Professional Experiences

Pharmaceutical experiences
2016-present: Chairman, Mycenax Biotech Inc. Taiwan.
2015-present: Vice President, BioEngine Technology Development Inc. Taiwan
2012 -2015: Vice President and Business Unit Head of Critical Medicine, TTY Biopharm, Taiwan.
Medical experiences
2012: Vice Secretary of the Infectious Diseases Society, Taiwan.
2004- 2012: Attending Physician, Division of Infectious Diseases, Taipei Veterans General Hospital, Taiwan.
2000- 2003: Fellowship of Division of Infectious Diseases, Taipei Veterans General Hospital, Taiwan.
1997 -1999: Medical Resident in Taipei Veterans General Hospital, Taiwan. Scientific experiences
2016- present: Professor, Graduate Institute of Life Science, National Defense Medical Center,Taiwan.
2012-2016 Associate Professor, School of Medicine, National Yang-Ming University,Taiwan.
2008- 2012: Assistant Professor, School of Medicine, National Yang-Ming University, Taiwan.
2003- 2008: Lecturer, School of Medicine, National Yang-Ming University, Taiwan.

Research Interests

Internal Medicine, Infectious diseases, Drug development
Medical and molecular microbiology, bussiness management,

Recent Publications ：(* corresponding author)

1. Yang YS, Chen HY, Hsu WJ, Chou YC, Perng CL, Shang HS, Hsiao YT, Sun JR; ACTION study group. Overexpression of AdeABC efflux pump associated with tigecycline resistance in clinical Acinetobacter nosocomialis isolates. Clin Microbiol Infect. 2019 Apr;25(4):512.e1-512.e6.

2. Liu YH, Kuo SC, Yao BY, Fang ZS, Lee YT, Chang YC, Chen TL*, CMJ Hu *. Colistin nanoparticle assembly by coacervate complexation with polyanionic peptides for treating drug-resistant gram-negative bacteria. Acta Biomater. 2018 Dec;82:133-142.

3. Lee IM, Yang FL, Chen TL, Liao KS, Ren CT, Lin NT, Chang YP, Wu CY, Wu SH. Pseudaminic acid on exopolysaccharide of Acinetobacter baumannii plays a critical role in phage-assisted preparation of glycoconjugate vaccine with high antigenicity. J Am Chem Soc. 2018 Jul 18;140(28):8639-8643.

4. Wang YC, Huang TW, Yang YS, Kuo SC, Chen CT, Liu CP, Liu YM, Chen TL, Chang FY, Wu SH, How CK, Lee YT. Biofilm formation is not associated with worse outcome in Acinetobacter baumannii bacteraemic pneumonia. Sci Rep. 2018 May 8;8(1):7289.

5. Liu CP, Chiang TT, Liu YM, Kuo SC, Yang YS, Lee YT, Chen TL, Shih SC; ACTION Study Group. A multicenter study on clinical characteristics of Acinetobacter bacteremia in patients with liver cirrhosis. J Microbiol Immunol Infect. 2018 Apr 25. pii: S1684-1182(18)30070-7.

6. Chang YY, Liu YM, Liu CP, Kuo SC, Chen TL; ACTION study group. Impact of reduced tigecycline susceptibility on clinical outcomes of Acinetobacter bacteremia. J Microbiol Immunol Infect. 2018 Feb;51(1):148-152.

7. Kuo SC, Huang WC, Huang TW, Wang HY, Lai JF, Chen TL, Lauderdale TL. Molecular Epidemiology of Emerging blaOXA-23-Like- and blaOXA-24-Like-Carrying Acinetobacter baumannii in Taiwan. Antimicrob Agents Chemother. 2018 Mar; 62(3): e01215-17.

8. Chen CT, Wang YC, Kuo SC, Shih FH, Chen TL, How CK, Yang YS, Lee YT. Community-acquired bloodstream infections caused by Acinetobacter baumannii: A matched case-control study. J Microbiol Immunol Infect. 2017 Jun 29. pii: S1684-1182(17)30106-8.

