Publication
1. Lin T.J., Wu C.Y., Tsai P.Y., Hsu WH, Hua K.F., Chu C.L., Lee Y.C., Chen A., Lee S.L., Lin Y.J., Hsieh C.Y., Yang S.R., Liu F.C.*, Ka S.M*. Accelerated and severe lupus nephritis benefits from M1, an active metabolite of ginsenoside, by regulating NLRP3 Inflammasome and T cell functions in mice. Front Immunol. 2019 Aug 14;10:195
2. Chiu H.W., Li L.H., Hsieh C.Y., Rao Y., Chen F.H., Chen A., Ka S.M.*, Hua K.F*. Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome. Scientific Reports. 2019 Apr 3;9(1):5603.
3. Hsu W.H., Hua K.F., Tuan L.H., Tsai Y.L., Chu L.J., Lee Y.C., Wong W.T., Lee S.L., Lai J.H., Chu C.L., Ho L.J., Chiu H.W., Hsu Y.J., Ka S.M.*, Chen A*. Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions. Nephrology, Dialysis and Transplantation, 2019 May 7. pii: gfz073. doi: 10.1093/ndt/gfz073.
4. Li L.H., Lin J.S., Chiu H.W., Lin W.Y., Ju T.C., Chen F.H., Chernikov O., Liu M.L., Chang J.C., Hsu C.H., Chen A., Ka S.M., Gao H.W., Hua K.F. Mechanistic insight into the activation of the NLRP3 inflammasome by Neisseria gonorrhoeae in macrophages. Frontiers Immunology. 2019 Jul 31;10:1815.
5. Liao W.J., Lin H., Cheng C.F., Ka S.M., Chen A., Yang R.B. SCUBE1-enhanced bone morphogenetic protein signaling protects against renal ischemia-reperfusion injury. Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):329-338.
6. Wu C.Y., Ka S.M., Hua K.F., Yang S.M., Arbiser J.L., Lee T.Y., Yang S.S., Chen A. Tris DBA ameliorates accelerated and severe lupus nephritis in mice by activating Treg cells and autophagy and by inhibiting the NLRP3 inflammasome. J Immunology. 2019 (revised).
7. Shih C.C., Liu P.Y., Chen J.H., Liao M.H., Hsieh C.M., Ka S.M., Wu C.C., Lin H.T., Wu T.H., Chen Y.C. Macrophage expression of E3 ubiquitin ligase Grail protects mice from lipopolysaccharide-induced hyperinflammation and organ injury. PLoS One. 2018 Dec 20;13(12):e0208279.
8. Tsai H.J., Liao M.H., Shih C.C., Ka S.M., Tsao C.M., Wu C.C. Angiotensin-(1-7) attenuates organ injury and mortality in rats with polymicrobial sepsis. Crit Care. 2018 Oct 27;22(1):269.
9. Wu CJ, Tsai YT, Lee IJ, Wu PY, Lu LS, Tsao WS, Huang YJ, Chang CC, Ka SM, Tao MH. Combination of radiation and interleukin 12 eradicates large orthotopic hepatocellular carcinoma through immunomodulation of tumor microenvironment. Oncoimmunology. 2018 Jul 23;7(9):e1477459
10. Chen A., Yang S.S., Lin T.J., Ka S.M. IgA nephropathy: Clearance kinetics of IgA-containing immune complexes. Seminars in Immunopathology. Review. 2018, 40(6), 539-543.
11. Lin YC, Hwu Y, Huang GS, Hsiao M, Lee TT, Yang SM, Lee TK, Chen NY, Yang SS, Chen A, Ka SM. Differential synchrotron X-ray imaging markers based on the renal microvasculature for tubulointerstitial lesions and glomerulopathy. Sci Rep. 2017 Jun 14;7(1):3488.
12. Huang HC, Tsai HJ, Wang CC, Tsao CM, Ka SM, Liaw WJ, Wu CC. Levosimendan mitigates coagulopathy and organ dysfunction in rats with endotoxemia. J Chin Med Assoc. 2017 May 3. pii: S1726-4901(17)30102-8.
13. Chi HH, Hua KF, Lin YC, Chu CL, Hsieh CY, Hsu YJ, Ka SM, Tsai YL, Liu FC, Chen A. IL-36 signaling facilitates the activation of NLRP3 inflammasome and IL-23/IL-17 axis in renal inflammation and fibrosis. J Am Soc Nephrol 2017 Feb 8. 2017 Jul;28(7):2022-2037.
14. Tsai YL, Hua KF, Chen A, Wei CW, Chen WS, Wu CY, Chu CL, Yu YL, Lo CW, Ka SM. NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy. Scientific Reports. 2017 Jan 24;7:41123.
