E-MAIL

wlchang@mail.ndmctsgh.edu.tw

Publication

1. Ding, H.Y.; Liu, M.Y.; Chang, W.L.*; Lin, H.C. Sesquiterpenoids from the Rhizomes of Atractylodes macrocephala. Chin. Pharm. J. 57, 37-42, 2005.

2.Chang, W.L.*; Wang, H.Y.; Shi, L.S.; Lai, J.H.; Lin, H.C. Immunosuppressive Iridoids from the Fruits of Gardenia jasminoides. J. Nat. Products 68 (11), 1683-1685, 2005. (SCI, IF=2.843)

3.Chen, Y.L.; Lin, S.Z.; Chang, W.L.; Cheng, Y.L.; Harn, H.J.* Requirement for ERK activation in acetone extract identified from Bupleurum scorzonerifolium induced A549 tumor cell apoptosis and keratin 8 phosphorylation. Life Sci, 76, 2409 -2420, 2005. (SCI, IF=2.583)

4.Tsai, N.M.; Lin, S.Z.; Lee, C.C.; Chen, S.P.; Su, H.C.; Chang, W.L.; Harn, H.J. The Antitumor Effects of Angelica sinensis on Malignant Brain Tumors in Vitro and in Vivo. Clin Cancer Res. 11 (9), 3475 –3484, 2005. (SCI, IF=6.488)

5.Cheng, Y.L.; Lee, S.C.; Lin, S.Z.; Chang, W.L.*; Chen, Y.L.; Tsai, N.M.; Liu, Y.G.; Tzao, C.; Yu, D.S.; Harn, H.J.* Anti-proliferative activity of Bupleurum scorzonerifolium in A549 human lung cancer cells in vitro and in vivo. Cancer Letters, 222, 183 - 193, 2005. (SCI, IF=3.504)

6.S.M. Pan; H.Y. Ding; W.L. Chang*, H.C. Lin. Phenols from the Aerial Parts of Leonurus sibiricus. Chin. Pharm. J. 58 (1): 35-40, 2006.

7.N.M. Tsai, Y.L. Chen, C.C. Lee, P.C. Lin, J.Y. Chang, Y.L. Cheng, W.L. Chang, S.Z. Lin, H.J. Harn*, The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo. J. Neurochem. 99 (4), 1251-1262, 2006. (SCI, IF=4.5)

8.W.H. Lee; J.S. Jin; W.L. Chang; Y.T. Chen; C.W. Yao; L.F. Sheu; A. Chen. Biological inhibitory effects of Chinese herb “Danggui” on brain glioblastoma multiforme. Pathobiology, 73: 141-148, 2006. (SCI, IF=1.818)

9.Y.L. Chen, S.Z. Lin, J.Y. Chang, Y.L. Cheng, N.M. Tsai, W.L. Chang*, H.J. Harn*, In vitro and in vivo Studies of a Novel Potential Anticancer Agent of Isochaihulactone on Human Lung Cancer A549 Cells. Biochem. Pharmacol. 72 (3), 308-319, 2006. (SCI, IF=4.838)

10.Shi, L.S.; Reddy, M. Vijaya Bhaskar; Yan, H.J.; Chang, W.L.*; Lin, H.C. A New Ent-trachylobane Diterpenoid from the Roots of Sapium sebiferum. J. Chin. Chem. Soc. 53, 751-754, 2006. (SCI, IF=0.77)

11.I.C. Yen, C.W. Yao, L.S. Shi, C.Y. Pai, W.L. Chang*, H.C. Lin. Anti-adenovirus cycloartane triterpenoids from the rhizome of Cyathea lepifera. Taiwan Pharm. J. 59: 189-193, 2007.

12.H.C. Lin , S.M. Pan; H.Y. Ding; W.L. Chang*. Antiplatelet Effect of Leonurine from Leonurus sibiricus. Taiwan Pharm. J. 59: 149-152, 2007.

