I F=2.582；R/C= 154/290 )

2. Gnu-Jiun Lin, Shu-Sheng Kao Chen, Shing-Hwa Huang, I-Hsun Li, Li-Chen Yen, Jang-Yi Chen, Huey-Kang Sytwu, Yuan-Wu Chen. (2015) Valproic acid exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo. J Med Sci 35(1):28-36

3. Bi-He Cai, Pei-Ching Hsu, I-Lun Hsin, Chung-Faye Chao, Mei-Hua Lu, Hwang-Chi Lin, Shih-Hwa Chiou, Pao-Luh Tao, and Jang-Yi Chen*. (2012) p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation. PLoS ONE 7(7): e41742. doi:10.1371/journal.pone.0041742. ( I F=3.23；R/C=9/57)

4. Cai BH, Chao CF, Lu MH, Lin HC, and Chen JY *. (2012) A half-site of the p53 binding site on the keratin 14 promoter is specifically activated by p63. J Biochem 152: 99-110 ( I F=2.582；R/C= 154/290 )

5. Cai BH, Chen JY, Lu MH, Chang LT, Lin HC, Chang YM, Chao CF*. Functional four-base A/T gap core sequence CATTAG of P53 response elements specifically bound tetrameric P53 differently than two-base A/T gap core sequence CATG bound both dimeric and tetrameric P53. Nucleic Acids Res. 2009;37(6):1984-1990. ( I F=9.112；R/C= 20/290 )

6. Lin HC, Shieh BH, Lu MH, Chen JY, Chang LT, Chao CF*. A method for quantifying melanosome transfer efficacy from melanocytes to keratinocytes in vitro. Pigment Cell Melanoma Res. 2008;21; 559–564. ( I F=5.509；R/C= 2/58 ).

7. Lu MH*, Chao CF, Tsai SH, Chen JY, and Chang LT Autocrine effects of endothelin on in vitro proliferation of vascular smooth muscle cells from spontaneously hypertensive and normotensive rats. Clin Exp Hypertens 2006; 28:463–474. SCI

8. Chang, W.C., Chen, J.Y., Chang, T., Liu, M.Y., Payne, W.J., LeGall, J. and Chang, W.C. The C-terminal Segment is Essential for Maintaining Quaternary and Structure the Enzyme Activity of the Nitric Oxide Forming Nitrite Reductase from Achromobacter cycloclastes. Biochem. Biophys. Res. Commun. 250:782-785. 1998. SCI

9. Chen, J.Y., Chang, W.C., Chang, T., Chang, W.C., Liu, M.Y., Payne, W.J. and LeGall, J. Cloning, Characterization and Expression of the Nitric Oxide-Generating Nitrite Reductase and of the Blue Copper Protein Genes of Achromobacter cycloclastes. Biochem. Biophys. Res. Commun. 219:423-428. 1996. SCI

10. Chen, J.Y., Chang, W.C. and Chao, C.F. The Induction and Characterization of Antiserum against Human Placenta 17--Hydroxysteroid Dehydrogenase. Proc. Natl. Sci. Counc. (B) ROC. 17:106-115. 1993.

得獎事蹟

2009年榮獲國防醫學院優良導師
2008年指導研究生參加第35屆國軍軍醫學術研討會碩士班論文海報組第三名
2009年指導研究生參加第36屆國軍軍醫學術研討會碩士班論文海報組第二名

E-mail

jychen01@mail.ndmctsgh.edu.tw