15. Lin TJ, Yang SS, Hua KF, Tsai YL, Lin SH, Ka SM. SPAK plays a pathogenic role in IgA nephropathy through the activation of NF-κB/MAPKs signaling pathway. Free Radic Biol Med. 2016 Aug 9;99:214-224
16. Ka SM, Chao KP, Lin JC, Chen ST, Li WT, Lin CN, Cheng JC, Jheng HL, Chen A, Hua KF. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free Radical Biology & Medicine. 2016 Feb;91:10-24.
17. Shih CC, Liao MH, Hsiao TS, Hii HP, Shen CH, Chen SJ, Ka SM, Chang YL, Wu CC. Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock. PLoS One. 2016 Sep 23;11(9):e0163690
18. Shih CC, Hii HP, Tsao CM, Chen SJ, Ka SM, Liao MH, Wu CC. Therapeutic Effects of Procainamide on Endotoxin-Induced Rhabdomyolysis in Rats. PLoS One. 2016 Feb 26;11(2):e0150319.
19. Wang S, Meng XM, Ng YY, Ma FY, Zhou S, Zhang Y, Yang C, Huang XR, Xiao J, Wang YY, Ka SM, Tang YJ, Chung AC, To KF, Nikolic-Paterson DJ, Lan HY. TGF-β/Smad3 signalling regulates the transition of bone marrow derived macrophages into myofibroblasts during tissue fibrosis. Oncotarget. 2015 Dec 14. doi: 10.18632/oncotarget.6604.
20. Ka SM, Lin JC, Lin TJ, Liu FC, Chao KP, Ho CL, Yeh LT, Sytwu HK, Hua KF, Chen A. Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation. Arthritis Research & Therapy. 2015 Nov 19;17(1):331.
21. Lai SF, Ko BH, Chien CC, Chang CJ, Yang SM, Chen HH, Petibois C, Hueng DY, Ka SM, Chen A, Margaritondo G, Hwu Y. Gold Nanoparticles as Imaging Agents for Brain Gliomas. Nanotechnology, 2015 Nov 20;13(1):85.
22. Chang YP, Ka SM, Hsu WH, Chen A, Chao LK, Lin CC, Hsieh CC, Chen MC, Chiu HW, Ho CL, Chiu YC, Liu ML, Hua KF. Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy. J Cell Physiol. 2015 Jul;230(7):1567-79
23. Hua KF, Chou JC, Ka SM, Tasi YL, Chen A, Wu SH, Chiu HW, Wong WT, Wang YF, Tsai CL, Ho CL, Lin CH. Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1β production. J Cell Physiol. 2015 Apr;230(4):863-74
24. Tsai HJ, Ding C, Tsao CM, Liao MH, Ka SM, Liaw WJ, Wu CC. Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis. Blood Coagul Fibrinolysis. 2015 Mar;26(2):175-84
25. Tsao CM, Li KY, Chen SJ, Ka SM, Liaw WJ, Huang HC, Wu CC. Levosimendan attenuates multiple organ injury and improves survival in peritonitis-induced septic shock: studies in a rat model. Crit Care. 2014 Nov 29;18(6):652
26. Yang SM, Chan YL, Hua KF, Chang JM, Chen HL, Tsai YJ, Hsu YJ, Chao LK, Feng-Ling Y, Tsai YL, Wu SH, Wang YF, Tsai CL, Chen A, Ka SM*. Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis. Free Radic Biol Med. 2014 May 22.
27. Tsao CM, Jhang JG, Chen SJ, Ka SM, Wu TC, Liaw WJ, Huang HC, Wu CC. Adjuvant potential of selegiline in attenuating organ dysfunction in septic rats with peritonitis. PLoS One. 2014 Sep 30;9(9):e108455.
28. Hsu SC, Huang SM, Lin SH, Ka SM, Chen A, Shih MF, Hsu YJ. Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway. Biochem J. 2014 Dec 1;464(2):221-9
29. Wang CW, Ka SM, Chen A. Robust image registration of biological microscopic images. Sci Rep. 2014 Aug 13;4:6050
30. Ka SM, Tsai PY, Chao TK, Yang SM, Hung YJ, Chen JS, Shui HA, Chen A. Urine annexin A1 as an index for glomerular injury in patients. Disease Markers, 2014;2014:854163
31. Hung CY, Huang FL, Shi LS, Ka SM, Wang JY, Tsai YC, Hung TJ, Ye YL. The Ethanol Extract of Osmanthus fragrans Flowers Reduces Oxidative Stress and Allergic Airway Inflammation in an Animal Model. Evid Based Complement Alternat Med. 2013;2013:304290.
