Professional Experiences

1.Resident of Pediatrics, Tri-Service General Hospital
( 1993-1996 )
2.Fellowship of Pediatric Neurology, Taipei Veterans General Hospital
( 1996-1998 )
3. Visting doctor of Pediatrics, Tri-Service General Hospital
( 1998-2001 and 2005-2008; 2016-2017)
4. PhD program, Institute of Medical Sciences, National Defense Medical Center, Taiwan( 2001-2005)
5.Chief of division of Pediatric cardiology, department of Pediatrics, Tri-Service General Hospital ( 2008-2011)
6.Chief of department of Pediatrics, Tri-Service General Hospital
(2011-2013)
7. Superintendent, of Penhu Branch, Tri-Service General Hospital
(2013-2016)
8. Chief of department of Pediatrics, Tri-Service General Hospital
(2017-present)
9. Secretary General, Taiwan Child Neurology Society
,Taiwan (2017- present)
10. Vice Chief, Academic Committee, Taiwan Child Neurology Society
,Taiwan (2017- present)
11. Chief of department of Microbiology and Immunology, National Defense Medical Center, Taiwan (2018-present)
12. Council, Vaccine Injury Compensation Program, Taiwan (2016-present)

Research Interest

1. General Pediatrics,
2. Pediatric Neurology,
3. Neuroimmunology
4. Autoimmunity
5. Neurogenetics

Specialty

1. Pediatrics,
2. Pediatric Neurology,
3. Pediatric Emergency Medicine
4. Critical Care Medicine
POSTDOCTAL TRAINING

Professional Experiences

1993-1996 Resident of pediatrics in Tri-Service General Hospital (TSGH)
Taipei, Taiwan
1996-1998 Fellow of pediatric neurology in Veteran General Hospital,
Taipei, Taiwan
Instructor: Director, Kai-Peng Chang M.D.
1998~ Pediatric neurologist and attending physician in Tri-Service General Hospital, Taipei, Taiwan
2006.7~2010-8 Assistant Professor
2010-8~ 2016.2 Associate Professor
2016.2~ Professor
2008.5~2011.7 Chief of Section of Neurology, Department of Pediatrics, TSGH
2011.7~2013.2 Director, Department of Pediatrics, TSGH, NDMC
2013-2~2016.9 Superintendent, Peing-Hu Branch, TSGH.
2017.3~ Director, Department of Pediatrics TSGH, NDMC
2018-1~ Director, Department of Microbiology and Immunology, NDMC
2004 Travel Award for Asian Young Researcher of Japan Child Neurology Society
2008 Best Military Doctor of Ministry of National defense R.O.C.
2009 Inviting Speaker in AOCNA annual meeting
2010 Inviting Speaker in 10th ISS and ISENMD international meeting
2012 Best Teacher of Ministry of National defense R.O.C.
2009 10th Asian & Oceanian Congress of Child Neurology. Inviting Speaker and ISENMD Inviting Speaker: Shyi-Jou Chen.
2012,8th ASPR, Seoul, Korea. Invited Speaker: Shyi-Jou Chen.
2015 ASPR , Japan. section Chair
2015 AOCCN Treasurer, and invited speaker
2017~ Secretary General, Taiwan Child Neurology Society (TCNS).

Other Info

1.          Huang JS, Chang CC, Tai YM, Huang CP, Chen SJ, Tzeng NS. Am J Ther. 2019 Jun 19. doi: 10.1097/MJT.0000000000001017. [Epub ahead of print] Rapid-Onset Psychotic Symptoms After Interferon-β-1a Treatment of Multiple Sclerosis.

2.          Chen SJ, Lin GJ, Chen JW⁶, Wang KC⁸, Tien CH, Hu CF, Chang CN, Hsu WF, Fan HC, Sytwu HK  Int J Mol Sci. 2019 Mar 16;20(6). pii: E1332. doi: 10.3390/ijms20061332. Immunopathogenic Mechanisms and Novel Immune-Modulated Therapies in Rheumatoid Arthritis.

3.          Lee CL, Wang KC, Chen SJ, Chen CM, Tsai CP, Chen SY. Repetitive intrathecal injection of human NMO-IgG with complement exacerbates disease severity with NMO pathology in experimental allergic encephalomyelitis mice. Mult Scler Relat Disord. 2019 May;30:225-230. doi: 10.1016/j.msard.2019.02.025. Epub 2019 Feb 25.