9. Lee YT, Wang YC, Kuo SC, Chen CT, Liu CP, Liu YM, Chen TL, Yang YS. Multicenter Study of Clinical Features of Breakthrough Acinetobacter Bacteremia during Carbapenem Therapy. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00931-17.

10. Wu MS, Collier S, Liu PY, Lee YT, Kuo SC, Yang YS, Chen TL, Shi ZY, Lin CF. Sensitivity and specificity of Matrix-Associated Laser Desorption/Ionization - Time of Flight Mass Spectrometry (MALDI-TOF MS) in discrimination at species level for Acinetobacter bacteremia. J Microbiol Methods. 2017 Jun 29;140:58-60.

11. Yang YS, Wang YC, Kuo SC, Chen CT, Liu CP, Liu YM, Chen TL, Lee YT. Multicenter Study of the Relationship between Carbapenem MIC Values and Clinical Outcome of Patients with Acinetobacter Bacteremia. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00661-17.

12. Chiang MH, Wu HH, Shih CJ, Chen YT, Kuo SC, Chen TL. Association between influenza vaccination and reduced risks of major adverse cardiovascular events in elderly patients. Am Heart J. 2017 Nov;193:1-7.

13. Liu YM, Lee YT, Kuo SC, Chen TL, Liu CP, Liu CE. Comparison between bacteremia caused by Acinetobacter pittii and Acinetobacter nosocomialis. J Microbiol Immunol Infect. 2017 Feb;50(1):62-67.

14. Lai JH, Yang JT, Chern J, Chen TL, Wu WL, Liao JH, Tsai SF, Liang SY, Chou CC, Wu SH. Comparative phosphoproteomics reveals the role of AmpC β-lactamase phosphorylation in the clinical imipenem-resistant strain Acinetobacter baumannii SK17. Mol Cell Proteomics. 2016 Jan;15(1):12-25.

15. Lin KH, Chen CM, Chen TL, Kuo SC, Kao CC, Jeng YC, Ho MW. Diabetes mellitus is associated with acquisition and increased mortality in HIV-uninfected patients with cryptococcosis: A population-based study. J Infect. 2016 May;72(5):608-14.

16. Yang YS, Lee Y, Tseng KC, Huang WC, Chuang MF, Kuo SC, Yang Lauderdale TL, Chen TL. In vivo and in vitro efficacy of minocycline-based combination therapy for minocycline-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4047-54.

17. Wang YC, Chen YT, Kuo SC, Chen TL, Chang FY. Rapid hypoglycemia onset associated with antimicrobial use in patients with diabetes: A nationwide population-based case-crossover study. Eur J Intern Med. 2016 May 24. pii: S0953-6205(16)30127-3.

18. Chiu CH, Liu YH, Wang YC, Lee YT, Kuo SC, Chen TL*, Lin JC, Wang FD.In vitro activity of SecA inhibitors in combination with carbapenems against carbapenem-hydrolysing class D β-lactamase-producing Acinetobacter baumannii. J Antimicrob Chemother. 2016 Dec;71(12):3441-3448.

19. Wang YC, Kuo SC, Yang YS, Lee YT, Chiu CH, Chuang MF, Lin JC, Chang FY, Chen TL*. Individual or Combined Effects of Meropenem, Imipenem, Sulbactam, Colistin, and Tigecycline on Biofilm-Embedded Acinetobacter baumannii and Biofilm Architecture. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4670-6.

20. Lee YT, Chiang MC, Kuo SC, Wang YC, Lee IH, Chen TL, Yang YS. Carbapenem Breakpoints for Acinetobacter baumannii Group: Supporting Clinical Outcome Data from Patients with Bacteremia. PLoS One. 2016 Sep 19;11(9):e0163271.

21. Lee Y, Lee YT, Wang YC, Chen CT, Sun JR, Liu CP, Liu YM, Kuo SC, Chiu CH, Yang YS, Lin JC, Chen TL. Risk of Mortality of Catheter-Related Bloodstream Infections Caused by Acinetobacter Species: Is Early Removal of the Catheters Associated With a Better Survival Outcome? J Intensive Care Med. 2018 Jun;33(6):361-369.