32. Yang SM, Ka SM*, Wu HL, Yeh YC, Hua HF, Shi GY, Hung YJ, Hsiao FC, Yang SS, Shieh YS, Lin SH, Wei CW, Lee JS, Yang CY, Chen A. Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis. Diabetologia 2014 Feb;57(2):424-34. (shared corresponding)
33. Hua KF, Chou JC, Lam YL, Tsai YL, Chen A, Ka SM, Fang ZX, Liu ML, Yang FL, Yang YL, Chiu YC, Wu SH. Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression through reduction of reactive oxygen species production and mitogen-activated protein kinase activation. PLoS ONE, 2013. Oct 7;8(10):e76754
34. Ho CL, Lin CY, Ka SM, Chen A, Tsai YL, Liu ML, Chiu YC, Hua KF. Bamboo vinegar decreases inflammatory mediator expression and NLRP3 inflammasome activation by inhibiting reactive oxygen species generation and protein kinase C-alpha/delta activation. PLoS ONE, 2013 Oct 4;8(10):e75738.
35. Hua KF, Yang SM, Kao TY, Chang JM, Chen HL, Tsai YL, Chen A, Yang SS, Chao KP, Ka SM*. Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-kB/NLRP3 pathway. PLOS ONE 2013 Oct 28;8(10):e77794.
36. Yang SM, Ka SM*, Hua KF, Wu TH, Chuang YP, Lin YW, Yang SS, Lin SH, Chang JM, Chen A. Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome. Free Radic Biol Med. 2013 Aug;61:285-97 (shared corresponding)
37. Yang SM, Hua KF, Lin YC, Chen A, Chang JM, Kuoping Chao L, Ho CL, Ka SM*. Citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating nrf2 pathway in mice. PLoS One. 2013 Sep 17;8(9):e74871.
38. Liao PC, Chao KP, Chou JC, Dong WC, Lin CN, Lin CY, Chen A, Ka SM, Ho CL, Hua KF. Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion, Inflammation Research, 2013, 62(1),pp89-96
39. Chian CF, Tsao CM, Chen SJ, Chen ZF, Liaw WJ, Ka SM, Huang HC, Wu CC. Hyperoncotic albumin attenuates lung and intestine injuries caused by peritonitis-induced sepsis in rats. J Surg Res. 2013 Jun 1;182(1):134-41.
40. Shih CC, Tsai MF, Chen SJ, Tsao CM, Ka SM, Huang HC, Wu CC. Effects of small-volume hypertonic saline on acid-base and electrolytes balance in rats with peritonitis-induced sepsis. Shock. 2012 Dec;38(6):649-55
41. Lee JL, Lo CW, Ka SM, Chen A, Chen WS. Prolonging the expression duration of ultrasound-mediated gene transfection using PEI nanoparticles. Journal of Controlled Release (March 2012), doi:10.1016/j.jconrel.2012.03.007
42. Tsai HJ, Tsao CM, Liao MH, Ka SM, Liaw WJ, Wu CC. Application of thrombelastography in liver injury induced by endotoxin in rat. Blood Coagul Fibrinolysis. 2012 Mar;23(2):118-26.
43. Ka SM, Yeh YC, Huang XR, Chao TK, Hung YJ, Yu CP, Lin TJ, Wu CC, Lan HY, Chen A. Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice. Diabetologia. 2012 Feb; 55 (2):509-19.
44. Tsai PY, Ka SM, Chang JM, Lai JH, Dai MS, Jheng HL, Kuo MT, Chen P, Chen A. Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis. Arthritis Rheum. 2012 Jan;64 (1):232-42.
45. Tsai PY, Ka SM*, Chao TK, Chang JM, Lin SH, Li CY, Kuo MT, Chen P, Chen A. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice. Free Radic Biol Med. 2011 Jun 1;50 (11):1503-16. (shared corresponding author)
46. Ka SM, Hsieh TT, Lin SH, Yang SS, Wu CC, Sytwu HK, Chen A. Decoy receptor 3 inhibits renal mononuclear leukocyte infiltration and apoptosis and prevents progression of IgA nephropathy in mice. Am J Physiol Renal Physiol. 2011 Dec;301 (6):F1218-30.
47. Tsai PY, Ka SM, Chang JM, Chen HC, Shui HA, Li CY, Hua KF, Chang WL, Huang JJ, Yang SS, Chen A. Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation. Free Radic Biol Med. 2011 Aug 1;51 (3):744-54.
48. Tsai PY, Ka SM, Chang JM, Chang WL, Huang YJ, Hung LM, Jheng HL, Wu RY, Chen A. Therapeutic potential of DCB-SLE1, an extract of a mixture of Chinese medicinal herbs, for severe lupus nephritis. Am J Physiol Renal Physiol. 2011 Oct;301 (4):F751-64.
