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張立乾 Associate Professor

張立乾 Associate Professor      
Li-Chien Chang

Position

Associate Professor

Education

Ph.D - University of Michigan, USA
Master / Bachelor - NDMC, ROC

Telephone Extension

18890

E-MAIL

lichien@mail.ndmctsgh.edu.tw

Publication

1. Chang LC*; Lee HF; Chung MJ; Yang VC. PEG-modified protamine with improved pharmacological/ pharmaceutical properties as a potential protamine substitute: synthesis and in-vitro evaluations, Bioconjugate Chemistry, 16, 147-155, 2005. (SCI; IF=4.5843)

2. Park YJ; Chang LC, Liang JF; Cheol M; Chung CP; Yang VC. Nontoxic membrane translocation peptide from protamine, low molecular weight protamine (LMWP), for enhanced intracellular drug delivery: in vitro and in vivo study, The FASEB Journal, 19(11), 1555-7, 2005. (SCI; IF=7.409)

3. Wann JG; Lin CS; Chang LC; Hsu YH; Chien CT; Tai DW; Chen JS; Yang CC; Yeung LK; Chen CF. Enhanced expression of glucose transporter 1 on erythrocyte membrane in hemodialysis patients: the possible role in erythrocyte ascorbate recycling, American Journal of Kidney Diseases, 47(6), 1055-1063, 2006. (SCI; IF=4.822)

4. Wu CC; Chen JS; Chen SJ; Lin SH; Chen A; Chang LC; Sytwu HK; Lin YF. Kinetics of adaptive immunity to cationic bovine serum albumin-induced membranous nephropathy, Kidney International, 72(7), 831-40, 2007. (SCI; IF=6.418)

5. Kwon YM, Li YT, Liang JF, Park YJ, Chang LC, and Yang VC, PTD-modified ATTEMPTS system for enhanced asparaginase therapy: A proof-of-concept investigation, Journal of Controlled Release, 130(3), 252-258, 2008. (SCI; IF=5.69)

6. Moon C, Kwon YM, Lee WK, Park YJ, Chang LC, Yang VC, A Novel Polyrotaxane-Based Intracellular Delivery System for Camptothecin: In Vitro Feasibility Evaluation, Journal of Biomedical Materials Research: Part A, 84A(1), 238-246, 2008. (SCI; IF=2.706)

7. Liu PY, Chan JY, Lin HC, Wang SL, Liu ST, Ho CL, Chang LC, Huang SM, Modulation of the cyclin-dependent kinase inhibitor p21 gene by Zac1 through the antagonistic regulators p53 and histone deacetylase 1 in HeLa cells, Molecular Cancer Research, 6(7),1204–14, 2008. (SCI; IF=4.533)

8. Yeh MK, Chang LC, Chiou AH, Improving Tenoxicam Solubility and Bioavailability by Cosolvent System, AAPS PharmSciTech., 10(1), 166-71, 2009. (SCI; IF=1.445)

9. Tsai YT, Chang LC*, Lin YF, Tsai CS, Lai CH, and Chen JS*, Protamine-associated hypotension in patients on hemodialysis: retrospective study and prevalence of antiprotamine antibodies, Clinical Nephrology, 72(2), 122-128, 2009. (SCI; IF=1.413)

10. Chen JS, Chan DC, Chung MJ, Chang LC*, VC Yang, Altered fibrinolytic activities in gastric cancer and uremic patients after intervention, Clinical Nephrology, 72(6), 468-472, 2009. (SCI; IF=1.413)

11. Chen JS, Huang JH, Chang LC, Wu CC, Lin YF, Attributes of antiangiogenic factor plasminogen kringle 5 in glomerulonephritis, Archives of Pathology & Laboratory medicine, 134(12), 1804-1812, 2010 (SCI; IF=2.279)

12. Huang JC, Chang LC, Lin YF, Shui HA, Chen JS. Effects of fungal statins on high-glucose-induced mouse mesangial cell hypocontractility may involve filamentous actin, t-complex polypeptide 1 subunit beta, and glucose regulated protein 78, Translational Research, 156, 80-90, 2010 (SCI; IF=2.903)

