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::: Full time Faculty & Staff

YI-PING CHUANG Associate Professor

YI-PING CHUANG Associate Professor      
YI-PING CHUANG, PhD

Contacts：

Department of Microbiology and Immunology
National Defense Medical Center, Taipei, Taiwan
886-2-8792-3100 ext 18541 (phone)
ypchuang@ndmctsgh.edu.tw

EDUCATIONS:

-B.S., Botany, National Taiwan University, Taipei, Taiwan, 1995~1999
-Ph.D., Microbiology, National Taiwan University, Taipei, Taiwan, 2001~2006
Thesis title: The cps Region Responsible for Capsular Serotype K1 in Klebsiella pneumoniae Causing Human Primary Pyogenic Liver Abscess

PROFESSIONAL EXPERIENCES:

-Postdoctoral Research Scholar (2006-2009)-National Defense Medical Center, Taipei, Taiwan
-Part-time Assistant Professor (2008-2010)-Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan
-Assistant Professor (2010~)-Department of Microbiology and Immunology/ Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

HONORS and Rewards

- 2004 Outstanding Graduate Paper Award, College of Medicine, National Taiwan University.
-2004 14th Wang Ming-Ning Award, Wang Ming-Ning Memorial Foundation.

RESEARCH INTERESTS:

 Bacteria-host interaction and pathogenesis
 Macrophage and tissue resilience

GRANT SUPPORTS:

-2012-2013 National Science Council
Investigation of the pathogenesis of a potential bacterial virulence factor, PI-PLC, in staphylococcal scarlet fever. (Principle Investigator)
-2013-2015 National Science Council
Investigation of the role of glycerophosphodiesterase 2 (glpQ2) in Streptococcus pneumoniae causing complicated pneumonia. (Principle Investigator)
-2016-2016 Ministry of Science and Technology
To Investigate the Immunopathogenesis of Streptococcus pneumoniae
Highly Expression of Phosphorylcholine. (Principle Investigator)
-2017-2017 National Defense Medical Research
Investigation of the role of phosphatidylinositol phospholipase C (PI-PLC) in the secondary bacterial pneumonia after influenza virus infection. (Principle Investigator)
-2018-2018 National Defense Medical Research
To identify pneumococcal choline-binding proteins triggering tissue damage. (Principle Investigator)
-2019-2019 Cheng Hsin General Hospital Foundation
To investigate the virulence role of competence induction during pneumococcal infection (Principle Investigator)
-2019-2020 Chi Mei Medical Center
The role of galectin-3 against pulmonary pneumococcal infection (Principle Investigator)