4.          Hueng-Chuen Fan, Kai-Ping Chang, Shyi-Jou Chen,Ting-Rong Hsu, Jeng-Dau Tsai (2017, Dec). Vagus Nerve Stimulation for 6-12 Years Children with Refractory Epilepsy: The Result of Seizures Frequency and Parenting Stress Index . Epilepsy & Behavior, accepted. (Accepted). 

5.          Po-Chang Hsu, Shyi-Jou Chen* (2017, Dec). Longitudinal extensive transverse myelitis with an abnormal uFLC ratio in a pediatric patient: Case report and literature review. Medicine, accepted. (Accepted). 

6.          Yi-Jhih Huang, Tsai-Wang Huang, Tsu-Yi Chao, Yu-Shan Sun, Shyi-Jou Chen, Der-Ming Chu, Wei-Liang Chen and Li-Wei Wu (2017, May). Elevated serum tartrate-resistant acid phosphatase isoform 5a levels in metabolic syndrome. Ontotarget, 8:78144-78152. (SCI, 51/217, oncology).

7.          Lai CJ, Hsu TR, Yang CF, Chen SJ (Chen Shyi-Jou), Chuang YC, Niu DM. (2016, Dec). Cognitive Development in Infantile-Onset Pompe Disease Under Very Early Enzyme Replacement Therapy. J Child Neurol , 2016;31(14):1617-1621. . (SCI, 66/120, pediatrics).

8.          Yung-Liang Liu, Sung-SenYang, Shyi-Jou Chen, Yu-Chun Lin, Chin-Chen Chu, Hsin-Hui Huang, Fung-Wei Chang, Mu-Hsien Yu, Shih-Hua Lin, Gwo-Jang Wu, Huey-Kang Sytwu (2016, Nov). OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis. Scientific Reports, 2016;6:37205.

9.          Chien-Ming Lin, Hueng-Chuen Fan, Tsu-Yi Chao, Der-Ming Chu, Chi-Chieh Lai, Chih-Chien Wang and Shyi-Jou Chen1* (2016, May). Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic childrena medical center experience. BMC Pediatrics, 16:61. (SCI, 41/120, Pediatrics). Lin CM, Fan HC, Chao TY, Chu DM, Lai CC, Wang CC, Chen SJ*. Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic children- a medical center experience. BMC Pediatr. 2016 May 3;16:61.

10.      Ding JJ, Lee CM, Chen SJ, Wang CC, Juan CJ, Fan HC. Herpes Simplex Virus-related Transverse Myelitis and Polyneuritis. Pediatr Neonatol. 2016;57(4):355-6.

11.      Chen SJ, Huang SH, Chen JW, Wang KC, Yang YR, Liu PF, Lin GJ, Sytwu HK. Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis. Int Immunopharmacol. 2016 Feb;31:169-77.

12.      Lin MH, Yeh LT, Chen SJ, Chiou HY, Chu CC, Yen LB, Lin KI, Chang DM, Sytwu HK.T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells.  Clin Immunol. 2014 Apr;151(2):101-13.

13.      Chen SJ*. An Extended Way to Predict Neonatal Hypoxic Ischemic Encephalopathy. Pediatr Neonatol. 2015 Oct;56(5):283-4.

14.      Wang LW, Chang YC, Chen SJ, Tseng CH, Tu YF, Liao NS, Huang CC, Ho CJ. TNFR1-JNK signaling is the shared pathway of neuroinflammation and neurovascular damage after LPS-sensitized hypoxic-ischemic injury in the immature brain. J Neuroinflammation. 2014 Dec 24;11:215.

15.      Wang KC, Lin KH, Lee TC, Lee CL, Chen SY, Chen SJ, Chin LT, Tsai CP. Poor responses to interferon-beta treatment in patients with neuromyelitis optica and multiple sclerosis with long spinal cord lesions. PLoS One. 2014 Jun 2;9(6):e98192.

16.      Wang, Chien-Ying; Chiou, Guang-Yuh; Chien, Yueh; Wu, Chia-Chao³; Wu, Tzee-Chung; Lo, Wen-Tsung; Chen, Shyi-Jou; Chiou, Shih-Hwa; Peng, Ho-Jen; Huang, Ching-Fen. Induced Pluripotent Stem Cells Without c-Myc Reduce Airway Responsiveness and Allergic Reaction in Sensitized Mice. Transplantation 2013; 96(11): 958–965

17.      Kai-Chen Wang, Ching-Piao Tsai, Chao-Lin Lee, Shao-Yuan Chen, Gu-Jiun Lin , Mao-Hsiung Yen, Huey-Kang Sytwu, and Shyi-Jou Chen ∗ Alpha lipoic acid enhances endogenous peroxisome proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis . Clin Sci (Lond). 2013 Oct;125(7):329-40

18.      C-F Hu, H-C Fan , C-F Chang , S-J Chen*. Current Approaches to the Treatment of Head Injury in Children.  Pediatr Neonatol. 2013 Apr;54(2):73-81.

