Education

Ph.D., Life Sciences, National Defense Medical Center, Taiwan

Professional Experiences

1.Assistant Professor, Graduate Institute of Life Sciences,
National Defense Medical Center, Taipei, Taiwan

2.Adjunct Assistant Professor, Graduate Institute of Pathology & Parasitology,
National Defense Medical Center, Taipei, Taiwan

Research Interests

Biochemistry and Molecular Biology、
Cell and Molecular Biology、Cancer Biology

Recent Publications

1. Ho JY, Hsu RJ, Liu JM, Chen SC, Liao GS, Gao HW, Yu CP. MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis. Oncotarget. 2017 Apr 4;8(14):22443-22459.

2. Ho JY, Hsu RJ, Wu CH, Liao GS, Gao HW, Wang TH, Yu CP. Reduced miR-550a-3p leads to breast cancer
initiation, growth, and metastasis by increasing levels of ERK1 and 2. Oncotarget. 2016 Aug 16;7(33):53853-53868.

3. Wu CL, Ho JY, Chou SC, Yu DS. MiR-429 reverses epithelial-mesenchymal transition by restoring E-cadherin expression in bladder cancer. Oncotarget. 2016 May 3;7(18):26593-603.

4. Ho JY, Chang FW, Huang FS, Liu JM, Liu YP, Chen SP, Liu YL, Cheng KC, Yu CP, Hsu RJ. Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERα-ΔNp63-Integrin β4 Signaling Pathway. PLoS One. 2016 Feb 4;11(2):e0148301.

5. Tsai YT, Chuang MJ, Tang SH, Wu ST, Chen YC, Sun GH, Hsiao PW, Huang SM, Lee HJ, Yu CP, Ho JY, Lin HK, Chen MR, Lin CC, Chang SY, Lin VC, Yu DS, Cha TL. Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf-DAPK Complex by Raf Inhibitor Combination Therapy. Cancer Res. 2015 Sep 1;75(17):3568-82.

6. Ho JY, Hsu RJ, Wu CL, Chen SH, Wu MY, Yu JC, Gao HW, Yen AM, Chen HH, Yu CP. BRCA1 mislocalization associated with breast carcinogenesis and poor prognosis in Taiwanese women. Eur J Cancer Prev. 2015 Sep;24(5):407-15.

7. Hsu RJ, Hsu YC, Chen SP, Fu CL, Yu JC, Chang FW, Chen YH, Liu JM, Ho JY*, Yu CP*. The triterpenoids of Hibiscus syriacus induce apoptosis and inhibit cell migration in breast cancer cells. BMC Complement Altern Med. 2015 March; 15:65. (equal correspondence)

8. Cha TL, Chuang MJ, Tang SH, Wu ST, Sun KH, Chen TT, Sun GH, Chang SY, Yu CP, Ho JY, Liu SY, Huang SM, Yu DS. Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growth. Mol Carcinog. 2015 Mar;54(3):167-77.

9. Wang TH, Yeh CT, Ho JY, Ng KF, Chen TC. OncomiR miR-96 and miR-182 promote cell proliferation and invasion through targeting ephrinA5 in hepatocellular carcinoma. Mol Carcinog. 2015 Feb 8. doi: 10.1002/mc.22286.

10. Huang CS, Tang SJ, Chung LY, Yu CP, Ho JY, Cha TL, Hsieh CC, Wang HH, Sun GH, Sun KH. Galectin-1 upregulates CXCR4 to promote tumor progression and poor outcome in kidney cancer. J Am Soc Nephrol. 2014 Jul;25(7):1486-95.

11. Lin CY, Ho JY, Hsieh MT, Chiang HL, Chuang JM, Whang-Peng J, Chang YC, Tseng YH, Chen SF, Nieh S, Hwang J. Reciprocal relationship of Tn/NF-κB and sTn as an indicator of the prognosis of oral squamous cell carcinoma. Histopathology. 2014 Apr;64(5):713-21.

12. Ho JY, Hsu RJ, Wu CL, Chang WL, Cha TL, Yu DS, Yu CP. Ovatodiolide targets β-catenin signaling in suppressing tumorigenesis and overcoming drug resistance in renal cell carcinoma. Evid Based Complement Alternat Med. 2013;2013:161628.

13. Yu CP, Ho JY, Huang YT, Cha TL, Sun GH, Yu DS, Chang FW, Chen SP, Hsu RJ. Estrogen Inhibits Renal Cell Carcinoma Cell Progression through Estrogen Receptor-β Activation. PLoS One. 2013;8(2):e56667.

14. Lin YC, Chang YM, Ho JY, Lin HC, Tsai YM, Chiang CP, Wang WM, Gao HW. C-kit Expression of Melanocytic Neoplasm and Association With Clinicopathological Parameters and Anatomic Locations in Chinese People. 2013 Jul;35(5):569-75.

15. Hsu RJ*, Ho JY*, Cha TL, Yu DS, Wu CL, Huang WP, Chu PL, Chen YH, Chen JT, Yu CP. WNT10A plays an oncogenic role in renal cell carcinoma by activating WNT/beta-catenin pathway. PLoS One. 2012;7(10):e47649. (These authors contributed equally to this work)

16. Chen YH, Liu JM, Hsu RJ, Hu SC, Harn HJ, Chen SP, Jeng JR, Wu CL, Ho JY*, Yu CP*. Angiotensin converting enzyme DD genotype is associated with severity and sudden cardiac death of acute coronary syndrome in Taiwan – a hospital-based emergency room study. BMC Cardiovasc Disord. 2012 Feb 15;12:6. (equal correspondence)

17. Wang TH*, Chang JL*, Ho JY*, Wu HC, Chen TC. EphrinA5 suppresses colon cancer development by negatively regulating epidermal growth factor receptor stability. FEBS J. 2012 Jan;279(2):251-63. (These authors contributed equally to this work)