49. Huang TH, Ka SM, Hsu YJ, Shui HA, Tang BL, Hu KY, Chen A. Rab23 plays a role in the pathophysiology of mesangial cells – a proteomic analysis. Proteomics, 2011; 11(3):380-94
50. Lee YM, Cheng PY, Chim LS, Kung CW, Ka SM, Chung MT, Sheu JR. Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses. J Ethnopharmacol. 2011 Apr 26;135(1):179-85
51. Ka SM, Kuo YC, Ho PJ, Tsai PY, Hsu YJ, Tsai WJ, Lin YL, Shen CC, Chen A. (S)-armepavine from Chinese medicine has therapeutic effects on experimental autoimmune crescentic glomerulonephritis. Rheumatol, 2010 ;49(10):1840-51
52. Huang TH, Shui HA, Ka SM, Tang BL, Chao TK, Chen A. Rab23 is expressed in the glomerulus and plays a role in the development of focal segmental glomerulosclerosis. Nephrol Dial Transplant 2009; 24:743-54
53. Cheng CW, Ka SM, Yang SM, Shui HA, Ho PC, Chen A. Urine and renal expression of nephronectin in nephrotoxic tubular necrosis. Nephrol Dial Transplant. 2008, 23(1):101-9.
54. Shui HA, Huang TH, Ka SM, Chen PH, Chen A. Urinary proteome and potential biomarkers associated with serial pathogenesis steps of focal segmental glomerulosclerosis. Nephrol Dial Transplant. 2008, 23(1):176-85
55. Ho MY, Sun GH, Leu SJJ, Ka SM, Tang SJ, Sun KH. Combination of FasL and GM-CSF confers synergistic antitumor immunity in an in vivo model of the murine lewis lung carcinoma. International Journal of Cancer. 2008 123(1):123-33.
56. Ka SM, Sytwu HK, Hsieh SL, Chen A. Decoy Receptor 3 Ameliorates Crescentic Lupus Nephritis Model. J Am Soc Nephrol 2007 18(9):2473-85
57. Ka SM, Cheng CW, Shui HA, Wu WM, Chang DM, Lin YJ and Chen A. Mesangial Cells of Lupus-Prone Mice are Sensitive to Chemokine Production. Arthritis Research & Therapy 2007, 9:R67
58. Shui HA, Ka SM, Lo YF, Lin YF, Shu LF and Chen A. Direct induction of mesangial-cell apoptosis by interleukin-18 in accelerated lupus nephritis model. Rheumatol 2007, 46:1277-84.
59. Ka SM, RH Xiao, Hui-Yao Lan, Pei-Yi Tsai, Shun-Min Yang, Hao-Ai Shui, Ann Chen. Smad7 gene therapy ameliorates a crescentic lupus nephritis in mice. J Am Soc Nephrol 2007, 18(6):1777-88.
60. Shui HA, Ka SM, Jin JS, Yang SM, Chen A. Osteopontin as an early biomarker for the development and progression of adriamycin-induced focal segmental glomerulosclerosis. Transl Res. 150: 216-22, 2007
61. Chao TK, Rifai A, Ka SM, Yang SM, Shui HA, Lin YF, Sytwu HK, Lee WH, Kung JT, Chen A. The endogenous immune response modulates the course of IgA-immune complex mediated nephropathy. Kidney Int 2006, 70(2):283-97
62. Shui HA, Ka SM, Lin JC, Lee JH, Jin JS, Lin YF, Sheu LF, Chen A. Fibronectin in blood invokes the development of focal segmental glomerulosclerosis in mouse model. Nephrol Dial Transplant 2006, 21(7):1794-802
63. Ka SM, Rifai A, Chen JH, Cheng CW, Shui HA, Lee HS, Lin YF, Hsu LF, Chen A. Glomerular crescent-related biomarkers in a murine model of chronic graft versus host disease. Nephrol Dial Transplant 2006, 21(2):288-98
64. Cheng CW, Rifai A, Ka SM, Shui HA, Lin YF, Lee WH, Chen A. Calcium-binding proteins annexin A2 and S100A6 are sensors of tubular injury and recovery in acute renal failure. Kidney Int 2005, 68(6):2694-703
65. Chen JS,Lee HS, Jin JS, Chen A, Lin SH, Ka SM, Lin YF. Attenuation of mouse mesangial cell contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase. J Biomed Sci 2004, 11(2):1 42-51
66. Jin JS, Yao CW, Ka SM, Chin TY, Chueh SH,Lee HS, Sheu LF,Lin YF, Lee WH, Chen A. IgA immune complex blunts the contraction of cultured mesangial cells through the inhibition of protein kinase C and intracellular calcium. Chin J Physiol 2004, 47(2):79-87