13. Y.L. Chen, P.C. Lin, S.P. Chen, C.C., Y.L. Cheng, W.L. Chang, S.Z. Lin, H.J. Harn. Activation of NAG-1 via ERK1/2 mitogen-activated protein kinase revealed a isochaihulatone-triggered apoptotic pathway in human lung cancer A549 cells. J. Pharmacol. Exp. Ther. 323 (2): 746-56, 2007. (SCI, IF=4.309)

14.T.C. Chang*, S.F. Huang, T.C. Yang, H.C. Lin, W.L. Chang*; The Effect of Ginsenosides on Glucose Uptake in Human Caco-2 Cells is Mediated through Altered Expression of Na+/coupled glucose transporter 1. J. Agric. Food Chem., 55(5): 1993-1998, 2007. (SCI, IF=2.562)

15.Y.L. Chen, M.H. Jian, C.C. Lin, J.C. Kang, S.P. Chen, P.C. Lin, P.J. Hung, J.R. Chen, W.L. Chang, S.Z. Lin, H.J. Harn. The induction of orphan nuclear receptor Nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma (HCC) cells therapy. Mol. Pharmacol. 74 (4), 1046-1058, 2008. (SCI, IF=4.711)

16.P.C. Lin, Y.L. Chen, S.C. Chiu, Y.L. Yu, S.P. Chen, M.H. Chien, K.Y. Chen, W.L. Chang, S.Z. Lin, T.W. Chiou, H.J. Harn. Orphan nuclear receptor, Nurr-77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor. J. Neurochemistry, 106 (3): 1017-26, 2008. (SCI, IF=4.5)

17.Y.L. Cheng*, S.C. Lee, H.J. Harn, C. Tzao, W.L. Chang *; The Extract of Hibiscus syriacus Inducing Apoptosis by Activating p53 and AIF in human lung cancer cells. Am. J Chinese Med. 36 (1): 171-184, 2008. (SCI, IF=1.058)

18.C.W Wei, C.C. Lin, Y.I. Yu, C.Y. Lin, P.C. Lin, M.T, Wu, C.J. Chen, W.L. Chang, S.Z Lin, Y.L.S. Chen, H.J. Harn. n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2α and telomerase activity. Acta Pharm. Sin. 2009: 1–10. SCI, 140/216 (Pharmacology & pharmacy), IF= 1.676.

19.Y.C. Huang, C.Y. Lin, S.F. Huang, H.C. Lin, W.L. Chang *, T.C. Chang*; The Effect of Ginsenosides CK and Rg1 on Stimulation of Glucose Uptake in 3T3-L1 Adiocytes. J. Agric. Food Chem., 2010, 58(10): 6039-6047. SCI, 15/124 (Food science), IF= 3.288.

20.Y.C. Huang, W.L. Chang *, C.Y. Lin, S.F. Huang, H.C. Lin*, T.C. Chang*; Pachymic acid stimulates glucose uptake through enhanced GLUT4 expression and translocation. Eur. J. Pharmacol., 2010, 648(10): 39-49. SCI, 106/261 (Pharmacology & pharmacy), IF= 2.592.

21.H.C. Lin*, Y.Y. Song, Y.C. Huang, W.L. Chang*; A 4,5-Secolanostane triterpenoid from the sclerotium of Poria cocos. J. Med. Sci., 2010, 30(6): 237-240.

22.P.Y. Tsai; S.M. Ka; J.M. Chang; H.C. Chen; H.A. Shui; C.Y. Li; K.F. Hua; W.L. Chang; J.J. Huang; S.S. Yang; A. Chen, Epigallocatechin-3-gallate prevent lupusnephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation. Free Radical Biol. Med., 2011, 51: 744-754. SCI, 17/122 (Endocrinology & Metabolism) IF= 5.271.

23.C.W. Cheng; W.L. Chang; L.C. Chang; C.C. Wu; Y.F. Lin; J.S. Chen; Ferulic acid, an Angelica sinensis-derived polyphenol slow the progression of membranous nephropathy in mouse model. Evidence-Based Complementary and Alternative Medicine, 2012, doi:10.1155/2012/161235. SCI, 8/22 (Integrative &Complementary Medicine), IF= 1.722.

24.A.R. Lee; C.W. Liao, W.L. Chang; C.W. Yao; W.H. Huang*, Synthesis and structure-activity relationships of flavonoids derived from Scutellaria baicalensis Georgi as potent anti-flu agents against tamiflu resistant H1N1 virus and H3N2 virus. J. Chinese Med. Res. Develop. 2012, 1 (1): 28-36.

25.T.Y. Shih; C.Y. Pai; P. Yang; W.L. Chang; N.C. Wang; O.Y.P. Hu, A novel mechanism underlies the hepatotoxicity of pyrazinamide. Antimicrobial Agents & Chemotherapy, 2013, 57(4): 1685-90. SCI, 31/261 (Pharmacology & pharmacy), IF= 4.565.

