E-MAIL

lar@mail.ndmctsgh.edu.tw

Experience

Professor, School of Pharmacy, National Defense Medical Center 1995/8- present
Dean, School of Pharmacy, National Defense Medical Center e 1999/3-2005/4
Associate Professor, School of Pharmacy, National Defense Medical Center 1983/10-1995/7
Assistant Professor, School of Pharmacy, National Defense Medical Center 1974/8-1978/7
Associate Research Fellow, Department of Biochemistry, Oregon University of Medicine 1987/5-1988/4
Associate Research Fellow, School of Pharmacy, University of Michigan 1979/5-1983/10

Research Interest

Synthesis and research novel anti-cancer, immunosuppressive and Chinese herbal active ingredients

Publications

1.Huang CM; HuangWH*; Lee AR*. Side products in preparation of leflunomide analogs using dicyclohexylcarbodiimide/N-hydroxysuccinimde as a coupling agent. Chinese Pharmaceutical Journal, 57: 105-109, 2005.

2. Huang WH*; Lee AR; Chien PU; Chou TC. Synthesis of baicalein derivatives as potential anti-aggregatory and anti-inflammatory agents. Journal of Pharmacy and Pharmacology, 57: 219-225, 2005. (SCI, IF=1.847)

3. Huang CM; Hsieh YH; Huang WH; Lee AR*. Synthesis of N-(4-Substituted Phenyl)-2-Hydroxynicotinanilides as Potential Anti-inflammatory Agents. Chinese Pharmaceutical Journal, 58: 105-113, 2006.

4. Huang WH; Lin IH; Tan KI, Chiang CH: Lee AR*. Synthesis and Ocular Hypotensive Activity of Magnolol. Chinese Pharmaceutical Journal, 58: 105-113, 2006.

5. Cherng SC; Huang WH; Shiau CY; Lee AR; Chou, TC. Mechanisms of antiplatelet activity of PC-09, a newly synthesized pyridazinone derivative. European Journal of Pharmacology, 532: 32-37, 2006. (SCI, IF=2.787)

6. Huang WH; Lee AR; Yang CH. Antioxidant and Anti-inflammatory Activities of Polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. Bioscience, Biotechnology and Biochemistry, 70: 2371-2380, 2006. (NSC 94-2320-B-016-030) (SCI, IF=1.39)

7. Huang CM; Yeh PW; Wang HC; Huang WH; Lee AR.* Anti-inflammatory Activity and Structure-activity Relationships of N-(Substitued phenyl)-5-methylisoxazole-3-carboxamides. Taiwan Pharmaceutical Journal, 59 (4), 203-210, 2007.

8. Shaw J; Liu CR;. Chen MB; Holtz R; Huang WH; Lee AR*. Inhibition of tumour necrosis factor-㬁 secretion from EpiDermTM tissues by a novel small molecule, UTL-5d. British Journal of Dermatology, 157: 575-579, 2007. (SCI, IF=3.489)

9. Huang, C.M.; Lee, A.R.; Kang, P.H.; Huang, W.H. (2010) Synthesis of Mannich base derivatives of oroxylin A endowed with anti-inflammatory activity. J. Med. Sci., 30 (2): 41-46.

10. Novel small-molecule tumor necrosis factor (TNF-a) inhibitors potentiate cisplatin against HCT-15 human colon cancer cells in vitro. J Pharm Biomed Sci 2011;11

11. Shaw J, Chen B, Wooley P, Huang WH, Lee AR, Zeng D. Anti-inflammatory and Anti-arthritic Effects of a Novel Leflunomide Analogue, UTL-5b (GBL-5b). Am. J. Biomed. Sci. 2011; 3(1):31-9

12. Shaw J, Chen B, Huang WH, Lee AR, Media J, Valeriote FA. The small-molecule TNF-α modulator, UTL-5g, reduces side effects induced by cisplatin and enhances the therapeutic effect of cisplatin in vivo. J. Exp. Ther. Oncol. 2011; 9: 129-37

13. Jiajiu Shaw, Ben Chen, Paul Wooley, Bruce Palfey, An-Rong Lee,Wen-Hsin Huang, Dustin Zeng. A Novel Leflunomide Analog, UTL-5b (GBL-5b), Suppresses JAK3, MAP3K2, and LITAF Genes. Am. J. Biomed. Sci. 2011, 3(3), 218-227

14. A.R. Lee; C.W. Liao, W.L. Chang; C.W. Yao; W.H. Huang*, Synthesis and structure-activity relationships of flavonoids derived from Scutellaria baicalensis Georgi as potent anti-flu agents against tamiflu resistant H1N1 virus and H3N2 virus. J. Chinese Med. Res. Develop. 2012, 1 (1): 28-36.

15. Chen PT, Lin WP, Lee AR, Hu MK. New 7-[4-(Carbopiperazin-1-yl)]piperazinyl Derivatives of Fluoroquinolones: Synthesis and Antimicrobial Evaluation. Molecules. 2013;27:18(7),7557-69

16. Song Y, Zhang Y, Lee AR, Huang WH, Chen B, Palfey B, Shaw J. Comparison of Two Molecular Scaffolds, 5-Methylisoxazole-3-Carboxamide and 5-Methylisoxazole-4-Carboxamide. Curr Pharm Des. 2014;20(1):146-52.

17. Chuang KA1, Lieu CH, Tsai WJ, Huang WH, Lee AR, Kuo YC. 3-Methoxyapigenin modulates β-catenin stability and inhibits Wnt/β-catenin signaling in Jurkat leukemic cells. Life Sci. 2013;92(12):677-86

18. Chien-Ming Huang, An-Rong Lee, Jiajiu Shaw, Wen-Hsin Huang. Synthesis and bioevaluation of novel heterostilbenes as potential anti-inflammatory and anti-angiogenic agents .MRI. 2013;2(3):37-45

19. Song Y, Zhang Y, Lee AR, Huang WH, Chen B, Palfey B, Shaw J. Comparison of Two Molecular Scaffolds, 5-Methylisoxazole-3-Carboxamide and 5-Methylisoxazole-4-Carboxamide. Current Pharmaceutic Design. 2014, 20, 146-52

20. Huang WH, Lee AR. Synthesis, preferentially hypoxic apoptosis and anti-angiogenic activity of 1,2,4-benzotrazin-3-amine 1,4-dioxide bearing alkyl linkers with 1,2,4-benzotrazin-3-amine 1-oxide derivatives. Anticancer Agents Med Chem. 2014, 14, 1428-1446.

21. Chung ST, Chien PY, Huang WH, Yao CW, Lee AR. Synthesis and anti-influenza activities of novel baicalein analogs. Chemical & Pharmaceutical Bulletin. 2014, 62, 415-421.

22. Chung ST, Huang YT, Hsiung HY, Huang WH, Yao CW, Lee AR. Novel daidzein analogs and their in vitro anti-influenza activities. Chemistry & Biodiversity. 2015, 12, 685-696.

23. Hui-Chen Wang, An-Rong Lee. Recent development in blood glucose sensors. Journal of Food and Drug Analysis. 2015, 23, 191-200.

24. Shu-Ting Chung, Wen-Hsin Huang, Chih-Kuo Huang, Feng-Cheng Liu, Ren-Yeong Huang, Chin-Chen Wu, An-Rong Lee. Synthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives. Research on Chemical Intermediates. 2015, in press.