13. Chang LC, Yang CY, Chua CN, Lin YJ, Lai SM. Sustained release of transgenic human factor IX: preparation, characterization, and in vivo efficacy, Molecular Pharmaceutics,8(5), 1767-1774, 2011. (SCI; IF=5.400)

14.Chang LC, Wu CC, Yeung LK, Lin YF, Chen JS. Involvement of F-actin in chaperonin-containing t-complex 1 beta regulating mouse mesangial cell functions in a glucose-induction cell model, Experimental Diabetes Research, doi:10.1155/2011/565647, 2011. (SCI; IF=1.528)

15.Cheng CW, Chang WL, Chang LC, Wu CC, Lin YF, Chen JS. Ferulic acid, an Angelica Sinensis-derived polyphenol, slows the progression of membranous nephropathy in a mouse model, Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2012/161235, 2012. (SCI)

16.Wang MT, Lo YW, Tsai CL, Chang LC, Malon DC, Chu CL, Liou JT. Statin use and risk of COPD exacerbation requiring hospitalization. American Journal of Medicine, 126(7):598-606.e2. doi: 10.1016/j.amjmed.2013.01.036., 2013. (SCI)

17.Hao WH, Yang LC, Wang JJ, Hsu CS, Chang LC*, Hsu KY*. A facile method for determination of deoxycytidine kinase (dCK) activity in biological milieus, Journal of Food and Drug Analysis, accepted, 2013. (SCI)

18.Liu ST, Lu GY, Hsu YJ, Chang LC*, Ho CL*, Huang SM*. Dual roles for lysine 490 of promyelocytic leukemia protein in the transactivation of glucocorticoid receptor-interacting protein 1, BBA Molecular Cell Research, 1833:1799-1810, 2013. (SCI)

19.Hao WH, Wang JJ, Hsueh SP, Hsu PJ, Chang LC, Hsu CS, Hsu KY. In vitro and in vivo studies of pharmacokinetics and antitumor efficacy of D07001-F4, an oral gemcitabine formulation, Cancer Chemotherapy and Pharmacology, 71:379–388, DOI 10.1007/s00280-012-2017-5, 2013. (SCI)

20.Cheng CW, Chang LC, Tseng TL, Wu CC, Lin YF, Chen JS, Phosphotriesterase-related Protein Sensed Albuminuria and Conferred Renal Tubular Cell Activation in Membranous Nephropathy, Journal of Biomedical Science, accepted, 2014. (SCI)

21. Chen JS, Chang LC, Huang SJ, Cheng CW, Targeting Spleen Tyrosine Kinase-Bruton's Tyrosine Kinase Axis for Immunologically Mediated Glomerulonephritis, Biomed Research International, accepted, 2014. (SCI)

22.WH Hao, LC Yang, JJ Wang, CS Hsu, LC Chang*, KY Hsu*. A facile method for determination of deoxycytidine kinase (dCK) activity in biological milieus, Journal of Food and Drug Analysis, 22:236-241, 2014. (SCI)

23.MT Wang, CL Chu, CB Yeh, LC Chang, DC Malone, JT Liou, Antidepressant Use and Risk of Recurrent Stroke: A Population-based Nested Case-Control Study, Journal of Clinical Psychiatry, accepted, 2014. (SCI)

24. MT Wang, CL Chu, CB Yeh, LC Chang, DC Malone, JT Liou, Antidepressant Use and Risk of Recurrent Stroke: A Population-based Nested Case-Control Study, Journal of Clinical Psychiatry, 76(7): e877-e885, 2015. (SCI)

25.CZ Wu, LC Chang, YF Lin, MY Lee, YJ Hung, D Pei, JS Chen, Chaperonin-containing t-complex protein-1 subunit as a possible biomarker for the phase of glomerularhyperfiltration of diabetic nephropathy. Disease Markers, Article ID 548101. http://dx.doi.org/10.1155/2015/548101, 2015. (SCI)

26 CZ Wu, LC Chang, YF Lin, YJ Hung, D Pei, NF Chu, JS Chen, Urokinase plasminogen activator receptor and its soluble form in common biopsy-proven kidney diseases and in staging of diabetic nephropathy, Clinical Biochemistry, http://dx.doi.org/10.1016/j.clinbiochem.2015.07.001, 2015. (SCI).

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  • Update Date:2022-09-16