PUBLICATIONS:
1. Lin YC, Liao YJ, Lee YH, Tseng SF, Liu JY, Chen YS, Shui HA, Lin FZ, Lin KH, Chen YC, Tsai MC, Sytwu HK, Wang CC*, Chuang YP*. Staphylococcal phosphatidylinositol-specific phospholipase C potentiates lung injury via complement sensitisation. Cell Microbiol. 2019 Oct;21(10):e13085. doi: 10.1111/cmi.13085. Epub 2019 Jul 17. PubMed PMID: 31290210.
2. Hsu CF, Hsiao CH, Tseng SF, Chen JR, Liao YJ, Chen SJ, Lin CS, Sytwu HK, Chuang YP*. PrtA immunization fails to protect against pulmonary and invasive infection by Streptococcus pneumoniae. Respir Res. 2018;19:187. doi: org/10.1186/s12931-018-0895-8
3. Teng IJ, Tsai MC, Shih SF, Tsuei BF, Chang H, Chuang YP, Lin CS, Chern CY *, Chen SJ *. Chalcone Derivative Enhance ATP-binding Cassette Transporters A1 in Human THP-1 Macrophages. Molecules. 2018;23(7):1620-1635. doi: 10.3390/molecules23071620
4. Lin CS, Hsieh PS, Hwang LL, Lee YH, Tsai SH, Tu YC, Hung YW, Liu CC, Chuang YP, Liao MT, Chien S, Tsai MC*. The CCL5/CCR5 Axis Promotes Vascular Smooth Muscle Cell Proliferation and Atherogenic Phenotype Switching. Cell Physiol Biochem. 2018;47(2):707-720. doi: 10.1159/000490024. Epub 2018 May 22. PubMed PMID: 29794461.
5. Chen SJ, Kao YH, Jing L, Chuang YP, Wu WL, Liu ST, Huang SM, Lai JH, Ho LJ, Tsai MC, Lin CS*. Epigallocatechin-3-gallate Reduces Scavenger Receptor A Expression and Foam Cell Formation in Human Macrophages. J Agric Food Chem. 2017 Apr 19;65(15):3141-3150. doi: 10.1021/acs.jafc.6b05832.
6. Chen SJ, Lai KC, Shih FY, Chuang YP, Mao YC, Liao WI , Yang PL , Lan KC*. Electronic Referral System for Transferred Patients with Acute Myocardial Infarction. J Med Sci. 2015 Dec;35(6):248-253. doi: 10.4103/1011-4564.173003.
7. Chuang YP*, Peng ZR, Tseng SF, Lin YC, Sytwu HK, Hsieh YC*. The impact of glpQ2 gene on virulence in a Streptococcus pneumoniae serotype 19AST320 strain. Infect Immun. 2015 Feb;83(2):682-92. doi: 10.1128/IAI.02357-14. Epub 2014 Nov 24. (Chuang and Hsieh are co-corresponding authors.)
8. Lin TL, Chuang YP, Huang YT, Hsieh PF, Lin YT, Wang JT*. Identification of an immuno-dominant protein from Klebsiella pneumoniae strains causing pyogenic liver abscess: implication in serodiagnosis. BMC Microbiol. 2014 Dec 21;14(1):321. [Epub ahead of print]
9. Yeh LT., Chuang YP, Chen SJ, Chu CC, Sytwu HK*. Diabetic animal models with infectious diseases: focus on the dysfunction of immune system. Journal of Diabetes & Metabolism 2014. 5:8
10. Yeh LT, Miaw SC, Lin MH, Chou FC, Shieh SJ, Chuang YP, Lin SH, Chang DM, Sytwu HK*. Different modulation of ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice. J Immunol. 2013 Jul 15;191(2):594-607.
11. Yang SM, Ka SM, Hua KF, Wu TH, Chuang YP, Lin YW, Yang FL, Wu SH, Yang SS, Lin SH, Chang JM, Chen A*. Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome. Free Radic Biol Med. 2013 Apr 6;61C:285-297.
12. Chuang YP, Wang CH, Wang NC, Chang DM, Sytwu HK*. Modulatory function of invariant natural killer T cells in systemic lupus erythematosus. Clin Dev Immunol. 2012;2012:478429. doi: 10.1155/2012/478429. Epub 2012 Jun 13. Review.
13. Chuang YP, Lin YC, Sytwu HK*. α-Galactosylceramide ameliorates autoimmunediabetes in non-obese diabetic mice through a suppressive effect mediated by CD8+T cells. Immunol Lett. 2011 Jul;138(1):54-62.
14. Chen YW, Lin GJ, Chuang YP, Chia WT, Hueng DY, Lin CK, Nieh S, Sytwu HK*. Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells. Anticancer Drugs. 2010 Jun;21(5):502-13.
15. Chen YW, Lin GJ, Chia WT, Lin CK, Chuang YP, Sytwu HK*. Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo. Oral Oncol. 2009 Jul;45(7):562-8.
16. Chuang YP, Chu CH, Sytwu HK*. Genetic manipulation of islet cells in autoimmune diabetes: from bench to bedside. Front Biosci. 2008 May 1;13:6155-69. Review.
17. Chuang YP, Fang CT, Lai SY, Chang SC, Wang JT*. Genetic determinants of capsular serotype K1 of Klebsiella pneumoniae causing primary pyogenic liver abscess. J Infect Dis. 2006 Mar 1;193(5):645-54.
18. Fang CT, Chuang YP, Shun CT, Chang SC, Wang JT*. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med. 2004 Mar 1;199(5):697-705. (Fang and Chuang are co-first authors.)
19. Fang CT, Chen HC, Chuang YP, Chang SC, Wang JT*. Cloning of a cation efflux pump gene associated with chlorhexidine resistance in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2002 Jun;46(6):2024-8.