26.J.Y. Ho; R.J. Hsu; C.L. Wu; W.L. Chang; T.L. Cha; D.S. Yu; C.P. Yu, Ovatadiolide targets b-catenin signaling in suppressing tumorigenesis and overcoming drug resistance in renal cell carcinoma. Evidence-Based Complementary and Alternative Medicine, 2013, doi:10,1155/2013/161628. SCI, 8/22 (Integrative &Complementary Medicine), IF= 1.722.

27.L.J. Ho; W.L. Chang; A. Chen; P. Chao; J.H. Lai, Differntial immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract is extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: potential therapeutics for arthritis and possible mechanisms explaining in part Chinese herbal theory "Junn-Chenn-Zuou-SS". J. Translational Med. 2013, 11:294 doi:10.1186/1479-5876-11-294. SCI, 36/121 (Medicine, Research & Experimental), IF= 3.459

28.W.L. Chang; Y.H. Ho; Y.C. Huang; S.F. Huang; J.Y. Lin; H.C. Lin; T.C. Chang, The inhibitory effect of ginsenoside Rg1 on glucose and lipid production in human HepG2 cells. Adaptive Medicine, 2013, doi: 10.4247/AM.2013.ABD068.

29.H.J. Wang; C.H. Hsiong; L.H. Pao; W.L. Chang; L.J. Zhang; M.J. Lin; S.T. Ho; P.W. Huang; Oliver Y.P. Hu, New finding of nalbuphine metabolites in men: NMR spectroscopy and UPLC-MS/MS spectrometry assays in a pilot human study. Metabolomics, 2013, doi:10.1007/s11306-013-0605y. SCI, 29/122 (Endocrinology & Metabolism), IF= 4.433

30.T.Y. Shih; P. Yang; Ho S.C. Ho; W.L. Chang; N.C. Wang,; O.Y.P. Hu. Xanthine Oxidase Genotype and Susceptibility to Anti-tuberculosis Drugs-induced Hepatotoxicity. AM J Gastroenterol 2013 (submitted) (IF=7.284; 7/74).

31.T.C. Yang; H.F. Chao, L.S. Shi; T.C. Chang; H.C. Lin; W.L. Chang *, Alkaloids from Coptis chinensis root promote glucose uptake in C2C12 myotubes. Fitoterapia, 2014, 93, 239-244.

32. L.S. Shi; C.H. Wu, T.C. Yang; C.W. Yao; H.C. Lin; W.L. Chang*, Cytotoxic effect of triterpenoids from the root bark of Hibiscus syriacus. Fitoterapia, 2014, 97, 184-91.. SCI, 128/261 (Pharmacology & pharmacy), IF= 2.231.

33. T.H. Hu; S.Y. Jiang; W.L. Chang; R.L. Eckert; T.M. Scharadin; T.C. Chang*, Involvement of RARRES3 in the regulation of Wnt proteins acylation and signaling activities in human breast cancer cells. Cell Death and Differentiation (2014), 1–14, SCI, 25/291 (Biochemistry & Molechlar Biology), IF= 8.385.

34. C.W. Wang; Y.C. Huang; F.N. Chan; S.C. Su; Y.H. Kuo; S.F. Huang; M.W. Hung; H.C. Lin; W.L. Chang*; T.C. Chang*. Ginsenoside compound K, a natural triterpene, induces intestinal glucose ab-sorption and Na+/glucose cotransporter 1 gene expression through activation of cAMP Response Element-Binding Protein. Molecular Nutrition and Food Research, 2015, 59, 670-684. SCI, 3/123 (Food Science & Technology), IF= 4.909.

35. I.C. Yen; C.W. Yao, M.T. Kuo, C.L. Chao, C.Y. Pai, W.L. Chang*. Anti-cancer agents derived from solid-state fermented Antrodia camphorate mycelium. Fitoterapia, 2015, 102, 115-119. SCI, 130/256 (Pharmacology & Pharmacy), IF= 2.345.