22. Siu LK, Tsai YK, Lin JC, Chen TL, Fung CP, Chang FY. Development of a Colloidal Gold-Based Immunochromatographic Strip for Rapid Detection of Klebsiella pneumoniae Serotypes K1 and K2. J Clin Microbiol. 2016 Dec;54(12):3018-3021.

23. Ku WW, Kung CH, Lee CH, Tseng CP, Wu PF, Kuo SC, Chen TL, Lee YT, Wang FD, Fung CP. Evolution of carbapenem resistance in Acinetobacter baumannii: An 18-year longitudinal study from a medical center in northern Taiwan. J Microbiol Immunol Infect. 2015 Feb;48(1):57-64.

24. Yang YS, Lee YT, Wang YC, Chiu CH, Kuo SC, Sun JR, Yin T, Chen TL*, Lin JC, Fung CP, Chang FY. Molecular epidemiology of carbapenem non-susceptible Acinetobacter nosocomialis in a medical center in Taiwan. Infect Genet Evol. 2015 Apr;31:305-11.

25. Kung CH, Ku WW, Lee CH, Fung CP, Kuo SC, Chen TL, Lee YT. Epidemiology and risk factors of community-onset urinary tract infection caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae in a medical center in Taiwan: a prospective cohort study. J Microbiol Immunol Infect. 2015 Apr;48(2):168-74.

26. Lee CH, Lee YT, Kung CH, Ku WW, Kuo SC, Chen TL, Fung CP. Risk factors of community-onset urinary tract infections caused by plasmid-mediated AmpC β-lactamase-producing Enterobacteriaceae. J Microbiol Immunol Infect. 2015 Jun;48(3):269-75.

27. Kuo SC, Lee YT, Yang Lauderdale TL, Huang WC, Chuang MF, Chen CP, Su SC, Lee KR, Chen TL*. Contribution of Acinetobacter-derived cephalosporinase-30 to sulbactam resistance in Acinetobacter baumannii. Frontiers in Microbiology. 2015. Mar 25;6:231.

28. Pan CY, Chen JC, Chen TL*, Wu JL, Hui CF, Chen JY*. Piscidin is Highly Active against Carbapenem- Resistant Acinetobacter baumannii and NDM-1- Producing Klebsiella pneumoniae in a Systemic Septicaemia Infection Mouse Model. Mar. Drugs 2015; 13: 2287-2305.
29. Wang YC, Lee YT, Yang YS, Chen CT,
Chiu CH, Yin T, Kuo SC, Chen TL*, Lin JC, Wang FD, Fung CP, Chang FY. Risk factors and outcome for colistin-resistant Acinetobacter nosocomialis bacteraemia in patients without previous colistin exposure. Clin Microbiol Infect. 2015 Aug;21(8):758-64.

30. Huang TW, Lauderdale TL, Liao TL, Hsu MC, Chang FY, Chang SC, Khong WX, Ng OT, Chen YT, Kuo SC, Chen TL, Mu JJ, Tsai SF. Effective transfer of a 47 kb NDM-1-positive plasmid among Acinetobacter species. J Antimicrob Chemother. 2015 Oct;70(10):2734-8.

31. Liao YT, Kuo SC, Chiang MH, Lee YT, Sung WC, Chen YH, Chen TL*, Fung CP. Acinetobacter baumannii extracellular OXA-58 is primarily and selectively released via outer membrane vesicles after Sec-dependent periplasmic translocation. Antimicrob Agents Chemother. 2015 Dec;59(12):7346-54.

32. Chiu CH, Lee YT, Wang YC, Yin T, Kuo SC, Yang YS, Chen TL*, Lin JC, Wang FD, Fung CP. A retrospective study of the incidence, clinical characteristics, identification, and antimicrobial susceptibility of bacteremic isolates of Acinetobacter ursingii. BMC Infect Dis. 2015 Sep 30;15(1):400.

33. Kung CH, Kuo SC, Chen TL, Weng WS. Isolation of vaccinia JX594 from pustules following therapy for hepatocellular carcinoma. BMC Cancer. 2015 Oct 15;15(1):704.