E-MAIL

hmk@mail.ndmctsgh.edu.tw

Experience

07/1980–08/1983 Army R.O.C.
08/1986–07/1990 Faculty, School of Pharmacy, National Defense Medical Center
02/1995–07/2002 Associate professor, School of Pharmacy, National Defense Medical Center
07/2001–10/2001 Visiting scholar at Harvard Medical School & Center for Neurologic Diseases, Brigham and Women’s Hospital
08/2002–present Professor, School of Pharmacy, National Defense Medical Center
08/2003–present Members of the Board of Examiners, Ministry of Examination
08/2013–07/2019 Dean, School of Pharmacy, National Defense Medical Center
01/2015–present Editorial board of the Chinese Pharmacopoeia

Academic Expertise

Medicinal chemistry, Organic synthesis, Peptide chemistry, Organic spectroscopy, Pharmacology

Introduction to Laboratory

The research interests in my Lab are focused on design, synthesis and biological evaluation of new synthetic compounds for relative pharmacological activities, based on current knowledge and technique on medicinal chemistry, organic synthesis, and spectroscopic analysis. The recent research activities include development of amino acid derivatives, small peptides, or multi-targeted molecules with -secretase inhibitory and amyloid- autophagic modulating activities, rational design of specific histone deacetylase inhibitors as new neurodegenerative entities, and exploration of selective histone deacetylase inhibitors for certain cancer therapies. You would make it easy to find career on biological, pharmaceutical, chemical or food technologies after graduation from the Institute.

