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Department of Biomedical Engineering

::: Faculty

陳耀昌 Professor, Head

陳耀昌 Professor, Head      
Yao-Chang Chen




Bachelor, Electrical Engineering, Culture University
Master, Medicine Engineering, Chung Yuan Christian University
Ph.D. National Sun Yat-sen University Institute of Marine Biotechnology and Resources






Lecturer in Biomedical Engineering, National Defense Medical Center
assistant professor
Associate Professor

Specialty discipline

1. Cardiac electrophysiology
2. Cell clamp and ion current
3. Electronic circuit design

Other Info

1.       Chen YC, Kao YH, Huang CF, Cheng CC, Chen YJ, Chen SA. Heat stress responses modulate calcium regulations and electrophysiological characteristics in atrial myocytes. J Mol Cell Cardiol. 2010 Apr;48(4):781-8.

2.       Tsai CF, Chen YC, Lin YK, Chen SA, Chen YJ*. Electromechanical effects of the direct renin inhibitor (aliskiren) on the pulmonary vein and atrium. Basic Res Cardiol. 2011 Nov;106(6):979-93.

3.       Lin YK, Chen YC, Chen JH, Chen SA, Chen YJ*. Adipocytes modulate the electrophysiology of atrial myocytes: implications in obesity-induced atrial fibrillation. Basic Res Cardiol. 2012 Sep;107(5):293.

4.       Lu YY, Chen YC, Kao YH, Chen SA, Chen YJ*. Extracellular matrix of collagen modulates arrhythmogenic activity of pulmonary veins through p38 MAPK activation. J Mol Cell Cardiol. 2013 Jun;59:159-66.

5.       Chang CJ, Chen YC, Kao YH, Lin YK, Chen SA, Chen YJ*. Dabigatran and thrombin modulate electrophysiological characteristics of pulmonary vein and left atrium. Circ Arrhythm Electrophysiol. 2012 Dec;5(6):1176-83.

6.       Lin YK, Chen YC, Huang JH, Lin YJ, Huang SS, Chen SA, Chen YJ. Leptin modulates electrophysiological characteristics and isoproterenol-induced arrhythmogenesis in atrial myocytes. J Biomed Sci. 2013 Dec 20;20:94.

7.       Chen YC, Lu YY, Cheng CC, Lin YK, Chen SA, Chen YJ. Sinoatrial node electrical activity modulates pulmonary vein arrhythmogenesis. Int J Cardiol. 2014 May 15;173(3):447-52.

8.       Lu YY, Chung FP, Chen YC, Tsai CF, Kao YH, Chao TF, Huang JH, Chen SA, Chen YJ. Distinctive electrophysiological characteristics of right ventricular out-flow tract cardiomyocytes. J Cell Mol Med. 2014 Aug;18(8):1540-8.

9.       Kao YH, Chen YC, Lin YK, Shiu RJ, Chao TF, Chen SA, Chen YJ. FGF-23 dysregulates calcium homeostasis and electrophysiological properties in HL-1 atrial cells. Eur J Clin Invest. 2014 Aug;44(8):795-801.

10.   Lin YK, Chen YC, Kao YH, Tsai CF, Yeh YH, Huang JL, Cheng CC, Chen SA, Chen YJ. A monounsaturated fatty acid (oleic acid) modulates electrical activity in atrial myocytes with calcium and sodium dysregulation. Int J Cardiol. 2014 Sep;176(1):191-8.

11.   Lkhagva B, Chang SL, Chen YC, Kao YH, Lin YK, Chiu CT, Chen SA, Chen YJ. Histone deacetylase inhibition reduces pulmonary vein arrhythmogenesis through calcium regulation. Int J Cardiol. 2014 Dec 20;177(3):982-9.

12.   Chen WT, Chen YC, Hsieh MH, Huang SY, Kao YH, Chen YA, Lin YK, Chen SA, Chen YJ. The Uremic Toxin Indoxyl Sulfate Increases Pulmonary Vein and Atrial Arrhythmogenesis. J Cardiovasc Electrophysiol. 2015 Feb;26(2):203-10.