Other Info

PUBLICATIONS:

  1. Lin YC, Liao YJ, Lee YH, Tseng SF, Liu JY, Chen YS, Shui HA, Lin FZ, Lin KH, Chen YC, Tsai MC, Sytwu HK, Wang CC*, Chuang YP*. Staphylococcal phosphatidylinositol-specific phospholipase C potentiates lung injury via complement sensitisation. Cell Microbiol. 2019 Oct;21(10):e13085. doi: 10.1111/cmi.13085. Epub 2019 Jul 17. PubMed PMID: 31290210 org/10.1186/s12931-018-0895-8 10.3390/molecules23071620
  2. Lin CS, Hsieh PS, Hwang LL, Lee YH, Tsai SH, Tu YC, Hung YW, Liu CC, Chuang YP, Liao MT, Chien S, Tsai MC*. The CCL5/CCR5 Axis Promotes Vascular Smooth Muscle Cell Proliferation and Atherogenic Phenotype Switching. Cell Physiol Biochem. 2018;47(2):707-720. doi: 10.1159/000490024. Epub 2018 May 22. PubMed PMID: 29794461.
  3. J Agric Food Chem. 2017 Apr 19;65(15):3141-3150. doi: 10.1021/acs.jafc.6b05832.
  4. Chen SJ, Lai KC, Shih FY, Chuang YP, Mao YC, Liao WI , Yang PL , Lan KC*. Electronic Referral System for Transferred Patients with Acute Myocardial Infarction. J Med Sci. 2015 Dec;35(6):248-253. doi: 10.4103/1011-4564.173003. (Chuang and Hsieh are co-corresponding authors.)
  5.   Lin TL, Chuang YP, Huang YT, Hsieh PF, Lin YT, Wang JT*. Identification of an immuno-dominant protein from Klebsiella pneumoniae strains causing pyogenic liver abscess: implication in serodiagnosis. BMC Microbiol. 2014 Dec 21;14(1):321. [Epub ahead of print]
  6. Yeh LT., Chuang YP, Chen SJ, Chu CC, Sytwu HK*. Diabetic animal models with infectious diseases: focus on the dysfunction of immune system. Journal of Diabetes & Metabolism 2014. 5:8
  7. Yeh LT, Miaw SC, Lin MH, Chou FC, Shieh SJ, Chuang YP, Lin SH, Chang DM, Sytwu HK*. Different modulation of ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice. J Immunol. 2013 Jul 15;191(2):594-607.
  8. Yang SM, Ka SM, Hua KF, Wu TH, Chuang YP, Lin YW, Yang FL, Wu SH, Yang SS, Lin SH, Chang JM, Chen A*. Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome. Free Radic Biol Med. 2013 Apr 6;61C:285-297.
  1. , Wang CH, Wang NC, Chang DM, Sytwu HK*. Modulatory function of invariant natural killer T cells in systemic lupus erythematosus. Clin Dev Immunol. 2012;2012:478429. doi: 10.1155/2012/478429. Epub 2012 Jun 13. Review.
  2. , Lin YC, Sytwu HK*. α-Galactosylceramide ameliorates autoimmunediabetes in non-obese diabetic mice through a suppressive effect mediated by CD8+T cells. Immunol Lett. 2011 Jul;138(1):54-62.
  3. Chen YW, Lin GJ, Chuang YP, Chia WT, Hueng DY, Lin CK, Nieh S, Sytwu HK*. Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells. Anticancer Drugs. 2010 Jun;21(5):502-13.
  4. Chen YW, Lin GJ, Chia WT, Lin CK, Chuang YP, Sytwu HK*. Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo. Oral Oncol. 2009 Jul;45(7):562-8., Chu CH, Sytwu HK*. Genetic manipulation of islet cells in autoimmune diabetes: from bench to bedside. Front Biosci. 2008 May 1;13:6155-69. Review.
  1. , Fang CT, Lai SY, Chang SC, Wang JT*. Genetic determinants of capsular serotype K1 of Klebsiella pneumoniae causing primary pyogenic liver abscess. J Infect Dis. 2006 Mar 1;193(5):645-54.
  2. Fang CT, Chuang YP, Shun CT, Chang SC, Wang JT*. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med. 2004 Mar 1;199(5):697-705. (Fang and Chuang are co-first authors.)
  3. Fang CT, Chen HC, Chuang YP, Chang SC, Wang JT*. Cloning of a cation efflux pump gene associated with chlorhexidine resistance in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2002 Jun;46(6):2024-8.

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  • Update Date:2023-09-28
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