Major Publications

1. Hu, M. K.,a* Liao, Y. F., b* Chen, J. F.,a Wang, B. J., b Tung, Y. T.,b Lin, H. C.,c Lee, K. P.a New 1,2,3,4-Tetrahydroisoquinoline derivatives as modulators of proteolytic cleavage of amyloid precursor proteins. Bioorg. Med. Chem. 2008, 16 (4), 1957-65. JCR 2016, IF = 2.930, 22/60 (Medicinal Chemistry)
2. Tung, Y. T., Hsu, W. M., Wang, B. J., Wu, S. Y., Yen, C. T., Hu, M. K.,* Liao, Y. F.* Sodium selenite inhibits -secretase activity through activation of ERK. Neurosci. Lett. 2008, 440, 38-43. JCR 2010, IF = 2.055, 161/239 (Neuroscience)
3. Lan-Hsin Kuo†§, Ming-Kuan Hu¶, Wen-Ming Hsu#, Ying-Tsen Tung†§, Wang- Wei Tsai†, Chen-Tung Yen§, and Yung-Feng Liao†§*. TNF-α-elicited stimulation of γ-secretase is mediated by JNK-dependent phosphorylation of presenilin and nicastrin. Mol. Biol. Cell 2008, 19, 4201-12. JCR 2010, IF = 5.861, 42/178 (Cell Biology)
4. Fu-Chu Yang, Kuo-HuiWu,* Ming-Jie Liu, Wen-Po Lin, Ming-Kuan Hu. Evaluation of the antibacterial efficacy of bamboo charcoal/silver biological protective material. Mater. Chem. Phys. 2009, 113, 474-479. JCR 2007, 42/190, IF = 1.871.
5. Fu-Chu Yang, Kuo-Hui Wu,* Wen-Po Lin, Ming-Kuan Hu. Preparation and antibacterial efficacy of bamboo charcoal/polyoxometalate biological protective material. Micropor. & Mesopor. Mat. 2009, 118, 467–472. JCR 2011, 39/232, IF = 3.285 (Materials Science, Multidisciplinary)
6. Fu-Chu Yang, Kuo-Hui Wu, Wen-Po Lin, Ming-Kuan Hu, Tsung-Sheng Sheu, and Deng-Nan Horng. Preparation and Antibacterial Effect of Bamboo Charcoal/Ag on Staphylococcus aureus and Pseudomonas aeruginosa. J. Chin. Chem. Soc. 2009, 56, 327-334. JCR 2011, 111/154, IF = 0.678.
7. Fu-Chu Yang, Kuo-Hui Wu, Hsiu-Wen Yang, Jen-Wei Huang, Wen-Po Lin, Deng-Nan Horng, and Ming-Kuan Hu. Preparation and Antibacterial activity of Non-woven Fabric with Titanium dioxide/Silver. Chemistry (Chin. Chem. Soc. Taipei) 2009, 67, 93-99.
8. Shi-Ping Lian, Ling-Yih Hsu, Wen-Po Lin, Fu-Chu Yang, and Ming-Kuan Hu. Synthetic N-(Hydroxy)urea-based Dipeptides as Potential Antibacterial Agents. J. Med. Sci. 2009, 29, 309-313.
9. Hsiu-Hao Chang, Hsinyu Lee, Ming-Kuan Hu, Po-Nien Tsao, Hsueh-Fen Juan, Min-Chuan Huang, Yu-Yin Shih, Bo-Jeng Wang, Yung-Ming Jeng, Christina Ling Chang, Shiu-Feng Huang, Yeou-Guang Tsay, Fon-Jou Hsieh, Kai-Hsin Lin, Wen-Ming Hsu, and Yung-Feng Liao. Notch1 Expression Predicts an Unfavorable Prognosis and Serves as a Therapeutic Target of Patients with Neuroblastoma. Clin. Cancer Res. 2010, 16(17), 4411-20. JCR 2010, IF = 7.338, 16/185 (Oncology).
10. Fu-Chu Yang, Kuo-Hui Wu, Jen-Wei Huang, Deng-Nan Horng, Chia-Feng Liang, Ming-Kuan Hu. Preparation and characterization of functional fabrics from bamboo charcoal/silver and titanium dioxide/silver composite powders and evaluation of their antibacterial efficacy. Mater. Sci. Engine. C 2012, 32, 1062-1067. JCR 2011, 10/25, IF=2.686 (Materials Science, Biomaterials).
11. Tung, Y.T., Wang, B. J., Hu, M. K., Hsu, W. M.; Lee, H.; Huang, W. P.; Liao, Y. F.* Autophagy: A double-edged sword in Alzheimer’s disease. J. Biosci. 2012, 37(1), 157-165. JCR 2016, IF = 1.422, 47/85 (Biology).
12. Bo-Jin Zhou, Ming-kung Yeh, Ming-Kuan Hu. The importance of Medication adherence. J. Taiwan Pharm. 2012, 28, 137-142.
13. Chen, P. T.; Lin, W.P.; Lee, A.-R.; Hu, M. K.* New 7-[4-(4-(un)Substituted)piperazine-1-carbonyl]-piperazin-1-yl] Derivatives of Fluoroquinolone: Synthesis and Antimicrobial Evaluation. Molecules 2013, 18, 7557-7569. IF = 2.861 (11/59, JCR 2016, Chemistry, Organic).
14. Tung, Y. T.; Her, G. M.; Wang, B. J.; Hsu, W. M.; Hu, M. K.; Huang, W. P., Liao, Y. F.* Presenilin-1 regulates the expression of p62 to govern p62-dependent Tau degradation. Mol. Neurobiol. 2014, 49, 10-27. IF = 5.471 (37/252 in Neuroscience).
15. Chen, C. Y., Liao, Y. F., Chang, M. Y., Hu, M. K.* Difluorophenylglycinols as new modulators of proteolytic processing of amyloid precursor proteins. Arch. Pharm. Chem. Life Sci. 2014, 347, 161-173. IF = 1.994 (81/165, JCR 2016, Chemistry Multidisciplinary).