13.   Chen YC, Wen ZH, Lee YH, Chen CL, Hung HC, Chen CH, Chen WF, Tsai MC. Dihydroaustrasulfone alcohol inhibits PDGF-induced proliferation and migration of human aortic smooth muscle cells through inhibition of the cell cycle. Mar Drugs. 2015 Apr 17;13(4):2390-406.

14.   Tsai WC, Lu YY, Chen YC, Chang CJ, Kao YH, Lin YK, Chen YH, Chen SA, Yang LY, Chen YJ. Ablation of androgen receptor gene triggers right ventricular outflow tract ventricular tachycardia. Int J Cardiol. 2015 Jun 15;189:172-81.

15.   Huang SY, Chen YC, Kao YH, Hsieh MH, Chen YA, Chen WP, Lin YK, Chen SA, Chen YJ. Renal failure induces atrial arrhythmogenesis from discrepant electrophysiological remodeling and calcium regulation in pulmonary veins, sinoatrial node, and atria. Int J Cardiol. 2016 Jan 1;202:846-857.

16.   Lu YY, Cheng CC, Chen YC, Lin YK, Chen SA, Chen YJ*. Electrolyte disturbances differentially regulate sinoatrial node and pulmonary vein electrical activity: A contribution to hypokalemia- or hyponatremia-induced atrial fibrillation. Heart Rhythm. 2016 Mar;13(3):781-8.

17.   Lu YY, Lin YK, Wen ZH, Chen YC*, Chen SA, Chen YJ. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Clin Sci (Lond). 2016 May;130(9):721-32. (SCI) *Corresponding Author

18.   Lu YY, Chen YC, Kao YH, Lin YK, Yeh YH, Chen SA, Chen YJ*. Colchicine modulates calcium homeostasis and electrical property of HL-1 cells. J Cell Mol Med. 2016 Jun;20(6):1182-90.

19.   Huang JH, Chen YC, Lee TI, Kao YH, Chazo TF, Chen SA, Chen YJ*. Glucagon-like peptide-1 regulates calcium homeostasis and electrophysiological activities of HL-1 cardiomyocytes. Peptides. 2016 Apr;78:91-8.

20.   Lkhagva B, Kao YH, Chen YC, Chao TF, Chen SA, Chen YJ*. Targeting histone deacetylases: A novel therapeutic strategy for atrial fibrillation. Eur J Pharmacol. 2016 Jun 15;781:250-7.

21.   Chang CJ, Cheng CC, Chen YC, Kao YH, Chen SA, Chen YJ*. Gap junction modifiers regulate electrical activities of the sinoatrial node and pulmonary vein: Therapeutic implications in atrial arrhythmogenesis. Int J Cardiol. 2016 Oct 15;221:529-36.

22.   Lin YK, Chen YC, Chen YA, Yeh YH, Chen SA, Chen YJ*. B-Type Natriuretic Peptide Modulates Pulmonary Vein Arrhythmogenesis: A Novel Potential Contributor to the Genesis of Atrial Tachyarrhythmia in Heart Failure. J Cardiovasc Electrophysiol. 2016 Dec;27(12):1462-1471.

23.   Huang SY, Chen YC, Kao YH, Hsieh MH, Lin YK, Chung CC, Lee TI, Tsai WC, Chen SA, Chen YJ*. Fibroblast growth factor 23 dysregulates late sodium current and calcium homeostasis with enhanced arrhythmogenesis in pulmonary vein cardiomyocytes. Oncotarget. 2016 Oct 25;7(43):69231-69242.

24.   Weng CH, Chung FP, Chen YC, Lin SF, Huang PH, Kuo TB, Hsu WH, Su WC, Sung YL, Lin YJ, Chang SL, Lo LW, Yeh HI, Chen YJ, Hong YR, Chen SA, Hu YF. Pleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia. Sci Rep. 2016 Dec 14;6:38894. doi: 10.1038/srep38894. (SCI)

25.   Lin YK, Cheng CC, Tsai MC, Wu PY, Chen YA, Chen YC*, Chen SA, Chen YJ*. Mitochondrial dysfunction on sinoatrial node and pulmonary vein electrophysiological activities. Exp Ther Med. 2017 May;13(5):2486-2492. (SCI) *equal to corresponding Author