19.      W-D Lin, K-P Chang, C-H Wang, S-J Chen, P-C Fan, W-C Weng, W-C Lin, Y Tsai, C-H Tsai, I-C Chou*, F-J Tsai. Molecular Aspects of Dravet Syndrome Patients in Taiwan. Clinica Chimica Acta (in press)

20.      K.-C. WANG, C.-P. TSAI, C.-L. LEE, S.-Y. CHEN, L.-T. CHIN * AND S.-J. CHEN * Elevated plasma high-mobility group box 1 protein is a potential marker for neuromyelitis optica. Neuroscience. 2012;226:510-6. (SCI, IF :3.38)

21.      K-C Wang, Lee C-L, Chen SY, Chen J-C, Yang C-W, Chen S-J, * and Ching-Piao, Tsai C-P* Distinct Serum Cytokine Profiles in Neuromyelitis Optica and Multiple Sclerosis  Journal of Interferon & Cytokine Research ( accepted, SCI )

22.      Liaw F-Y, Wang C-C, Chang Y-W, Chen S-J*. Community-acquired Streptococcus Viridans Pneumonia in a Healthy Child. Indian Pediatr 2012; 49:48-50. (SCI)

23.      Wang YL, Chou FC, Chen SJ, Lin SH, Chang DM, Sytwu HK. Targeting pre-ligand assembly domain of TNFR1 ameliorates autoimmune diseases - An unrevealed role in downregulation of Th17 cells. Journal of Autoimmunity 2011;37:160-170. (SCI)

24.      Wang K.C., Tsai C.P., Lee C.L., Chen S.Y., Chen S.J.* The Prevalence of Long Spinal Cord Lesions and Anti-Aquaporin 4 Antibodies in Neuromyelitis Optica Patients in Taiwan, European Neurology (accepted). (SCI)

25.      Fan HC, Hu CF, Jung CJ, Chen SJ*. Current Proceedings of Childhood Stroke. (accepted) Stroke Research and Treatment (PubMed and PubMed Central)

26.      Wang K.C., Tsai C.P., Lee C.L., Chen S.Y., Chen S.J.* The Prevalence of Long Spinal Cord Lesions and Anti-Aquaporin 4 Antibodies in Neuromyelitis Optica Patients in Taiwan, European Neurology 2011;65:99–104 (SCI)

27.      Chen SJ, Wang YL, Fan HC, Lo WT, Wang CC, Sytwu HK * Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis. Clinical and Developmental Immunology (accepted) (SCI)

28.      Chen SJ, Liu YL, Huey-Kang Sytwu HK*. Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation. Clinical and Developmental Immunology 2012: Article ID 258391, 10 pages

29.      Lu YC, Chen SJ, Lo WT*. Scarlet fever caused by community-associated methicillin-resistant Staphylococcus aureus. Indian Pediatr 2011;48970;563-5. (SCI)

30.      Hu CF, Fan HC, Chang CF, Lai CC, Lee YJ, Chen SJ*. Chorea: a Rare Presentation of Moyamoya Disease: A Case Report and Literature Review. Fu-Jen Journal of Medicine 2011; 9(2):107-112.

31.      Fan HC, Giiang LH, Huang TY, Juan CJ, Chen JY, Wang AC, Chen SJ*. Cerebrospinal Fluid Flow Quantification of the Cerebral Aqueduct in Children and Adults with Two-Dimensional Cine Phase-Contrast Magnetic Resonance Imaging. Fu-Jen Journal of Medicine 2011; 9(2):59-72.

32.      Fan HC, Hu CF, Jung CJ, Chen SJ*. Current Proceedings of Childhood Stroke. (accepted) Stroke Research and Treatment 2011 Feb 7;2011:432839.

33.      Hu CF, Fan HC, Chang CF, Chen SJ*. Successful treatment of Dandy-Walker syndrome via endoscopic third ventriculostomy in a 6-month-old girl with progressive hydrocephalus: one case report and literature review. Perinatology and Pediatrics 2011 Feb;52(1):42-5. (SCI)