16. Lai, W. B.; Wang, B. J.; Hu, M. K.; Hsu, W. M.; Her, G. M.; Yung-Feng Liao, Y. F.* Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway. Molecular Neurobiology 2014, 49, 1055-1068. (IF = 5.471, 37/252 in Neuroscience)
17. Chang, W. K.;* Yeh, M. K.; Hsu, H. C.; Chen H. W. and Hu, M. K. Efficacy of simethicone and N-acetylcysteine as premedication in improving visibility during upper endoscopy. Journal of Gastroenterology and Hepatology 2014, 29, 769-774. (IF = 3.325)
18. Liao, Y. F.; Tang, Y. C.; Chang, M. Y.; Wang, B. J.; Hu, M. K.* Discovery of small molecular (D)-leucinamides as potent, Notch-sparing -secretase modulators. Eur. J. Med. Chem. 2014, 79, 143-151. (May 22). IF = 4.519 (4/60, 2015, JCR 2016, Chemistry, Medicinal)
19. Kang-Po Li, Ming-Kuan Hu, Clifton Kwang-Fu Shen, Wei-Yu Lin, Shuang Hou, Li-Bo Zhao, Cheng-Yi Cheng, Daniel. H. Shen. Improved and optimized one-pot method for N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) synthesis using microwaves. Appl. Radiat. Isot. 2014, 94, 113-117. (SCI, IF = 1.231)
20. Jia-Suey Gau, Wen-Pao Lin, Li-Ching Kuo, Ming-Kuan Hu*. Nitazoxanide analogues as antimicrobial agents against nosocomial pathogens. Med. Chem. 2016, 12 (6), 544-552. (Chemistry, Medicinal, 35/60, 2015, JCR, IF = 2.331)
21. Chin-Lan Fu, Li-Hsin Hsu, Yung-Feng Liao, Ming-Kuan Hu.* New Hydroxyquinoline-based Derivatives as Potent Modulators of Amyloid- Aggregations. Arch. Pharm. Chem. Life Sci. 2016, 349, 327-341. IF = 1.994 (81/165, JCR 2016, Chemistry Multidisciplinary).
22. Bo-Jen Wang, Guor Mour Her, Ming-Kuan Hu, Yun-Wen Chen, Ying-Tsen Tung, Pei-Yi Wu, Wen-Ming Hsu, Hsinyu Lee, Lee-Way Jin, Sheng-Ping Hwang, Rita Chen, Chang-Jen Huang, Yung-Feng Liao. ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. PNAS 2017, E3129-E3138. (IF = 9.661, JCR 2016; IF = 9.580, JCR 2018, 7/69, Multidisciplinary Sciences). www.pnas.org/cgi/doi/10.1073/pnas.1618804114.
23. Kang-Po Li, Ming-Kuan Hu, Cheng-Yi Cheng, Li-Fan Hsu, Ta-Kai Chou, Chyng-Yann Shiue, Daniel H. Shen. A practical and pyrogen-free preparation of 11C-L-methionine in a good manufacturing practice-compliant approach. J. Med. Sci. 2017, 37, 7-11.
24. Hue-Yu Wang, Ming-Kung Yeh, Chung-Han Ho, Ming-Kuan Hu and Yaw-Bin Huang. Cross-sectional investigation of drug-related problems among adults in a medical center outpatient clinic: application of virtual medicine records in the cloud. Pharmacoepidemiol. Drug Safety 2017, 26, 71-80. (IF = 2.908, 82/255, Pharmacology & Pharmacy, JCR 2015).
25. Lu JW, Hsieh PS, Lin CC, Hu MK, Huang SM, Liang CY, Gong Z, Ho YJ. Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus. Biochem. Biophys. Res. Commun. 2017, 491, 595-602. (IF = 2.466; R/C=163/286, Biochemistry & Molecular Biology)
26. Kuo-Feng Huang, Kuo-Hsing Ma, Yu-Chien Hung, Liang-Chuan Lo, Kuo-Chen Lin, Pei-Shan Liu, Ming-Kuan Hu,* Sheau-Huei Chueh.* A new copper ionophore DPMQ protects cells against ultraviolet B irradiation by inhibiting TRPV1 channel. J. Cell. Physio. 2018, 233, 9594-9610. DOI: 10.1002/jcp.26861 (IF = 4.522, JCR 2018, 11/81, Physiology)
27. Yi-Jung Ho, Feng-Cheng Liu, Chia-Tsui Yeh, Chuen Mi Yang, Chang-Chi Lin, Te-Yu Lin, Po-Shiuan Hsieh, Ming-Kuan Hu, Zhiyuan Gong, Jeng-Wei Lu. Micafungin is a novel anti-viral agent of chikungunya virus through multiple mechanisms. Antiviral Res. 2018, 159, 134-142. (IF = 4.13, JCR, 9/36, Virology)
28. Fu-Kai Chuang, Ching-Len Liao, Ming-Kuan Hu, Yi-Lin Chiu, An-Rong Lee,
Shih-Ming Huang, Yu-Lung Chiu, Pei-Ling Tsai, Bo-Cyuan Su, Tsung-Hsien Chang, Chang-Chi Lin, Chih-Chin Shih and Li-Chen Yen.* Antiviral Activity of Compound L3 against Dengue and Zika Viruses In Vitro and In Vivo. Int. J. Mol. Sci. 2020, 21, 4050; doi:10.3390/ijms21114050
29. Ting-Yu Chin,* Che-Chuan Wang,* Kuo-Hsing Ma,* Chia-Wei Kuo, Ming-Kuan Hu,* and Sheau-Huei Chueh.* Antioxidative effect of DJ-1 is enhanced in NG108-15 cells by DPMQ induced copper influx. Am. J. Physiol. Cell Physiol. 2021, 320, C635-C651.