26.   Chang JH, Chang SL, Hong PD, Chen PN, Hsu CH*, Lu YY*, Chen YC*. Epigallocatechin-3-gallate modulates arrhythmogenic activity and calcium homeostasis of left atrium. Int J Cardiol. 2017 Jun 1;236:174-180. (SCI) *equal to corresponding Author

27.   Huang SY, Chen YC, Kao YH, Hsieh MH, Lin YK, Chen SA, Chen YJ*. Redox and Activation of Protein Kinase A Dysregulates Calcium Homeostasis in Pulmonary Vein Cardiomyocytes of Chronic Kidney Disease. J Am Heart Assoc. 2017 Jul 12;6(7). pii: e005701. doi: 10.1161/JAHA.117.005701. (SCI)

28.   Lu YY, Wu WS, Lin YK, Cheng CC, Chen YC*, Chen SA, Chen YJ*. Angiotensin 1-7 modulates electrophysiological characteristics and calcium homoeostasis in pulmonary veins cardiomyocytes via MAS/PI3K/eNOS signalling pathway. Eur J Clin Invest. 2018 Jan;48(1). (SCI) *equal to corresponding Author

29.   Lin YK, Chen YC, Chen YA, Huang JH, Chen SA, Chen YJ*. Levosimendan differentially modulates electrophysiological activities of sinoatrial nodes, pulmonary veins, and the left and right atria. J Cardiovasc Electrophysiol. 2018 Aug;29(8):1150-1158. (SCI)

30.   Chang CJ, Cheng CC, Chen YC, Higa S, Huang JH, Chen SA, Chen YJ*. Factor Xa inhibitors differently modulate electrical activities in pulmonary veins and the sinoatrial node. Eur J Pharmacol. 2018 Aug 15;833:462-471. (SCI)

31.   Chung CC, Lin YK, Chen YC, Kao YH, Yeh YH, Chen YJ*. Factor Xa inhibition by rivaroxaban regulates fibrogenesis in human atrial fibroblasts with modulation of nitric oxide synthesis and calcium homeostasis. J Mol Cell Cardiol. 2018 Oct;123:128-138. (SCI)

32.     Chan CS, Chen YC, Chang SL, Lin YK, Kao YH, Chen SA, Chen YJ*. Heart Failure Differentially Modulates the Effects of Ivabradine on the Electrical Activity of the Sinoatrial Node and Pulmonary Veins. J Card Fail. 2018 Oct 5. pii: S1071-9164(18)31061-3. (SCI)

33.    Chang CC, Li SJ, Chen YC, Huang SY, Chen SA, Chen YJ*. Histone deacetylase inhibition attenuates atrial arrhythmogenesis in sterile pericarditis. Translational Research, 2018 200:p54-64. (SCI)

34.   Lee TI, Chen YC, Lin YK, Chung CC, Lu YY, Kao YH, Chen YJ. Empagliflozin Attenuates Myocardial Sodium and Calcium Dysregulation and Reverses Cardiac Remodeling in Streptozotocin-Induced Diabetic Rats. Int J Mol Sci. 2019 Apr 4;20(7).

35.   Huang JH, Chen YC, Lu YY, Lin YK, Chen SA, Chen YJ. Arginine vasopressin modulates electrical activity and calcium homeostasis in pulmonary vein cardiomyocytes. J Biomed Sci. 2019 Sep 17;26(1):71. doi: 10.1186/s12929-019-0564-3.

36.   Lu YY, Cheng CC, Wu HJ, Lin YK*, Chen YC*, Chen SA, Chen YJ. Effects of ANP on pulmonary vein electrophysiology, Ca2+ homeostasis and adrenergic arrhythmogenesis via PKA. Clin Exp Pharmacol Physiol. 2019 Oct 22. doi: 10.1111/1440-1681.13199.

37.   Cheng WL, Kao YH, Chen YC, Lin YK, Chen SA, Chen YJ. Macrophage migration inhibitory factor increases atrial arrhythmogenesis through CD74 signaling. Transl Res. 2019 Oct 5. pii: S1931-5244(19)30213-0. doi: 10.1016/j.trsl.2019.10.002.

  • Update Date:2019-10-03