36. C.W. Wang; W.L. Chang; Y.C. Huang; F.C. Chou; F.N. Chan; S.C. Su; S.F. Huang; H.H. Ko; Y.L. Ko; H.C. Lin; T.C. Chang*. An essential role of cAMP response element-binding protein in epidermal growth factor-mediated induction of sodium/glucose cotransporter 1 gene expression and intestinal glucose uptake. Int. J. Biochem. Cell Biol. 2015, 64, 239–251. SCI, 72/291 (Biochemistry & Molecular Biology), IF= 4.240.

37. C.Y. Chiang; H.T. Tsai, W.L. Chang, Y.T. Chin; W.J. Chang; H.P. Tu; H.C. Chiu, E. Fu. Salvia milti-orrhiza ethanol extract ameliorates tissue destraction caused by experimental periodontitis in rats. J. Periodontal Res. 2016, 51 (1): 133-9. SCI, 16/87 (Dentistry, Oral surgery & Medicine), IF= 2.466.

38. H.T. Tsai, W.L. Chang, H.P. Tu, E. Fu, Y.D. Hsieh, C.Y. Chiang. Effects of Salvia miltiorrhiza etha-nolic extract on lipopolysaccharide-induced dental alveolar bone resorption in rats. J. Dental Sci. 2016, 11, 35-40. SCI, 78/87 (Dentistry, Oral surgery & Medicine), IF= 0.556.

39. C.W. Wang; S.C. Su; S.F. Huang; Y.C. Huang; F.N. Chan; Y.H. Kuo; S.F. Huang; M.W. Hung; H.C. Lin; W.L. Chang; T.C. Chang*. An essential role of cAMP Response Element-Binding Protein in Ginsenoside Rg1-mediated inhibition of Na+/glucose cotransporter 1 gene expression. Mol. Phar-macol. 2015, 88: 1072-1083. SCI, 40/255 (Pharmacology & Pharmacy), IF= 4.128.

40. C.L. Chao; H.C. Huang; H.C. Lin; T.C. Chang; W.L. Chang. Sesquiterpenes from Baizhu stimulate glucose uptake by activating AMPK and PI3K. Am. J. Chinese Med., 2016, 44 (5): 963-979. SCI, 3/24 (Integrative & Complementary Medicine), IF= 2.959.

41. I.C. Yen; S.Y. Lee; K.T. Lin; F.Y. Lai; M.T. Kuo; W.L. Chang*. In vitro anticancer activity and struc-tural characterization of ubiquinones from Antrodia cinnamomea mycelium. Molecules 2017, 22, 747; doi:10.3390/molecules22050747. SCI, 24/59 (Chemistry, organic), IF= 2.465.

42. M.C. Chen; W.L. Hsu; W.L. Chang; T.C. Chou. Antiangiogenic activity of phthalides-enriched An-gelica sinensis extract by suppressing WSB-1/pVHL/HIF-1a/VEGF signaling in bladder cancer. Scientific Reports, 2017, 7: 5376. DOI:10.1038/s41598-017-05512-9. SCI, 10/64 (Multidisciplinary science), IF= 4.259.

43. M.W. Hung; H.C. Lin; W.L. Chang*; T.C. Chang*. Astragaloside II promotes intestinal epithelial repair via enhancement of L-arginine uptake and activation of the mTOR pathway. Scientific Re-ports, 2017, 7: 12302. DOI:10.1038/s41598-017-12435-y. SCI, 10/64 (Multidisciplinary science), IF= 4.259.

44. C.Y. Yang; C.C. Hsieh, C.K. Lin; C.S. Lin; B. Peng; G.J. lin; H.K. Sytwu; W.L. Chang; Y.W.Chen. Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells. BMC Complementary and Alternative Medicine, 2017, 17: 555.

45. S.Y. Lee; W.L. Chang; Z.X. Li; N.S. Kirkby, W.C. Tsai; S.F. Huang; C.H. Ou; T.C. Chang. Astraga-loside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo. Phytomedicine, 2018, 38: 183-191.

46. C.L. Chao; H.C. Huang; H.Y. Ding; J.H. Lai; H.C. Lin; W.L. Chang. A new macrocyclic diterpenoid from Anisomeles indica. Nat. Prod. Res. 2019, 25:1-9. DOI: 10.1080/14786419.2019.1586692.

47. Y.T. Kao; H.Y. Li; I.C. Yen; W.L. Chang; T.C. Chang. A new phenylethanoids from the flower of Osmanthus fragrans and their bioactivities in human dermal fibroblasts. Phytochemistry Letters, 2020. (accepted)