Patent

1. Hu, M. K. N-Benzoyl-alpha-alkylated azatyrosines as anticancer agents. 2000, U.S. Patent 6037357.
2. Hu, M. K.; Shaw, J. Tacrine Derivatives for Treating Alzheimer’s Disease. 2001, U.S. Patent 6194403.
3. Manufacturing method of bamboo charcoal supporting silver and products thereof. Kuo-Hui Wu, Fu-Chu Yang, Wen-Po Lin, Ming-Kuan Hu. US 7,629,293 B2, 2009, term 10 yr.
4. Ming-Kuan Hu and Yung-Feng Liao. 1,2,3,4-Tetrahydroisoquinoline derivatives, preparation process therefor and pharmaceutical composition containing the same. May 8, 2012, US 8,173,648 B2. (Term, 2028/7/18)
5. Ming-Kuan Hu and Yung-Feng Liao. 1,2,3,4-Tetrahydroisoquinoline derivatives, preparation process therefor and pharmaceutical composition containing the same. 2012, ROC I 364279 (Term 2028/4/30).

Major Conference Papers

1. Ming-Kuan Hu,* Jun-Fong Chern, Kang-Po Li, Yung-Feng Liao. Conformationally restricted derivatives of selegiline as modulators of proteolytic processing of amyloid precursor proteins. 1st European Chemistry Congress. Aug. 27-31, 2006, Budapest, Hungary.
2. Shy-Ping Liang, Ming-Kuan Hu. Synthesis and Antibacterial Activities of N-(Hydroxy)ureido Dipeptides. 1st Pharmaceutical Science World Congress, April 22-25, 2007, Amsterdam, Netherlands.
3. Po-Jung Chen, Yung-Feng Liao, Ming-Kuan Hu. Development of a type of N-ubstituted-4-arylsulfonylpiperidine derivatives as new -secretase inhibitors. Tenth Tetrahedron Symposium. 23-26, June 2009, Paris, France.
4. Ming-Kuan Hu, Po-Ting Chen and Wen-Po Lin. Synthesis and antibacterial activities of new ciprofloxacin-based derivatives, March 14-17, 2010, Muster, Germany.
5. Po-Jung Chen, Yung-Feng Liao, Ming-Kuan Hu. Development of a type of N-ubstituted-4-arylsulfonylpiperidine derivatives as new -secretase inhibitors. Lipid Symposium. June 6-11, 2010, Kyoto, Japan.
6. Ming-Kuan Hu and Po-Ting Chen. 7-(4’-Piperazino)carbonyl Derivatives of Ciprofloxacin: Synthesis and Antibacterial Activities. 2011 3rd International Symposium on Metallomics, June 15-18, 2011, Munster, Germany.
7. Ming-Kuan Hu, Chia-Yu Chen, Yung-Feng Liao. (R)- and (S)-Difluorophenylglycinols: Efficient synthesis and biological activities. 19th International Symposium on Organic Synthesis, July 1-6, 2012, Melbourne, Australia.
8. Ming-Kuan Hu. Curriculum of National Defense Medical Center School of Pharmacy (4-Yr Program). 3rd Asian Association of School of Pharmacy (AASP) Pharmacy Dean Forum. June 28-29, 2014, Tokyo, Japan.
9. Ming-Kuan Hu*, Chin-Lan Fu, Yei-Yang Yeh. Bifunctional modulators of Aβ aggregation as potential agents for Alzheimer’s disease therapy. Neurological Disease Summit, July 6-8, 2015, San Francisco, USA.
10. Ming-Kuan Hu*, Chin-Lan Fu, Yei-Yang Yeh. Bifunctional modulators of Aβ aggregation as potential agents for Alzheimer’s disease therapy. 2015 Asian Association of Schools of Pharmacy (AASP) Conference, Oct. 30- Nov. 2, 2015, Taipei, Taiwan.
11. Ming-Kuan Hu*, Chin-Lan Fu, Li-Hsin Hsu. Quinoline-based molecules as advanced modulators of amyloid- aggregation. 10th International Symposium for Chinese Medicinal Chemists (10th ISCMC). Jan. 18-24, 2016, Miaoli, Taiwan.
12. Ming-Kuan Hu*, Chin-Lan Fu, Li-Hsin Hsu. Spectrometric analysis for quinoline derivatives as modulators of amyloid- aggregation. 44th International Symposium on High Performance Liquid Phase Separations and Related Techniques. June 19-24, 2016, San Francisco, CA, USA.
13. Ming-Kuan Hu* Yung-Feng Liao2, Yu-Chia Hsu, Yeu-Cherng Tang1, Ming-Yun Chang2, Bo-Jeng Wang.2 New N-Arylsulfonyl-(D)-leucinamides as Multi-targeted -Secretase Modulators. 3rd Neurological Disease Summit, July 6-8, 2017, San Francisco, USA.
14. Ming-Kuan Hu*, Shi-Yaw Tan, Ann Chen. Exploration of autophagic modulators of Aβ production for inactivating the targeted inflammasomes. 2018 Annual Meeting of the Federation of Clinical Immunology Societies. June 20-23, 2018, San Francisco, CA, USA.
15. Ming-Kuan Hu*, Yung-Feng Liao, An-Syun Liou, Jia-Hao Hsu, Fu-Chu Yang. Exploration of kinase inhibitors as autophagic modulators of Abeta production. 11th Joint Meeting on Medicinal Chemistry 2019 (JMMC-1029). June 27-30, 2019, Praha, CZ.