E-MAIL

hueiru_yan@mail.ndmctsgh.edu.tw

Experience

2002/8 ~ 2012/10 Hygiene Administrator, General Work Office, Tri-Service Hygiene Supplies Division
2009/8 ~ 2010/7 Adjunct Lecturer, School of Pharmacy, National Defense Medical Center
2012/10 ~ 2013/8 Purchasing Officer, Hygiene Supplies and Maintenance Department, Tri-Service General Hospital
2013/9 ~ 2021/10 Research Assistant, Institute of Preventive Medicine, National Defense Medical Center
2020/8 ~ 2021/11 Adjunct Assistant Professor, School of Pharmacy, National Defense Medical Center
2021/11 ~ nowFull-time assistant professor, School of Pharmacy, National Defense Medical Center

Research Interest

Medicinal Chemistry, Pharmaceutical Analysis, Biomedical Applications of Nanomaterials

Short Biography

I am mainly committed to the development of novel nanocarriers and their applications in biomedicine. The main nano-carriers include: polysaccharide nanoparticles, nano-gold, nano-silver, etc. To make medicines utilizatized by organism, my idea is to use the low toxicity, biocompatibility, biodegradability, different charges and high water solubility of natural polymer molecules to make the above-mentioned nanocarriers stable in aqueous solution, and to accelerate the above-mentioned nanocarriers. The research results include: the application of gold nanoparticles in the transportation of cancer targets; and the breakthrough research discoveries of glycan nanospheres in the transportation of proteins and as vaccine adjuvants.

Publications

1. Tsung-Neng Tsai, Hui-Ju Yen, Cheng-cheung Chen, Ying-chuan Chen, Yen-an Young, Kuang-ming Cheng, Jenn-jong Young* and Po-da Hong, “Novel protein-loaded chondroitin sulfate-N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan nanoparticles with reverse zeta potential: Preparation, characterization, and ex vivo assessment” Journal of Materials Chemistry B 3 (44), 8729-8737 (Oct. 2015). IF=6.331

2. Jenn-jong Young, Cheng-cheung Chen, Ying-chuan Chen, Kuang-ming Cheng, Hui-Ju Yen, Yu-chuan Huang and Tsung-Neng Tsai*, “Positively and negatively surface-charged chondroitin sulfate-trimethylchitosan nanoparticles as protein carriers” Carbohydrate Polymers 137, 532-540 (Feb. 2016). IF=9.381

3.Jenn-jong Young, Kuang-ming Cheng, Yen-an Young, Xin-an Chen, Yu-hao Chen, Tein-yao Chang, Hui-ju Yen, Cheng-cheung Chen*, “Chondroitin sulfate-stabilized silver nanoparticles improved synthesis and their catalytic, antimicrobial, and biocompatible activities” Carbohydrate Research 457 (Jan. 2018) 14-24. IF=1.873

4. Hui-ju Yen, Yen-an Young, Tsung-neng Tsai, Kuang-ming Cheng, Xin-an Chen, Yin-chuan Chen, Cheng-cheung Chen, Jenn-jong Young*, Po-da Hong*, “Positively charged gold nanoparticles capped with folate quaternary chitosan: Synthesis, cytotoxicity and uptake by cancer cells” Carbohydrate Polymers 183, 140-150 (March 2018). IF=9.381

5. Chuan-Chang Chuang, Meng-Hung Tsai, Hui-ju Yen, Huey-Fen Shyu, Kuang-ming Cheng, Xin-an Chen, Cheng-cheung Chen, Jenn-jong Young*, Jyh-Hwa Kau*, “A fucoidan-quaternary chitosan nanoparticle adjuvant for anthrax vaccineas an alternative to CpG oligodeoxynucleotides” Carbohydrate Polymers 229 (2020) 1154032 (Feb. 2020). IF=9.381

6. Meng-Hung Tsai, Chuan-Chang Chuang, Cheng-cheung Chen, Hui-ju Yen, Kuang-ming Cheng, Xin-an Chen, Huey-Fen Shyu, Chia-ying Lee, Jenn-jong Young*, Jyh-Hwa Kau*, “Nanoparticles assembled from fucoidan and trimethylchitosan as anthrax vaccine adjuvant: In vitro and in vivo efficacy in comparison to CpG” Carbohydrate Polymers 236 (2020) 116041 (May, 2020). IF=9.381

7. Chia-ying Chin, Cheng-cheung Chen, Xin-an Chen, Hui-ju Yen, Hsin-lun Hsien, Jenn-jong Young*, Yin-chuan Chen**, “High sensitivity enhancement of multi-shaped silver-nanoparticle-decorated hydrophilic PVDF-based SERS substrates using solvating pretreatment” Sensors and Actuators: B. Chemical 347 (2021) 130614 (Aug. 2021). IF=7.46

8.Cheng-Cheung Chen, Yih-Yuan Chen, Chang-Ching Yeh, Chia-Wei Hsu, Shang-Jie Yu, Chih-Hao Hsu, Ting-Chun Wei, Sin-Ni Ho, Pei-Chu Tsai, Yung-Deng Song, Hui-Ju Yen, Xin-An Chen, Jenn-Jong Young, Chuan-Chung Chuang and Horng-Yunn Dou*, “Alginate-capped silver nanoparticles as a potent anti-mycobacterial agent against Mycobacterium tuberculosis” Frontiers in Pharmacology 12 (2021) 746496 (Nov.2021) IF=2.975